Determination of the substrate repertoire of ADAMTS2, 3, and 14 significantly broadens their functions and identifies extracellular matrix organization and TGF-β signaling as primary targets

ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis

(2015) Lauriane Janssen et al.   ANGIOGENESIS

The procollagen N-proteinases ADAMTS2, 3 and 14 in pathophysiology

(2015) Mourad Bekhouche et al.   MATRIX BIOLOGY

Proteolytic control of TGF-β co-receptor activity by BMP-1/tolloid-like proteases revealed by quantitative iTRAQ proteomics

(2014) Frédéric Delolme et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

CCBE1 Enhances Lymphangiogenesis via A Disintegrin and Metalloprotease With Thrombospondin Motifs-3–Mediated Vascular Endothelial Growth Factor-C Activation

(2014) Michael Jeltsch et al.   CIRCULATION

ProteomeXchange provides globally coordinated proteomics data submission and dissemination

(2014) Juan A Vizcaíno et al.   NATURE BIOTECHNOLOGY

ADAMTS14 gene polymorphism associated with knee osteoarthritis in Thai women

(2013) T. Poonpet et al.   GENETICS AND MOLECULAR RESEARCH

Downregulation of Dickkopf-3 disrupts prostate acinar morphogenesis through TGF- /Smad signalling

(2013) D. Romero et al.   JOURNAL OF CELL SCIENCE

Dickkopf Homolog 3 (DKK3) Plays a Crucial Role Upstream of WNT/β-CATENIN Signaling for Sertoli Cell Mediated Regulation of Spermatogenesis

(2013) Deepika Sharma Das et al.   PLoS One

A genome-wide association study identifies a gene network of ADAMTS genes in the predisposition to pediatric stroke

(2012) A. Arning et al.   BLOOD

The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10

(2012) Tamara Jefferson et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Granzyme B Cleaves Decorin, Biglycan and Soluble Betaglycan, Releasing Active Transforming Growth Factor-β1

(2012) Wendy A. Boivin et al.   PLoS One

Microenvironmental Regulation by Fibrillin-1

(2012) Gerhard Sengle et al.   PLoS Genetics

Protease profiling of liver fibrosis reveals the ADAM metallopeptidase with thrombospondin type 1 motif, 1 as a central activator of transforming growth factor beta

(2011) Katia Bourd-Boittin et al.   HEPATOLOGY

Expression of ADAMTS-2, -3, -13, and -14 in culprit coronary lesions in patients with acute myocardial infarction or stable angina

(2011) Cheol Whan Lee et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Identifying and quantifying proteolytic events and the natural N terminome by terminal amine isotopic labeling of substrates

(2011) Oded Kleifeld et al.   Nature Protocols

ADAMTS-2 functions as anti-angiogenic and anti-tumoral molecule independently of its catalytic activity

(2010) J. Dubail et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Broad Coverage Identification of Multiple Proteolytic Cleavage Site Sequences in Complex High Molecular Weight Proteins Using Quantitative Proteomics as a Complement to Edman Sequencing

(2010) Alain Doucet et al.   MOLECULAR & CELLULAR PROTEOMICS

Multiplex N-terminome Analysis of MMP-2 and MMP-9 Substrate Degradomes by iTRAQ-TAILS Quantitative Proteomics

(2010) Anna Prudova et al.   MOLECULAR & CELLULAR PROTEOMICS

Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products

(2010) Oded Kleifeld et al.   NATURE BIOTECHNOLOGY

Emerging roles of fibronectin in thrombosis

(2010) Lisa M. Maurer et al.   THROMBOSIS RESEARCH

Betaglycan has Two Independent Domains Required for High Affinity TGF-β Binding: Proteolytic Cleavage Separates the Domains and Inactivates the Neutralizing Activity of the Soluble Receptor

(2009) Valentín Mendoza et al.   BIOCHEMISTRY

Improved visualization of protein consensus sequences by iceLogo

(2009) Niklaas Colaert et al.   NATURE METHODS

Dkk3, downregulated in cervical cancer, functions as a negative regulator of β-catenin

(2008) Eun-Ju Lee et al.   INTERNATIONAL JOURNAL OF CANCER

Bone Morphogenetic Proteins Signal through the Transforming Growth Factor-β Type III Receptor

(2008) Kellye C. Kirkbride et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes

(2008) J. Rodriguez-Lopez et al.   OSTEOARTHRITIS AND CARTILAGE