The inhibition of IGF-1 signaling promotes proteostasis by enhancing protein aggregation and deposition

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

The Roles of Cellular and Organismal Aging in the Development of Late-Onset Maladies

(2015) Filipa Carvalhal Marques et al.   Annual Review of Pathology-Mechanisms of Disease

Alzheimer's disease-causing proline substitutions lead to presenilin 1 aggregation and malfunction

(2015) T. Ben-Gedalya et al.   EMBO JOURNAL

BiP and Its Nucleotide Exchange Factors Grp170 and Sil1: Mechanisms of Action and Biological Functions

(2015) Julia Behnke et al.   JOURNAL OF MOLECULAR BIOLOGY

Blocking IGF Signaling in Adult Neurons Alleviates Alzheimer's Disease Pathology through Amyloid-β Clearance

(2015) Géraldine Gontier et al.   JOURNAL OF NEUROSCIENCE

Human Hsp70 Disaggregase Reverses Parkinson’s-Linked α-Synuclein Amyloid Fibrils

(2015) Xuechao Gao et al.   MOLECULAR CELL

Phosphorylation of LC3 by the Hippo Kinases STK3/STK4 Is Essential for Autophagy

(2015) Deepti S. Wilkinson et al.   MOLECULAR CELL

A novel inhibitor of the insulin/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity

(2013) Tayir El-Ami et al.   AGING CELL

IGF-1 receptor antagonism inhibits autophagy

(2013) Maurizio Renna et al.   HUMAN MOLECULAR GENETICS

Insulin/IGF-1-mediated longevity is marked by reduced protein metabolism

(2013) G. J. Stout et al.   Molecular Systems Biology

Insulin/IGF-1 Signaling Regulates Proteasome Activity through the Deubiquitinating Enzyme UBH-4

(2013) Olli Matilainen et al.   Cell Reports

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

RPN-6 determines C. elegans longevity under proteotoxic stress conditions

(2012) David Vilchez et al.   NATURE

Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers

(2012) B. Mannini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quality Control Compartments Coming of Age

(2012) Tziona Ben-Gedalya et al.   TRAFFIC

New Insights into Translational Regulation in the Endoplasmic Reticulum Unfolded Protein Response

(2012) G. D. Pavitt et al.   Cold Spring Harbor Perspectives in Biology

p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects

(2011) Bryan J. Bartlett et al.   Autophagy

TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin/IGF-1 signaling

(2011) Tao Zhang et al.   HUMAN MOLECULAR GENETICS

Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans : rescue by the DAF-16 and HSF-1 pathways

(2011) Andreia Teixeira-Castro et al.   HUMAN MOLECULAR GENETICS

Cyclosporin-A-induced prion protein aggresomes are dynamic quality-control cellular compartments

(2011) T. Ben-Gedalya et al.   JOURNAL OF CELL SCIENCE

Sequestration of Toxic Oligomers by HspB1 as a Cytoprotective Mechanism

(2011) J. Ojha et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

The Extending Network of FOXO Transcriptional Target Genes

(2010) Kristan E. van der Vos et al.   ANTIOXIDANTS & REDOX SIGNALING

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Autophagy gone awry in neurodegenerative diseases

(2010) Esther Wong et al.   NATURE NEUROSCIENCE

Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice

(2009) Ehud Cohen et al.   CELL

Neuronal IGF-1 resistance reduces Aβ accumulation and protects against premature death in a model of Alzheimer’s disease

(2009) Susanna Freude et al.   FASEB JOURNAL

Lifespan extension by suppression of autophagy genes inCaenorhabditis elegans

(2009) Yasufumi Hashimoto et al.   GENES TO CELLS

Prions: Protein Aggregation and Infectious Diseases

(2009) Adriano Aguzzi et al.   PHYSIOLOGICAL REVIEWS

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE