SARS-CoV-2 human T cell epitopes: Adaptive immune response against COVID-19

Adaptive immunity to SARS-CoV-2 and COVID-19

(2021) Alessandro Sette et al.   CELL

Cutting Edge: Mouse SARS-CoV-2 Epitope Reveals Infection and Vaccine-Elicited CD8 T Cell Responses

(2021) Vineet Joag et al.   JOURNAL OF IMMUNOLOGY

SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques

(2021) Yashavanth Shaan Lakshmanappa et al.   Nature Communications

Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity

(2021) Emma C. Thomson et al.   CELL

Innate and adaptive immune responses to SARS‐CoV‐2 in humans: relevance to acquired immunity and vaccine responses

(2021) S. C. Jordan   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

SARS-CoV-2–specific CD8+ T cell responses in convalescent COVID-19 individuals

(2021) Hassen Kared et al.   JOURNAL OF CLINICAL INVESTIGATION

Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection

(2021) Nina Le Bert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Emergence of a SARS-CoV-2 variant of concern with mutations in spike glycoprotein

(2021) Houriiyah Tegally et al.   NATURE

Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7

(2021) Pengfei Wang et al.   NATURE

SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8+ T cell responses

(2021) Benedikt Agerer et al.   Science Immunology

T cell and antibody kinetics delineate SARS-CoV-2 peptides mediating long-term immune responses in COVID-19 convalescent individuals

(2021) Tatjana Bilich et al.   Science Translational Medicine

SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8+ T cell activation in COVID-19 patients

(2021) Sunil Kumar Saini et al.   Science Immunology

T Cell Epitope Predictions

(2020) Bjoern Peters et al.   Annual Review of Immunology

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

(2020) Alba Grifoni et al.   CELL

Benchmarking predictions of MHC class I restricted T cell epitopes in a comprehensively studied model system

(2020) Sinu Paul et al.   PLoS Computational Biology

SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls

(2020) Nina Le Bert et al.   NATURE

Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans

(2020) Jose Mateus et al.   SCIENCE

Sequence-based prediction of SARS-CoV-2 vaccine targets using a mass spectrometry-based bioinformatics predictor identifies immunogenic T cell epitopes

(2020) Asaf Poran et al.   Genome Medicine

SARS-CoV-2 T cell immunity: Specificity, function, durability, and role in protection

(2020) Daniel M. Altmann et al.   Science Immunology

T cell immunity to SARS-CoV-2 following natural infection and vaccination

(2020) Anthony T. DiPiazza et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

(2020) Takuya Sekine et al.   CELL

Unbiased screens show CD8+ T cells of COVID-19 patients recognize shared epitopes in SARS-CoV-2, most of which are not located in the Spike protein

(2020) Andrew P. Ferretti et al.   IMMUNITY

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

(2020) Yanchun Peng et al.   NATURE IMMUNOLOGY

SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition

(2020) Annika Nelde et al.   NATURE IMMUNOLOGY

T cells in COVID-19 — united in diversity

(2020) Leo Swadling et al.   NATURE IMMUNOLOGY

Suboptimal SARS-CoV-2−specific CD8+ T cell response associated with the prominent HLA-A*02:01 phenotype

(2020) Jennifer R. Habel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SARS-CoV-2–specific T cells are rapidly expanded for therapeutic use and target conserved regions of the membrane protein

(2020) Michael D. Keller et al.   BLOOD

Case Study: Prolonged Infectious SARS-CoV-2 Shedding from an Asymptomatic Immunocompromised Individual with Cancer

(2020) Victoria A. Avanzato et al.   CELL

Low-Avidity CD4+ T Cell Responses to SARS-CoV-2 in Unexposed Individuals and Humans with Severe COVID-19

(2020) Petra Bacher et al.   IMMUNITY

SARS-CoV-2 Epitopes Are Recognized by a Public and Diverse Repertoire of Human T Cell Receptors

(2020) Alina S. Shomuradova et al.   IMMUNITY

PD-1-Expressing SARS-CoV-2-Specific CD8+ T Cells Are Not Exhausted, but Functional in Patients with COVID-19

(2020) Min-Seok Rha et al.   IMMUNITY

T and B cell Epitope analysis of SARS‐CoV‐2 S protein based on immunoinformatics and experimental research

(2020) Ziwei Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Recent endemic coronavirus infection is associated with less-severe COVID-19

(2020) Manish Sagar et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of HLA-A*02:01-restricted candidate epitopes derived from the non-structural polyprotein 1a of SARS-CoV-2 that may be natural targets of CD8+ T cell recognition in vivo

(2020) Akira Takagi et al.   JOURNAL OF VIROLOGY

Identification and validation of 174 COVID-19 vaccine candidate epitopes reveals low performance of common epitope prediction tools

(2020) Marek Prachar et al.   Scientific Reports

The Human Leukocyte Antigen Class II Immunopeptidome of the SARS-CoV-2 Spike Glycoprotein

(2020) Michael D. Knierman et al.   Cell Reports

mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2

(2020) Mariah Hassert et al.   PLoS Pathogens

The known unknowns of T cell immunity to COVID-19

(2020) Annika C. Karlsson et al.   Science Immunology

Most viral peptides displayed by class I MHC on infected cells are immunogenic

(2019) Nathan P. Croft et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue-Resident T Cells and Other Resident Leukocytes

(2019) David Masopust et al.   Annual Review of Immunology

ImmunomeBrowser: a tool to aggregate and visualize complex and heterogeneous epitopes in reference proteins

(2018) Sandeep Kumar Dhanda et al.   BIOINFORMATICS

Development of a novel clustering tool for linear peptide sequences

(2018) Sandeep Kumar Dhanda et al.   IMMUNOLOGY

Determination of a Predictive Cleavage Motif for Eluted Major Histocompatibility Complex Class II Ligands

(2018) Sinu Paul et al.   Frontiers in Immunology

The Length Distribution and Multiple Specificity of Naturally Presented HLA-I Ligands

(2018) David Gfeller et al.   JOURNAL OF IMMUNOLOGY

The Immune Epitope Database (IEDB): 2018 update

(2018) Randi Vita et al.   NUCLEIC ACIDS RESEARCH

Quantifiable predictive features define epitope-specific T cell receptor repertoires

(2017) Pradyot Dash et al.   NATURE

Identifying specificity groups in the T cell receptor repertoire

(2017) Jacob Glanville et al.   NATURE

Comparative analysis of activation induced marker (AIM) assays for sensitive identification of antigen-specific CD4 T cells

(2017) Samantha Reiss et al.   PLoS One

Carbohydrates as T-cell antigens with implications in health and disease

(2016) Lina Sun et al.   GLYCOBIOLOGY

A Cytokine-Independent Approach To Identify Antigen-Specific Human Germinal Center T Follicular Helper Cells and Rare Antigen-Specific CD4+T Cells in Blood

(2016) Jennifer M. Dan et al.   JOURNAL OF IMMUNOLOGY

The Length Distribution of Class I–Restricted T Cell Epitopes Is Determined by Both Peptide Supply and MHC Allele–Specific Binding Preference

(2016) Thomas Trolle et al.   JOURNAL OF IMMUNOLOGY

Comprehensive Analysis of HLA-DR- and HLA-DP4-Restricted CD4+ T Cell Response Specific for the Tumor-Shared Antigen Survivin in Healthy Donors and Cancer Patients

(2014) X.-F. Wang et al.   JOURNAL OF IMMUNOLOGY

Dissociation between Epitope Hierarchy and Immunoprevalence in CD8 Responses to Vaccinia Virus Western Reserve

(2014) C. Oseroff et al.   JOURNAL OF IMMUNOLOGY

Naive Precursor Frequencies and MHC Binding Rather Than the Degree of Epitope Diversity Shape CD8+ T Cell Immunodominance

(2014) M. F. Kotturi et al.   JOURNAL OF IMMUNOLOGY

Human Circulating PD-1+CXCR3−CXCR5+ Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses

(2013) Michela Locci et al.   IMMUNITY

A strategy to determine HLA class II restriction broadly covering the DR, DP, and DQ allelic variants most commonly expressed in the general population

(2013) Denise M. McKinney et al.   IMMUNOGENETICS

Immunoprevalence and Immunodominance of HLA-Cw*0801-Restricted T Cell Response Targeting the Hepatitis B Virus Envelope Transmembrane Region

(2013) A. T. Tan et al.   JOURNAL OF VIROLOGY

Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8+ T cells

(2013) D. Weiskopf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV and HLA Class I: An Evolving Relationship

(2012) Philip J.R. Goulder et al.   IMMUNITY

The immune epitope database: a historical retrospective of the first decade

(2012) Nima Salimi et al.   IMMUNOLOGY

Functional classification of class II human leukocyte antigen (HLA) molecules reveals seven different supertypes and a surprising degree of repertoire sharing across supertypes

(2011) Jason Greenbaum et al.   IMMUNOGENETICS

Post-translationally modified T cell epitopes: immune recognition and immunotherapy

(2009) Jan Petersen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

HLA class I supertypes: a revised and updated classification

(2008) John Sidney et al.   BMC IMMUNOLOGY

A Systematic Assessment of MHC Class II Peptide Binding Predictions and Evaluation of a Consensus Approach

(2008) Peng Wang et al.   PLoS Computational Biology