Palmitic acid induces insulin resistance by a mechanism associated with energy metabolism and calcium entry in neuronal cells

Palmitate Is Increased in the Cerebrospinal Fluid of Humans with Obesity and Induces Memory Impairment in Mice via Pro-inflammatory TNF-α

(2020) Helen M. Melo et al.   Cell Reports

Brain-derived neurotrophic factor (BDNF) promotes molecular polarization and differentiation of immature neuroblastoma cells into definitive neurons

(2020) Lenka Hromadkova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Molecular effects of dietary fatty acids on brain insulin action and mitochondrial function

(2019) Chantal Chudoba et al.   BIOLOGICAL CHEMISTRY

Palmitic Acid-Induced NAD+ Depletion is Associated with the Reduced Function of SIRT1 and Increased Expression of BACE1 in Hippocampal Neurons

(2019) Manuel Flores-León et al.   NEUROCHEMICAL RESEARCH

A high-fat diet induces rapid changes in the mouse hypothalamic proteome

(2019) Fiona H. McLean et al.   Nutrition & Metabolism

Insulin modulates hippocampally-mediated spatial working memory via glucose transporter-4

(2018) J. Pearson-Leary et al.   BEHAVIOURAL BRAIN RESEARCH

Different phosphorylation patterns regulate α 1D -adrenoceptor signaling and desensitization

(2018) Marco A. Alfonzo-Méndez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

mTORC1 and IRS1: Another Deadly Kiss

(2018) Amin Ardestani et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

PI3K Signaling in Neurons: A Central Node for the Control of Multiple Functions

(2018) Karina Sánchez-Alegría et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Long-term exposition to a high fat diet favors the appearance of β-amyloid depositions in the brain of C57BL/6J mice. A potential model of sporadic Alzheimer’s disease

(2017) Oriol Busquets et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Palmitic acid stimulates energy metabolism and inhibits insulin/PI3K/AKT signaling in differentiated human neuroblastoma cells: The role of mTOR activation and mitochondrial ROS production

(2017) Erika Calvo-Ochoa et al.   NEUROCHEMISTRY INTERNATIONAL

Co-ordinated activation of classical and novel PKC isoforms is required for PMA-induced mTORC1 activation

(2017) Mengling Liu et al.   PLoS One

Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a

(2017) Matteo Spinelli et al.   Nature Communications

Association between fatty acid metabolism in the brain and Alzheimer disease neuropathology and cognitive performance: A nontargeted metabolomic study

(2017) Stuart G. Snowden et al.   PLOS MEDICINE

Palmitic Acid-BSA enhances Amyloid-β production through GPR40-mediated dual pathways in neuronal cells: Involvement of the Akt/mTOR/HIF-1α and Akt/NF-κB pathways

(2017) Jeong Yeon Kim et al.   Scientific Reports

Effects of Lipoic Acid on High-Fat Diet-Induced Alteration of Synaptic Plasticity and Brain Glucose Metabolism: A PET/CT and 13C-NMR Study

(2017) Zhigang Liu et al.   Scientific Reports

Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning

(2016) Dianxin Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Hippocampal insulin resistance and cognitive dysfunction

(2015) Geert Jan Biessels et al.   NATURE REVIEWS NEUROSCIENCE

Roles and Regulation of Ketogenesis in Cultured Astroglia and Neurons Under Hypoxia and Hypoglycemia

(2014) Shinichi Takahashi et al.   ASN Neuro

Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells

(2014) Bumsup Kwon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

GPR40 activation leads to CREB and ERK phosphorylation in primary cultures of neurons from the mouse CNS and in human neuroblastoma cells

(2014) Marta Zamarbide et al.   HIPPOCAMPUS

Short-Term High-Fat-and-Fructose Feeding Produces Insulin Signaling Alterations Accompanied by Neurite and Synaptic Reduction and Astroglial Activation in the Rat Hippocampus

(2014) Erika Calvo-Ochoa et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice

(2014) Steven E. Arnold et al.   NEUROBIOLOGY OF DISEASE

Increasing Fatty Acid Oxidation Remodels the Hypothalamic Neurometabolome to Mitigate Stress and Inflammation

(2014) Joseph W. McFadden et al.   PLoS One

Fatty Acids in Energy Metabolism of the Central Nervous System

(2014) Alexander Panov et al.   Biomed Research International

Why does Brain Metabolism not Favor Burning of Fatty Acids to Provide Energy? - Reflections on Disadvantages of the Use of Free Fatty Acids as Fuel for Brain

(2013) Peter Schönfeld et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A Ceramide-Centric View of Insulin Resistance

(2012) Jose A. Chavez et al.   Cell Metabolism

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Type 2 Diabetes Associated Changes in the Plasma Non-Esterified Fatty Acids, Oxylipins and Endocannabinoids

(2012) Dmitry Grapov et al.   PLoS One

Activation of KATP channels suppresses glucose production in humans

(2011) Preeti Kishore et al.   JOURNAL OF CLINICAL INVESTIGATION

Brain insulin signaling: A key component of cognitive processes and a potential basis for cognitive impairment in type 2 diabetes

(2011) Ewan C. McNay et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Consumption of a high-fat diet induces central insulin resistance independent of adiposity

(2011) Deborah J. Clegg et al.   PHYSIOLOGY & BEHAVIOR

Protein Kinase C: The "Masters" of Calcium and Lipid

(2011) P. Lipp et al.   Cold Spring Harbor Perspectives in Biology

The Effects of Palmitate on Hepatic Insulin Resistance Are Mediated by NADPH Oxidase 3-derived Reactive Oxygen Species through JNK and p38MAPKPathways

(2010) Dan Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Palmitate Attenuates Insulin Signaling and Induces Endoplasmic Reticulum Stress and Apoptosis in Hypothalamic Neurons: Rescue of Resistance and Apoptosis through Adenosine 5′ Monophosphate-Activated Protein Kinase Activation

(2009) Christopher M. Mayer et al.   ENDOCRINOLOGY

Palmitic acid mediates hypothalamic insulin resistance by altering PKC-θ subcellular localization in rodents

(2009) Stephen C. Benoit et al.   JOURNAL OF CLINICAL INVESTIGATION

Insulin/PI3K signaling protects dentate neurons from oxygen–glucose deprivation in organotypic slice cultures

(2009) Xiaolu Sun et al.   JOURNAL OF NEUROCHEMISTRY

Oleic Acid Directly Regulates POMC Neuron Excitability in the Hypothalamus

(2009) Young-Hwan Jo et al.   JOURNAL OF NEUROPHYSIOLOGY

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

(2008) Kelly A. Posey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Saturated Fatty Acids Inhibit Hepatic Insulin Action by Modulating Insulin Receptor Expression and Post-receptor Signalling

(2008) M. W. Ruddock et al.   JOURNAL OF BIOCHEMISTRY

CPT1c Is Localized in Endoplasmic Reticulum of Neurons and Has Carnitine Palmitoyltransferase Activity

(2008) Adriana Y. Sierra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY