Dysregulated development of IL-17- and IL-21-expressing follicular helper T cells and increased germinal center formation in the absence of RORγt

Regulation of Autoimmune Germinal Center Reactions in Lupus-Prone BXD2 Mice by Follicular Helper T Cells

(2015) Young Uk Kim et al.   PLoS One

Nasal Anti-CD3 Antibody Ameliorates Lupus by Inducing an IL-10-Secreting CD4+CD25-LAP+ Regulatory T Cell and Is Associated with Down-Regulation of IL-17+CD4+ICOS+CXCR5+ Follicular Helper T Cells

(2014) H. Y. Wu et al.   JOURNAL OF IMMUNOLOGY

Neutrophils Contribute to Excess Serum BAFF Levels and Promote CD4+ T Cell and B Cell Responses in Lupus-Prone Mice

(2014) Christine M. Coquery et al.   PLoS One

Combined Inhibition of Tumor Necrosis Factor α and Interleukin-17 As a Therapeutic Opportunity in Rheumatoid Arthritis: Development and Characterization of a Novel Bispecific Antibody

(2014) Jens A. A. Fischer et al.   Arthritis & Rheumatology

Transition from an autoimmune-prone state to fatal autoimmune disease in CCR7 and RORγt double-deficient mice is dependent on gut microbiota

(2013) Katharina Wichner et al.   JOURNAL OF AUTOIMMUNITY

Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria

(2013) Matthew R. Hepworth et al.   NATURE

Dynamic regulatory network controlling TH17 cell differentiation

(2013) Nir Yosef et al.   NATURE

T follicular helper cell diversity and plasticity

(2013) Jennifer L. Cannons et al.   TRENDS IN IMMUNOLOGY

A Validated Regulatory Network for Th17 Cell Specification

(2012) Maria Ciofani et al.   CELL

Developing connections amongst key cytokines and dysregulated germinal centers in autoimmunity

(2012) Rebecca A Sweet et al.   CURRENT OPINION IN IMMUNOLOGY

Interferon-γ Excess Leads to Pathogenic Accumulation of Follicular Helper T Cells and Germinal Centers

(2012) Sau K. Lee et al.   IMMUNITY

The origins, function, and regulation of T follicular helper cells

(2012) Cindy S. Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation

(2012) N. Bollig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

Anti IL-17A therapy inhibits bone loss in TNF-α-mediated murine arthritis by modulation of the T-cell balance

(2011) Karin Zwerina et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion

(2011) Rimpei Morita et al.   IMMUNITY

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

(2011) Yeonseok Chung et al.   NATURE MEDICINE

Foxp3+ follicular regulatory T cells control the germinal center response

(2011) Michelle A Linterman et al.   NATURE MEDICINE

Multiple checkpoints keep follicular helper T cells under control to prevent autoimmunity

(2010) Di Yu et al.   Cellular & Molecular Immunology

The cytokine milieu in the interplay of pathogenic Th1/Th17 cells and regulatory T cells in autoimmune disease

(2010) Stewart Leung et al.   Cellular & Molecular Immunology

Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORγt and LTi cells

(2010) Matthias Lochner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Signaling Pathways in T Follicular Helper Cells

(2010) J. Rolf et al.   JOURNAL OF IMMUNOLOGY

The elusive identity of T follicular helper cells

(2010) Di Yu et al.   TRENDS IN IMMUNOLOGY

Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus

(2009) Nicholas Simpson et al.   ARTHRITIS AND RHEUMATISM

Inhibition of Th17 Cells Regulates Autoimmune Diabetes in NOD Mice

(2009) J. A. Emamaullee et al.   DIABETES

The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment

(2009) Di Yu et al.   IMMUNITY

Analysis of Interleukin-21-Induced Prdm1 Gene Regulation Reveals Functional Cooperation of STAT3 and IRF4 Transcription Factors

(2009) Hyokjoon Kwon et al.   IMMUNITY

Follicular helper T cells are required for systemic autoimmunity

(2009) Michelle A. Linterman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Suppression of murine SLE by oral anti-CD3: inducible CD4+CD25-LAP+ regulatory T cells control the expansion of IL-17+ follicular helper T cells

(2009) HY Wu et al.   LUPUS

Bcl6 Mediates the Development of T Follicular Helper Cells

(2009) R. I. Nurieva et al.   SCIENCE

RORγ-Expressing Th17 Cells Induce Murine Chronic Intestinal Inflammation via Redundant Effects of IL-17A and IL-17F

(2008) Moritz Leppkes et al.   GASTROENTEROLOGY

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

(2008) Xuexian O. Yang et al.   IMMUNITY

The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

(2008) Aurelie T Bauquet et al.   NATURE IMMUNOLOGY

Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis

(2008) Q. Lai Kwan Lam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype

(2008) M. Huber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA