Anticancer effects of radiation therapy combined with Polo-Like Kinase 4 (PLK4) inhibitor CFI-400945 in triple negative breast cancer

TTK inhibition radiosensitizes basal-like breast cancer through impaired homologous recombination

(2020) Benjamin C. Chandler et al.   JOURNAL OF CLINICAL INVESTIGATION

Combination of Olaparib and Radiation Therapy for Triple Negative Breast Cancer: Preliminary Results of the RADIOPARP Phase 1 Trial

(2020) Pierre Loap et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Safety and tolerability of CFI-400945, a first-in-class, selective PLK4 inhibitor in advanced solid tumours: a phase 1 dose-escalation trial

(2019) Zachary W. Veitch et al.   BRITISH JOURNAL OF CANCER

Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer

(2019) Ye Yao et al.   Cell Stem Cell

CDK 4/6 inhibitors and stereotactic radiation in the management of hormone receptor positive breast cancer brain metastases

(2019) Nicholas B. Figura et al.   JOURNAL OF NEURO-ONCOLOGY

Inhibiting polo-like kinase 1 enhances radiosensitization via modulating DNA repair proteins in non-small-cell lung cancer

(2018) Da Yao et al.   Biochemistry and Cell Biology

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

(2018) Norman Sachs et al.   CELL

Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers

(2018) Masanori Kawakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TREATMENT OUTCOMES OF BREAST CANCER LIVER METASTASIS TREATED WITH STEREOTACTIC BODY RADIOTHERAPY

(2018) Cem Onal et al.   BREAST

Targeting the cell cycle in breast cancer: towards the next phase

(2018) KL Thu et al.   CELL CYCLE

Concurrent Chemotherapy and Radiation Therapy for Inoperable Locally Advanced Non–Small-Cell Lung Cancer

(2017) Kenneth E. Rosenzweig et al.   JOURNAL OF CLINICAL ONCOLOGY

Mechanisms of Normal Tissue Injury From Irradiation

(2017) Deborah E. Citrin et al.   SEMINARS IN RADIATION ONCOLOGY

Inhibition of polo-like kinase 4 (PLK4): a new therapeutic option for rhabdoid tumors and pediatric medulloblastoma

(2017) Simone Treiger Sredni et al.   Oncotarget

Centrosome amplification induces high grade features and is prognostic of worse outcomes in breast cancer

(2016) Ryan A. Denu et al.   BMC CANCER

Clinical development of new drug–radiotherapy combinations

(2016) Ricky A. Sharma et al.   Nature Reviews Clinical Oncology

Activity of the novel polo-like kinase 4 inhibitor CFI-400945 in pancreatic cancer patient-derived xenografts

(2016) Ines Lohse et al.   Oncotarget

Targeting Mitosis in Cancer: Emerging Strategies

(2015) Carmen Dominguez-Brauer et al.   MOLECULAR CELL

Numerical chromosomal instability mediates susceptibility to radiation treatment

(2015) Samuel F. Bakhoum et al.   Nature Communications

Delayed Numerical Chromosome Aberrations in Human Fibroblasts by Low Dose of Radiation

(2015) Yoon Cho et al.   International Journal of Environmental Research and Public Health

Functional Characterization of CFI-400945, a Polo-like Kinase 4 Inhibitor, as a Potential Anticancer Agent

(2014) Jacqueline M. Mason et al.   CANCER CELL

Nek2 and Plk4: prognostic markers, drivers of breast tumorigenesis and drug resistance

(2014) Mihaela Marina   Frontiers in Bioscience-Landmark

The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1R,2S)-2-(3-((E)-4-(((cis)-2,6-Dimethylmorpholino)methyl)styryl)-1H-indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,3′-indolin]-2′-one (CFI-400945) as a Potent, Orally Active Antitumor Agent

(2014) Peter B. Sampson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Does Radiotherapy Have Curative Potential in Metastatic Patients? The Concept of Local Therapy in Oligometastatic Breast Cancer

(2011) Kathrin Dellas   Breast Care

Oligometastases Treated With Stereotactic Body Radiotherapy: Long-Term Follow-Up of Prospective Study

(2011) Michael T. Milano et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Radiation pharmacogenomics: A genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines

(2010) N. Niu et al.   GENOME RESEARCH

Prognostic factors for survival and intracerebral control after irradiation for brain metastases from gynecological cancer

(2009) Dirk Rades et al.   GYNECOLOGIC ONCOLOGY