Article
Biochemistry & Molecular Biology
Jakub Rok, Zuzanna Rzepka, Justyna Kowalska, Klaudia Banach, Artur Beberok, Dorota Wrzesniok
Summary: The study showed that minocycline can enhance melanin synthesis and this effect is intensified by irradiation, especially with the UVB spectrum. The results confirmed the potential role of melanin and UV radiation in minocycline-induced skin hyperpigmentation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ponsawan Netcharoensirisuk, Kaoru Umehara, Wanchai De-Eknamkul, Chatchai Chaotham
Summary: The study found that cajanin can effectively inhibit proliferation and reduce melanin content in human melanoma cells by decreasing the expression levels of proteins such as MITF, rather than directly inhibiting enzymatic activity. This suggests the potential of cajanin as an effective treatment for human hyperpigmented disorders.
Article
Dermatology
Chi-Hyun Park, Goeun Kim, Yuri Lee, Haesoo Kim, Min Ji Song, Dong Hun Lee, Jin Ho Chung
Summary: The study showed that harmine reduces melanin synthesis by regulating the DYRK1A/NFATC3 pathway, suggesting it as a potential target for depigmenting agents.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Article
Immunology
Feifei Yu, Yishan Lu, Zhiming Zhong, Bingliang Qu, Meifang Wang, Xiangyong Yu, Jiayu Chen
Summary: The study characterized the Mitf gene in Pteria penguin, showing its involvement in melanin synthesis and innate immunity in the bivalve. PpMitf plays a key role in regulating melanin synthesis and innate immunity through controlling tyrosinase expression in P. penguin.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Agricultural Engineering
Zhuang Meng, Shandang Shi, Haitao Shen, Quanliang Xie, Hongbin Li
Summary: Whole genome duplication is an important driving force in plant evolution and diversification. This study discovered a spontaneously doubling autotetraploid sugarcane and developed a set of haplotype-specific FISH probes based on its genome. Comparative FISH assay showed no chromosomal aberrations between the spontaneously doubled sugarcane and its parental plant at the cytogenetic level.This study successfully applied the haplotype-specific FISH technology to autotetraploid sugarcane for the first time.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Chemistry, Medicinal
Lu Cao, Xiaoyan Li, Jing Zhao, Qing Du, Jiening Dun
Summary: This study investigated the safety and efficacy of resveratrol microemulsion gel in improving pigmentation. The microemulsion gel was found to enhance the ability of resveratrol to inhibit melanin formation without causing side effects.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2023)
Article
Biochemistry & Molecular Biology
Joong-Hyun Shim
Summary: The study demonstrated that cycloheterophyllin decreases melanin production by inhibiting the expression of TYRP1/TYRP2/TYR/MITF genes and reducing tyrosinase activity, resulting in whitening effects. Therefore, cycloheterophyllin is a potent ingredient for skin whitening, and further investigation into its mechanism of action for the development of functional materials is warranted.
Article
Dermatology
Alec Sevilla, Jeremy Cheret, Wendy Lee, Ralf Paus
Summary: This pilot study aimed to investigate the effects of melatonin on melanin production and melanocytes in intact human epidermis. The results showed that melanin content and melanocyte dendricity increased with melatonin treatment, while tyrosinase activity was inhibited. Higher doses of melatonin increased the number and proliferation of melanocytes and keratinocytes, as well as the expression of the premelanosomal marker gp100. These findings suggest that long-term melatonin therapy may stimulate melanogenesis and increase the activity of epidermal melanocytes.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Chemistry, Medicinal
Romeo Romagnoli, Paola Oliva, Filippo Prencipe, Stefano Manfredini, Federico Ricci, Diana Corallo, Sanja Aveic, Elena Mariotto, Giampietro Viola, Roberta Bortolozzi, Maria Paola Germano, Laura De Luca
Summary: A series of cinnamide compounds linked with 1-aryl piperazines, derived from cinnamic acid derivatives, were synthesized and evaluated for their inhibitory activity against mushroom tyrosinase. The presence of a 3-chloro-4-fluorophenyl moiety at the N-1 position of the piperazine ring was found to be essential for a potent inhibitory effect. Molecular docking studies were conducted to investigate the interactions between the compounds and the active site of the enzyme. Some of the highly active compounds also showed potential in inhibiting melanogenesis. However, certain compounds exhibited toxicity at high concentrations.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Dermatology
Jingpei Shi, Yanfang Guo, Hanying Wang, Yun Xiao, Weimin Liu, Lechun Lyu
Summary: This review systematically introduces the ubiquitin-proteasome system (UPS) as a key regulator of melanin metabolism. UPS plays an important role in regulating different steps of melanin synthesis and metabolism.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Review
Oncology
Gabriel E. Bertolesi, Sarah McFarlane
Summary: Plastic adaptation of skin color to match the environment is crucial for survival, involving both physiological and morphological responses. Unique molecules in teleosts, such as melanin-concentrating hormone like and somatolactin, play a key role in regulating skin pigmentation. These molecules form a previously unknown link between physiological and morphological pigmentation in fish.
PIGMENT CELL & MELANOMA RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Thomas Desvignes, Philippe Bardou, Jerome Montfort, Jason Sydes, Cervin Guyomar, Simon George, John H. Postlethwait, Julien Bobe
Summary: FishmiRNA is a miRNA annotation and expression database for ray-finned fishes, providing detailed manually curated miRNA annotations with orthology relationships, expression data for each mature miRNA, and convenient download formats and search options for user-friendly access.
MOLECULAR BIOLOGY AND EVOLUTION
(2022)
Article
Fisheries
Feifei Yu, Zhiming Zhong, Jing Zhang, Yong Liu, Jiayu Chen, Baogui Tang
Summary: Light intensity affects the growth and body color formation of hybrid grouper. 1250 lx light enhances the color contrast and melanin content in the skin, as well as increases tyrosinase activity. Through the Creb2-Mitf-Tyr-Tyrp1 axis, light stress influences body color formation in hybrid grouper.
AQUACULTURE REPORTS
(2022)
Article
Chemistry, Physical
Jiangtao Su, Dan Li, Yuchen Hu, Xiangyu You, Xiaoxia Guo, Xican Li, Ban Chen
Summary: A novel C6-sulfonated celastrol analog (CENFN) was designed and synthesized, and its tyrosinase and melanin inhibitory effects were compared to celastrol (CE) using in silico and in vitro experiments. The results confirmed the rationality of the synthetic reactions and showed that CENFN has a higher level of tyrosinase and melanin inhibition compared to CE. These findings provide insights for the design and synthesis of celastrol analogs as tyrosinase and melanin inhibitors.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Plant Sciences
Shu-Chun Liu, Meei-Ling Sheu, Yi-Ching Tsai, Yu-Chin Lin, Ching-Wen Chang, De-Wei Lai
Summary: Chi-Bai-San, a traditional Chinese medicine skin whitening agent, has been proven to reduce melanin production and wrinkles. This study extracted and tested the seven compounds in Chi-Bai-San, finding that it can safely reduce melanin production and inhibit key factors involved in melanogenesis.
Review
Orthopedics
Stephanie Graser, Elisa Riekert, Daniel Liedtke
Summary: This brief review describes the role of tissue-nonspecific alkaline phosphatase (TNAP) in dental development and the relationship between hypophosphatasia (HPP) and dental phenotype. Through the analysis of transgenic models in different animals, the molecular causes of different symptoms of HPP are investigated, and the dental development processes in humans, mice, and zebrafish are compared.
Article
Genetics & Heredity
Andrew W. Thompson, Harrison Wojtas, Myles Davoll, Ingo Braasch
Summary: The Rio Pearlfish is a killifish species that inhabits seasonal pools in the Rio de Janeiro region of Brazil. Its embryos enter dormant diapause stages in the soil and hatch when the habitat is inundated. The genome of the Rio Pearlfish provides important insights into the genetic control of hatching and the adaptation to harsh conditions.
G3-GENES GENOMES GENETICS
(2022)
Article
Genetics & Heredity
Mark Kirkpatrick, Jason M. Sardell, Brendan J. Pinto, Groves Dixon, Catherine L. Peichel, Manfred Schartl
Summary: This study focuses on the sex chromosomes of the guppy and its close relatives, finding no evidence of a nonrecombining sex-determining region and suggesting that the evolution of sex-determining regions in certain relatives occurred independently. It also addresses conflicting results in previous studies and proposes best practices for future research.
G3-GENES GENOMES GENETICS
(2022)
Article
Cell Biology
Indrajit Nanda, Susanne Schories, Ivan Simeonov, Mateus Contar Adolfi, Kang Du, Claus Steinlein, Manfred Alsheimer, Thomas Haaf, Manfred Schartl
Summary: The conspicuous color sexual dimorphism makes guppies ideal study objects for sex-linked traits and sex chromosome evolution. The Y-chromosome in Micropoecilia. picta has been found to be highly degenerated compared to the X-chromosome, with a low SNP density and high heterochromatin content. This is in contrast to other species in the Poecilia group, indicating that the evolution of sex chromosomes is not parallel.
