Have microfluidics delivered for drug discovery?

Innovation in the pharmaceutical industry: New estimates of R&D costs

(2016) Joseph A. DiMasi et al.   JOURNAL OF HEALTH ECONOMICS

3D high throughput screening and profiling of embryoid bodies in thermoformed microwell plates

(2016) E. J. Vrij et al.   LAB ON A CHIP

Biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct surgical anastomosis

(2016) Boyang Zhang et al.   NATURE MATERIALS

Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs

(2016) Carlota Oleaga et al.   Scientific Reports

High-Throughput Assessment of Cellular Mechanical Properties

(2015) Eric M. Darling et al.   Annual Review of Biomedical Engineering

A phenotypic in vitro model for the main determinants of human whole heart function

(2015) Maria Stancescu et al.   BIOMATERIALS

High-throughput screening for modulators of cellular contractile force

(2015) Chan Young Park et al.   Integrative Biology

Microscale screening systems for 3D cellular microenvironments: platforms, advances, and challenges

(2014) Sara I. Montanez-Sauri et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Human airway musculature on a chip: an in vitro model of allergic asthmatic bronchoconstriction and bronchodilation

(2014) Alexander Peyton Nesmith et al.   LAB ON A CHIP

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Aqueous two-phase printing of cell-containing contractile collagen microgels

(2013) Christopher Moraes et al.   BIOMATERIALS

On being the right size: scaling effects in designing a human-on-a-chip

(2013) Christopher Moraes et al.   Integrative Biology

Microfluidic heart on a chip for higher throughput pharmacological studies

(2013) Ashutosh Agarwal et al.   LAB ON A CHIP

A new mechanobiological era: microfluidic pathways to apply and sense forces at the cellular level

(2012) Felix Kurth et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Direct assessment of living cell mechanical responses during deformation inside microchannel restrictions

(2011) Nadine Walter et al.   Biointerphases

Epithelium damage and protection during reopening of occluded airways in a physiologic microfluidic pulmonary airway model

(2011) Hossein Tavana et al.   BIOMEDICAL MICRODEVICES

Impact of high-throughput screening in biomedical research

(2011) Ricardo Macarron et al.   NATURE REVIEWS DRUG DISCOVERY

Spending on new drug development

(2009) Christopher Paul Adams et al.   HEALTH ECONOMICS

Microfluidic single cell arrays to interrogate signalling dynamics of individual, patient-derived hematopoietic stem cells

(2009) Shannon L. Faley et al.   LAB ON A CHIP