Polyampholyte physics: Liquid–liquid phase separation and biological condensates

A Guide to Regulation of the Formation of Biomolecular Condensates

(2020) Anna Bratek‐Skicki et al.   FEBS Journal

The (un)structural biology of biomolecular liquid-liquid phase separation using NMR spectroscopy

(2020) Anastasia C. Murthy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arginine-Enriched Mixed-Charge Domains Provide Cohesion for Nuclear Speckle Condensation

(2020) Jamie A. Greig et al.   MOLECULAR CELL

Valence and patterning of aromatic residues determine the phase behavior of prion-like domains

(2020) Erik W. Martin et al.   SCIENCE

Physical basis of the disorder-order transition

(2020) Andrea Soranno   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Single-Protein Collapse Determines Phase Equilibria of a Biological Condensate

(2020) Han-Yi Chou et al.   Journal of Physical Chemistry Letters

Composition-dependent thermodynamics of intracellular phase separation

(2020) Joshua A. Riback et al.   NATURE

Liquid network connectivity regulates the stability and composition of biomolecular condensates with many components

(2020) Jorge R. Espinosa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Connecting Coil-to-Globule Transitions to Full Phase Diagrams for Intrinsically Disordered Proteins

(2020) Xiangze Zeng et al.   BIOPHYSICAL JOURNAL

Analysis of Partitioning of Salt through Doping of Polyelectrolyte Complex Coacervates

(2020) Mohsen Ghasemi et al.   MACROMOLECULES

Solid-to-Liquid Phase Transition in Polyelectrolyte Complexes

(2020) Siqi Meng et al.   MACROMOLECULES

Complete Phase Diagram for Liquid–Liquid Phase Separation of Intrinsically Disordered Proteins

(2019) James McCarty et al.   Journal of Physical Chemistry Letters

Sequence Effects on Size, Shape, and Structural Heterogeneity in Intrinsically Disordered Proteins

(2019) Upayan Baul et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Molecular Dynamics Simulations Combined with Nuclear Magnetic Resonance and/or Small-Angle X-ray Scattering Data for Characterizing Intrinsically Disordered Protein Conformational Ensembles

(2019) Maud Chan-Yao-Chong et al.   Journal of Chemical Information and Modeling

Phase separation: Bridging polymer physics and biology

(2019) Sarah L. Perry   CURRENT OPINION IN COLLOID & INTERFACE SCIENCE

Single-molecule fluorescence studies of intrinsically disordered proteins and liquid phase separation

(2019) Irem Nasir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Molecular design of self-coacervation phenomena in block polyampholytes

(2019) Scott P. O. Danielsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Simulation methods for liquid–liquid phase separation of disordered proteins

(2019) Gregory L Dignon et al.   Current Opinion in Chemical Engineering

Designing Electrostatic Interactions via Polyelectrolyte Monomer Sequence

(2019) Tyler K. Lytle et al.   ACS Central Science

Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly

(2019) Xinrui Gui et al.   Nature Communications

Controlling Complex Coacervation via Random Polyelectrolyte Sequences

(2019) Artem M. Rumyantsev et al.   ACS Macro Letters

First-generation predictors of biological protein phase separation

(2019) Robert M Vernon et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The Role of Post-Translational Modifications in the Phase Transitions of Intrinsically Disordered Proteins

(2019) Izzy Owen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ion Content of Polyelectrolyte Complex Coacervates and the Donnan Equilibrium

(2019) Joseph B. Schlenoff et al.   MACROMOLECULES

Relationship of Sequence and Phase Separation in Protein Low-Complexity Regions

(2018) Erik W. Martin et al.   BIOCHEMISTRY

In Aqua Veritas: The Indispensable yet Mostly Ignored Role of Water in Phase Separation and Membrane-less Organelles

(2018) Boris Y. Zaslavsky et al.   BIOCHEMISTRY

OUP accepted manuscript

(2018)   Briefings in Functional Genomics

A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins

(2018) Jie Wang et al.   CELL

An Extended Guinier Analysis for Intrinsically Disordered Proteins

(2018) Wenwei Zheng et al.   JOURNAL OF MOLECULAR BIOLOGY

On the Calculation of SAXS Profiles of Folded and Intrinsically Disordered Proteins from Computer Simulations

