期刊
JOURNAL OF PROTEOME RESEARCH
卷 15, 期 1, 页码 332-338出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jproteome.5b00666
关键词
interactomics; interaction filtering; affinity purification-mass spectrometry; protein-protein interactions; interaction detection
资金
- Methusalem grant
- PRIME-XS project - European Union seventh Framework Program [262067]
- Ghent University Multidisciplinary Research Partnership Bioinformatics: From Nucleotides to Networks
- Ghent University Concerted Research Action grant [BOF12/GOA/014]
- Fund for Scientific Research - Flanders [G.0113.12, G.0903.13N, G.0747.10N, G.0864.10]
- IUAP [P6/36]
- GROUP-ID MRP-UGent
- ERC Advanced grant (CYRE) [340941]
Affinity purification-mass spectrometry is one of the most common techniques for the analysis of protein-protein interactions, but inferring bona fide interactions from the resulting data sets remains notoriously difficult. We introduce SFINX, a Straightforward Filtering INdeX that identifies true-positive protein interactions in a fast, user-friendly, and highly accurate way. SFINX outperforms alternative techniques on two benchmark data sets and is available via the Web interface at http://sfinx.ugent.be/.
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