RANK as a therapeutic target in cancer

Receptor Activator of NF-κB Ligand Promotes the Production of CCL17 from RANK+ M2 Macrophages

(2015) Taku Fujimura et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Possible Interaction between Receptor Activator of Nuclear Factor Kappa-B Ligand Expressed by Extramammary Paget Cells and its Ligand on Dermal Macrophages

(2015) Yumi Kambayashi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Aberrant Activation of the RANK Signaling Receptor Induces Murine Salivary Gland Tumors

(2015) Maria M. Szwarc et al.   PLoS One

RANK expression as a prognostic and predictive marker in breast cancer

(2014) Berit Maria Pfitzner et al.   BREAST CANCER RESEARCH AND TREATMENT

Enhancement of an anti-tumor immune response by transient blockade of central T cell tolerance

(2014) Imran S. Khan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RANKL Promotes Migration and Invasion of Hepatocellular Carcinoma Cells via NF-κB-Mediated Epithelial-Mesenchymal Transition

(2014) Fang-Nan Song et al.   PLoS One

Manipulation of receptor oligomerization as a strategy to inhibit signaling by TNF superfamily members

(2014) J. T. Warren et al.   Science Signaling

Biology of the RANKL–RANK–OPG System in Immunity, Bone, and Beyond

(2014) Matthew C. Walsh et al.   Frontiers in Immunology

RANK expression on breast cancer cells promotes skeletal metastasis

(2013) Michelle L. Blake et al.   CLINICAL & EXPERIMENTAL METASTASIS

Osteoprotegerin: Multiple partners for multiple functions

(2013) Marc Baud’huin et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Importance of reverse signaling of the TNF superfamily in immune regulation

(2013) Kata Juhász et al.   Expert Review of Clinical Immunology

Alternative splicing generates a truncated isoform of human TNFRSF11A (RANK) with an altered capacity to activate NF-κB

(2013) Chaido Sirinian et al.   GENE

Activated human T cells express alternative mRNA transcripts encoding a secreted form of RANKL

(2013) N C Walsh et al.   GENES AND IMMUNITY

NOTCH and NF-κB interplay in chronic lymphocytic leukemia is independent of genetic lesion

(2013) Stefano Baldoni et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Progesterone/RANKL Is a Major Regulatory Axis in the Human Breast

(2013) T. Tanos et al.   Science Translational Medicine

Constitutive activation of RANK disrupts mammary cell fate leading to tumorigenesis

(2013) Pasquale Pellegrini et al.   STEM CELLS

A “vicious cycle” of NK-cell immune evasion in acute myeloid leukemia mediated by RANKL?

(2013) Benjamin Joachim Schmiedel et al.   OncoImmunology

RANK Induces Epithelial-Mesenchymal Transition and Stemness in Human Mammary Epithelial Cells and Promotes Tumorigenesis and Metastasis

(2012) M. Palafox et al.   CANCER RESEARCH

Receptor Activator for NF- B Ligand in Acute Myeloid Leukemia: Expression, Function, and Modulation of NK Cell Immunosurveillance

(2012) B. J. Schmiedel et al.   JOURNAL OF IMMUNOLOGY

Overall Survival Improvement in Patients with Lung Cancer and Bone Metastases Treated with Denosumab Versus Zoledronic Acid: Subgroup Analysis from a Randomized Phase 3 Study

(2012) Giorgio Vittorio Scagliotti et al.   Journal of Thoracic Oncology

Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival

(2012) Steffen Walter et al.   NATURE MEDICINE

Bench to bedside: elucidation of the OPG–RANK–RANKL pathway and the development of denosumab

(2012) David L. Lacey et al.   NATURE REVIEWS DRUG DISCOVERY

Evidence for a link between TNFRSF11A and risk of breast cancer

(2011) Núria Bonifaci et al.   BREAST CANCER RESEARCH AND TREATMENT

Molecular Pathways: Osteoclast-Dependent and Osteoclast-Independent Roles of the RANKL/RANK/OPG Pathway in Tumorigenesis and Metastasis

(2011) W. C. Dougall   CLINICAL CANCER RESEARCH

CCL17 Promotes Intestinal Inflammation in Mice and Counteracts Regulatory T Cell–Mediated Protection From Colitis

(2011) Alexander F. Heiseke et al.   GASTROENTEROLOGY

A RANKL G278R mutation causing osteopetrosis identifies a functional amino acid essential for trimer assembly in RANKL and TNF

(2011) Eleni Douni et al.   HUMAN MOLECULAR GENETICS

RANK-dependent autosomal recessive osteopetrosis: Characterization of five new cases with novel mutations

(2011) Alessandra Pangrazio et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Randomized, Double-Blind Study of Denosumab Versus Zoledronic Acid in the Treatment of Bone Metastases in Patients With Advanced Cancer (Excluding Breast and Prostate Cancer) or Multiple Myeloma

(2011) David H. Henry et al.   JOURNAL OF CLINICAL ONCOLOGY

RANK Is Expressed in Metastatic Melanoma and Highly Upregulated on Melanoma-Initiating Cells

(2011) Verena Kupas et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double-blind study

(2011) Karim Fizazi et al.   LANCET

Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling

(2011) Wei Tan et al.   NATURE

Hormone replacement therapy and the risk of breast cancer

(2011) Steven A. Narod   Nature Reviews Clinical Oncology

Bone metastasis: mechanisms and therapeutic opportunities

(2011) Larry J. Suva et al.   Nature Reviews Endocrinology

Receptor Activator of NF-kB (RANK) Expression in Primary Tumors Associates with Bone Metastasis Occurrence in Breast Cancer Patients

(2011) Daniele Santini et al.   PLoS One

Receptor activator of NF- B (RANK) stimulates the proliferation of epithelial cells of the epidermo-pilosebaceous unit

(2011) V. Duheron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross talk between the bone and immune systems: osteoclasts function as antigen-presenting cells and activate CD4+ and CD8+ T cells

(2010) H. Li et al.   BLOOD

Shedding of RANKL by Tumor-Associated MT1-MMP Activates Src-Dependent Prostate Cancer Cell Migration

(2010) A. L. Sabbota et al.   CANCER RESEARCH

Involvement of integrin up-regulation in RANKL/RANK pathway of chondrosarcomas migration

(2010) Chin-Jung Hsu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis

(2010) Eva Gonzalez-Suarez et al.   NATURE

Control of mammary stem cell function by steroid hormone signalling

(2010) Marie-Liesse Asselin-Labat et al.   NATURE

Progesterone induces adult mammary stem cell expansion

(2010) Purna A. Joshi et al.   NATURE

Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer

(2010) Daniel Schramek et al.   NATURE

Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland

(2010) M. Beleut et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The RANKL signaling axis is sufficient to elicit ductal side-branching and alveologenesis in the mammary gland of the virgin mouse

(2009) Rodrigo Fernandez-Valdivia et al.   DEVELOPMENTAL BIOLOGY

RANK-RANKL Signaling Pathway Is Critically Involved in the Function of CD4 + CD25 + Regulatory T Cells in Chronic Colitis

(2009) Teruji Totsuka et al.   JOURNAL OF IMMUNOLOGY

RANKL Is Necessary and Sufficient to Initiate Development of Antigen-Sampling M Cells in the Intestinal Epithelium

(2009) K. A. Knoop et al.   JOURNAL OF IMMUNOLOGY

Increased RANKL expression is related to tumour migration and metastasis of renal cell carcinomas

(2009) Shuji Mikami et al.   JOURNAL OF PATHOLOGY

Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma

(2009) Mara Compagno et al.   NATURE

Human Osteoclast-Poor Osteopetrosis with Hypogammaglobulinemia due to TNFRSF11A (RANK) Mutations

(2008) Matteo M. Guerrini et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: A twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial

(2008) Stanley B. Cohen et al.   ARTHRITIS AND RHEUMATISM

Juvenile Paget's disease, familial expansile osteolysis and other genetic osteolytic disorders

(2008) Stuart H. Ralston   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

The Tumor Necrosis Factor Family Receptors RANK and CD40 Cooperatively Establish the Thymic Medullary Microenvironment and Self-Tolerance

(2008) Taishin Akiyama et al.   IMMUNITY

RANK ligand inhibition plus docetaxel improves survival and reduces tumor burden in a murine model of prostate cancer bone metastasis

(2008) R. E. Miller et al.   MOLECULAR CANCER THERAPEUTICS