Article
Nursing
Leilei Liang, Yuanchao Hu, Junsong Fei, Tongshuang Yuan, Ren Gao, Jingyi Yue, Qianqian Song, Xixi Zhao, Songli Mei
Summary: This study investigates the relationship between burnout and PTSD among frontline nurses who went to assist the outbreak in Wuhan during the COVID-19 pandemic. The study also explores the mediating role of depression and the moderating role of age in this relationship.
JOURNAL OF CLINICAL NURSING
(2023)
Article
Multidisciplinary Sciences
Victoria M. E. Bridgland, Ella K. Moeck, Deanne M. Green, Taylor L. Swain, Diane M. Nayda, Lucy A. Matson, Nadine P. Hutchison, Melanie K. T. Takarangi
Summary: Despite not fitting into existing PTSD models, COVID-19 can be understood as a traumatic stressor event capable of eliciting PTSD-like responses and exacerbating other related mental health problems. Participants showed PTSD-like symptoms for events that had not happened, whether they had been directly (e.g., contact with virus) or indirectly exposed to COVID-19 (e.g., through media).
Article
Biochemistry & Molecular Biology
Yiheng Tu, Yuqi Zhang, Yu Li, Qing Zhao, Yanzhi Bi, Xuejing Lu, Yazhuo Kong, Li Wang, Zhijie Lu, Li Hu
Summary: The study suggests that COVID-19 survivors may experience deteriorations in PTSS, with PCL-5 scores positively correlated with duration after discharge and potential changes in brain structural volumes in bilateral hippocampus and amygdala.
MOLECULAR PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Mayssam Nehme, Laure Vieux, Laurent Kaiser, Francois Chappuis, Catherine Chenaud, HealthCo Study Team, Idris Guessous
Summary: Experts have conducted an online follow-up on healthcare workers at Geneva University Hospitals to assess the evolution of pandemic burden and long-term effects of post-COVID symptoms. The study found that over time, more individuals reported various symptoms, functional impairment, and decreased quality of life, with a larger increase in symptoms among the SARS-CoV-2 negative group. The findings highlight the urgent need for action and solutions to address the long-term consequences faced by healthcare workers.
SCIENTIFIC REPORTS
(2023)
Article
Psychiatry
Claudia Carmassi, Annalisa Cordone, Carlo Antonio Bertelloni, Andrea Cappelli, Virginia Pedrinelli, Gaia Sampogna, Gabriele Massimetti, Valerio Dell'Oste, Liliana Dell'Osso
Summary: This study aimed to investigate the effects of the COVID-19 emergency on the clinical course of BD patients. The results revealed three distinct symptom trajectories in this population, including the Acute reaction group, the Increasing severity group, and the Low symptoms group. Females had a higher prevalence in the Acute reaction group, while the Increasing severity group had higher rates of previous hospitalization and manic symptoms at baseline.
EUROPEAN PSYCHIATRY
(2022)
Article
Nursing
Kristina Struksnes Fjone, Eirik Alnes Buanes, Milada Cvancarova Smastuen, Jon Henrik Laake, Jan Stubberud, Kristin Hofso
Summary: The aim of this study was to investigate the prevalence of post-traumatic stress symptoms and identify the predictive factors in Norwegian ICU survivors with COVID-19. Results showed that 22.5% of patients reported post-traumatic stress symptoms 6 months after admission, with female gender, younger age, and high respiratory rate at admission being significant predictive factors.
JOURNAL OF CLINICAL NURSING
(2023)
Article
Psychiatry
Samuel Cyr, Marie-Joelle Marcil, Marie-France Marin, Jean-Claude Tardif, Stephane Guay, Marie-Claude Guertin, Camille Rosa, Christine Genest, Jacques Forest, Patrick Lavoie, Melanie Labrosse, Alain Vadeboncoeur, Shaun Selcer, Simon Ducharme, Judith Brouillette
Summary: This study investigated modifiable factors for burnout in healthcare workers during the COVID-19 pandemic, finding that resilience and perceived organizational support were significantly associated with burnout and other outcomes. Future research should focus on these factors to promote mental health.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Behavioral Sciences
Jose Adan Miguel-Puga, Davis Cooper-Bribiesca, Francisco Jose Avelar-Garnica, Luis Alejandro Sanchez-Hurtado, Tania Colin-Martinez, Eliseo Espinosa-Poblano, Juan Carlos Anda-Garay, Jorge Ivan Gonzalez-Diaz, Oscar Bernardo Segura-Santos, Luz Cristina Vital-Arriaga, Kathrine Jauregui-Renaud
Summary: This study found that compared to men, women with pre-existing anxiety were more prone to acute stress; and younger age was associated with more common pre-existing psychological symptoms and lower resilience. Additionally, the study indicated poor overall sleep quality and persistent burnout had impacts on state anxiety, acute stress, and symptoms of depersonalization/derealization.
BRAIN AND BEHAVIOR
(2021)
Article
Clinical Neurology
Claudia Carmassi, Valerio Dell'Oste, Eric Bui, Claudia Foghi, Carlo Antonio Bertelloni, Anna Rita Atti, Rodolfo Buselli, Marco Di Paolo, Arianna Goracci, Paolo Malacarne, Maria Giulia Nanni, Camilla Gesi, Giancarlo Cerveri, Liliana Dell'Osso
Summary: This study investigates the mental symptoms and functioning impairment of frontline healthcare workers in different regions during the COVID-19 pandemic. The study finds that depression and post-traumatic stress symptoms are the main factors affecting the functioning impairment of healthcare workers.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Multidisciplinary
Mohammad Ali Zakeri, Elham Rahiminezhad, Farzaneh Salehi, Hamid Ganjeh, Mahlagha Dehghan
Summary: This study compared burnout, anxiety, stress, and depression in nurses before and during the first wave of the COVID-19 pandemic. The results showed that anxiety, stress, and depression significantly increased during the pandemic, while burnout levels remained relatively stable.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Psychiatry
Samuel Cyr, Marie-Joelle Marcil, Cylia Houchi, Marie-France Marin, Camille Rosa, Jean-Claude Tardif, Stephane Guay, Marie-Claude Guertin, Christine Genest, Jacques Forest, Patrick Lavoie, Melanie Labrosse, Alain Vadeboncoeur, Shaun Selcer, Simon Ducharme, Judith Brouillette
Summary: This study aimed to examine the long-term psychological impacts of the COVID-19 pandemic on healthcare workers. The results showed that the occupational and mental health of healthcare workers remained stable or improved between three and twelve months after the pandemic onset. Resilience and perceived organizational support were identified as the predominant protective factors against burnout, while social support played an important role in PTSD, anxiety, and depression over time.
Article
Multidisciplinary Sciences
Johannes Herrmann, Kerstin Mueller, Quirin Notz, Martha Huebsch, Kirsten Haas, Anna Horn, Julia Schmidt, Peter Heuschmann, Jens Maschmann, Matthias Frosch, Juergen Deckert, Hermann Einsele, Georg Ertl, Stefan Frantz, Patrick Meybohm, Christopher Lotz
Summary: This study aimed to determine the health-related quality of life (HRQoL) in non-intensive care unit (ICU) and ICU patients after COVID-19 hospitalization. The study found that COVID-19 ICU patients have lower HRQoL at 3- and 12-months post hospitalization compared to non-ICU patients. Additionally, mental disorders were common among ICU patients, highlighting the importance of addressing mental well-being after COVID-19.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Carola Dell'Acqua, Tania Moretta, Elisa Dal Bo, Simone Messerotti Benvenuti, Daniela Palomba
Summary: This longitudinal study examined the differential role of anxiety and depressive symptoms in predicting posttraumatic stress symptoms (PTSS) severity related to the COVID-19 pandemic. The results showed significant interactions between anxiety symptoms and Late Positive Potential (LPP) amplitude in predicting pandemic-related PTSS. The findings suggest that assessing anxiety symptoms and pre-trauma LPP to emotional stimuli may be useful for identifying individuals at higher risk for developing PTSS during times of crisis.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Lijuan Quan, Wei Lu, Rui Zhen, Xiao Zhou
Summary: The COVID-19 pandemic has resulted in increased psychiatric disorders in college students, including PTSD, depression, and anxiety. This study investigated the prevalence of these disorders and their comorbidity, highlighting the importance of targeted interventions for college students.
Article
Psychiatry
Antonio Lorenzo, Altea Kthupi, Weihan Liu, Chloe Hamza, Antoaneta A. Todorova, Sarah Kuburi, Anne K. Ellis, Charles Keown-Stoneman, Shaza A. Fadel, France Gagnon
Summary: This prospective longitudinal study measured sex-specific changes in depression, anxiety, and stress scores using validated questionnaires in a cohort of post-secondary students. The study found that the stringency of public health measures was significantly associated with increased stress levels. Demographic factors had a greater influence on female students' mental health outcomes compared to males. Targeted interventions could be beneficial in allocating mental health resources during a pandemic.
PSYCHIATRY RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Thomas Aparicio, Olivier Bouche, Pierre-Luc Etienne, Emilie Barbier, Laurent Mineur, Romain Desgrippes, Veronique Guerin-Meyer, Faycal Hocine, Jean Martin, Valerie Le Brun-Ly, Jacques Cretin, Jerome Desrame, Yves Rinaldi, Laurent Cany, Claire Falandry, Leila Bengrine Lefevre, Miguelle Marous, Eric Terrebonne, Laurent Mosser, Justine Turpin, Anthony Turpin, Lucille Bauguion, Cynthia Reichling, Marc Van den Eynde, Elisabeth Carola, Sandrine Hiret
Summary: In the preliminary tolerance analysis of the ADAGE-PRODIGE 34 trial, it was found that in patients over 70 years old, the group of patients treated with oxaliplatin and fluoropyrimidine had more grade 3-5 toxicities compared to the group treated with fluoropyrimidine alone in the fit patients.
DIGESTIVE AND LIVER DISEASE
(2023)
Editorial Material
Gastroenterology & Hepatology
Mariana Milashka-Brihay, Mariana Figueiredo, Miguel Pantaleon Sanchez, Clara Yzet, Sophie Collardeau-Frachon, Jerome Rivory, Mathieu Pioche
Article
Anesthesiology
Martin Ruste, Charlotte Chabanol, Jean-Luc Fellahi, Matthias Jacquet-Lagreze
Summary: Bioelectrical impedance analysis (BIA) is used to evaluate the body composition of critically-ill patients. This study aimed to assess the value of BIA as a fluid management monitoring tool. The results showed that BIA-derived hydration variables were significantly correlated with cumulative fluid balance, but there were limitations in the agreement between the measurements, indicating they cannot be used interchangeably.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)
Article
Pediatrics
Margaux Richou, Olivier L. Mantha, Noel Perettic, Beatrice Dubern, Emmanuel Mas, Regis Hankard, Arnaud De Luca, ePINUT Study Grp
Summary: In 2019, the French National Authority for Health (HAS) published guidelines on the diagnosis of undernutrition. This study aimed to assess the impact of switching from the 2012 guidelines of the Nutrition Committee of the French Paediatric Society (CNSFP) to the HAS guidelines on the frequency of hospital undernutrition in children. The results showed that the frequency of undernutrition increased almost twofold when using the HAS criteria compared to the CNSFP criteria. Malnourished children had longer hospital stays, gained more weight during hospitalization, and received nutritional support more frequently.
ARCHIVES DE PEDIATRIE
(2023)
Article
Cardiac & Cardiovascular Systems
Clemence Delhomme, Marina Urena, Oualid Zouaghi, Francisco Campelo-Parada, Patrick Ohlmann, Gilles Rioufol, Eric Van Belle, Frederic Pinaud, Nicolas Meneveau, Patrick Staat, Olivier Morel, Francois Derimay, Flavien Vincent, Frederic Rouleau, Eric Brochet, Caroline Chong-Nguyen, Dominique Himbert
Summary: This study evaluated the effectiveness of transcatheter aortic valve implantation using the SAPIEN 3 transcatheter heart valve in patients with pure aortic regurgitation. The results showed a device success rate of 94.6%, a 30-day all-cause mortality rate of 8.1%, and a one-year all-cause mortality rate of 16.2%. This method appears promising for treating high-risk patients with pure aortic regurgitation, but further research is needed.
ARCHIVES OF CARDIOVASCULAR DISEASES
(2023)
Review
Endocrinology & Metabolism
Anais Alves, Beatrice Morio
Summary: This review discusses the metabolic changes associated with obesity, including a decrease in plasma glycine concentration, which is closely related to insulin resistance and predicts the risk of developing chronic metabolic diseases. Recent studies have made progress in understanding the underlying causes of decreased glycine levels and in developing strategies to replenish glycine stores and improve insulin resistance in obesity.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
(2023)
Review
Geriatrics & Gerontology
Lodovico Balducci, Claire Falandry, Alan List
Summary: Age is associated with the decline of multiple organ systems. Two molecules, trilaciclib and ALRN-6924, have emerged as novel strategies to prevent chemotherapy toxicity by inducing cell-cycle arrest. Trilaciclib inhibits CDK 4/6 to cause cell-cycle arrest, while ALRN-6924 activates p53. These drugs have shown promising results in preventing hematological toxicities in patients with small cell lung cancer and may also preserve the stem cell reserve of other tissues with high turnover.
Article
Nutrition & Dietetics
Claire Bordat, Donato Vairo, Charlotte Cuerq, Charlotte Halimi, Franck Peiretti, Armelle Penhoat, Aurelie Vieille-Marchiset, Teresa Gonzalez, Marie-Caroline Michalski, Marion Nowicki, Noel Peretti, Emmanuelle Reboul
Summary: Abetalipoproteinemia (FHBL-SD1) and chylomicron retention disease (FHBL-SD3) are rare recessive disorders caused by mutations in the MTTP and SAR1B genes, respectively. These mutations lead to defective chylomicron formation and secretion, resulting in lipid and fat-soluble vitamin malabsorption and severe neuro-ophthalmic complications. Current treatment options are not fully effective in normalizing serum vitamin E levels and providing complete ophthalmic protection.
Review
Surgery
Robin Bayoux, Benoit Gignoux, Camille Barani, Jean-Yves Mabrut, Ali Mojallal
Summary: A training method for endoscopic treatment of diastasis rectus abdominis was developed and evaluated on fresh cadaver models. The results showed that laparoscopic surgery is an efficient and safe approach to correct diastasis of the rectus muscles.
