Tumor Energy Metabolism and Potential of 3-Bromopyruvate as an Inhibitor of Aerobic Glycolysis: Implications in Tumor Treatment
出版年份 2019 全文链接
标题
Tumor Energy Metabolism and Potential of 3-Bromopyruvate as an Inhibitor of Aerobic Glycolysis: Implications in Tumor Treatment
作者
关键词
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出版物
Cancers
Volume 11, Issue 3, Pages 317
出版商
MDPI AG
发表日期
2019-03-07
DOI
10.3390/cancers11030317
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- 18F-fluorodeoxyglucose positron emission tomography/computed tomography in the evaluation of clinically node-negative non-small cell lung cancer
- (2019) Yusuke Takahashi et al. Thoracic Cancer
- Suppression of Tumor Energy Supply by Liposomal Nanoparticle-Mediated Inhibition of Aerobic Glycolysis
- (2018) Yinlong Zhang et al. ACS Applied Materials & Interfaces
- Synergistic in-vitro effects of combining an antiglycolytic, 3-bromopyruvate, and a bromodomain-4 inhibitor on U937 myeloid leukemia cells
- (2018) Nicolette Kapp et al. ANTI-CANCER DRUGS
- Protective and recuperative effects of 3-bromopyruvate on immunological, hepatic and renal homeostasis in a murine host bearing ascitic lymphoma: Implication of niche dependent differential roles of macrophages
- (2018) Saveg Yadav et al. BIOMEDICINE & PHARMACOTHERAPY
- The specific role of O6-methylguanine-DNA methyltransferase inhibitors in cancer chemotherapy
- (2018) Guohui Sun et al. Future Medicinal Chemistry
- Antitumor action of 3-bromopyruvate implicates reorganized tumor growth regulatory components of tumor milieu, cell cycle arrest and induction of mitochondria-dependent tumor cell death
- (2018) Saveg Yadav et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- 3-Bromopyruvate as an Alternative Option for the Treatment of Protothecosis
- (2018) Tomasz Jagielski et al. Frontiers in Pharmacology
- Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
- (2018) Freddie Bray et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Enhancing anticancer effects, decreasing risks and solving practical problems facing 3-bromopyruvate in clinical oncology: 10 years of research experience
- (2018) Salah Mohamed El Sayed International Journal of Nanomedicine
- Valproate sensitizes human glioblastoma cells to 3-bromopyruvate-induced cytotoxicity
- (2018) Yuri Ishiguro et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- 3‑Bromopyruvate sensitizes human breast cancer cells to TRAIL‑induced apoptosis via the phosphorylated AMPK‑mediated upregulation of DR5
- (2018) Yuzhong Chen et al. ONCOLOGY REPORTS
- Positron emission tomography/computed tomography in the diagnosis, staging, and prognostic evaluation of natural killer/T-cell lymphoma
- (2018) Jian-Jun Ding et al. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
- The potential of combi-molecules with DNA-damaging function as anticancer agents
- (2017) Guohui Sun et al. Future Medicinal Chemistry
- 3-Bromopyruvate treatment induces alterations of metabolic and stress-related pathways in glioblastoma cells
- (2017) Davide Chiasserini et al. Journal of Proteomics
- The promising anticancer drug 3-bromopyruvate is metabolized through glutathione conjugation which affects chemoresistance and clinical practice: An evidence-based view
- (2017) Salah Mohamed El Sayed et al. MEDICAL HYPOTHESES
- PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
- (2017) Fabao Liu et al. NATURE CELL BIOLOGY
- 3-bromopyruvate and buthionine sulfoximine effectively kill anoikis-resistant hepatocellular carcinoma cells
- (2017) Minjong Lee et al. PLoS One
- The anticancer agent 3-bromopyruvate: a simple but powerful molecule taken from the lab to the bedside
- (2016) J. Azevedo-Silva et al. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- ABCB1-overexpressing MDCK-II cells are hypersensitive to 3-bromopyruvic acid
- (2016) Izabela Sadowska-Bartosz et al. LIFE SCIENCES
- The HK2 Dependent “Warburg Effect” and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate
- (2016) Paweł Lis et al. MOLECULES
- Anticancer agent 3-bromopyruvic acid forms a conjugate with glutathione
- (2016) Izabela Sadowska-Bartosz et al. Pharmacological Reports
- Candidate cancer drug suspected after death of three patients at an alternative medicine clinic
- (2016) Hinnerk Feldwisch-Drentrup SCIENCE
- The Warburg Effect: How Does it Benefit Cancer Cells?
- (2016) Maria V. Liberti et al. TRENDS IN BIOCHEMICAL SCIENCES
- Glutathione may have implications in the design of 3-bromopyruvate treatment protocols for both fungal and algal infections as well as multiple myeloma
- (2016) Katarzyna Niedźwiecka et al. Oncotarget
- Effect of 3-Bromopyruvate and Atovaquone on Infection duringIn VitroInteraction of Toxoplasma gondii and LLC-MK2 Cells
- (2015) Loyze Paola O. de Lima et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- The cytotoxicity of 3-bromopyruvate in breast cancer cells depends on extracellular pH
- (2015) João Azevedo-Silva et al. BIOCHEMICAL JOURNAL
- Targeting glycolysis by 3-bromopyruvate improves tamoxifen cytotoxicity of breast cancer cell lines
- (2015) Yasmin M. Attia et al. BMC CANCER
- Enhanced Antitumor Activity of 3-Bromopyruvate in Combination with Rapamycin In Vivo and In Vitro
- (2015) Q. Zhang et al. Cancer Prevention Research
- Abstract 2673: Idelalisib has activity at clinically achievable drug concentrations in a subset of ABC and GCB diffuse large B-cell lymphoma and transformed follicular lymphoma cell lines
- (2015) Jia Y. Liu et al. CANCER RESEARCH
- 3-Bromopyruvate induces rapid human prostate cancer cell death by affecting cell energy metabolism, GSH pool and the glyoxalase system
- (2015) Daniela Valenti et al. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- Effect of 3-bromopyruvate acid on the redox equilibrium in non-invasive MCF-7 and invasive MDA-MB-231 breast cancer cells
- (2015) Ewa Kwiatkowska et al. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- Advances in Mycobacterial Isocitrate Lyase Targeting and Inhibitors
- (2015) M. Kratky et al. CURRENT MEDICINAL CHEMISTRY
- The antitumor agent 3-bromopyruvate has a short half-life at physiological conditions
- (2014) Matthew Glick et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Investigations on the Effect of O6-Benzylguanine on the Formation of dG-dC Interstrand Cross-Links Induced by Chloroethylnitrosoureas in Human Glioma Cells Using Stable Isotope Dilution High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry
- (2014) Guohui Sun et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer
- (2014) J. Chapiro et al. CLINICAL CANCER RESEARCH
- 3-bromopyruvate inhibits glycolysis, depletes cellular glutathione, and compromises the viability of cultured primary rat astrocytes
- (2014) Eric Ehrke et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Glycolysis inhibition and its effect in doxorubicin resistance in neuroblastoma
- (2014) Jonathan F. Bean et al. JOURNAL OF PEDIATRIC SURGERY
- Local delivery of cancer-cell glycolytic inhibitors in high-grade glioma
- (2014) Robert T. Wicks et al. NEURO-ONCOLOGY
- The Reversal Effects of 3-Bromopyruvate on Multidrug Resistance In Vitro and In Vivo Derived from Human Breast MCF-7/ADR Cells
- (2014) Long Wu et al. PLoS One
- 3-Bromopyruvate: A novel antifungal agent against the human pathogen Cryptococcus neoformans
- (2013) Mariusz Dyląg et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Antiglycolytic Therapy Combined with an Image-guided Minimally Invasive Delivery Strategy for the Treatment of Breast Cancer
- (2013) Manon Buijs et al. JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
- The Expression of Glyceraldehyde-3-Phosphate Dehydrogenase Associated Cell Cycle (GACC) Genes Correlates with Cancer Stage and Poor Survival in Patients with Solid Tumors
- (2013) Dunrui Wang et al. PLoS One
- Aerosolized 3-Bromopyruvate Inhibits Lung Tumorigenesis without Causing Liver Toxicity
- (2012) Q. Zhang et al. Cancer Prevention Research
- Novel insight into the role of GAPDH playing in tumor
- (2012) Chunmei Guo et al. Clinical & Translational Oncology
- Erratum to: Experimental results using 3-bromopyruvate in mesothelioma: in vitro and in vivo studies
- (2012) Philippe Icard et al. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- Over-expression of GAPDH in human colorectal carcinoma as a preferred target of 3-Bromopyruvate Propyl Ester
- (2012) Zhenjie Tang et al. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- A translational study “case report” on the small molecule “energy blocker” 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside
- (2012) Y. H. Ko et al. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- Targeting aerobic glycolysis: 3-bromopyruvate as a promising anticancer drug
- (2012) Simone Cardaci et al. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- 3-bromopyruvate: Targets and outcomes
- (2012) Maria C. Shoshan JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors
- (2012) Kivanç Birsoy et al. NATURE GENETICS
- Separate and concurrent use of 2-deoxy-D-glucose and 3-bromopyruvate in pancreatic cancer cells
- (2012) HUIJIE XIAO et al. ONCOLOGY REPORTS
- Human Hepatocellular Carcinoma in a Mouse Model: Assessment of Tumor Response to Percutaneous Ablation by Using Glyceraldehyde-3-Phosphate Dehydrogenase Antagonists
- (2012) Shanmugasundaram Ganapathy-Kanniappan et al. RADIOLOGY
- Final results of a prematurely discontinued Phase 1/2 study of eniluracil with escalating doses of 5-fluorouracil administered orally in patients with advanced hepatocellular carcinoma
- (2011) Gilberto de Lima Lopes et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Intracellular ATP Levels Are a Pivotal Determinant of Chemoresistance in Colon Cancer Cells
- (2011) Y. Zhou et al. CANCER RESEARCH
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- The monocarboxylate transporter family-Role and regulation
- (2011) Andrew P. Halestrap et al. IUBMB LIFE
- Targeting cancer metabolism: a therapeutic window opens
- (2011) Matthew G. Vander Heiden NATURE REVIEWS DRUG DISCOVERY
- Glycolysis Inhibition Inactivates ABC Transporters to Restore Drug Sensitivity in Malignant Cells
- (2011) Ayako Nakano et al. PLoS One
- 3-Bromopyruvate induces necrotic cell death in sensitive melanoma cell lines
- (2010) J.-Z. Qin et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The diverse functions of GAPDH: Views from different subcellular compartments
- (2010) Carlos Tristan et al. CELLULAR SIGNALLING
- The combination of the novel glycolysis inhibitor 3-BrOP and rapamycin is effective against neuroblastoma
- (2010) Alejandro G. Levy et al. INVESTIGATIONAL NEW DRUGS
- Human pyruvate kinase M2: A multifunctional protein
- (2010) Vibhor Gupta et al. PROTEIN SCIENCE
- Identification of small molecule inhibitors of pyruvate kinase M2
- (2009) Matthew G. Vander Heiden et al. BIOCHEMICAL PHARMACOLOGY
- Role of mitochondria-associated hexokinase II in cancer cell death induced by 3-bromopyruvate
- (2009) Zhao Chen et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Transport by SLC5A8 with subsequent inhibition of histone deacetylase 1 (HDAC1) and HDAC3 underlies the antitumor activity of 3-bromopyruvate
- (2009) Muthusamy Thangaraju et al. CANCER
- LDH correlation with survival in advanced melanoma from two large, randomised trials (Oblimersen GM301 and EORTC 18951)
- (2009) Sanjiv S. Agarwala et al. EUROPEAN JOURNAL OF CANCER
- Targets of 3-Bromopyruvate, A New, Energy Depleting, Anticancer Agent
- (2009) P. Dell'Antone Medicinal Chemistry
- Analyses of Resected Human Brain Metastases of Breast Cancer Reveal the Association between Up-Regulation of Hexokinase 2 and Poor Prognosis
- (2009) D. Palmieri et al. MOLECULAR CANCER RESEARCH
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- Sodium-coupled Monocarboxylate Transporters in Normal Tissues and in Cancer
- (2008) Vadivel Ganapathy et al. AAPS Journal
- Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate1
- (2008) Ana Paula Pereira Da Silva et al. BIOCHEMICAL JOURNAL
- Synergistic Antipancreatic Tumor Effect by Simultaneously Targeting Hypoxic Cancer Cells With HSP90 Inhibitor and Glycolysis Inhibitor
- (2008) X. Cao et al. CLINICAL CANCER RESEARCH
- Glycolytic enzyme inhibitors in cancer treatment
- (2008) Roberto Scatena et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
- (2008) Pierre Sonveaux et al. JOURNAL OF CLINICAL INVESTIGATION
- 3-Bromopyruvate as inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs
- (2008) Linda Strandberg Ihrlund et al. Molecular Oncology
- Pyruvate kinase M2 is a phosphotyrosine-binding protein
- (2008) Heather R. Christofk et al. NATURE
- The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
- (2008) Heather R. Christofk et al. NATURE
- Hexokinase-2 bound to mitochondria: Cancer's stygian link to the “Warburg effect” and a pivotal target for effective therapy
- (2008) Saroj P. Mathupala et al. SEMINARS IN CANCER BIOLOGY
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