The AMP analog AICAR modulates the Treg/Th17 axis through enhancement of fatty acid oxidation

Immunometabolism of regulatory T cells

(2016) Ryan Newton et al.   NATURE IMMUNOLOGY

Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice

(2016) Isabelle Serr et al.   Nature Communications

Sirolimus and everolimus in kidney transplantation

(2015) Dirk Jan A.R. Moes et al.   DRUG DISCOVERY TODAY

Essential role of mitochondrial energy metabolism in Foxp3+ T-regulatory cell function and allograft survival

(2015) Ulf H. Beier et al.   FASEB JOURNAL

The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo

(2015) Julianna Blagih et al.   IMMUNITY

Normalization of CD4 + T cell metabolism reverses lupus

(2015) Yiming Yin et al.   Science Translational Medicine

Metformin Ameliorates Inflammatory Bowel Disease by Suppression of the STAT3 Signaling Pathway and Regulation of the between Th17/Treg Balance

(2015) Seon-Yeong Lee et al.   PLoS One

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development

(2014) David O’Sullivan et al.   IMMUNITY

Suppression of Murine Allergic Airway Disease by IL-2:Anti-IL-2 Monoclonal Antibody-Induced Regulatory T Cells

(2014) M. S. Wilson et al.   JOURNAL OF IMMUNOLOGY

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(2014) Dae Won Park et al.   MOLECULAR MEDICINE

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

(2014) Luciana Berod et al.   NATURE MEDICINE

Differential effects of AMPK agonists on cell growth and metabolism

(2014) E E Vincent et al.   ONCOGENE

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

mTOR and lymphocyte metabolism

(2013) Hu Zeng et al.   CURRENT OPINION IN IMMUNOLOGY

AMPKα1: A glucose sensor that controls CD8 T-cell memory

(2013) Julia Rolf et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

AMPKα1 deficiency amplifies proinflammatory myeloid APC activity and CD40 signaling

(2013) Kelly Casey Carroll et al.   JOURNAL OF LEUKOCYTE BIOLOGY

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

(2013) Hu Zeng et al.   NATURE

The transcription factor IRF4 is essential for TCR affinity–mediated metabolic programming and clonal expansion of T cells

(2013) Kevin Man et al.   NATURE IMMUNOLOGY

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

(2013) E. L. Pearce et al.   SCIENCE

The Duration of T Cell Stimulation Is a Critical Determinant of Cell Fate and Plasticity

(2013) N. Miskov-Zivanov et al.   Science Signaling

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

Integrated T-cell receptor and costimulatory signals determine TGF-β-dependent differentiation and maintenance of Foxp3+ regulatory T cells

(2011) Leona Gabryšová et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

AMP-activated protein kinase enhances the phagocytic ability of macrophages and neutrophils

(2011) Hong-Beom Bae et al.   FASEB JOURNAL

Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

(2011) Sandra Galic et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

AMPK agonist downregulates innate and adaptive immune responses in TNBS-induced murine acute and relapsing colitis

(2010) Aiping Bai et al.   BIOCHEMICAL PHARMACOLOGY

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

The Protein Tyrosine Kinase Tec Regulates a CD44highCD62L- Th17 Subset

(2010) N. Boucheron et al.   JOURNAL OF IMMUNOLOGY

Novel Anti-Inflammatory Action of 5-Aminoimidazole-4-carboxamide Ribonucleoside with Protective Effect in Dextran Sulfate Sodium-Induced Acute and Chronic Colitis

(2010) A. Bai et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Targeting glucose metabolism with 2-deoxy-D-glucose for improving cancer therapy

(2009) BS Dwarakanath et al.   Future Oncology

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

The multiple facets of mTOR in immunity

(2009) Thomas Weichhart et al.   TRENDS IN IMMUNOLOGY

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

(2008) S. Sauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA