CDK 4/6 inhibitors and stereotactic radiation in the management of hormone receptor positive breast cancer brain metastases

First-in-human phase I trial of the combination of two adenoviral vectors expressing HSV1-TK and FLT3L for the treatment of newly diagnosed resectable malignant glioma: Initial results from the therapeutic reprogramming of the brain immune system.

(2019) Pedro R. Lowenstein et al.   JOURNAL OF CLINICAL ONCOLOGY

A phase II study of abemaciclib in patients (pts) with brain metastases (BM) secondary to HR+, HER2- metastatic breast cancer (MBC).

(2019) Carey K. Anders et al.   JOURNAL OF CLINICAL ONCOLOGY

Safety of Combined PD-1 Pathway Inhibition and Intracranial Radiation Therapy in Non–Small Cell Lung Cancer

(2018) Harper G. Hubbeling et al.   Journal of Thoracic Oncology

Ribociclib plus endocrine therapy for premenopausal women with hormone-receptor-positive, advanced breast cancer (MONALEESA-7): a randomised phase 3 trial

(2018) Debu Tripathy et al.   LANCET ONCOLOGY

Preliminary results of the association of Palbociclib and radiotherapy in metastatic breast cancer patients

(2018) Sophie Hans et al.   RADIOTHERAPY AND ONCOLOGY

Immunotherapy and Symptomatic Radiation Necrosis in Patients With Brain Metastases Treated With Stereotactic Radiation

(2018) Allison M. Martin et al.   JAMA Oncology

Ribociclib plus letrozole and concomitant palliative radiotherapy for metastatic breast cancer

(2018) Icro Meattini et al.   BREAST

Blocking cyclin-dependent kinase 4/6 during single dose vs. fractionated radiation therapy leads to opposite effects on acute gastrointestinal toxicity in mice

(2018) Chang-Lung Lee et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Severe acute radiation-induced enterocolitis after combined palbociclib and palliative radiotherapy treatment

(2018) Terufumi Kawamoto et al.   RADIOTHERAPY AND ONCOLOGY

Phase 1 Study of Ipilimumab Combined With Whole Brain Radiation Therapy or Radiosurgery for Melanoma Patients With Brain Metastases

(2017) Noelle L. Williams et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

MONARCH 3: Abemaciclib As Initial Therapy for Advanced Breast Cancer

(2017) Matthew P. Goetz et al.   JOURNAL OF CLINICAL ONCOLOGY

Outcomes targeting the PD-1/PD-L1 axis in conjunction with stereotactic radiation for patients with non-small cell lung cancer brain metastases

(2017) Kamran A. Ahmed et al.   JOURNAL OF NEURO-ONCOLOGY

Clinical outcomes of melanoma brain metastases treated with stereotactic radiosurgery and anti-PD-1 therapy, anti-CTLA-4 therapy, BRAF/MEK inhibitors, BRAF inhibitor, or conventional chemotherapy

(2016) K. A. Ahmed et al.   ANNALS OF ONCOLOGY

BRAF inhibitor and stereotactic radiosurgery is associated with an increased risk of radiation necrosis

(2016) Kirtesh R. Patel et al.   MELANOMA RESEARCH

EXTH-63. PRECLINICAL EFFICACY OF A CDK INHIBITOR (TG02) IN GLIOBLASTOMA

(2016) Kristine Pelton et al.   NEURO-ONCOLOGY

Inhibition of DNA damage repair by the CDK4/6 inhibitor palbociclib delays irradiated intracranial atypical teratoid rhabdoid tumor and glioblastoma xenograft regrowth

(2016) Rintaro Hashizume et al.   NEURO-ONCOLOGY

Palbociclib and Letrozole in Advanced Breast Cancer

(2016) Richard S. Finn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Response assessment criteria for brain metastases: proposal from the RANO group

(2015) Nancy U Lin et al.   LANCET ONCOLOGY

The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study

(2015) Richard S Finn et al.   LANCET ONCOLOGY

Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine

(2014) Lawrence M. Gelbert et al.   INVESTIGATIONAL NEW DRUGS

LINAC-based stereotactic radiosurgery to the brain with concurrent vemurafenib for melanoma metastases

(2014) Kamran A. Ahmed et al.   JOURNAL OF NEURO-ONCOLOGY

Stereotactic radiosurgery for brain metastases: analysis of outcome and risk of brain radionecrosis

(2011) Giuseppe Minniti et al.   Radiation Oncology

Mechanisms of Endocrine Resistance in Breast Cancer

(2010) C. Kent Osborne et al.   Annual Review of Medicine

Stereotactic radiosurgery as primary and salvage treatment for brain metastases from breast cancer

(2010) Douglas Kondziolka et al.   JOURNAL OF NEUROSURGERY

Biology and Therapy of Neoplastic Meningitis

(2010) Aaron G. Mammoser et al.   Current Oncology Reports

Expression of ER-α36, a Novel Variant of Estrogen Receptor α, and Resistance to Tamoxifen Treatment in Breast Cancer

(2009) Liang Shi et al.   JOURNAL OF CLINICAL ONCOLOGY

Crosstalk between the Estrogen Receptor and the HER Tyrosine Kinase Receptor Family: Molecular Mechanism and Clinical Implications for Endocrine Therapy Resistance

(2008) Grazia Arpino et al.   ENDOCRINE REVIEWS