Article
Chemistry, Applied
Sivan Gelley, Hodaya Lankry, Jovana Glusac, Ayelet Fishman
Summary: Results suggest that yeast-derived patatin properties are comparable to those from potatoes, indicating potential use in various plant-based products.
Review
Biochemistry & Molecular Biology
Giovanni Davide Barone, Anita Emmerstorfer-Augustin, Antonino Biundo, Isabella Pisano, Paola Coccetti, Valeria Mapelli, Andrea Camattari
Summary: Since the mid-1960s, the methylotrophic yeast Komagataella phaffii has gained scientific attention for its industrial production of proteins. This review provides a summary of fundamental and specific information in this field, including the products produced at industrial levels by various companies and the patents and workflow for protein production with this strain.
Article
Engineering, Environmental
Minjie Gao, Yuchen Zhou, Jiajun Yan, Li Zhu, Zhitao Li, Xiuyu Hu, Xiaobei Zhan
Summary: Rhodium is widely used in catalysis, but its adsorption by microorganisms is not well studied. In this work, waste P. pastoris and recombinant P. pastoris GS-R were used as novel adsorbents for Rh(III) adsorption, showing high adsorption capacity and selectivity. The study developed an environmentally-friendly strategy for recovering Rh(III) and other precious metals using P. pastoris.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Luca Zinzula, Jerome Basquin, Stefan Bohn, Florian Beck, Sven Klumpe, Gunter Pfeifer, Istvan Nagy, Andreas Bracher, F. Ulrich Hartl, Wolfgang Baumeister
Summary: The Covid-19 pandemic caused by SARS-CoV-2 is a global health crisis with unprecedented casualties and socio-economic burden. The N nucleocapsid phosphoprotein of SARS-CoV-2 plays a crucial role in oligomerizing and packaging the viral genome, making it a potential antiviral target. Structural and biophysical studies have revealed the importance of the N C-terminal domain in N protein oligomerization and ssRNA binding.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Environmental Sciences
Carolyn A. Robinson, Hsin-Yeh Hsieh, Shu-Yu Hsu, Yang Wang, Braxton T. Salcedo, Anthony Belenchia, Jessica Klutts, Sally Zemmer, Melissa Reynolds, Elizabeth Semkiw, Trevor Foley, XiuFeng Wan, Chris G. Wieberg, Jeff Wenzel, Chung-Ho Lin, Marc C. Johnson
Summary: The genetic material of SARS-CoV-2 has been detected in raw wastewater around the world during the COVID-19 pandemic, showing high detectability in feces and household wastewater both before and after a positive qPCR test. However, the study found that pasteurization of raw wastewater did not reduce the SARS-CoV-2 signal if RNA was extracted immediately after, with a decrease in signal observed when extraction was delayed. Surprisingly, the recovery of SARS-CoV-2 signal after concentration was consistently higher than that of a control virus, indicating potential differences in the nature of the genetic material detected in wastewater.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Maria Joao Moreno, Patricia Alexandra Teles Martins, Eva F. Bernardino, Biebele Abel, Suresh V. Ambudkar
Summary: This study characterized the lipidome and lipid/protein ratio of membranes from High Five™ insect cells overexpressing mouse P-glycoprotein, providing insight into the lipid environment surrounding P-glycoprotein and its properties. Phosphatidylethanolamines were the most abundant phospholipids, followed by phosphatidylcholines. The membranes also contained negatively charged lipids such as phosphatidylserines, phosphatidylinositols, and phosphatidylglycerols.
Article
Biochemical Research Methods
Hannes Russmayer, Markus Buchetics, Matthias Mattanovich, Stefan Neubauer, Matthias Steiger, Alexandra B. Graf, Gunda Koellensperger, Stephan Hann, Michael Sauer, Brigitte Gasser, Diethard Mattanovich
Summary: This study investigated the impact of engineering amino acid metabolism on the production of recombinant proteins. Overexpression of genes related to amino acid metabolism increased intracellular amino acid levels and improved recombinant protein production. The results showed that overexpression of pathway genes and the regulator GCN4 can significantly enhance the production of recombinant proteins.
BIOTECHNOLOGY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Khadijah A. Altammar, Jonathan Guyang Ling, Hussein M. Al-Bajalan, Iuan-Sheau Chin, Mukram Mohamed Mackeen, Nor Muhammad Mahadi, Abdul Munir Abdul Murad, Farah Diba Abu Bakar
Summary: Cutinases are hydrolytic enzymes that can degrade plant cutin. A new cutinase homolog, AnCUT3, has been identified and characterized in this study. The recombinant AnCUT3 exhibited optimal temperature and pH, as well as high catalytic efficiency. It also showed potential for degrading and modifying the surface of certain polymers.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biology
Izan Chalen, Maria Mercedes Cobo, Bernardo Gutierrez, Andres Carrazco-Montalvo, Patricio Ponce, Diego F. Cisneros-Heredia
Summary: The COVID-19 pandemic had a severe impact on Ecuador, attracting international media attention due to its high death toll and overwhelmed healthcare system. Ecuador's reliance on imported biotechnological products for its healthcare system highlights the need for policies to develop the biotechnological industry.
Article
Cell Biology
Marta T. Borowska, Christopher T. Boughter, Jeffrey J. Bunker, Jenna J. Guthmiller, Patrick C. Wilson, Benoit Roux, Albert Bendelac, Erin J. Adams
Summary: This study investigates the molecular basis of polyreactivity in antibodies. It is found that polyreactive antigen-binding fragments (Fabs) bind their targets with low affinities, comparable to T cell receptor recognition. Mutagenic studies suggest that polyreactive antibodies use multiple strategies for engagement. The crystal structures and molecular dynamics simulations reveal increased rigidity in polyreactive Fabs, providing a neutral and accessible platform for diverse antigens to bind.
Article
Biochemistry & Molecular Biology
Isabel Schulien, Janine Kemming, Valerie Oberhardt, Katharina Wild, Lea M. Seidel, Saskia Killmer, Sagar, Franziska Daul, Marilyn Salvat Lago, Annegrit Decker, Hendrik Luxenburger, Benedikt Binder, Dominik Bettinger, Oezlem Sogukpinar, Siegbert Rieg, Marcus Panning, Daniela Huzly, Martin Schwemmle, Georg Kochs, Cornelius F. Waller, Alexandra Nieters, Daniel Duerschmied, Florian Emmerich, Henrik E. Mei, Axel Ronald Schulz, Sian Llewellyn-Lacey, David A. Price, Tobias Boettler, Bertram Bengsch, Robert Thimme, Maike Hofmann, Christoph Neumann-Haefelin
Summary: The study found that SARS-CoV-2 infection induces and forms functionally competent memory CD8(+) T cell responses, which can persist in some SARS-CoV-2 convalescent individuals. Even in the absence of virus-specific antibodies, these virus epitope-specific CD8(+) T cell responses are induced following infection.
Article
Biotechnology & Applied Microbiology
Yichun Xu, Kunshan Liu, Yu Han, Yanzi Xing, Yuanxing Zhang, Qiuying Yang, Mian Zhou
Summary: The study found a direct correlation between codon translation efficiency and usage frequency, with N-terminal signal peptides showing tolerance towards codon changes. Full-length codon optimization differentially affects the expression profiles of genes with different levels of structural disorder, and can potentially cause protein conformation changes in structurally disordered proteins.
MICROBIAL CELL FACTORIES
(2021)
Article
Fisheries
Zixuan Wu, Yujie Liu, Jiaqi Zheng, Yongzhao Zhou, Kefan Xing, Yuying Sun, Jiquan Zhang
Summary: Arginine kinase is crucial for organisms with high energy demands, and in Exopalaemon carinicauda, it may play a similar role as in other crustaceans. Its expression is predominantly in muscle and can change in response to bacterial challenges. Recombinant expression and purification of EcAK showed similar enzymatic characteristics to AK from Euphausia superba.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Biochemical Research Methods
Zhiqian Wang, Yunjun Yan, Houjin Zhang
Summary: Pichia pastoris has traditionally been regulated through methanol induction, which is toxic and flammable. In this study, a novel one-component optogenetic system based on the photosensitive protein EL222 was designed to induce gene expression under blue light and rapidly deactivate it upon switching back to darkness. The intensity of induction in the optogenetic system correlates positively with the dose and periodicity of blue light, and it demonstrates good spatial control.
ACS SYNTHETIC BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nishant Vaikath, Indulekha Sudhakaran, Ilham Abdi, Vijay Gupta, Nour Majbour, Simona Ghanem, Houari Abdesselem, Kostas Vekrellis, Omar El-Agnaf
Summary: The aggregation of alpha-synuclein into neurotoxic oligomers and fibrils is a key pathological feature in diseases such as Alzheimer's and Parkinson's. This study generated and characterized distinct alpha-synuclein oligomers in vitro in the presence of oxidative stress products. These oligomers were found to be stable and toxic, accelerating alpha-synuclein aggregation and causing cytotoxicity in cells. This research provides valuable insights into the pathogenesis of synucleinopathies and offers potential biomarkers for disease diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Sarah M. Bartsch, Kelly J. O'Shea, Patrick T. Wedlock, Ulrich Strych, Marie C. Ferguson, Maria Elena Bottazzi, Samuel L. Randall, Sheryl S. Siegmund, Sarah N. Cox, Peter J. Hotez, Bruce Y. Lee
Summary: During a pandemic, waiting for a vaccine with higher efficacy is not always the best choice, as it may result in more hospitalizations and costs, except for early on in the pandemic and for vaccines that prevent infection effectively.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2021)
Article
Biochemical Research Methods
Zhuyun Liu, Rakhi Kundu, Surafel Damena, Amadeo B. Biter, Mun Peak Nyon, Wen-Hsiang Chen, Bin Zhan, Ulrich Strych, Peter J. Hotez, Maria Elena Bottazzi
Summary: Researchers successfully developed a process for large-scale production of recombinant PpSP15 and validated its reproducibility, laying the foundation for future pilot manufacturing technology transfer. The study also demonstrated the high stability and purity level of PpSP15 recombinant protein.
PROTEIN EXPRESSION AND PURIFICATION
(2021)
Article
Multidisciplinary Sciences
Julio Cruz-Chan, Liliana E. Villanueva-Lizama, Leroy Versteeg, Ashish Damania, Maria Jose Villar, Cristina Gonzalez-Lopez, Brian Keegan, Jeroen Pollet, Fabian Gusovsky, Peter J. Hotez, Maria Elena Bottazzi, Kathryn M. Jones
Summary: Therapeutic treatment with a reduced dose of benznidazole combined with vaccine treatment induces a T(H)17 immune response, enhancing the production of specific cytokines and T lymphocytes, resulting in reduced cardiac inflammation, fibrosis, and parasite burdens, as well as improved survival in acutely infected mice. Low dose treatments show comparable efficacy to high dose treatments, suggesting potential dose sparing effects and bridging the gaps of current drug treatment in Chagasic patients by inducing T(H)17 immune responses through vaccine-linked chemotherapeutic strategies.
SCIENTIFIC REPORTS
(2021)
Article
Biochemical Research Methods
Wen-Hsiang Chen, Jeroen Pollet, Ulrich Strych, Jungsoon Lee, Zhuyun Liu, Rakhi Tyagi Kundu, Leroy Versteeg, Maria Jose Villar, Rakesh Adhikari, Junfei Wei, Cristina Poveda, Brian Keegan, Aaron Oakley Bailey, Yi-Lin Chen, Portia M. Gillespie, Jason T. Kimata, Bin Zhan, Peter J. Hotez, Maria Elena Bottazzi
Summary: SARS-CoV-2 protein subunit vaccine is being evaluated for its immunogenicity and protective efficacy in mice. The recombinant protein produced through yeast expression and purification processes showed promising results in inducing immune response and protection in mice against SARS-CoV-2 challenge infections. This candidate vaccine demonstrates potential for technology transfer and further evaluation in human clinical trials.
PROTEIN EXPRESSION AND PURIFICATION
(2022)
Article
Biology
Kamal Rawal, Robin Sinha, Swarsat Kaushik Nath, P. Preeti, Priya Kumari, Srijanee Gupta, Trapti Sharma, Ulrich Strych, Peter Hotez, Maria Elena Bottazzi
Summary: The article presents Vaxi-DL, a web-based deep learning software that evaluates the potential of protein sequences as vaccine target antigens. The software accurately predicts target antigens in bacteria, protozoa, fungi, and viruses that cause infectious diseases in humans. The tool has demonstrated a high sensitivity, making it useful for prioritizing potential vaccine candidates.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Immunology
Jeroen Pollet, Ulrich Strych, Wen-Hsiang Chen, Leroy Versteeg, Brian Keegan, Bin Zhan, Junfei Wei, Zhuyun Liu, Jungsoon Lee, Rakhi Kundu, Rakesh Adhikari, Cristina Poveda, Maria Jose Villar, Syamala Rani Thimmiraju, Brianna Lopez, Portia M. Gillespie, Shannon Ronca, Jason T. Kimata, Martin Reers, Vikram Paradkar, Peter Hotez, Maria Elena Bottazzi
Summary: In this study, a yeast-produced SARS-CoV-2 RBD subunit vaccine candidate formulated with aluminum hydroxide (alum) and CpG deoxynucleotides was evaluated in preclinical studies using mice. The results showed that the RBD/alum + CpG vaccine induced a stronger cellular immune response and could neutralize various variants of SARS-CoV-2.
Review
Immunology
Wen-Hsiang Chen, Ulrich Strych, Maria Elena Bottazzi, Yi-Pin Lin
Summary: This review summarizes the challenges faced in the development of Lyme disease vaccines and the antigen engineering approaches and mechanisms that can be utilized to improve the safety and efficacy of these vaccines.
EXPERT REVIEW OF VACCINES
(2022)
Article
Immunology
Cristina Gonzalez-Lopez, Wen-Hsiang Chen, Andrea Alfaro-Chacon, Liliana E. Villanueva-Lizama, Miguel Rosado-Vallado, Maria Jesus Ramirez-Sierra, Christian F. Teh-Poot, Jeroen Pollet, Oluwatoyin Asojo, Kathryn M. Jones, Peter J. Hotez, Maria Elena Bottazzi, Julio Vladimir Cruz-Chan
Summary: A therapeutic vaccine containing multiple antigenic epitopes has been developed for Chagas disease, showing promising effects in enhancing cellular immune responses and reducing parasite levels. This study provides a potential strategy for the development of a vaccine candidate for Chagas disease.
Article
Immunology
Nor-Aziyah MatRahim, Kathryn Marie Jones, Brian P. Keegan, Ulrich Strych, Bin Zhan, Hai-Yen Lee, Sazaly AbuBakar
Summary: The study evaluated the immunogenicity of A. baumannii TonB-dependent receptors (TBDRs) displayed on the surface of Bacillus subtilis spores in orally vaccinated mice. The results showed that the vaccinated mice remained healthy throughout the study and exhibited mucosal and humoral antibody responses to the vaccine antigen. The sera also demonstrated bactericidal activities against A. baumannii clinical isolates. These findings suggest that the B. subtilis spore-displayed TBDRs have potential as oral vaccine candidates against A. baumannii.
Article
Veterinary Sciences
Rebecca M. Legere, Angelica R. Allegro, Yvonne Affram, Bibiana Petri da Silveira, Jennifer L. Fridley, Kelsey M. Wells, Numan Ozgun, Robert C. Burghardt, Gus A. Wright, Jeroen Pollet, Angela I. Bordin, Paul de Figueiredo, Julian L. Leibowitz, Noah D. Cohen
Summary: The susceptibility of cultured primary equine bronchial epithelial cells (EBECs) to a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pseudovirus was examined and found to be lower than that of human bronchial epithelial cells (HBECs), suggesting that horses are unlikely to be an important zoonotic host of SARS-CoV-2.
AMERICAN JOURNAL OF VETERINARY RESEARCH
(2023)
Article
Multidisciplinary Sciences
Zongyuan Liu, Rebecca Ulrich vonBargen, April L. Kendricks, Kate Wheeler, Ana Carolina Leao, Krithivasan Sankaranarayanan, Danya A. Dean, Shelley S. Kane, Ekram Hossain, Jeroen Pollet, Maria Elena Bottazzi, Peter J. Hotez, Kathryn M. Jones, Laura-Isobel McCall
Summary: This study reveals the molecular mechanisms of Chagas disease treatment, including simultaneous effects on the pathogen and on host small molecule responses. It also highlights the link between persistent small molecule perturbation and clinical treatment failure in chronic infection.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Syamala Rani Thimmiraju, Rakesh Adhikari, Maria Jose Villar, Jungsoon Lee, Zhuyun Liu, Rakhi Kundu, Yi-Lin Chen, Suman Sharma, Karm Ghei, Brian Keegan, Leroy Versteeg, Portia M. Gillespie, Allan Ciciriello, Nelufa Y. Islam, Cristina Poveda, Nestor Uzcategui, Wen-Hsiang Chen, Jason T. Kimata, Bin Zhan, Ulrich Strych, Maria Elena Bottazzi, Peter J. Hotez, Jeroen Pollet
Summary: The study describes the development and characterization of a next-generation SARS-CoV-2 vaccine adapted to the XBB variants. The XBB.1.5 RBD/CpG/alum vaccine elicited a robust antibody response in mice and demonstrated potent neutralization against several Omicron pseudoviruses. These findings highlight the potential for an updated vaccine formulation utilizing the XBB.1.5 RBD antigen.
