期刊
CELL HOST & MICROBE
卷 4, 期 6, 页码 519-527出版社
CELL PRESS
DOI: 10.1016/j.chom.2008.10.011
关键词
-
资金
- Intramural NIH HHS [Z01 SC010074, Z01 BC011032-01, Z01 SC010074-12, Z01 BC011032] Funding Source: Medline
Infectious organisms have to cope with demanding and rapidly changing environments during establishment in the host. This is particularly relevant for pathogens that utilize different hosts to complete their life cycle. In addition to homeotic environmental challenges, other stressful factors, such as oxidative bursts, are often triggered in response to infection. It is not surprising that many successful pathogens have developed robust chaperone systems to conquer the stressful environments in the host. In addition to discussing ingenious ways by which pathogens have utilized chaperones, the potential of exploiting pathogen chaperones as drug targets is also discussed.
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