Article
Endocrinology & Metabolism
Han Zeng, Hong Qin, Meng Liao, Enze Zheng, Xiaoqing Luo, Anhua Xiao, Yiyu Li, Lin Chen, Li Wei, Lei Zhao, Xiong Z. Ruan, Ping Yang, Yaxi Chen
Summary: This study found that CD36 plays a role in the development of NAFLD by facilitating the uptake of free fatty acids and enhancing de novo lipogenesis in hepatocytes. CD36 forms a complex with INSIG2, disrupting the interaction between SCAP and INSIG2, leading to the translocation of SREBP1 for processing. These findings provide new evidence for targeting CD36 as a potential therapeutic approach for NAFLD.
MOLECULAR METABOLISM
(2022)
Article
Environmental Sciences
Ting Li, Xiaojie Liu, Xiaoyi Long, Yangyou Li, Jin Xiang, Yuanxia Lv, Xiaoyang Zhao, Shaoqing Shi, Wei Chen
Summary: In this study, the role of brexpiprazole in cell proliferation and lipogenesis in colorectal cancer (CRC) was investigated. Brexpiprazole was found to significantly suppress cell proliferation and lipogenesis in CRC, possibly through the inhibition of SREBP1 and the stimulation of AMPK.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Xiangyun Tan, Yi Sun, Liang Chen, Junjie Hu, Yan Meng, Ming Yuan, Qi Wang, Shan Li, Guohua Zheng, Zhenpeng Qiu
Summary: This study aimed to evaluate the therapeutic efficacy of caffeine in a NASH mouse model. The results showed that caffeine improved hepatic steatosis and inflammatory injury by inhibiting two signaling pathways and reducing the production of proinflammatory mediators. These findings suggest that caffeine may be beneficial in the prevention and therapy of NASH.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Oncology
Tengfei Liu, Junming Yu, Chao Ge, Fangyu Zhao, Jing Chen, Chunxiao Miao, Wenjiao Jin, Qingqing Zhou, Qin Geng, Hechun Lin, Hua Tian, Taoyang Chen, Haiyang Xie, Ying Cui, Ming Yao, Xiuying Xiao, Jinjun Li, Hong Li
Summary: The study demonstrates that SPAG4 plays an oncogenic role in hepatocellular carcinoma (HCC) progression by affecting lipid metabolism. Combining orlistat with sorafenib reverses SPAG4-mediated oncogenesis in HCC cells and xenograft tumors, suggesting a potential therapeutic strategy for HCC treatment.
Article
Multidisciplinary Sciences
Daniel Gonzalez-Bohorquez, Isabel M. Gallego Lopez, Baptiste N. Jaeger, Sibylle Pfammatter, Megan Bowers, Clay F. Semenkovich, Sebastian Jessberger
Summary: The fate and behavior of neural progenitor cells play crucial roles in mammalian brain development. This study reveals the importance of de novo lipogenesis, mediated by fatty acid synthase (FASN), in regulating progenitor cell polarity and proliferation during mouse and human brain development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Cong Zhang, Yuzhen Lu, Yingying Song, Liang Chen, Junjie Hu, Yan Meng, Xin Chen, Shan Li, Guohua Zheng, Zhenpeng Qiu
Summary: Mounting evidence suggests that hepatic de novo lipogenesis is common in patients with non-alcoholic fatty liver disease (NAFLD). This study investigates the potential of the selective COX-2 inhibitor, celecoxib, to alleviate hepatic steatosis by targeting an Akt-driven lipogenic pathway. The results show that celecoxib effectively suppresses Akt/mTORC1 signaling and its downstream lipogenic cascade, thereby ameliorating hepatic steatosis in Akt-triggered NAFLD mice. However, its efficacy is limited in fructose-fed NAFLD mice.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Oncology
Junru Chen, Chaofeng Ding, Yunhao Chen, Wendi Hu, Chengkuan Yu, Chuanhui Peng, Xiaode Feng, Qiyang Cheng, Wenxuan Wu, Yuejie Lu, Haiyang Xie, Lin Zhou, Jian Wu, Shusen Zheng
Summary: Lipid metabolic reprogramming is crucial for hepatocellular carcinoma (HCC) development, with long chain acyl CoA synthetase 4 (ACSL4) playing a key role in modulating de novo lipogenesis and promoting HCC progression. Mechanistically, ACSL4 upregulates SREBP1 to regulate lipogenesis in HCC cells, with a positive correlation between ACSL4 and SREBP1 expression in HCC patients, suggesting a potential combinational biomarker for predicting HCC.
