期刊
BIOMATERIALS
卷 275, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2021.120935
关键词
Second near infrared light; Photothermal therapy; Fluorescence imaging; Starvation therapy; Glycolysis metabolism; Thermal sensitization
资金
- National Natural Science Foundation of China [21575069, 21904070]
- Natural Science Foundation of Jiangsu Higher Education Institutions [20KJA430012, 19KJB150035]
- Natural Science Foundation of Jiangsu Province [BK20190722]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) [YX030003]
- Postgraduate Research & Practice Innovation Program of Jiangsu Province [SJCX20_0233, KYCX20_0753]
The study proposed a tumor-specific enhanced NIR-II PTT strategy through starvation-mediated thermal sensitization, using a semiconducting polymer and glycolysis inhibitor 2DG encapsulated into folate modified liposomes. By targeting and triggering NIR-II photothermal effect, spatial-temporal release of 2DG was achieved and enhanced the tumor thermal sensitivity towards PTT.
Photothermal therapy (PTT) is hampered by limited light penetration depth and cell thermoresistance induced by over-expressed heat shock proteins (HSPs). Herein, we proposed a tumor-specific enhanced NIR-II PTT through the starvation mediated thermal sensitization strategy. A semiconducting polymer with superior NIR-II fluorescence imaging (FI) performance and NIR-II PTT efficacy was synthesized and encapsulated into folate modified liposomes, together with a glycolysis inhibitor, 2-deoxy-D-glucose (2DG). Upon specifically targeting folate receptors and guidance of NIR-II FI, spatiotemporal 2DG release could be achieved by the trigger of NIR-II photothermal effect. The released 2DG could not only deplete the energy supply of tumor cells by inhibiting tumor anaerobic glycolysis, but also decrease the ATP levels and hamper the production of HSPs, ultimately enhancing the tumor thermal sensitivity toward PTT. Owing to the sensitization effect of 2DG, tumor cells with overexpressed folate receptors could be significantly damaged by NIR-II PTT with an enhanced therapeutic efficiency. The work provided a promising strategy for specific starvation/NIR-II PTT synergistic therapy towards tumors.
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