Article
Multidisciplinary Sciences
Heiner Kuhl, Kang Du, Manfred Schartl, Lukas Kalous, Matthias Stoeck, Dunja K. Lamatsch
Summary: Understanding genome evolution of polyploids involves analyzing their similar subgenomes and haplotypes. In this study, the genome of the asexual Prussian carp was sequenced, resulting in a haplotype-resolved chromosome-scale assembly of a hexaploid animal. Comparisons with ancestral diploid cyprinids and goldfish revealed the genome structure, phylogeny, and genome duplication history.
NATURE COMMUNICATIONS
(2022)
Correction
Multidisciplinary Sciences
Heiner Kuhl, Kang Du, Manfred Schartl, Lukas Kalous, Matthias Stock, Dunja K. Lamatsch
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Miriam Zink, Anne Seewald, Mareike Rohrbach, Andreas Brodehl, Daniel Liedtke, Tatjana Williams, Sarah J. Childs, Brenda Gerull
Summary: In this study, transgenic zebrafish models were used to investigate the pathogenesis of TMEM43-associated cardiomyopathy. The findings reveal that TMEM43 mutations lead to cardiomyocyte hypertrophy, cardiac morphological defects, and dysregulated gene expression. These results provide new insights into the development of TMEM43-associated cardiomyopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Meeting Abstract
Toxicology
B. Bauer, D. Liedtke, J. Unsoeld, E. Klopocki, A. Mally
TOXICOLOGY LETTERS
(2022)
Article
Cell Biology
Toya Motoshima, Ayumi Nagashima, Chihiro Ota, Haruka Oka, Kohei Hosono, Ingo Braasch, Hidenori Nishihara, Akira Kato
Summary: Solute carrier 12 (Slc12) is a family of electroneutral cation-coupled chloride cotransporters. The evolutionary relationship between slc12a10 and ncc3 remains unresolved, and the presence of slc12a10 in mammals has not been clarified. Our results elaborate on the evolution of Nkcc/Ncc subfamily of Slc12 in vertebrates.
PHYSIOLOGICAL GENOMICS
(2023)
Editorial Material
Multidisciplinary Sciences
Manfred Schartl, Dunja K. Lamatsch
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Genetics & Heredity
Manfred Schartl, Arthur Georges, Jennifer A. Marshall Graves
Summary: Genetic sex determination in most vertebrates is controlled by a single master sex gene, but there are also more complex systems, such as polygenic sex determination, where multiple genes interact to determine sex. However, many of the claims for polygenic sex determination in vertebrates are either transient states during sex chromosome turnover or aberrant systems in species hybrids. To avoid confusion, a consistent nomenclature for genetic sex determination systems is proposed.
TRENDS IN GENETICS
(2023)
Article
Biology
Victoria C. C. Moris, Lars Podsiadlowski, Sebastian Martin, Jan Philip Oeyen, Alexander Donath, Malte Petersen, Jeanne Wilbrandt, Bernhard Misof, Daniel Liedtke, Markus Thamm, Ricarda Scheiner, Thomas Schmitt, Oliver Niehuis
Summary: This study reveals a group of genes in honey bees that play an important role in the synthesis of cuticular hydrocarbons, and the predicted functions of these genes are consistent with current knowledge of cuticular hydrocarbon metabolism.
COMMUNICATIONS BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Jan Stundl, Megan L. Martik, Donglei Chen, Desingu Ayyappa Raja, Roman Franek, Anna Pospisilova, Martin Psenicka, Brian D. Metscher, Ingo Braasch, Tatjana Haitina, Robert Cerny, Per E. Ahlberg, Marianne E. Bronner
Summary: Neural crest cells in ray-finned fish can differentiate into osteoblasts that form the bony part of the dermal armor, and these cells retain a neural crest gene signature. This discovery is significant for understanding the origin and evolution of skeletal structures.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Meeting Abstract
Pharmacology & Pharmacy
B. Bauer, D. Liedtke, M. Kruse, J. Unsoeld, E. Klopocki, A. Mally
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
M. Miriam Zink, A. Seewald, M. C. Nguyen, T. Williams, D. Liedtke, C. Stigloher, S. Childs, B. Gerull
EUROPEAN JOURNAL OF HEART FAILURE
(2022)