Article
Pharmacology & Pharmacy
Huannan Meng, Mengqin Shen, Jiajin Li, Ruixue Zhang, Xi Li, Li Zhao, Gang Huang, Jianjun Liu
Summary: In this study, it was demonstrated that CBF effectively inhibited HCC by promoting cell apoptosis, inducing cell cycle arrest, and suppressing lipogenesis. The results showed a significant reduction in tumor growth rate and changes in fatty acid profiles after CBF treatment. Mechanistically, CBF selectively targeted SREBP1 to hinder lipid synthesis, suggesting its potential as a therapeutic agent for HCC.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Nan Wang, Tianzi Li, Wanyu Liu, Jinhua Lin, Ke Zhang, Zhenhao Li, Yanfei Huang, Yufei Shi, Meilan Xu, Xuekui Liu
Summary: PRMT5-mediated G3BP2-R468me2 enhances the binding to deubiquitinase USP7, ensuring the deubiquitination and stabilization of G3BP2. PRMT5-dependent methylation of G3BP2 is required for its deubiquitination and stabilization by USP7. The PRMT5-USP7-G3BP2 regulatory axis serves as a lipid metabolism reprogramming mechanism in tumorigenesis and could be a potential therapeutic target for head and neck squamous carcinoma.
CELL DEATH & DISEASE
(2023)
Article
Nutrition & Dietetics
Woo Yong Park, Gahee Song, Joon Hak Noh, Taegon Kim, Jae Jin Kim, Seokbeom Hong, Jinbong Park, Jae-Young Um
Summary: The study investigated the pharmacological effect of RSWE on alcoholic fatty liver disease (AFLD) and found that RSWE has the potential to improve AFLD by inhibiting de novo lipogenesis in the liver. Supplementation with RSWE decreased liver fat accumulation and improved tissue structure in both mouse and cell models.
Article
Oncology
Fei Shao, Xueli Bian, Juhong Wang, Daqian Xu, Wei Guo, Hongfei Jiang, Gaoxiang Zhao, Lei Zhu, Shuai Wang, Dongming Xing, Yibo Gao, Jie He, Zhimin Lu
Summary: Metabolic enzyme PCK1 plays a role in NSCLC progression by activating nuclear SREBP1, and its levels are associated with TNM stage and prognosis of the tumor. Targeting PCK1's protein kinase activity may hold potential for the diagnosis and treatment of NSCLC.
FRONTIERS IN ONCOLOGY
(2021)
Review
Endocrinology & Metabolism
Bettina Geidl-Flueck, Philipp A. Gerber
Summary: This article examines the impact of sugar/fructose intake on hepatic de novo lipogenesis (DNL) and suggests that fructose is a more potent inducer of hepatic lipogenesis than glucose. The disruption of fructose metabolism under pathological conditions may lead to increased expression of fructolytic and lipogenic enzymes, contributing to ectopic fat deposition and impairment of various metabolic processes.
JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yawen Lu, Yimeng Chen, Wenxin Hu, Meng Wang, Xiaodong Wen, Jie Yang
Summary: This study aimed to investigate the role and mechanism of acetyl-CoA synthetase 2 (ACSS2) in acute alcohol-induced lipogenesis. The results showed that alcohol challenge induced hepatic lipid deposition and upregulated lipogenic genes, while ACSS2 knockdown blocked histone acetylation and lipogenic gene induction. Ethanol metabolism promoted ACSS2 nuclear import and supported lipogenesis via H3K9 acetylation. In alcohol-feeding mice, liver-specific ACSS2 knockdown blocked the interaction between PCAF and H3K9 and suppressed lipogenic gene induction.
LIVER INTERNATIONAL
(2023)
Article
Oncology
Yonghua Zheng, Jingjing Lu, Xiaoyan Hu, Xiaobiao Hu, Xiwen Gao, Jie Zhou
Summary: This study investigates the function of PRMT5 and FGFR3/Akt signaling axis in the EMT of human lung cancer. The results show that PRMT5 and FGFR3 are highly expressed in lung cancer tissues and are closely related to lymphatic metastasis. Inhibition of PRMT5 attenuates FGFR3 expression, Akt phosphorylation, and lung cancer cell proliferation. Silencing PRMT5 impairs EMT-related markers, while ectopic expression of PRMT5 increases FGFR3 expression and Akt phosphorylation. The study suggests that PRMT5/FGFR3/Akt signaling axis controls lung cancer progression and metastasis.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2023)
Review
Biochemistry & Molecular Biology
Mohsin Ali Khan, Zaw Ali Khan, Fouzia Shoeb, Ghizal Fatima, Rizwan Hasan Khan, Mohammad M. Khan
Summary: Patients with Alzheimer's disease often have insulin resistance in both peripheral tissues and the brain, which can contribute to cognitive dysfunction. Elevated levels of intracellular fatty acids, specifically saturated fatty acids, could induce insulin resistance and inflammation. Regulating de novo lipogenesis may be an effective therapy for improving insulin sensitivity and cognitive function in Alzheimer's disease patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Oncology
Liu Liu, Xiaoping Zhao, Li Zhao, Jiajin Li, Hao Yang, Zongping Zhu, Jianjun Liu, Gang Huang
Article
Medicine, General & Internal
Ruohua Chen, Yumei Chen, Liu Liu, Xiang Zhou, Jianjun Liu, Gang Huang
Article
Biotechnology & Applied Microbiology
Liu Liu, Bei Lei, Lihua Wang, Cheng Chang, Hao Yang, Jianjun Liu, Gang Huang, Wenhui Xie
ONCOTARGETS AND THERAPY
(2019)
Article
Neurosciences
Yingying Tang, Xiong Jiao, Junjie Wang, Tianyuan Zhu, Jie Zhou, Zhenying Qian, Tianhong Zhang, Huiru Cui, Hui Li, Xiaochen Tang, Lihua Xu, Ling Zhang, Yanyan Wei, Jianhua Sheng, Liu Liu, Jijun Wang
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Maomei Ruan, Liu Liu, Lihua Wang, Bei Lei, Xiaoyan Sun, Cheng Chang, Yan Shen, Wenhui Xie
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2020)
Article
Biochemistry & Molecular Biology
Lihua Wang, Maomei Ruan, Hui Yan, Bei Lei, Xiaoyan Sun, Cheng Chang, Liu Liu, Wenhui Xie
Article
Oncology
Lihua Wang, Maomei Ruan, Bei Lei, Hui Yan, Xiaoyan Sun, Cheng Chang, Liu Liu, Wenhui Xie
Article
Engineering, Biomedical
Yi Zhang, Meng Wang, Xunpeng Xia, Dandan Sun, Xinhong Zhou, Yao Wang, Qian Dai, Mingming Jin, Liu Liu, Gang Huang
Summary: This study proposes an image decomposition method based on quasicross bilateral filtering to improve the performance of image fusion. The method decomposes the image into energy and structure layers and uses visual saliency detection map and improved multi-level morphology gradient to guide the fusion process, thus enhancing the edge contour sharpness and detail retention of the fused image.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Oncology
Meng Wang, Liu Liu, Qian Dai, Mingming Jin, Gang Huang
Summary: The study aimed to investigate whether the combined PET/CT radiomic features could predict lymph node metastasis of resectable NSCLC. A total of 192 NSCLC patients who underwent surgery and PET/CT scanning were included in this retrospective study. The results showed that the combination of CT and PET radiomic features could non-invasively predict lymph node metastasis in NSCLC, which may assist in developing more rational therapeutic strategies.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hao Yang, Xiaoping Zhao, Jianjun Liu, Mingming Jin, Xiyu Liu, Jun Yan, Xufeng Yao, Xinyi Mao, Nan Li, Beibei Liang, Wei Xie, Kunchi Zhang, Jian Zhao, Liu Liu, Gang Huang
Summary: This study reveals the role of IDH1 acetylation in the development of drug resistance in colorectal cancer. Hyperacetylation of IDH1 sensitizes CRC cells to chemotherapy and promotes antitumor redox homeostasis, making it a potential marker for predicting patient response to chemotherapy.
Article
Biochemistry & Molecular Biology
Liu Liu, Jingmian Zhang, Mark K. Ferguson, Daniel Appelbaum, James X. Zhang, Yonglin Pu
Summary: This study developed a clinical and PET/CT volumetric prognostic (CPVP) index for assessing the prognosis of non-small cell lung cancer (NSCLC) patients. The CPVP index showed greater prognostic power than individual prognostic variables and other indices, providing a practical tool for personalized treatment and monitoring strategy for NSCLC patients.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)