Review
Immunology
Lucas Albacete-Albacete, Miguel Sanchez-alvarez, Miguel Angel del Pozo
Summary: ECM composition and architecture are tightly regulated, with diseases associated to alterations in the levels of proteins such as TnC. EV-dependent ECM secretion may be a key mechanism underlying diseases related to ECM integrity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Daixi Ren, Yongzhen Mo, Mei Yang, Dan Wang, Yumin Wang, Qijia Yan, Can Guo, Wei Xiong, Fuyan Wang, Zhaoyang Zeng
Summary: Transfer RNAs (tRNAs) play crucial roles in genetic information transmission and their abnormalities can lead to translation disorders and diseases, including cancer. Complex modifications enable tRNA to perform its delicate biological functions. Dysregulation of tRNA modifications has been confirmed to play an important role in carcinogenesis. Moreover, impaired tRNA stability can result in the cleavage of tRNAs into small tRNA fragments (tRFs) by specific RNases. Although tRFs have been found to have vital regulatory roles in tumorigenesis, the process of their formation remains unclear. Understanding improper tRNA modifications and abnormal formation of tRFs in cancer is beneficial for uncovering the role of tRNA metabolism under pathological conditions and may lead to new avenues for cancer prevention and treatment.
Review
Chemistry, Multidisciplinary
Meng-Ke Wang, Chun-Chun Gao, Yun-Gui Yang
Summary: This article explores the roles of RNA modifications in various developmental processes. The distribution characteristics, catalytic enzymes, binding proteins, and development of sequencing technologies of different RNA modifications are discussed. Various RNA modifications play important roles in regulating RNA metabolism, translation, stability, and export, and are involved in physiological and pathological processes such as stress regulation, immune response, development, and tumorigenesis.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Review
Immunology
Yingnan Liao, Kui Liu, Liyuan Zhu
Summary: Cardiovascular diseases are a major health problem globally, and inflammasomes play a significant role in these diseases. Among them, NLRP3 inflammasome has been extensively studied for its involvement in immune response and disease development.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Ming Yue, Mengjiao Hu, Fangda Fu, Hongfeng Ruan, Chengliang Wu
Summary: In allergic asthma, platelets are abnormally activated and recruited to the lungs, interacting with other immune cells and releasing biochemical mediators to promote allergic sensitization and airway inflammatory response. However, the comprehensive roles of platelets in allergic asthma have not been fully clarified, and the efficacy of antiplatelet treatments remains uncertain.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Qinglan Wang, Danni Yang, Yinan Zuo, Dan Wang, Weimin Li
Summary: Tuberculosis is a global health issue, and circRNAs are a new class of noncoding RNAs that can regulate host anti-TB immune responses, potentially serving as diagnostic biomarkers.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Mingyan Wu, Guangdong Li, Wenjun Wang, Hongsheng Ren
Summary: This paper reviews the role of microRNAs in septic cardiomyopathy and aims to provide new targets for the diagnosis and treatment of septic cardiomyopathy.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Cell Biology
Dean Rao, Chengpeng Yu, Jiaqi Sheng, Enjun Lv, Wenjie Huang
Summary: Circular RNAs (circRNAs) are a class of stable and resistant non-coding RNAs widely expressed in eukaryotic cells, playing important roles in various diseases. CircRNA Foxhead box O3 (circFOXO3) has been studied extensively in cancers as a molecular sponge. Understanding the roles of circFOXO3 can enrich our knowledge of circRNA functions in cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Jiaqi Shi, Ning Yang, Mingzhi Han, Chen Qiu
Summary: This review provides an overview of the characteristics, key regulators, and pathways of ferroptosis in glioma treatment. The crosstalk between ferroptosis and other programmed cell death in glioma is also discussed, along with the potential application and prospects of ferroptosis as a target for glioma treatment.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Hanadi Ananbeh, Petr Vodicka, Helena Kupcova Skalnikova
Summary: Exosomes may play a role in the spreading of toxic proteins in neurodegenerative diseases and carry molecules with neuroprotective effects. Due to their ability to cross the blood-brain barrier, exosomes hold potential as a source of biomarkers and carriers for HD diagnosis and therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Vasudha Tandon, Laureano de la Vega, Sourav Banerjee
Summary: DYRK2 has been reported as a tumor suppressor in various cancers, but inhibitors of DYRK2 have shown robust antiproliferative properties. DYRK2 regulates proteostasis in cancer and promotes survival in specific cancers.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Review
Oncology
Xiaoyun He, Gaoyan Kuang, Yongrong Wu, Chunlin Ou
Summary: Exosomes are small vesicles secreted by cells and can carry various cargo including RNA, DNA, proteins, and metabolites. Studies have shown that exosomal microRNAs play a crucial role in the progression of diseases such as diabetes mellitus, affecting processes like pancreatic beta-cell injury and insulin resistance. Understanding the mechanisms of exosomal miRNAs in diabetes mellitus can provide valuable insights for identifying diagnostic biomarkers and drug targets.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Immunology
Sindhu Manivasagam, Robyn S. Klein
Summary: IFNLs are antimicrobial cytokines that play key roles in immune host defense and have been identified as a potential therapeutic target for autoimmune diseases by regulating T cell differentiation towards Th1 cells. The signaling pathways of IFNLs during antimicrobial immunity, immunomodulation of immune cells, and induction of autoimmunity have been summarized.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Environmental Sciences
Zongqin Mei, Guofen Liu, Bo Zhao, Zuoshun He, Shiyan Gu
Summary: This article summarizes the harm of lead to the nervous system and the mechanisms of lead-induced neurological diseases, mainly including the roles of DNA methylation, histone modifications, and non-coding RNAs. The summary provides a theoretical basis and direction for the prevention, diagnosis, and treatment of lead-induced neurological diseases in the future.
ENVIRONMENT INTERNATIONAL
(2023)
Review
Geriatrics & Gerontology
Hongyang Shu, Yizhong Peng, Weijian Hang, Na Li, Ning Zhou, Dao Wen Wang
Summary: Ceramide plays a crucial role in cardiovascular diseases and its regulation could be a potential therapeutic target for improving cardiovascular disorders. Controlling ceramide levels may offer new insights into treating cardiovascular diseases in the future.
Review
Biochemistry & Molecular Biology
Lisa M. Maurer, Wenjiang Ma, Deane F. Mosher
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Jielin Xu, Lisa M. Maurer, Brian R. Hoffmann, Douglas S. Annis, Deane F. Mosher
JOURNAL OF BIOLOGICAL CHEMISTRY
(2010)
Article
Biochemistry & Molecular Biology
Lisa M. Maurer, Wenjiang Ma, Nathan L. Eickstaedt, Ian A. Johnson, Bianca R. Tomasini-Johansson, Douglas S. Annis, Deane F. Mosher
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Article
Biochemistry & Molecular Biology
Gemma Harris, Wenjiang Ma, Lisa M. Maurer, Jennifer R. Potts, Deane F. Mosher
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Biochemical Research Methods
S. Farshid Moussavi-Harami, Douglas S. Annis, Wenjiang Ma, Scott M. Berry, Emma E. Coughlin, Lindsay N. Strotman, Lisa M. Maurer, Michael S. Westphall, Joshua J. Coon, Deane F. Mosher, David J. Beebe
JOURNAL OF PROTEOME RESEARCH
(2013)
Article
Multidisciplinary Sciences
Lisa M. Maurer, Douglas S. Annis, Deane F. Mosher
Letter
Hematology
Jillian Lapinski, Lisa M. Maurer, Margaret V. Ragni, Cheryl McShea, James D. Cooper, Frederico Xavier
Letter
Oncology
Rosemarie E. Venier, Lisa M. Maurer, Elena M. Kessler, Sarangarajan Ranganathan, Richard L. McGough, Kurt R. Weiss, Marcus M. Malek, Julia Meade, Jean M. Tersak, Kelly M. Bailey
PEDIATRIC BLOOD & CANCER
(2019)
Article
Medicine, Research & Experimental
Jing Cheng, Linda R. Klei, Nathaniel E. Hubel, Ming Zhang, Rebekka Schairer, Lisa M. Maurer, Hanna B. Klei, Heejae Kang, Vincent J. Concel, Phillip C. Delekta, Eric Dang, Michelle A. Mintz, Mathijs Baens, Jason G. Cyster, Narayanan Parameswaran, Margot Thome, Peter C. Lucas, Linda M. McAllister-Lucas
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Review
Cell Biology
Jing Cheng, Lisa M. Maurer, Heejae Kang, Peter C. Lucas, Linda M. McAllister-Lucas
CELLULAR IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
CL Abram, DF Seals, I Pass, D Salinsky, L Maurer, TM Roth, SA Courtneidge
JOURNAL OF BIOLOGICAL CHEMISTRY
(2003)
Article
Microbiology
C Kirkpatrick, LM Maurer, NE Oyelakin, YN Yoncheva, R Maurer, JL Slonczewski
JOURNAL OF BACTERIOLOGY
(2001)
Article
Microbiology
LM Maurer, E Yohannes, SS Bondurant, M Radmacher, JL Slonczewski
JOURNAL OF BACTERIOLOGY
(2005)
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)