The miR‐455‐3p/HDAC2 axis plays a pivotal role in the progression and reversal of liver fibrosis and is regulated by epigenetics

Exosomes derived from human umbilical cord mesenchymal stem cells ameliorate IL-6-induced acute liver injury through miR-455-3p

(2020) Mingyang Shao et al.   Stem Cell Research & Therapy

Blockade of YAP alleviates hepatic fibrosis through accelerating apoptosis and reversion of activated hepatic stellate cells

(2019) Hai-xia Yu et al.   MOLECULAR IMMUNOLOGY

miR-455-3p Alleviates Hepatic Stellate Cell Activation and Liver Fibrosis by Suppressing HSF1 Expression

(2019) Song Wei et al.   Molecular Therapy-Nucleic Acids

The roles of microRNAs in epigenetic regulation

(2019) Qian Yao et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Protective effect of bicyclol against pulmonary fibrosis via regulation of microRNA‐455‐3p in rats

(2019) Ying Zhou et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223

(2019) Carolina Jimenez Calvente et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA 223 3p Negatively Regulates the NLRP3 Inflammasome in Acute and Chronic Liver Injury

(2019) Carolina Jimenez Calvente et al.   MOLECULAR THERAPY

Cinnamic acid rescues behavioral deficits in a mouse model of traumatic brain injury by targeting miR-455-3p/HDAC2

(2019) Shewei Guo et al.   LIFE SCIENCES

Loss of Histone H3 K79 Methyltransferase Dot1l Facilitates Kidney Fibrosis by Upregulating Endothelin 1 through Histone Deacetylase 2

(2019) Long Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

MicroRNAs in the pathogenesis and treatment of progressive liver injury in NAFLD and liver fibrosis

(2018) Qiaozhu Su et al.   ADVANCED DRUG DELIVERY REVIEWS

MiR-455-3p suppresses renal fibrosis through repression of ROCK2 expression in diabetic nephropathy

(2018) Jian Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2

(2018) Tian Lan et al.   HEPATOLOGY

DNA Methylation of PTGIS Enhances Hepatic Stellate Cells Activation and Liver Fibrogenesis

(2018) Xue-yin Pan et al.   Frontiers in Pharmacology

Hepatocyte-specific suppression of microRNA-221-3p mitigates liver fibrosis

(2018) Hsin-Chieh Tsay et al.   JOURNAL OF HEPATOLOGY

Suppression of SUN2 by DNA methylation is associated with HSCs activation and hepatic fibrosis

(2018) Xin Chen et al.   Cell Death & Disease

MicroRNA-455-3p as a potential peripheral biomarker for Alzheimer’s disease

(2017) Subodh Kumar et al.   HUMAN MOLECULAR GENETICS

Effects of dynamic changes in histone acetylation and deacetylase activity on pulmonary fibrosis

(2017) Mingwei Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Methylation of Septin9 mediated by DNMT3a enhances hepatic stellate cells activation and liver fibrogenesis

(2017) Yuting Wu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

MicroRNA-455-3p modulates cartilage development and degeneration through modification of histone H3 acetylation

(2016) Weishen Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Role of histone deacetylases(HDACs) in progression and reversal of liver fibrosis

(2016) Xing Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

PTP1B confers liver fibrosis by regulating the activation of hepatic stellate cells

(2016) Pei-Jie Chen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Unraveling the Mysterious Interactions Between Hepatitis C Virus RNA and Liver-Specific MicroRNA-122

(2016) Peter Sarnow et al.   Annual Review of Virology

Basic mechanisms of longevity: A case study of Drosophila pro-longevity genes

(2015) Ekaterina N. Proshkina et al.   AGEING RESEARCH REVIEWS

Hepatic fibrosis: Concept to treatment

(2015) Christian Trautwein et al.   JOURNAL OF HEPATOLOGY

Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion

(2015) Yuting Wu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program

(2015) Shicheng Su et al.   Nature Communications

Predicting effective microRNA target sites in mammalian mRNAs

(2015) Vikram Agarwal et al.   eLife

The complexity of miRNA-mediated repression

(2014) A Wilczynska et al.   CELL DEATH AND DIFFERENTIATION

MicroRNA-148a is silenced by hypermethylation and interacts with DNA methyltransferase 1 in hepatocellular carcinogenesis

(2014) XIAO-RAN LONG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Selective Non-nucleoside Inhibitors of Human DNA Methyltransferases Active in Cancer Including in Cancer Stem Cells

(2014) Sergio Valente et al.   JOURNAL OF MEDICINAL CHEMISTRY

MicroRNA-101 suppresses liver fibrosis by targeting the TGFβ signalling pathway

(2014) Xiaolong Tu et al.   JOURNAL OF PATHOLOGY

SILAC-based quantitative proteomic analysis of secretome between activated and reverted hepatic stellate cells

(2014) Hongyu Zhang et al.   PROTEOMICS

Brief Communication: The Relationship of Regression of Cirrhosis to Outcome in Chronic Hepatitis C

(2013) Vincent Mallet et al.   ANNALS OF INTERNAL MEDICINE

Histone deacetylases as targets for treatment of multiple diseases

(2013) Jinhua Tang et al.   CLINICAL SCIENCE

Hepatic stellate cells in liver development, regeneration, and cancer

(2013) Chunyue Yin et al.   JOURNAL OF CLINICAL INVESTIGATION

The HDAC interaction network

(2013) I. Livyatan et al.   Molecular Systems Biology

Binge Alcohol-Induced Microvesicular Liver Steatosis and Injury are Associated with Down-Regulation of Hepatic Hdac1, 7, 9, 10, 11 and Up-Regulation of Hdac3

(2012) Irina Kirpich et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Deactivation of Hepatic Stellate Cells During Liver Fibrosis Resolution in Mice

(2012) Juliane S. Troeger et al.   GASTROENTEROLOGY

MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis

(2012) Tomohiro Ogawa et al.   GUT

Inhibitory effects of microRNA 19b in hepatic stellate cell-mediated fibrogenesis

(2012) Ashley M. Lakner et al.   HEPATOLOGY

Fibrogenic cell reversion underlies fibrosis regression in liver

(2012) S. L. Friedman   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

(2012) T. Kisseleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in rats

(2012) Er-Bao Bian et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Distinct Populations of Hepatic Stellate Cells in the Mouse Liver Have Different Capacities for Retinoid and Lipid Storage

(2011) Diana N. D'Ambrosio et al.   PLoS One

Current status of novel antifibrotic therapies in patients with chronic liver disease

(2011) Michal Cohen-Naftaly et al.   Therapeutic Advances in Gastroenterology

The Silencing of MicroRNA 148a Production by DNA Hypermethylation Is an Early Event in Pancreatic Carcinogenesis

(2010) N. Hanoun et al.   CLINICAL CHEMISTRY

Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis

(2010) Christoph Roderburg et al.   HEPATOLOGY

A Sustained Viral Response Is Associated With Reduced Liver-Related Morbidity and Mortality in Patients With Hepatitis C Virus

(2009) Amit G. Singal et al.   Clinical Gastroenterology and Hepatology

Hepatic stellate cell lipid droplets: A specialized lipid droplet for retinoid storage

(2008) William S. Blaner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS