Furthering our understanding of SUDEP: the role of animal models

Abnormalities of serotonergic neurotransmission in animal models of SUDEP

(2017) Hua-Jun Feng et al.   EPILEPSY & BEHAVIOR

Omega-3 Fatty Acids in the Management of Epilepsy

(2016) Silvia Tejada et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Inhibition of adenosine metabolism induces changes in post-ictal depression, respiration, and mortality in genetically epilepsy prone rats

(2016) Srinivasa P. Kommajosyula et al.   EPILEPSY RESEARCH

Treatment of Depression in Patients with Concomitant Cardiac Disease

(2016) Robyn M. Teply et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Cardiac Toxicity in Selective Serotonin Reuptake Inhibitor Users

(2015) Monia Lusetti et al.   AMERICAN JOURNAL OF FORENSIC MEDICINE AND PATHOLOGY

Use of selective serotonin re-uptake inhibitors and the heart rate corrected QT interval in a real-life setting: the population-based Rotterdam Study

(2015) Nevena M. Maljuric et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Prolongation of Action Potential Duration and QT Interval During Epilepsy Linked to Increased Contribution of Neuronal Sodium Channels to Cardiac Late Na+Current

(2015) Michael Biet et al.   Circulation-Arrhythmia and Electrophysiology

Epilepsy

(2015) Vikram R. Rao et al.   CURRENT BIOLOGY

Premature ventricular complexes: How benign are they in epilepsy?

(2015) Aline P. Pansani et al.   EPILEPSY & BEHAVIOR

Phenytoin is not involved with changes in heart rate of rats with epilepsy

(2015) Diego B. Colugnati et al.   EPILEPSY & BEHAVIOR

Fluoxetine prevents respiratory arrest without enhancing ventilation in DBA/1 mice

(2015) Chang Zeng et al.   EPILEPSY & BEHAVIOR

5-HT2A receptor activation is necessary for CO2-induced arousal

(2015) Gordon F. Buchanan et al.   JOURNAL OF NEUROPHYSIOLOGY

Epilepsy: new advances

(2015) Solomon L Moshé et al.   LANCET

Spreading depolarization in the brainstem mediates sudden cardiorespiratory arrest in mouse SUDEP models

(2015) Isamu Aiba et al.   Science Translational Medicine

Evaluation of Cardiovascular Risk Factors in the Wistar Audiogenic Rat (WAR) Strain

(2015) Rubens Fazan et al.   PLoS One

Pathophysiogenesis of Mesial Temporal Lobe Epilepsy: Is Prevention of Damage Antiepileptogenic?

(2014) G. Curia et al.   CURRENT MEDICINAL CHEMISTRY

The Kv1.1 null mouse, a model of sudden unexpected death in epilepsy (SUDEP)

(2014) Brian M. Moore et al.   EPILEPSIA

Two-hit rodent seizure model: A promising new design for research in SUDEP

(2014) Fulvio A. Scorza et al.   EPILEPSY & BEHAVIOR

Serotonin and sudden death: Differential effects of serotonergic drugs on seizure-induced respiratory arrest in DBA/1 mice

(2014) Carl L. Faingold et al.   EPILEPSY & BEHAVIOR

Epilepsy & Behavior: 15th Anniversary Research on omega-3 fatty acids for epilepsy

(2014) Christopher M. DeGiorgio et al.   EPILEPSY & BEHAVIOR

Fish oil (n-3 fatty acids) in drug resistant epilepsy: a randomised placebo-controlled crossover study

(2014) Christopher M DeGiorgio et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Serotonin neurones have anti-convulsant effects and reduce seizure-induced mortality

(2014) Gordon F. Buchanan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Hyper-SUMOylation of the Kv7 Potassium Channel Diminishes the M-Current Leading to Seizures and Sudden Death

(2014) Yitao Qi et al.   NEURON

SUDEP research: Challenges for the future

(2013) Carla A. Scorza et al.   EPILEPSY & BEHAVIOR

Sleep and epilepsy

(2013) Christopher P. Derry et al.   EPILEPSY & BEHAVIOR

Relation of autonomic and cardiac abnormalities to ventricular fibrillation in a rat model of epilepsy

(2013) Isaac Naggar et al.   EPILEPSY RESEARCH

Sudden unexpected death in a mouse model of Dravet syndrome

(2013) Franck Kalume et al.   JOURNAL OF CLINICAL INVESTIGATION

The kainic acid model of temporal lobe epilepsy

(2013) Maxime Lévesque et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Altered Cardiac Electrophysiology and SUDEP in a Model of Dravet Syndrome

(2013) David S. Auerbach et al.   PLoS One

Sudden unexpected death in epilepsy: Fatal post-ictal respiratory and arousal mechanisms

(2013) Levi P. Sowers et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Cardiac dysfunction in rats prone to audiogenic epileptic seizures

(2013) Denis D. Damasceno et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Adenosine A1 Receptors in Mouse Pontine Reticular Formation Depress Breathing, Increase Anesthesia Recovery Time, and Decrease Acetylcholine Release

(2012) George C. Gettys et al.   ANESTHESIOLOGY

Sudden Unexpected Death in Epilepsy

(2012) Dale C. Hesdorffer et al.   CNS DRUGS

Sudden unexpected death in epilepsy

(2012) Rainer Surges et al.   CURRENT OPINION IN NEUROLOGY

Impact of periictal interventions on respiratory dysfunction, postictal EEG suppression, and postictal immobility

(2012) Masud Seyal et al.   EPILEPSIA

Hypoxia Markers are Expressed in Interneurons Exposed to Recurrent Seizures

(2012) Fabio Gualtieri et al.   NEUROMOLECULAR MEDICINE

Cardiovascular dysautonomia after seizures induced by maximal electroshock in Wistar rats

(2012) Denis D. Damasceno et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Differences in serotonin receptor expression in the brainstem may explain the differential ability of a serotonin agonist to block seizure-induced sudden death in DBA/2 vs. DBA/1 mice

(2011) Carl L. Faingold et al.   BRAIN RESEARCH

Seizure-related cardiac repolarization abnormalities are associated with ictal hypoxemia

(2011) Masud Seyal et al.   EPILEPSIA

The serotonin axis: Shared mechanisms in seizures, depression, and SUDEP

(2011) George B. Richerson et al.   EPILEPSIA

Combined analysis of risk factors for SUDEP

(2011) Dale C. Hesdorffer et al.   EPILEPSIA

Repeated amygdala-kindled seizures induce ictal rebound tachycardia in rats

(2011) Aline P. Pansani et al.   EPILEPSY & BEHAVIOR

Prevention of seizure-induced sudden death in a chronic SUDEP model by semichronic administration of a selective serotonin reuptake inhibitor

(2011) Carl L. Faingold et al.   EPILEPSY & BEHAVIOR

Sudden, Unexpected Death in Epilepsy

(2011) Orrin Devinsky   NEW ENGLAND JOURNAL OF MEDICINE

Sudden Unexpected Death in Epilepsy

(2010) Maromi Nei et al.   Current Neurology and Neuroscience Reports

Serotonin reuptake inhibitors are associated with reduced severity of ictal hypoxemia in medically refractory partial epilepsy

(2010) Lisa M. Bateman et al.   EPILEPSIA

Ictal hypoventilation contributes to cardiac arrhythmia and SUDEP: Report on two deaths in video-EEG-monitored patients

(2010) Lisa M. Bateman et al.   EPILEPSIA

What can be done to reduce the risk of SUDEP?

(2010) Fulvio A. Scorza et al.   EPILEPSY & BEHAVIOR

Tachycardias and sudden unexpected death in epilepsy: A gold rush by an experimental route

(2010) Aline P. Pansani et al.   EPILEPSY & BEHAVIOR

DBA/1 mice exhibit chronic susceptibility to audiogenic seizures followed by sudden death associated with respiratory arrest

(2010) Carl L. Faingold et al.   EPILEPSY & BEHAVIOR

Kv1.1 Potassium Channel Deficiency Reveals Brain-Driven Cardiac Dysfunction as a Candidate Mechanism for Sudden Unexplained Death in Epilepsy

(2010) E. Glasscock et al.   JOURNAL OF NEUROSCIENCE

Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders

(2010) Massimo Mantegazza et al.   LANCET NEUROLOGY

Sudden unexpected death in epilepsy (SUDEP) and sleep

(2010) Lino Nobili et al.   SLEEP MEDICINE REVIEWS

Status epilepticus induces cardiac myofilament damage and increased susceptibility to arrhythmias in rats

(2009) Cameron S. Metcalf et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mortality in captive baboons with seizures: A new model for SUDEP?

(2009) C. Ákos Szabó et al.   EPILEPSIA

Pathologic cardiac repolarization in pharmacoresistant epilepsy and its potential role in sudden unexpected death in epilepsy: A case-control study

(2009) Rainer Surges et al.   EPILEPSIA

A novel mouse model for sudden unexpected death in epilepsy (SUDEP): Role of impaired adenosine clearance

(2009) Hai-Ying Shen et al.   EPILEPSIA

Sudden unexpected death in epilepsy and winter temperatures: It’s important to know that it’s c-c-c-c-cold outside

(2009) Fulvio A. Scorza et al.   EPILEPSY & BEHAVIOR

Respiratory Physiology of Seizures

(2009) Andrew S. Blum   JOURNAL OF CLINICAL NEUROPHYSIOLOGY

Could sudden death syndrome (SDS) in chickens (Gallus gallus) be a valid animal model for sudden unexpected death in epilepsy (SUDEP)?

(2009) F.A. Scorza et al.   MEDICAL HYPOTHESES

Sudden unexpected death in epilepsy: risk factors and potential pathomechanisms

(2009) Rainer Surges et al.   Nature Reviews Neurology

Sudden Unexpected Death in Epilepsy (SUDEP): Update and Reflections

(2009) Lina Nashef et al.   NEUROLOGIC CLINICS

Is cold the new hot in sudden unexpected death in epilepsy? Effect of low temperature on heart rate of rats with epilepsy

(2008) Eliza Y.F. Sonoda et al.   ARQUIVOS DE NEURO-PSIQUIATRIA

Ictal hypoxemia in localization-related epilepsy: analysis of incidence, severity and risk factors

(2008) L. M. Bateman et al.   BRAIN

What is known about the mechanisms underlying SUDEP?

(2008) Elson L. So   EPILEPSIA

Autonomic consequences of kainic acid-induced limbic cortical seizures in rats: Peripheral autonomic nerve activity, acute cardiovascular changes, and death

(2008) Kenichi Sakamoto et al.   EPILEPSIA

Status epilepticus produces chronic alterations in cardiac sympathovagal balance

(2008) Cameron S. Metcalf et al.   EPILEPSIA

Cardiac sympathetic nerve activity during kainic acid-induced limbic cortical seizures in rats

(2008) Harumi Hotta et al.   EPILEPSIA

The other side of the coin: Beneficiary effect of omega-3 fatty acids in sudden unexpected death in epilepsy

(2008) Fulvio A. Scorza et al.   EPILEPSY & BEHAVIOR