Article
Immunology
Xiaomei Chen, Yulian Wang, Xin Huang, Suxia Geng, Chao Li, Lingji Zeng, Lisi Huang, Xin Du, Jianyu Weng, Peilong Lai
Summary: This study found that Bcl-6 inhibitor could prevent sclerodermatous chronic graft-versus-host disease in mice by inhibiting the function of T cells and the production of immunoglobulins, suggesting that Bcl-6 inhibition may be a potential treatment for patients with cGVHD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Ming Zhao, Sujie Jia, Xiaofei Gao, Hong Qiu, Ruifang Wu, Haijing Wu, Qianjin Lu
Summary: This study revealed 802 upregulated and 598 downregulated proteins in iTfh cells compared to naive CD4(+) T cells. Intensive bioinformatics analysis provided insights into the biological processes, cellular compartments, molecular functions, KEGG pathways, and protein-protein interactions of these differentially expressed proteins. The acetylome data showed differential levels of lysine acetylation in iTfh cells, with a specific focus on core histones, suggesting a role for protein acetylation and epigenetic mechanisms in regulating Tfh cell differentiation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Han Feng, Xiaohong Zhao, Jenny Xie, Xue Bai, Weiwei Fu, Hairong Chen, Hong Tang, Xiaohu Wang, Chen Dong
Summary: This study systematically compared the transcriptomic profiles of Tfh cells from different types of immune responses and found differential induction of gene clusters corresponding to effector Th cells. It also discovered a subset of Tfh cells producing IFN-gamma in influenza virus infection, which had a unique developmental regulation. Selective ablation of these cells impaired immune response and control of infection.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Review
Allergy
Han Feng, Zixuan Zhao, Chen Dong
Summary: This article reviews the plasticity of T-FH cells in various types of immune responses and highlights their important implications in understanding and treating human diseases, particularly allergy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Immunology
Amania A. Sheikh, Joanna R. Groom
Summary: During viral infection, CD4(+) T cells differentiate into Th1 cells for inflammation and pathogen clearance, or Tfh cells for enhancing germinal center reactions. The lineage-defining transcription factors T-bet and Bcl6 play key roles in determining the fate of CD4(+) T cells toward Th1 or Tfh. Transcriptional networks guided by cytokine cues dynamically shape the fate and function of these cells during infection.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jian Lu, Jing Wu, Xueli Xia, Huiyong Peng, Shengjun Wang
Summary: RA is a chronic autoimmune disease characterized by joint and systemic inflammation, with Tfh cells playing a crucial role in the pathogenesis of the disease and affecting disease activity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Immunology
Patricia Sole, Jun Yamanouchi, Josep Garnica, Muhammad Myn Uddin, Robert Clarke, Joel Moro, Nahir Garabatos, Shari Thiessen, Mireia Ortega, Santiswarup Singha, Debajyoti Mondal, Cesar Fandos, Julio Saez-Rodriguez, Yang Yang, Pau Serra, Pere Santamaria
Summary: Chronic antigenic stimulation can induce the differentiation of CD4(+) T cells into T regulatory type 1 (TR1) cells, which produce interleukin-10 and do not express FOXP3. The progenitors and transcriptional regulators of this T-cell subset are still unknown.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Fabienne Burger, Kapka Miteva, Daniela Baptista, Aline Roth, Rodrigo A. Fraga-Silva, Catherine Martel, Nikolaos Stergiopulos, Francois Mach, Karim J. Brandt
Summary: The study shows that follicular regulatory helper T cells (T-FR) can control regulatory B cell (B-REG) populations in mice models on a high-cholesterol diet, leading to the suppression of proatherogenic processes. This suggests that T-FR cells may have atheroprotective effects by modulating immune processes related to atherosclerosis.
CARDIOVASCULAR RESEARCH
(2021)
Review
Immunology
Nengqi Lin, Wei Yin, Heather Miller, Maria G. Byazrova, Andres A. Herrada, Kamel Benlagha, Pamela Lee, Fei Guan, Jiahui Lei, Quan Gong, Youqing Yan, Alexander Filatov, Chaohong Liu
Summary: Hepatitis B has become a major health threat worldwide, particularly in developing countries and regions. Infection with hepatitis B virus significantly increases the risk of liver diseases such as cirrhosis and cancer. The immune response against hepatitis B is mainly regulated by CD8+ T cells, which play a key role in fighting viral infections, while regulatory T cells prevent excessive immune response. Additionally, follicular T helper cells have a critical role in B-cell activation, proliferation, differentiation, and the formation of germinal centers. The development of hepatitis B virus is generally associated with immune system disorders or dysfunctions. This review focuses on the important functions and biological processes of regulatory T cells and follicular T helper cells during HBV infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Xindi Wei, Xiaoyin Niu
Summary: Tfh cells, a new subset of CD4+ T cells, mainly express CXCR5 and ICOS surface molecules, secrete IL-21, and require BCL-6 transcription factor. They exist in germinal centers (GCs) of lymphoid organs and peripheral blood, playing critical roles in B cell development, GC formation, and antibody production. Aberrant proliferation and function of Tfh cells contribute to autoimmune diseases, and they can potentially be used as therapeutic targets.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Cell Biology
Bradley Salvatore, Rachel S. Resop, Brent R. Gordon, Marta Epeldegui, Otoniel Martinez-Maza, Begona Comin-Anduix, Alex Lam, Ting-Ting Wu, Christel H. Uittenbogaart
Summary: Humoral immune response plays a crucial role in combating pathogens by producing specific antibodies. T follicular helper (TFH) cells contribute to both B-cell antibody production and HIV persistence. T follicular regulatory (TFR) cells, which suppress TFH cell function, exhibit similar surface markers. The increase in TFH cells observed in HIV infection may partially be due to an increase in TFR cells. Using multicolor flow cytometry, we identified peripheral blood TFH (pTFH) and peripheral blood TFR (pTFR) cells and found that the frequency of pTFH cells was higher in HIV-infected individuals. Additionally, pTFH cells expressed lower levels of CCR5, a key factor in HIV persistence. The constitutive expression of CCR5 in TFR cells indicates their potential contribution to HIV persistence.
Article
Rheumatology
Qinglian Jiang, Jiakai Wang, Hongkun Jiang, Wei Li, Yini Sun, Yu Shan, Tong Wei, Xuyang Chi, Shihan Yu, Xiaoxue Ma
Summary: This study found that Tph cells are increased in SLE patients and are strongly associated with disease activity and renal involvement. The synergy of IFN-alpha and IL-2 increases Tph cells through competitive transcriptional regulation, which could be one of the mechanisms responsible for pathological formation of ELSs.
Article
Immunology
Matthew T. T. Ollerton, Joy M. M. Folkvord, Andriana La Mantia, David A. A. Parry, Amie L. L. Meditz, Martin D. D. McCarter, Richard T. D'Aquila, Elizabeth Connick
Summary: Follicular helper CD4(+) T cells (TFH) are major sites of HIV replication, but follicular regulatory CD4(+) T cells (TFR) limit HIV replication by suppressing TFH through IL-2 restriction. TFR reduce TFH viability and HIV infected TFH, and IL-2 enhances TFH viability but decreases HIV replication in the presence of TFR.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Hiroyuki Yoshitomi, Hideki Ueno
Summary: The interactions between CD4(+)T cells and B cells are crucial for antibody responses and autoimmune diseases. Recent studies identified a new subset of CD4(+)B helper T cells called peripheral helper T (Tph) cells, which provide help to B cells in inflamed tissues and share some functions with Tfh cells.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Andrew Baessler, Bryce Fuchs, Bryant Perkins, Andrew W. Richens, Camille L. Novis, Malia Harrison-Chau, Linda M. Sircy, Kendall A. Thiede, J. Scott Hale
Summary: This study reveals the important role of Tet2 in CD4+ T cell differentiation and memory formation, which in turn affects the enhancement of immune response. The absence of Tet2 leads to preferential recall of Tfh phenotype in memory cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
