Review
Hematology
Sabine Kayser, Mark J. Levis
Summary: Research on the pathogenic mechanisms of AML has made remarkable advances in recent years, especially in the importance of cytogenetic and molecular aberrations. The development of new compounds targeting AML at a molecular level, based on increased understanding of AML pathogenesis facilitated by next-generation sequencing, has turned many hopeful predictions into therapeutic realities.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Review
Hematology
Elizabeth Herrity, Mariana Pinto Pereira, Dennis Dong Hwan Kim
Summary: This study describes the mechanistic diversity of relapse after hematopoietic stem cell transplantation and emphasizes the importance of these mechanisms in treatment selection and future research inspiration.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Review
Immunology
Nikeshan Jeyakumar, Melody Smith
Summary: Cellular therapies have revolutionized the treatment of relapsed/refractory diffuse large B-cell lymphoma (r/r DLBCL). Autologous CAR T cells have shown promising results in achieving complete remission, but a significant portion of patients still relapse or progress. Allogeneic CAR T cells may offer a solution by addressing the limitations of autologous therapy and providing a more sustainable platform for cell therapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Hematology
Pietro Merli
Summary: The report highlights the importance of pursuing a curative approach to improve prognosis in childhood acute myeloid leukemia.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Review
Hematology
Erin M. Kropp, Qing Li
Summary: This review focuses on the mechanisms of resistance to targeted therapies in relapsed or refractory AML.
EXPERIMENTAL HEMATOLOGY
(2022)
Article
Hematology
Nianci Chen, Jiajia Pan, Yile Zhou, Liping Mao, Yinjun Lou, Jiejing Qian, Gaixiang Xu, Juying Wei, De Zhou, Lihong Shou, Li Huang, Minchao Yan, Hui Zeng, Cuihua Fan, Gongqiang Wu, Weiying Feng, Hongyan Tong, Jie Jin, Huafeng Wang
Summary: This retrospective analysis investigated the efficacy and safety of different gilteritinib-based combination therapies in relapsed/refractory FLT3-mutated AML patients. The study found that gilteritinib plus hypomethylating agent and venetoclax combination therapy showed higher response rates and may serve as an effective bridge to transplantation.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Review
Immunology
Sangeeta Goswami, Swetha Anandhan, Deblina Raychaudhuri, Padmanee Sharma
Summary: This study describes current therapies that aim to modulate the functional activities of myeloid cell populations in the tumor microenvironment, impacting their recruitment, survival, and activity. Myeloid cells are the most abundant immune components in the tumor microenvironment and have diverse functions. The authors highlight key features of monocyte and macrophage biology as potential targets for cancer therapies and discuss the need for a deeper understanding of myeloid cells to improve clinical outcomes.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Hematology
Fateeha Furqan, Kwang W. Ahn, Yue Chen, Manmeet Kaur, Syed A. Abutalib, Nausheen Ahmed, Sairah Ahmed, Mohamed A. Kharfan-Dabaja, Johnathan Friedberg, Tara Gregory, LaQuisa Hill, Cole Sterling, Stephan K. Barta, Mazyar Shadman, Miguel-Angel Perales, Jasmine Zain, Alex F. Herrera, Craig Sauter, Mehdi Hamadani
Summary: This study evaluated the outcomes of allo-HCT in patients with relapsed/refractory ALCL and found that it can result in durable disease control in a significant proportion of patients. However, refractory disease and racial minority status predicted inferior outcomes after allo-HCT.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Gabriele Casirati, Andrea Cosentino, Adele Mucci, Mohammed Salah Mahmoud, Iratxe Ugarte Zabala, Jing Zeng, Scott B. Ficarro, Denise Klatt, Christian Brendel, Alessandro Rambaldi, Jerome Ritz, Jarrod A. Marto, Danilo Pellin, Daniel E. Bauer, Scott A. Armstrong, Pietro Genovese
Summary: Epitope engineering of donor haematopoietic stem/progenitor cells endows haematopoietic lineages with selective resistance to CAR T cells or monoclonal antibodies, without affecting protein function or regulation, enabling the targeting of genes that are essential for leukaemia survival and reducing the risk of tumour immune escape.
Review
Medicine, General & Internal
Jorge Cortes, Carolina Pavlovsky, Susanne Saussele
Summary: Tyrosine-kinase inhibitors have significantly altered the natural course of chronic myeloid leukaemia, allowing some patients to approach a near-normal life expectancy. Successful treatment requires understanding the patient's treatment goals, monitoring optimal response hallmarks, timely interventions, recognition of adverse events, and management of comorbidities.
Review
Hematology
Hagop Kantarjian, Nicholas J. Short, Courtney DiNardo, Eytan M. Stein, Naval Daver, Alexander E. Perl, Eunice S. Wang, Andrew Wei, Martin Tallman
Summary: Since 2017, the US FDA has approved nine agents for acute myeloid leukaemia, including Bcl-2 inhibitors, FLT3 inhibitors, and IDH inhibitors. Some of the approved agents are used as single-agent therapies or specific combinations for narrow indications, offering limited treatment value.
LANCET HAEMATOLOGY
(2021)
Article
Hematology
Momoko Nakamura, Yasuyuki Arai, Shigeki Hirabayashi, Tadakazu Kondo, Noriko Doki, Naoyuki Uchida, Takahiro Fukuda, Yukiyasu Ozawa, Masatsugu Tanaka, Masashi Sawa, Yuta Katayama, Yoshinobu Kanda, Souichi Shiratori, Hirohisa Nakamae, Satoshi Yoshioka, Makoto Onizuka, Tatsuo Ichinohe, Yoshiko Atsuta, Shinichi Kako
Summary: The study identified several prognostic risk factors for acute lymphoblastic leukaemia patients undergoing allogeneic haematopoietic stem cell transplantation in non-complete remission status, including age, bone marrow blast count, performance status, HCT-comorbidity index, and disease relapse status, among which bone marrow blast count was the most significant. A predictive scoring system composed of these risk factors effectively stratified patient overall survival rates, emphasizing the importance of blast control before transplantation for better prognosis.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Oncology
E. Dianne Pulte, Kelly J. Norsworthy, Yaping Wang, Qing Xu, Hisham Qosa, Ramadevi Gudi, Donna Przepiorka, Wentao Fu, Olanrewaju O. Okusanya, Kirsten B. Goldberg, R. Angelo De Claro, Ann T. Farrell, Richard Pazdur
Summary: Gilteritinib, a small-molecule FLT3 inhibitor, has been approved by the FDA for the treatment of relapsed or refractory acute myeloid leukemia with a FLT3 mutation. Clinical trials have shown improvements in overall survival compared to standard chemotherapy. The revised labeling includes warnings for potential side effects and the need for frequent monitoring for safe use.
CLINICAL CANCER RESEARCH
(2021)
Review
Hematology
Shyam A. Patel, Mark R. Litzow, Jan Cerny
Summary: In recent years, FDA has approved multiple therapeutics for AML, but the role of maintenance therapy in AML is still relatively unrealized. Many clinical trials have demonstrated benefits of using various therapeutics in the maintenance setting for AML patients. Oral hypomethylating agent therapy has shown benefits in overall survival and disease-free survival in the maintenance setting for AML.
Article
Medical Laboratory Technology
Qi Hao, Xinyue Liu, Yongping Zhang, Dongmei Zhang, Boran Li, Jingbo Wang
Summary: The study retrospectively analyzed data from AML patients undergoing allo-HCT, finding that abnormal expression of CD7+, CD56+, HLA-DR-, and CD38- was associated with poor outcomes. Additionally, the more abnormal antigens expressed, the worse the prognosis.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)