Toxoplasma gondii secreted effectors co-opt host repressor complexes to inhibit necroptosis

RIPK3 facilitates host resistance to oral Toxoplasma gondii infection

(2021) Patrick W. Cervantes et al.   INFECTION AND IMMUNITY

In Vitro Characterization of Protein Effector Export in the Bradyzoite Stage of Toxoplasma gondii

(2020) Joshua Mayoral et al.   mBio

Toxoplasma Mechanisms for Delivery of Proteins and Uptake of Nutrients Across the Host-Pathogen Interface

(2020) Yifan Wang et al.   Annual Review of Microbiology

The Toxoplasma effector TEEGR promotes parasite persistence by modulating NF-κB signalling via EZH2

(2019) Laurence Braun et al.   Nature Microbiology

Toxoplasma gondii effector TgIST blocks type I interferon signaling to promote infection

(2019) Sumit K. Matta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translocation of effector proteins into host cells by Toxoplasma gondii

(2019) Suchita Rastogi et al.   CURRENT OPINION IN MICROBIOLOGY

Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis

(2018) Joseph Sarhan et al.   CELL DEATH AND DIFFERENTIATION

A latent ability to persist: differentiation in Toxoplasma gondii

(2018) Victoria Jeffers et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

CRISPOR: intuitive guide selection for CRISPR/Cas9 genome editing experiments and screens

(2018) Jean-Paul Concordet et al.   NUCLEIC ACIDS RESEARCH

Essential cGMP Signaling in Toxoplasma Is Initiated by a Hybrid P-Type ATPase-Guanylate Cyclase

(2018) Kevin M. Brown et al.   Cell Host & Microbe

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Interferons Transcriptionally Up-Regulate MLKL Expression in Cancer Cells

(2018) Anne-Kathrin Knuth et al.   NEOPLASIA

The eukaryotic linear motif resource – 2018 update

(2017) Marc Gouw et al.   NUCLEIC ACIDS RESEARCH

Structure of the MeCP2–TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders

(2017) Valdeko Kruusvee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calmodulin-like proteins localized to the conoid regulate motility and cell invasion by Toxoplasma gondii

(2017) Shaojun Long et al.   PLoS Pathogens

Parsing the Interferon Transcriptional Network and Its Disease Associations

(2016) Sara Mostafavi et al.   CELL

Toxoplasma Effector Recruits the Mi-2/NuRD Complex to Repress STAT1 Transcription and Block IFN-γ-Dependent Gene Expression

(2016) Philipp Olias et al.   Cell Host & Microbe

RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus

(2016) Shoko Nogusa et al.   Cell Host & Microbe

The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis

(2016) Claudia Günther et al.   JOURNAL OF CLINICAL INVESTIGATION

Toxoplasma gondiiTgIST co-opts host chromatin repressors dampening STAT1-dependent gene regulation and IFN-γ–mediated host defenses

(2016) Gabrielle Gay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Spatially resolved proteomic mapping in living cells with the engineered peroxidase APEX2

(2016) Victoria Hung et al.   Nature Protocols

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

A Novel Secreted Protein, MYR1, Is Central to Toxoplasma ’s Manipulation of Host Cells

(2016) Magdalena Franco et al.   mBio

In Vivo Biotinylation of the Toxoplasma Parasitophorous Vacuole Reveals Novel Dense Granule Proteins Important for Parasite Growth and Pathogenesis

(2016) Santhosh M. Nadipuram et al.   mBio

APEX Fingerprinting Reveals the Subcellular Localization of Proteins of Interest

(2016) Song-Yi Lee et al.   Cell Reports

Optimized Sleeping Beauty transposons rapidly generate stable transgenic cell lines

(2015) Eric Kowarz et al.   Biotechnology Journal

The aspartyl protease TgASP5 mediates the export of theToxoplasmaGRA16 and GRA24 effectors into host cells

(2015) Aurélie Curt-Varesano et al.   CELLULAR MICROBIOLOGY

SFINX: Straightforward Filtering Index for Affinity Purification–Mass Spectrometry Data Analysis

(2015) Kevin Titeca et al.   JOURNAL OF PROTEOME RESEARCH

Rett syndrome: a complex disorder with simple roots

(2015) Matthew J. Lyst et al.   NATURE REVIEWS GENETICS

Novel Approaches Reveal that Toxoplasma gondii Bradyzoites within Tissue Cysts Are Dynamic and Replicating Entities In Vivo

(2015) Elizabeth Watts et al.   mBio

Fundamental Roles of the Golgi-Associated Toxoplasma Aspartyl Protease, ASP5, at the Host-Parasite Interface

(2015) Pierre-Mehdi Hammoudi et al.   PLoS Pathogens

Optimized Sleeping Beauty transposons rapidly generate stable transgenic cell lines

(2015) Eric Kowarz et al.   Biotechnology Journal

An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell

(2015) Michael J Coffey et al.   eLife

Activation of p53 Transcriptional Activity by SMRT: a Histone Deacetylase 3-Independent Function of a Transcriptional Corepressor

(2014) A. K. Adikesavan et al.   MOLECULAR AND CELLULAR BIOLOGY

Directed evolution of APEX2 for electron microscopy and proximity labeling

(2014) Stephanie S Lam et al.   NATURE METHODS

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Necroptosis

(2014) Andreas Linkermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Toxoplasma GRA7 effector increases turnover of immunity-related GTPases and contributes to acute virulence in the mouse

(2014) A. Alaganan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual Role for Inflammasome Sensors NLRP1 and NLRP3 in Murine Resistance to Toxoplasma gondii

(2014) G. Gorfu et al.   mBio

Efficient Gene Disruption in Diverse Strains of Toxoplasma gondii Using CRISPR/CAS9

(2014) B. Shen et al.   mBio

Inflammasome Sensor NLRP1 Controls Rat Macrophage Susceptibility to Toxoplasma gondii

(2014) Kimberly M. Cirelli et al.   PLoS Pathogens

Host Cell Subversion by Toxoplasma GRA16, an Exported Dense Granule Protein that Targets the Host Cell Nucleus and Alters Gene Expression

(2013) Alexandre Bougdour et al.   Cell Host & Microbe

Emerging roles of the corepressors NCoR1 and SMRT in homeostasis

(2013) A. Mottis et al.   GENES & DEVELOPMENT

Cell Death of Gamma Interferon-Stimulated Human Fibroblasts upon Toxoplasma gondii Infection Induces Early Parasite Egress and Limits Parasite Replication

(2013) Wendy Niedelman et al.   INFECTION AND IMMUNITY

Toxoplasma gondii within skeletal muscle cells: a critical interplay for food-borne parasite transmission

(2013) Izabela J. Swierzy et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

AToxoplasmadense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation

(2013) Laurence Braun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor

(2013) Matthew J Lyst et al.   NATURE NEUROSCIENCE

The Co-Repressor SMRT Delays DNA Damage-Induced Caspase Activation by Repressing Pro-Apoptotic Genes and Modulating the Dynamics of Checkpoint Kinase 2 Activation

(2013) Claudio Scafoglio et al.   PLoS One

Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases

(2013) R. J. Thapa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Viral modulation of programmed necrosis

(2013) William J Kaiser et al.   Current Opinion in Virology

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Interferon-γ Restricts Toxoplasma gondii Development in Murine Skeletal Muscle Cells via Nitric Oxide Production and Immunity-Related GTPases

(2012) Anna C. Takács et al.   PLoS One

A Patatin-Like Protein Protects Toxoplasma gondii from Degradation in a Nitric Oxide-Dependent Manner

(2011) Crystal M. Tobin et al.   INFECTION AND IMMUNITY

Nuclear hormone receptor co-repressors: Structure and function

(2011) Peter J. Watson et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Regulation of SMRT corepressor dimerization and composition by MAP kinase phosphorylation

(2010) Natalia Varlakhanova et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Deconstructing repression: evolving models of co-repressor action

(2010) Valentina Perissi et al.   NATURE REVIEWS GENETICS

Tagging of Endogenous Genes in aToxoplasma gondiiStrain Lacking Ku80

(2009) My-Hang Huynh et al.   EUKARYOTIC CELL

Toxoplasma gondiiinfection and cerebral toxoplasmosis in HIV-infected patients

(2009) Vera Lucia Pereira-Chioccola et al.   Future Microbiology

Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways

(2009) S. Ghisletti et al.   GENES & DEVELOPMENT

Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates

(2009) Lajos Mátés et al.   NATURE GENETICS

TOPCONS: consensus prediction of membrane protein topology

(2009) A. Bernsel et al.   NUCLEIC ACIDS RESEARCH

PKR, a p53 target gene, plays a crucial role in the tumor-suppressor function of p53

(2009) C.-H. Yoon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global Sequencing of Proteolytic Cleavage Sites in Apoptosis by Specific Labeling of Protein N Termini

(2008) Sami Mahrus et al.   CELL

TBL1 and TBLR1 Phosphorylation on Regulated Gene Promoters Overcomes Dual CtBP and NCoR/SMRT Transcriptional Repression Checkpoints

(2008) Valentina Perissi et al.   MOLECULAR CELL