The rise and fall of the CD28 superagonist TGN1412 and its return as TAB08: a personal account

In vivo activation of Treg cells with a CD28 superagonist prevents and ameliorates chronic destructive arthritis in mice

(2016) Stephanie J. Win et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulatory T Cells Ameliorate Intrauterine Growth Retardation in a Transgenic Rat Model for PreeclampsiaNovelty and Significance

(2015) Lukasz Przybyl et al.   HYPERTENSION

Foxp3 + CD4 + T Cells Improve Healing After Myocardial Infarction by Modulating Monocyte/Macrophage Differentiation

(2014) Johannes Weirather et al.   CIRCULATION RESEARCH

Cytokine release assays: Current practices and future directions

(2014) D. Finco et al.   CYTOKINE

Cell Contact-Dependent Priming and Fc Interaction with CD32+ Immune Cells Contribute to the TGN1412-Triggered Cytokine Response

(2014) P. Bartholomaeus et al.   JOURNAL OF IMMUNOLOGY

Human regulatory T cells are selectively activated by low-dose application of the CD28 superagonist TGN1412/TAB08

(2013) Paula Tabares et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Low-Dose Interleukin-2 Therapy Restores Regulatory T Cell Homeostasis in Patients with Chronic Graft-Versus-Host Disease

(2013) K.-i. Matsuoka et al.   Science Translational Medicine

ICOS-LICOS interaction is critically involved in TGN1412-mediated T-cell activation

(2012) S. Weissmuller et al.   BLOOD

Regulatory T cells attenuate neuropathic pain following peripheral nerve injury and experimental autoimmune neuritis

(2012) Paul J. Austin et al.   PAIN

CD28 Superagonist Antibody Treatment Attenuated Obliterative Bronchiolitis in Rat Allo-Orthotopic Tracheal Transplantation by Preferentially Expanding Foxp3-Expressing Regulatory T Cells

(2012) Q. Shi et al.   TRANSPLANTATION PROCEEDINGS

Preculture of PBMCs at high cell density increases sensitivity of T-cell responses, revealing cytokine release by CD28 superagonist TGN1412

(2011) P. S. Romer et al.   BLOOD

Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells

(2010) D Eastwood et al.   BRITISH JOURNAL OF PHARMACOLOGY

CD28 superagonist-induced regulatory T cell expansion ameliorates mesangioproliferative glomerulonephritis in rats

(2010) Kenro Miyasato et al.   Clinical and Experimental Nephrology

The effects of Foxp3-expressing regulatory T cells expanded with CD28 superagonist antibody in DSS-induced mice colitis

(2010) Jiajie Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Relative Over-Reactivity of Human versus Chimpanzee Lymphocytes: Implications for the Human Diseases Associated with Immune Activation

(2010) P. C. Soto et al.   JOURNAL OF IMMUNOLOGY

Type 1 Diabetes in BioBreeding Rats Is Critically Linked to an Imbalance between Th17 and Regulatory T Cells and an Altered TCR Repertoire

(2010) J. van den Brandt et al.   JOURNAL OF IMMUNOLOGY

Regulatory T Cells Protect from Local and Systemic Bone Destruction in Arthritis

(2010) M. M. Zaiss et al.   JOURNAL OF IMMUNOLOGY

Safety and immunotoxicity assessment of immunomodulatory monoclonal antibodies

(2010) Frank R. Brennan et al.   mAbs

Superagonistic CD28 stimulation of allogeneic T cells protects from acute graft-versus-host disease

(2009) N. Beyersdorf et al.   BLOOD

Rapid Regulatory T-Cell Response Prevents Cytokine Storm in CD28 Superagonist Treated Mice

(2009) Tea Gogishvili et al.   PLoS One

Superagonistic CD28 Antibody Induces Donor-Specific Tolerance in Rat Renal Allografts

(2008) H. Azuma et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Proliferative signals mediated by CD28 superagonists require the exchange factor Vav1 but not phosphoinositide 3-kinase in primary peripheral T cells

(2008) Tea Gogishvili et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Toward experimental assessment of receptor occupancy: TGN1412 revisited

(2008) Zoe Waibler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Foxp3-expressing Regulatory T Cells Expanded With CD28 Superagonist Antibody Can Prevent Rat Cardiac Allograft Rejection

(2008) Yusuke Kitazawa et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Experimental Expansion of the Regulatory T Cell Population Increases Resistance to African Trypanosomiasis

(2008) Martin Guilliams et al.   JOURNAL OF INFECTIOUS DISEASES

Signaling Signatures and Functional Properties of Anti-Human CD28 Superagonistic Antibodies

(2008) Zoe Waibler et al.   PLoS One