Comparison of UV‐ and Raman‐based monitoring of the Protein A load phase and evaluation of data fusion by PLS models and CNNs

A critical review of recent trends, and a future perspective of optical spectroscopy as PAT in biopharmaceutical downstream processing

(2020) Laura Rolinger et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

High-Throughput Raman Spectroscopy Combined with Innovate Data Analysis Workflow to Enhance Biopharmaceutical Process Development

(2020) Stephen Goldrick et al.   Processes

Real‐time monitoring and model‐based prediction of purity and quantity during a chromatographic capture of fibroblast growth factor 2

(2019) Dominik Georg Sauer et al.   BIOTECHNOLOGY AND BIOENGINEERING

Prediction of the Quantity and Purity of an Antibody Capture Process in Real Time

(2019) Nicole Walch et al.   Biotechnology Journal

A new flow cell and chemometric protocol for implementing in‐line Raman spectroscopy in chromatography

(2019) Fabian Feidl et al.   BIOTECHNOLOGY PROGRESS

Combining Mechanistic Modeling and Raman Spectroscopy for Monitoring Antibody Chromatographic Purification

(2019) Feidl et al.   Processes

An NIR‐based PAT approach for real‐time control of loading in Protein A chromatography in continuous manufacturing of monoclonal antibodies

(2019) Garima Thakur et al.   BIOTECHNOLOGY AND BIOENGINEERING

Normal-subtracted preprocessing of Raman spectra aiming to discriminate skin actinic keratosis and neoplasias from benign lesions and normal skin tissues

(2019) Landulfo Silveira et al.   LASERS IN MEDICAL SCIENCE

Selective protein quantification for preparative chromatography using variable pathlength UV/Vis spectroscopy and partial least squares regression

(2018) Nina Brestrich et al.   CHEMICAL ENGINEERING SCIENCE

Glucose monitoring and adaptive feeding of mammalian cell culture in the presence of strong autofluorescence by near infrared Raman spectroscopy

(2018) Thomas E. Matthews et al.   BIOTECHNOLOGY PROGRESS

Real-time monitoring and control of the load phase of a protein A capture step

(2016) Matthias Rüdt et al.   BIOTECHNOLOGY AND BIOENGINEERING

Variable selection in multi-block regression

(2016) Alessandra Biancolillo et al.   CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS

Data fusion methodologies for food and beverage authentication and quality assessment – A review

(2015) Eva Borràs et al.   ANALYTICA CHIMICA ACTA

Advances in inline quantification of co-eluting proteins in chromatography: Process-data-based model calibration and application towards real-life separation issues

(2015) Nina Brestrich et al.   BIOTECHNOLOGY AND BIOENGINEERING

Identification of Subvisible Particles in Biopharmaceutical Formulations Using Raman Spectroscopy Provides Insight into Polysorbate 20 Degradation Pathway

(2015) Miguel Saggu et al.   PHARMACEUTICAL RESEARCH

Performance monitoring of a mammalian cell based bioprocess using Raman spectroscopy

(2013) Boyan Li et al.   ANALYTICA CHIMICA ACTA

Raman spectroscopy of proteins: a review

(2013) A. Rygula et al.   JOURNAL OF RAMAN SPECTROSCOPY

In situ Raman spectroscopy for simultaneous monitoring of multiple process parameters in mammalian cell culture bioreactors

(2012) Jessica Whelan et al.   BIOTECHNOLOGY PROGRESS

Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in-line Raman spectroscopy probe

(2010) Nicholas R. Abu-Absi et al.   BIOTECHNOLOGY AND BIOENGINEERING

Rapid characterization and quality control of complex cell culture media solutions using raman spectroscopy and chemometrics

(2010) Boyan Li et al.   BIOTECHNOLOGY AND BIOENGINEERING

Some common misunderstandings in chemometrics

(2010) Karin Kjeldahl et al.   JOURNAL OF CHEMOMETRICS

Variable selection in regression-a tutorial

(2010) C. M. Andersen et al.   JOURNAL OF CHEMOMETRICS