(2018) João Henriques et al.   JOURNAL OF MOLECULAR BIOLOGY

Complex Coacervate of Weakly Charged Polyelectrolytes: Diagram of States

(2018) Artem M. Rumyantsev et al.   MACROMOLECULES

Phase Behavior and Salt Partitioning in Polyelectrolyte Complex Coacervates

(2018) Lu Li et al.   MACROMOLECULES

Salt Partitioning in Complex Coacervation of Symmetric Polyelectrolytes

(2018) Pengfei Zhang et al.   MACROMOLECULES

Controlling compartmentalization by non-membrane-bound organelles

(2018) Richard J. Wheeler et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Imaging dynamic and selective low-complexity domain interactions that control gene transcription

(2018) Shasha Chong et al.   SCIENCE

Phase separation of a yeast prion protein promotes cellular fitness

(2018) Titus M. Franzmann et al.   SCIENCE

Structure and rheology of polyelectrolyte complex coacervates

(2018) Amanda B. Marciel et al.   Soft Matter

Why Do Disordered and Structured Proteins Behave Differently in Phase Separation?

(2018) Huan-Xiang Zhou et al.   TRENDS IN BIOCHEMICAL SCIENCES

Protein Phase Separation: A New Phase in Cell Biology

(2018) Steven Boeynaems et al.   TRENDS IN CELL BIOLOGY

Self-interaction of NPM1 modulates multiple mechanisms of liquid–liquid phase separation

(2018) Diana M. Mitrea et al.   Nature Communications

Sequence determinants of protein phase behavior from a coarse-grained model

(2018) Gregory L. Dignon et al.   PLoS Computational Biology

Pi-Pi contacts are an overlooked protein feature relevant to phase separation

(2018) Robert McCoy Vernon et al.   eLife

Molecular Origin of the Glass Transition in Polyelectrolyte Assemblies

(2018) Yanpu Zhang et al.   ACS Central Science

The molecular language of membraneless organelles

(2018) Edward Gomes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Relation between single-molecule properties and phase behavior of intrinsically disordered proteins

(2018) Gregory L. Dignon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational preferences and phase behavior of intrinsically disordered low complexity sequences: insights from multiscale simulations

(2018) Kiersten M Ruff et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs

(2017) Yuan Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Random-phase-approximation theory for sequence-dependent, biologically functional liquid-liquid phase separation of intrinsically disordered proteins

(2017) Yi-Hsuan Lin et al.   JOURNAL OF MOLECULAR LIQUIDS

Influence of Hydrophobicity on Polyelectrolyte Complexation

(2017) Kazi Sadman et al.   MACROMOLECULES

Molecular Connectivity and Correlation Effects on Polymer Coacervation

(2017) Mithun Radhakrishna et al.   MACROMOLECULES

Phase behaviour of disordered proteins underlying low density and high permeability of liquid organelles

(2017) Ming-Tzo Wei et al.   Nature Chemistry

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Charge pattern matching as a ‘fuzzy’ mode of molecular recognition for the functional phase separations of intrinsically disordered proteins

(2017) Yi-Hsuan Lin et al.   NEW JOURNAL OF PHYSICS

Explicit description of complexation between oppositely charged polyelectrolytes as an advantage of the random phase approximation over the scaling approach

(2017) Artem M. Rumyantsev et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Structural and hydrodynamic properties of an intrinsically disordered region of a germ cell-specific protein on phase separation

(2017) Jacob P. Brady et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of transcriptional activity by design of charge patterning in the intrinsically disordered RAM region of the Notch receptor

(2017) Kathryn P. Sherry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intrinsically Disordered Proteome of Human Membrane-Less Organelles

(2017) April L. Darling et al.   PROTEOMICS

Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water

(2017) Joshua A. Riback et al.   SCIENCE

Rheological characterization of liquid-to-solid transitions in bulk polyelectrolyte complexes

(2017) Yalin Liu et al.   Soft Matter

Transfer matrix theory of polymer complex coacervation

(2017) Tyler K. Lytle et al.   Soft Matter

Sequence and entropy-based control of complex coacervates

(2017) Li-Wei Chang et al.   Nature Communications

Phase separation in biology; functional organization of a higher order

(2016) Diana M. Mitrea et al.   Cell Communication and Signaling

Liquid–liquid phase separation in cellular signaling systems

(2016) P Andrew Chong et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Recent Developments in Fully Fluctuating Field-Theoretic Simulations of Polymer Melts and Solutions

(2016) Kris T. Delaney et al.   JOURNAL OF PHYSICAL CHEMISTRY B

A Molecular Thermodynamic Model of Complexation in Mixtures of Oppositely Charged Polyelectrolytes with Explicit Account of Charge Association/Dissociation

(2016) Ali Salehi et al.   MACROMOLECULES

Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein

(2016) Chi W. Pak et al.   MOLECULAR CELL

Decoding ALS: from genes to mechanism

(2016) J. Paul Taylor et al.   NATURE

Sequence-Specific Polyampholyte Phase Separation in Membraneless Organelles

(2016) Yi-Hsuan Lin et al.   PHYSICAL REVIEW LETTERS

Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA

(2016) Diana M Mitrea et al.   eLife

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

(2015) Amandine Molliex et al.   CELL

Functional roles of transiently and intrinsically disordered regions within proteins

(2015) Vladimir N. Uversky   FEBS Journal

Residue-by-Residue View of In Vitro FUS Granules that Bind the C-Terminal Domain of RNA Polymerase II

(2015) Kathleen A. Burke et al.   MOLECULAR CELL

Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles

(2015) Timothy J. Nott et al.   MOLECULAR CELL

Polymer physics of intracellular phase transitions

(2015) Clifford P. Brangwynne et al.   Nature Physics

Chirality-selected phase behaviour in ionic polypeptide complexes

(2015) Sarah L. Perry et al.   Nature Communications

The Polyelectrolyte Complex/Coacervate Continuum

(2014) Qifeng Wang et al.   MACROMOLECULES

The Effect of Salt on the Complex Coacervation of Vinyl Polyelectrolytes

(2014) Sarah Perry et al.   Polymers

Dual Specificity Kinase DYRK3 Couples Stress Granule Condensation/Dissolution to mTORC1 Signaling

(2013) Frank Wippich et al.   CELL

Complex coacervation of poly(ethylene-imine)/polypeptide aqueous solutions: Thermodynamic and rheological characterization

(2013) Dimitrios Priftis et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Linear Viscoelasticity of Polyelectrolyte Complex Coacervates

(2013) Evan Spruijt et al.   MACROMOLECULES

Polyelectrolyte Molecular Weight and Salt Effects on the Phase Behavior and Coacervation of Aqueous Solutions of Poly(acrylic acid) Sodium Salt and Poly(allylamine) Hydrochloride

(2013) Rungsima Chollakup et al.   MACROMOLECULES

A nuclear F-actin scaffold stabilizes ribonucleoprotein droplets against gravity in large cells

(2013) Marina Feric et al.   NATURE CELL BIOLOGY

Conformations of intrinsically disordered proteins are influenced by linear sequence distributions of oppositely charged residues

(2013) R. K. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Energy Component Analysis of π Interactions

(2012) C. David Sherrill   ACCOUNTS OF CHEMICAL RESEARCH

Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels

(2012) Masato Kato et al.   CELL

Thermodynamic Characterization of Polypeptide Complex Coacervation

(2012) Dimitrios Priftis et al.   LANGMUIR

Polymer scaling laws of unfolded and intrinsically disordered proteins quantified with single-molecule spectroscopy

(2012) H. Hofmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P granules extend the nuclear pore complex environment in theC. elegansgerm line

(2011) Dustin L. Updike et al.   JOURNAL OF CELL BIOLOGY

Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes

(2011) C. P. Brangwynne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biogenesis and function of nuclear bodies

(2011) Yuntao S. Mao et al.   TRENDS IN GENETICS

Sequence Determinants of Compaction in Intrinsically Disordered Proteins

(2010) Joseph A. Marsh et al.   BIOPHYSICAL JOURNAL

Complexation of oppositely charged polyelectrolytes: Effect of discrete charge distribution along the chain

(2010) Igor I. Potemkin et al.   PHYSICAL REVIEW E

Relaxation Dynamics at Different Time Scales in Electrostatic Complexes: Time-Salt Superposition

(2010) Evan Spruijt et al.   PHYSICAL REVIEW LETTERS

Net charge per residue modulates conformational ensembles of intrinsically disordered proteins

(2010) A. H. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Charge interactions can dominate the dimensions of intrinsically disordered proteins

(2010) S. Muller-Spath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biogenesis of Nuclear Bodies

(2010) M. Dundr et al.   Cold Spring Harbor Perspectives in Biology

Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

(2009) C. P. Brangwynne et al.   SCIENCE