ANNALES DE CHIRURGIE PLASTIQUE ESTHETIQUE
(2023)
Article
Nutrition & Dietetics
Laure Meiller, Valerie Sauvinet, Anne-Esther Breyton, Harimalala Ranaivo, Christelle Machon, Anne Mialon, Alexandra Meynier, Stephan C. Bischoff, Jens Walter, Audrey M. Neyrinck, Martine Laville, Nathalie M. Delzenne, Sophie Vinoy, Julie-Anne Nazare
Summary: This pilot study aimed to analyze the kinetics of C-13-labeled gut-derived metabolites from C-13-labeled wheat bran in breath, plasma, and stools. The study found differential fermentation profiles among subjects and identified distinct excretion patterns of gases in high-CH4 producers compared to low-CH4 producers. The study also revealed different kinetics of C-13-labelled short-chain fatty acids in plasma.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Geriatrics & Gerontology
Emilie Bres, Julia Bouvier, Aymeric Courtay, Leo Delaire, Joannes Humblot, Charlotte Cuerq, Stephanie Tripoz-Dit-Masson, Mathieu Fauvernier, Thomas Gilbert, Marc Bonnefoy
Summary: This study aimed to determine the correlation between serum fibroblast growth factor 19 (FGF19) levels and functional muscle tests and muscle ultrasound parameters. The results showed significant correlations between FGF19 levels and muscle ultrasound parameters, suggesting that FGF19 may promote the development of large muscle fibers. However, high FGF19 levels were unexpectedly associated with a low SPPB score. Further studies are needed to validate and further elucidate these exploratory findings.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Psychiatry
Leo Delaire, Aymeric Courtay, Benjamin Pageaux, Christele Gautier, Francoise Jay Rayon, France Mourey, Antoine Noel Racine, Joannes Humblot, Marc Bonnefoy
Summary: The implementation of exercise-focused strategies in preventing mobility disability in at-risk seniors is crucial for public health. These strategies should be practical, structured, and personalized, involving coordination of adapted physical exercise programs and incorporation of best practices. Clear guidelines should be established to ensure effective programs supported by evidence-based literature and consensus among multi-professional experts. These guidelines should address frequency, intensity, duration, type, volume, and individual progressiveness. Programs should also prioritize a personalized approach to educate and empower participants for long-term health-related behaviors, with supervision from trained professionals to ensure safety and effectiveness. These guidelines will support national policies for the prevention of loss of autonomy and mobility throughout the country.
GERIATRIE ET PSYCHOLOGIE NEUROPSYCHIATRIE DE VIEILLISSEMENT
(2023)
Article
Critical Care Medicine
Romain Arrestier, Anis Chaba, Asma Mabrouki, Clement Saccheri, Emmanuel Canet, Marc Pineton de Chambrun, Annabelle Stoclin, Muriel Picard, Florent Wallet, Francois Perier, Matthieu Turpin, Laurent Argaud, Maxens Decavele, Nahema Issa, Cyril Cadoz, Kada Klouche, Johana Cohen, Djamel Mokart, Julien Grouille, Tomas Urbina, Camille Hua, Olivier Chosidow, Armand Mekontso-Dessap, Elie Azoulay, Nicolas de Prost
Summary: This retrospective multicentre cohort study aimed to describe the characteristics and management of neutropenic patients with necrotizing soft tissue infections (NSTIs) in intensive care units (ICUs). The study found that compared to non-neutropenic patients, neutropenic patients had different clinical and microbiological characteristics and higher in-hospital mortality. The administration of granulocyte colony-stimulating factor (G-CSF) was associated with improved hospital survival.
ANNALS OF INTENSIVE CARE
(2023)
Article
Clinical Neurology
Anke Wouters, Lauranne Scheldeman, Hannelore Liessens, Patrick Dupont, Florent Boutitie, Bastian Cheng, Martin Ebinger, Matthias Endres, Jochen B. Fiebach, Christian Gerloff, Keith W. Muir, Norbert Nighoghossian, Salvador Pedraza, Claus Z. Simonsen, Vincent Thijs, Goetz Thomalla, Robin Lemmens
Summary: This study aimed to explore the differences between women and men in acute ischemic stroke. The results showed that although there were more men in the WAKE-UP trial, sex did not modify the treatment effect of alteplase.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Urology & Nephrology
Matthias Jacquet-Lagreze, Martin Ruste, William Fornier, Pierre-Louis Jacquemet, Remi Schweizer, Jean-Luc Fellahi
Summary: This study aimed to investigate the ability of plasma protein concentration variations to detect a decrease in cardiac index (CI) during mechanical fluid removal and to assess other predictive factors of CI change. The results showed that haemoconcentration and passive leg raising failed to accurately predict a decrease in CI.
JOURNAL OF NEPHROLOGY
(2023)