The zebrafish eye—a paradigm for investigating human ocular genetics

Rapid reverse genetic screening using CRISPR in zebrafish

(2015) Arish N Shah et al.   NATURE METHODS

CERKL interacts with mitochondrial TRX2 and protects retinal cells from oxidative stress-induced apoptosis

(2014) Chang Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Genes and signaling networks regulated during zebrafish optic vesicle morphogenesis

(2014) Jun Yin et al.   BMC GENOMICS

The myosin chaperone UNC45B is involved in lens development and autosomal dominant juvenile cataract

(2014) Lars Hansen et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

myosin 7aa−/− mutant zebrafish show mild photoreceptor degeneration and reduced electroretinographic responses

(2014) Meagan M. Wasfy et al.   EXPERIMENTAL EYE RESEARCH

Methods for targeted mutagenesis in zebrafish using TALENs

(2014) Woong Y. Hwang et al.   METHODS

Lens Extrusion fromLaminin Alpha 1Mutant Zebrafish

(2014) Mallika Pathania et al.   TheScientificWorldJOURNAL

RNAi-Mediated Gene silencing in Zebrafish Triggered by Convergent Transcription

(2014) Omozusi E. Andrews et al.   Scientific Reports

Mutations in C10orf11, a Melanocyte-Differentiation Gene, Cause Autosomal-Recessive Albinism

(2013) Karen Grønskov et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Disruption of Autoregulatory Feedback by a Mutation in a Remote, Ultraconserved PAX6 Enhancer Causes Aniridia

(2013) Shipra Bhatia et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Comparison of upstream regulators in human ex vivo cultured cornea limbal epithelial stem cells and differentiated corneal epithelial cells

(2013) Zoltán Veréb et al.   BMC GENOMICS

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

oca2regulation of chromatophore differentiation and number is cell type specific in zebrafish

(2013) Alisha J. Beirl et al.   Pigment Cell & Melanoma Research

ZNF408 is mutated in familial exudative vitreoretinopathy and is crucial for the development of zebrafish retinal vasculature

(2013) R. W. J. Collin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A simple strategy for heritable chromosomal deletions in zebrafish via the combinatorial action of targeting nucleases

(2013) Shimin Lim et al.   GENOME BIOLOGY

High efficiency TALENs enable F0 functional analysis by targeted gene disruption in Xenopus laevis embryos

(2013) K.-i. T. Suzuki et al.   Biology Open

Clinical and mutation analysis of 51 probands with anophthalmia and/or severe microphthalmia from a single center

(2013) Christina Gerth-Kahlert et al.   Molecular Genetics & Genomic Medicine

Turning gene function ON and OFF using sense and antisense photo-morpholinos in zebrafish

(2012) A. Tallafuss et al.   DEVELOPMENT

Gucy2f zebrafish knockdown – a model for Gucy2d-related leber congenital amaurosis

(2012) Hadas Stiebel-Kalish et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Aniridia

(2012) Melanie Hingorani et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Pax2 regulates a fadd-dependent molecular switch that drives tissue fusion during eye development

(2012) Ishaq A. Viringipurampeer et al.   HUMAN MOLECULAR GENETICS

β-catenin/Wnt signaling controls progenitor fate in the developing and regenerating zebrafish retina

(2012) Jason R Meyers et al.   Neural Development

The Role of Mislocalized Phototransduction in Photoreceptor Cell Death of Retinitis Pigmentosa

(2012) Takeshi Nakao et al.   PLoS One

Functional Assessment of Human Coding Mutations Affecting Skin Pigmentation Using Zebrafish

(2012) Zurab R. Tsetskhladze et al.   PLoS One

Simple Methods for Generating and Detecting Locus-Specific Mutations Induced with TALENs in the Zebrafish Genome

(2012) Timothy J. Dahlem et al.   PLoS Genetics

Harmonin (Ush1c) is required in zebrafish Muller glial cells for photoreceptor synaptic development and function

(2011) J. B. Phillips et al.   Disease Models & Mechanisms

Discovery and assessment of conserved Pax6 target genes and enhancers

(2011) Pedro Coutinho et al.   GENOME RESEARCH

The N-terminal region of centrosomal protein 290 (CEP290) restores vision in a zebrafish model of human blindness

(2011) Lisa M. Baye et al.   HUMAN MOLECULAR GENETICS

Update of PAX2 mutations in renal coloboma syndrome and establishment of a locus-specific database

(2011) Matthew Bower et al.   HUMAN MUTATION

Ascl1a/Dkk/ -catenin signaling pathway is necessary and glycogen synthase kinase-3  inhibition is sufficient for zebrafish retina regeneration

(2011) R. Ramachandran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in Zebrafish lrp2 Result in Adult-Onset Ocular Pathogenesis That Models Myopia and Other Risk Factors for Glaucoma

(2011) Kerry N. Veth et al.   PLoS Genetics

Discovery and Functional Analysis of a Retinitis Pigmentosa Gene, C2ORF71

(2010) Darryl Y. Nishimura et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genetic defects of GDF6 in the zebrafish out of sight mutant and in human eye developmental anomalies

(2010) Anneke I den Hollander et al.   BMC GENETICS

Comparative transcriptional profiling of the limbal epithelial crypt demonstrates its putative stem cell niche characteristics

(2010) Bina B Kulkarni et al.   BMC GENOMICS

von Hippel-Lindau tumor suppressor mutants faithfully model pathological hypoxia-driven angiogenesis and vascular retinopathies in zebrafish

(2010) E. van Rooijen et al.   Disease Models & Mechanisms

PDZD7 is a modifier of retinal disease and a contributor to digenic Usher syndrome

(2010) Inga Ebermann et al.   JOURNAL OF CLINICAL INVESTIGATION

Lmx1b is essential for survival of periocular mesenchymal cells and influences Fgf-mediated retinal patterning in zebrafish

(2009) Carrie McMahon et al.   DEVELOPMENTAL BIOLOGY

Retinal homeobox 1 is required for retinal neurogenesis and photoreceptor differentiation in embryonic zebrafish

(2009) Steve M. Nelson et al.   DEVELOPMENTAL BIOLOGY

Zebrafish Rpgr is required for normal retinal development and plays a role in dynein-based retrograde transport processes

(2009) Xinhua Shu et al.   HUMAN MOLECULAR GENETICS

Small molecule screen for compounds that affect vascular development in the zebrafish retina

(2009) Satish S. Kitambi et al.   MECHANISMS OF DEVELOPMENT

Corneal dystrophies

(2009) Gordon K Klintworth   Orphanet Journal of Rare Diseases

Pigmentary function and evolution oftyrp1gene duplicates in fish

(2009) Ingo Braasch et al.   Pigment Cell & Melanoma Research

Selective Inhibition of Retinal Angiogenesis by Targeting PI3 Kinase

(2009) Yolanda Alvarez et al.   PLoS One

An essential role for Radar (Gdf6a) in inducing dorsal fate in the zebrafish retina

(2009) N. J. Gosse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ophthalmological Aspects of Pierson Syndrome

(2008) Cecilie Bredrup et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Morphological Differences between the Trabecular Meshworks of Zebrafish and Mammals

(2008) Chun-Chen Chen et al.   CURRENT EYE RESEARCH

Characterization of pip5k3 fleck corneal dystrophy-linked gene in zebrafish

(2008) Gaëlle Boisset et al.   GENE EXPRESSION PATTERNS

The Primary open-angle glaucoma gene WDR36 functions in ribosomal RNA processing and interacts with the p53 stress-response pathway

(2008) J. M. Skarie et al.   HUMAN MOLECULAR GENETICS

Translational bypass of nonsense mutations in zebrafish rep1, pax2.1 and lamb1 highlights a viable therapeutic option for untreatable genetic eye disease

(2008) M. Moosajee et al.   HUMAN MOLECULAR GENETICS

Subfunctionalization of Duplicated Zebrafish pax6 Genes by cis-Regulatory Divergence

(2008) Dirk A. Kleinjan et al.   PLoS Genetics