Nano-based rescue of dysfunctional autophagy in chronic obstructive lung diseases

Fine-tuning autophagy: from transcriptional to posttranslational regulation

(2016) Joëlle Botti-Millet et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Derailed Proteostasis as a Determinant of Cardiac Aging

(2016) Marit Wiersma et al.   CANADIAN JOURNAL OF CARDIOLOGY

A novel treatment of cystic fibrosis acting on-target: cysteamine plus epigallocatechin gallate for the autophagy-dependent rescue of class II-mutated CFTR

(2016) A Tosco et al.   CELL DEATH AND DIFFERENTIATION

Nicotine exposure induces bronchial epithelial cell apoptosis and senescence via ROS mediated autophagy-impairment

(2016) Manish Bodas et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neutrophil targeted nano-drug delivery system for chronic obstructive lung diseases

(2016) Neeraj Vij et al.   Nanomedicine-Nanotechnology Biology and Medicine

Dendrimer-Based Selective Proteostasis-Inhibition Strategy to Control NSCLC Growth and Progression

(2016) Kyla Walworth et al.   PLoS One

Role of Cigarette Smoke–Induced Aggresome Formation in Chronic Obstructive Pulmonary Disease–Emphysema Pathogenesis

(2015) Ian Tran et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Lactosylceramide-accumulation in lipid-rafts mediate aberrant-autophagy, inflammation and apoptosis in cigarette smoke induced emphysema

(2015) Manish Bodas et al.   APOPTOSIS

Health effects associated with waterpipe smoking

(2015) Ziad M El-Zaatari et al.   TOBACCO CONTROL

Toxicant content, physical properties and biological activity of waterpipe tobacco smoke and its tobacco-free alternatives

(2015) Alan Shihadeh et al.   TOBACCO CONTROL

Cysteamine as a Future Intervention in Cystic Fibrosis Against Current and Emerging Pathogens: A Patient-based ex vivo Study Confirming its Antimicrobial and Mucoactive Potential in Sputum

(2015) Graham Devereux et al.   EBioMedicine

Second-Hand Cigarette Smoke Impairs Bacterial Phagocytosis in Macrophages by Modulating CFTR Dependent Lipid-Rafts

(2015) Inzer Ni et al.   PLoS One

Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation

(2014) Daniela De Stefano et al.   Autophagy

Cigarette smoke and calcium conspire to impair CFTR function in airway epithelia

(2014) Andrew P Braun   Channels

Role of Infections

(2014) Kamen Rangelov et al.   CLINICS IN CHEST MEDICINE

Does a single Pseudomonas aeruginosa isolation predict COPD mortality?

(2014) A. K. Boutou et al.   EUROPEAN RESPIRATORY JOURNAL

Cigarette Smoke-induced Ca2+Release Leads to Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Dysfunction

(2014) Julia E. Rasmussen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD

(2014) Kenji Mizumura et al.   JOURNAL OF CLINICAL INVESTIGATION

Acquired defects in CFTR-dependent β-adrenergic sweat secretion in chronic obstructive pulmonary disease

(2014) Clifford A Courville et al.   RESPIRATORY RESEARCH

Cigarette smoke and CFTR: implications in the pathogenesis of COPD

(2013) Andras Rab et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Yin and Yang of Cystic Fibrosis Transmembrane Conductance Regulator Function

(2013) Neeraj Vij et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cigarette Smoke Induces Systemic Defects in Cystic Fibrosis Transmembrane Conductance Regulator Function

(2013) S. Vamsee Raju et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The acute effects of waterpipe smoking on lung function and exercise capacity in a pilot study of healthy participants

(2013) Feras I. Hawari et al.   INHALATION TOXICOLOGY

Autophagy and Autoimmunity Crosstalks

(2013) Abhisek Bhattacharya et al.   Frontiers in Immunology

Role of p97/VCP (Cdc48) in genome stability

(2013) Bruno Vaz et al.   Frontiers in Genetics

Acute cigarette smoke exposure impairs proteasome function in the lung

(2012) Sabine H. van Rijt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

p97/VCP- and Lys48-linked polyubiquitination form a new signaling pathway in DNA damage response

(2012) Kristijan Ramadan   CELL CYCLE

Editorial (Hot Topic: Proteostasis-Imbalance and Pathogenesis of Chronic Obstructive Lung Diseases)

(2012) Neeraj Vij   CURRENT MOLECULAR MEDICINE

Can Correcting the ΔF508-CFTR Proteostasis-Defect Rescue CF Lung Disease?

(2012) C. W. Valle et al.   CURRENT MOLECULAR MEDICINE

Therapeutic Strategies to Correct Proteostasis-Imbalance in Chronic Obstructive Lung Diseases

(2012) M. Bodas et al.   CURRENT MOLECULAR MEDICINE

The Effect of Cysteamine Bitartrate on Adiponectin Multimerization in Non-Alcoholic Fatty Liver Disease and Healthy Subjects

(2012) Ranjan Dohil et al.   JOURNAL OF PEDIATRICS

Health Status Assessment in Routine Clinical Practice: The Chronic Obstructive Pulmonary Disease Assessment Test Score in Outpatients

(2012) Julia L. Kelly et al.   RESPIRATION

In vitro cytotoxicity and mutagenicity of mainstream waterpipe smoke and its functional consequences on alveolar type II derived cells

(2012) Mayyasa Rammah et al.   TOXICOLOGY LETTERS

Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease

(2012) Satoko Fujii et al.   OncoImmunology

Critical role of CFTR-dependent lipid rafts in cigarette smoke-induced lung epithelial injury

(2011) Manish Bodas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Everything Prevents Emphysema

(2011) Andrew Churg et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Prevalence and correlates of waterpipe tobacco smoking by college students in North Carolina

(2011) Erin L. Sutfin et al.   DRUG AND ALCOHOL DEPENDENCE

Nano-based theranostics for chronic obstructive lung diseases: challenges and therapeutic potential

(2011) Neeraj Vij   Expert Opinion on Drug Delivery

The case for therapeutic proteostasis modulators

(2011) Neeraj Vij   EXPERT OPINION ON THERAPEUTIC TARGETS

Critical role of proteostasis-imbalance in pathogenesis of COPD and severe emphysema

(2011) Taehong Min et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks

(2011) Mayura Meerang et al.   NATURE CELL BIOLOGY

Targeting Nrf2 Signaling Improves Bacterial Clearance by Alveolar Macrophages in Patients with COPD and in a Mouse Model

(2011) C. J. Harvey et al.   Science Translational Medicine

Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for theF508del-CFTRmutation

(2011) J P Clancy et al.   THORAX

Cystic fibrosis: A disorder with defective autophagy

(2010) Alessandro Luciani et al.   Autophagy

SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress

(2010) Samuel Caito et al.   FASEB JOURNAL

Autophagy is activated by proteasomal inhibition and involved in aggresome clearance in cultured astrocytes

(2010) Sven B. Jänen et al.   GLIA

The effects of waterpipe tobacco smoking on health outcomes: a systematic review

(2010) E. A. Akl et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Critical Modifier Role of Membrane-Cystic Fibrosis Transmembrane Conductance Regulator-Dependent Ceramide Signaling in Lung Injury and Emphysema

(2010) M. Bodas et al.   JOURNAL OF IMMUNOLOGY

Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition

(2010) Alessandro Luciani et al.   NATURE CELL BIOLOGY

Effect of VX-770 in Persons with Cystic Fibrosis and the G551D-CFTRMutation

(2010) Frank J. Accurso et al.   NEW ENGLAND JOURNAL OF MEDICINE

Early-Age-Related Changes in Proteostasis Augment Immunopathogenesis of Sepsis and Acute Lung Injury

(2010) Manish Bodas et al.   PLoS One

Development of PEGylated PLGA nanoparticle for controlled and sustained drug delivery in cystic fibrosis

(2010) Neeraj Vij et al.   JOURNAL OF NANOBIOTECHNOLOGY

Biological and Chemical Approaches to Diseases of Proteostasis Deficiency

(2009) Evan T. Powers et al.   Annual Review of Biochemistry

Accelerated lung aging: a novel pathogenic mechanism of chronic obstructive pulmonary disease (COPD)

(2009) William MacNee   BIOCHEMICAL SOCIETY TRANSACTIONS

COPD as a Disease of Accelerated Lung Aging

(2009) Kazuhiro Ito et al.   CHEST

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

(2009) A. Ben-Zvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the Unfolded Protein Response by ΔF508 CFTR

(2008) Rafal Bartoszewski et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Enhanced cell-surface stability of rescued ΔF508 cystic fibrosis transmembrane conductance regulator (CFTR) by pharmacological chaperones

(2008) Karoly Varga et al.   BIOCHEMICAL JOURNAL

Chemical and Biological Approaches Synergize to Ameliorate Protein-Folding Diseases

(2008) Ting-Wei Mu et al.   CELL

AAA ATPase p97/VCP: cellular functions, disease and therapeutic potential

(2008) Neeraj Vij   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Aging and induced senescence as factors in the pathogenesis of lung emphysema

(2008) Stefan Karrasch et al.   RESPIRATORY MEDICINE

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE

The heavy metal cadmium induces valosin-containing protein (VCP)-mediated aggresome formation

(2008) Changcheng Song et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Inflammatory Profile of New Bacterial Strain Exacerbations of Chronic Obstructive Pulmonary Disease

(2007) Sanjay Sethi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE