Huperzine A as a neuroprotective and antiepileptic drug: a review of preclinical research

Huperzine A Inhibits CCL2 Production in Experimental Autoimmune Encephalomyelitis Mice and in Cultured Astrocyte

(2017) G.X. Tian et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

JapaneseHuperzia serrataextract and the constituent, huperzine A, ameliorate the scopolamine-induced cognitive impairment in mice

(2015) Takuya Ohba et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Commentary on IL-1β associations with posttraumatic epilepsy development: A genetics and biomarker cohort study

(2015) Alexander Rotenberg   EPILEPSIA

Huperzine A prophylaxis against pentylenetetrazole-induced seizures in rats is associated with increased cortical inhibition

(2015) R. Gersner et al.   EPILEPSY RESEARCH

Progress report on new antiepileptic drugs: A summary of the Twelfth Eilat Conference (EILAT XII)

(2015) Meir Bialer et al.   EPILEPSY RESEARCH

Activation of the anti-inflammatory reflex blocks lipopolysaccharide-induced decrease in synaptic inhibition in the temporal cortex of the rat

(2015) Francisco Garcia-Oscos et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Diversity of native nicotinic receptor subtypes in mammalian brain

(2015) Michele Zoli et al.   NEUROPHARMACOLOGY

IL-1β associations with posttraumatic epilepsy development: A genetics and biomarker cohort study

(2014) Matthew L. Diamond et al.   EPILEPSIA

A nicotinic receptor-mediated anti-inflammatory effect of the flavonoid rhamnetin in BV2 microglia

(2014) Joseph A. Lutz et al.   FITOTERAPIA

The Neurovascular Protective Effects of Huperzine A on D-Galactose-Induced Inflammatory Damage in the Rat Hippocampus

(2014) Qingwei Ruan et al.   GERONTOLOGY

Huperzine A Ameliorates Cognitive Deficits in Streptozotocin-Induced Diabetic Rats

(2014) Xiao-Yuan Mao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibiting β-Amyloid-Associated Alzheimer’s Pathogenesis In Vitro and In Vivo by a Multifunctional Dimeric Bis(12)-hupyridone Derived from Its Natural Analogue

(2014) Shengquan Hu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Alpha-7 nicotinic acetylcholine receptor agonist treatment reduces neuroinflammation, oxidative stress, and brain injury in mice with ischemic stroke and bone fracture

(2014) Zhenying Han et al.   JOURNAL OF NEUROCHEMISTRY

Cholinesterase inhibitors for Parkinson's disease: a systematic review and meta-analysis

(2014) Gennaro Pagano et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Direct excitation of parvalbumin-positive interneurons by M1muscarinic acetylcholine receptors: roles in cellular excitability, inhibitory transmission and cognition

(2014) Feng Yi et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Protective Effect of Huperzine A Against Hepatic Ischemia Reperfusion Injury in Mice

(2014) Y. Yang et al.   TRANSPLANTATION PROCEEDINGS

Epilepsy and Inflammation in the Brain: Overview and Pathophysiology

(2014) Annamaria Vezzani   Epilepsy Currents

Phase I study on the pharmacokinetics and tolerance of ZT-1, a prodrug of huperzine A, for the treatment of Alzheimer's disease

(2013) Jing-ying Jia et al.   ACTA PHARMACOLOGICA SINICA

Causes of CNS Inflammation and Potential Targets for Anticonvulsants

(2013) Mercé Falip et al.   CNS DRUGS

Traumatic Brain Injury: Central and Peripheral Role of ?7 Nicotinic Acetylcholine Receptors

(2013) Matthew L. Kelso et al.   CURRENT DRUG TARGETS

Controlled Iontophoretic Transport of Huperzine A across Skin in Vitro and in Vivo: Effect of Delivery Conditions and Comparison of Pharmacokinetic Models

(2013) Dhaval R. Kalaria et al.   MOLECULAR PHARMACEUTICS

Neuroprotection of rat retinal ganglion cells mediated through alpha7 nicotinic acetylcholine receptors

(2013) K. Iwamoto et al.   NEUROSCIENCE

Long-term nicotine treatment suppresses IL-1β release and attenuates substance P- and 5-HT-evoked Ca2+ responses in astrocytes

(2013) Anna Westerlund et al.   NEUROSCIENCE LETTERS

Neuregulin Upregulates Microglial α7 Nicotinic Acetylcholine Receptor Expression in Immortalized Cell Lines: Implications for Regulating Neuroinflammation

(2013) Malwina Mencel et al.   PLoS One

A combination of [+] and [−]-Huperzine A improves protection against soman toxicity compared to [+]-Huperzine A in guinea pigs

(2012) Ying Wang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Acetylcholinesterase deficiency decreases apoptosis in dopaminergic neurons in the neurotoxin model of Parkinson's disease

(2012) Xuejin Zhang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

An Efficient Total Synthesis of (−)-Huperzine A

(2012) Rui Ding et al.   ORGANIC LETTERS

Nicotinic acetylcholine receptors: From basic science to therapeutics

(2012) Raymond Hurst et al.   PHARMACOLOGY & THERAPEUTICS

Epilepsy and brain inflammation

(2011) Annamaria Vezzani et al.   EXPERIMENTAL NEUROLOGY

A new measure of cortical inhibition by mechanomyography and paired-pulse transcranial magnetic stimulation in unanesthetized rats

(2011) Tsung-Hsun Hsieh et al.   JOURNAL OF NEUROPHYSIOLOGY

Brain Infiltration of Leukocytes Contributes to the Pathophysiology of Temporal Lobe Epilepsy

(2011) M. Zattoni et al.   JOURNAL OF NEUROSCIENCE

[+]-Huperzine A Protects Against Soman Toxicity in Guinea Pigs

(2011) Ying Wang et al.   NEUROCHEMICAL RESEARCH

Pre-clinical validation of a novel alpha-7 nicotinic receptor radiotracer, [3H]AZ11637326: Target localization, biodistribution and ligand occupancy in the rat brain

(2011) Donna L. Maier et al.   NEUROPHARMACOLOGY

Inflammation and prevention of epileptogenesis

(2011) Teresa Ravizza et al.   NEUROSCIENCE LETTERS

Interleukin-1β Biosynthesis Inhibition Reduces Acute Seizures and Drug Resistant Chronic Epileptic Activity in Mice

(2011) Mattia Maroso et al.   Neurotherapeutics

PRiMA directs a restricted localization of tetrameric AChE at synapses

(2010) Heidi Q. Xie et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Conformations and Biological Activities of Amyloid Beta Peptide 25-35

(2010) L. Millucci et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Presynaptic muscarinic receptor subtypes involved in the enhancement of spontaneous GABAergic postsynaptic currents in hippocampal neurons

(2010) J. C. González et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The role of inflammation in epilepsy

(2010) Annamaria Vezzani et al.   Nature Reviews Neurology

The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner

(2010) B. Poulin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Patterned activity within the local cortical architecture

(2010) Farran Briggs   Frontiers in Neuroscience

Pharmacokinetic behavior of huperzine A in plasma and cerebrospinal fluid after intranasal administration in rats

(2009) Qiao Wang et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Huperzine A protects isolated rat brain mitochondria against β-amyloid peptide

(2009) Xin Gao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Total Synthesis of (−)-Huperzine A

(2009) Takahiro Koshiba et al.   ORGANIC LETTERS

Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function

(2009) Edson X. Albuquerque et al.   PHYSIOLOGICAL REVIEWS

The role of cytokines in the pathophysiology of epilepsy

(2008) Annamaria Vezzani et al.   BRAIN BEHAVIOR AND IMMUNITY

[+]-Huperzine A treatment protects against N-methyl-d-aspartate-induced seizure/status epilepticus in rats

(2008) Brian R. Coleman et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Allosteric modulation of α7 nicotinic receptors selectively depolarizes hippocampal interneurons, enhancing spontaneous GABAergic transmission

(2008) J. J. Arnaiz-Cot et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Pharmacokinetics of Huperzine A after transdermal and oral administration in beagle dogs

(2008) J.C. Ye et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Huperzine A exhibits anti-inflammatory and neuroprotective effects in a rat model of transient focal cerebral ischemia

(2008) Zhi-Fei Wang et al.   JOURNAL OF NEUROCHEMISTRY

Huperzine A attenuates mitochondrial dysfunction after middle cerebral artery occlusion in rats

(2008) Chun Yan Zheng et al.   JOURNAL OF NEUROSCIENCE RESEARCH