Human cystatin C monomer, dimer, oligomer, and amyloid structures are related to health and disease

Cystatin C as a p53-inducible apoptotic mediator that regulates cathepsin L activity

(2016) Jinichi Mori et al.   CANCER SCIENCE

Amyloid properties of the leader peptide of variant B cystatin C: implications for Alzheimer and macular degeneration

(2016) Ricardo Sant'Anna et al.   FEBS LETTERS

Review: Novel treatment strategies targeting alpha-synuclein in multiple system atrophy as a model of synucleinopathy

(2016) E. Valera et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Significant Correlation between Cystatin C, Cerebral Infarction, and Potential Biomarker for Increased Risk of Stroke

(2015) Qiong Zeng et al.   CURRENT NEUROVASCULAR RESEARCH

A missense variant in CST3 exerts a recessive effect on susceptibility to age-related macular degeneration resembling its association with Alzheimer’s disease

(2015) Joe M. Butler et al.   HUMAN GENETICS

Limited Proteolysis Reveals That Amyloids from the 3D Domain-Swapping Cystatin B Have a Non-Native β-Sheet Topology

(2015) Peter J. Davis et al.   JOURNAL OF MOLECULAR BIOLOGY

Exploring the ‘aggregation-prone’ core of human Cystatin C: A structural study

(2015) Paraskevi L. Tsiolaki et al.   JOURNAL OF STRUCTURAL BIOLOGY

Reduction in glomerular pore size is not restricted to pregnant women. Evidence for a new syndrome: ‘Shrunken pore syndrome’

(2015) Anders Grubb et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Cystatin C Is Not Causally Related to Coronary Artery Disease

(2015) Patrik Svensson-Färbom et al.   PLoS One

Generation of a New Cystatin C-Based Estimating Equation for Glomerular Filtration Rate by Use of 7 Assays Standardized to the International Calibrator

(2014) A. Grubb et al.   CLINICAL CHEMISTRY

The pentapeptide LQVVR plays a pivotal role in human cystatin C fibrillization

(2014) Paraskevi L. Tsiolaki et al.   FEBS LETTERS

Fertility Defects in Mice Expressing the L68Q Variant of Human Cystatin C

(2014) Sandra Whelly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two new types of assays to determine protein concentrations in biological fluids using mass spectrometry of intact proteins with cystatin C in spinal fluid as an example

(2014) Niklas Tyrefors et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Stabilization, Characterization, and Selective Removal of Cystatin C Amyloid Oligomers

(2013) Gustav Östner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

(2013) Mathias Jucker et al.   NATURE

The association between cystatin C and incident type 2 diabetes is related to central adiposity

(2013) Anne T. Reutens et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Steered molecular dynamics simulations on the binding of the appendant structure and helix-β2 in domain-swapped human cystatin C dimer

(2012) Manli Shen et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Steered molecular dynamics simulation of the binding of the β2 and β3 regions in domain-swapped human cystatin C dimer

(2012) Jianwei He et al.   JOURNAL OF MOLECULAR MODELING

Immunotherapy in prion disease

(2012) Yvonne Roettger et al.   Nature Reviews Neurology

Influence of point mutations on the stability, dimerization, and oligomerization of human cystatin C and its L68Q variant

(2012) Aneta Szymańska et al.   Frontiers in Molecular Neuroscience

Cystatin C in Alzheimer's disease

(2012) Gurjinder Kaur et al.   Frontiers in Molecular Neuroscience

Crystallization and preliminary X-ray diffraction analysis of Val57 mutants of the amyloidogenic protein human cystatin C

(2011) Marta Orlikowska et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Identification of the epitope for anti-cystatin C antibody

(2011) Anna Śladewska et al.   JOURNAL OF MOLECULAR RECOGNITION

Cystatin C, Renal Function, and Atherosclerosis in Rheumatoid Arthritis

(2011) R. LERTNAWAPAN et al.   JOURNAL OF RHEUMATOLOGY

Low-resolution structure of a vesicle disrupting  -synuclein oligomer that accumulates during fibrillation

(2011) L. Giehm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High throughput testing of drug library substances and monoclonal antibodies for capacity to reduce formation of cystatin C dimers to identify candidates for treatment of hereditary cystatin C amyloid angiopathy

(2011) Gustav Östner et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Cathepsin B in synovial cells at the site of joint destruction in rheumatoid arthritis

(2010) Andreas Trabandt et al.   ARTHRITIS AND RHEUMATISM

Cathepsins and cystatin C in atherosclerosis and obesity

(2010) Jean-Charles Lafarge et al.   BIOCHIMIE

Crystal structure of human cystatin C stabilized against amyloid formation

(2010) Robert Kolodziejczyk et al.   FEBS Journal

Mysterious oligomerization of the amyloidogenic proteins

(2010) Vladimir N. Uversky   FEBS Journal

Amyloid oligomers: formation and toxicity of Aβ oligomers

(2010) Masafumi Sakono et al.   FEBS Journal

Development of an immunoassay for the detection of cystatin C dimers

(2010) Heidi Hyytiä et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Hinge-loop mutation can be used to control 3D domain swapping and amyloidogenesis of human cystatin C

(2010) Marta Orlikowska et al.   JOURNAL OF STRUCTURAL BIOLOGY

Albuminuria and the risk of incident stroke and stroke types in older adults

(2010) M. I. Aguilar et al.   NEUROLOGY

Immunization Therapy for Alzheimer Disease: A Comprehensive Review of Active Immunization Strategies

(2010) Takeshi Tabira   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

The role of the Val57 amino-acid residue in the hinge loop of the human cystatin C. Conformational studies of the beta2-L1-beta3 segments of wild-type human cystatin C and its mutants

(2009) Sylwia Rodziewicz-Motowidło et al.   BIOPOLYMERS

Cystatins: Biochemical and structural properties, and medical relevance

(2008) ">Vito Turk   Frontiers in Bioscience-Landmark

Dimers Initiate and Propagate Serine Protease Inhibitor Polymerisation

(2007) Aiwu Zhou et al.   JOURNAL OF MOLECULAR BIOLOGY