Article
Biochemistry & Molecular Biology
A. Prabakaran, Amit Alexander
Summary: The molecular interactions and mucoadhesive nature of chitosan-coated liposomes with mucin are crucial for the development of an effective drug delivery system. The positively charged SA-CH-LPs showed stronger interaction and better mucoadhesive properties compared to negatively charged SALPs, thereby improving drug retention in the nasal cavity and enhancing therapeutic efficacy.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Maryam Noei-Khesht Masjedi, Esmaeil Sadroddiny, Jafar Ai, Saeed Balalaie, Yazdan Asgari
Summary: This study discovered an effective strategy for cargo sorting within exosomes by incorporating an appropriate cleavage site, providing further insight into the potential of exosomes as nano-shuttles bearing therapeutic biomolecules.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Pei -Gee Yap, Chee-Yuen Gan
Summary: This study collected the sequences of 128 tyrosinase inhibitory peptides and analyzed their hydrophobicity/hydrophilicity properties and amino acid profiles. Molecular docking analysis was used to investigate the binding interactions between peptides and tyrosinase. The study found that hydrophobic and/or polar neutral properties facilitate or stabilize peptide binding with tyrosinase, and short peptides with cysteine and tyrosine tend to bind to the active site of tyrosinase. These findings provide detailed explanations for the relationship between peptide/amino acid structures and tyrosinase inhibition, as well as potential anti-melanogenesis mechanisms for peptide-based treatments against skin hyperpigmentation.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Ye Yang, Hai-Lian Chen, Su Fang Wu, Wei Bao
Summary: The study found that CHMP4B and VPS4A play an important role in reversing GSDMD-mediated pyroptosis by facilitating cell membrane remodeling in endometrial carcinoma.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Aya Al Othman, Dmitry Bagrov, Julian M. Rozenberg, Olga Glazova, Gleb Skryabin, Elena Tchevkina, Alexandre Mezentsev, Mikhail Durymanov
Summary: Arc protein is found in glutamatergic neurons of vertebrates and can be transferred between neurons in extracellular vesicles (EVs). In glioma cells, Arc protein is also present in EVs and can facilitate the transfer of mRNA, potentially contributing to tumor progression and affecting synaptic plasticity in cancer patients.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Nan Zhang, Meng-yu Shen, Qing-li Meng, Hao-ping Sun, Fang-yi Fan, Hai Yi, Yong-jian Yang
Summary: In this study, it was demonstrated for the first time that FAT1 inhibited AML proliferation by reducing autophagy level. FAT1 achieved this by decreasing the expression of ATG4B, which is related to autophagy. Mechanistically, FAT1 decreased the levels of phosphorylated and intranuclear smad2/3, thus decreasing the activity of the ATG4B gene promoter. It was also found that FAT1 competitively bound to TGF-beta R II, leading to reduced phosphorylation of TGF-beta R I and smad2/3. Knockdown of FAT1 promoted AML autophagy and proliferation in vivo.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Oleh Demianchuk, Myroslava Vatashchuk, Dmytro Gospodaryov, Viktoria Hurza, Marian Ivanochko, Vitalii Derkachov, Vladyslav Berezovskyi, Oleh Lushchak, Kenneth B. Storey, Maria Bayliak, Volodymyr I. Lushchak
Summary: This study investigated the effects of a high-fat high-fructose diet (HFFD) on the behavior, energy metabolism, and oxidative stress markers in the cerebral cortex of mice. The results showed that HFFD stimulated locomotion and defecation, while an AKG-supplemented diet had a tendency to promote anxiety-like behavior. Additionally, there were significant differences in glutathione-dependent detoxification and processes related to autophagy between the two diets.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Yusaku Chukai, Ginga Ito, Yasuo Miki, Koichi Wakabayashi, Ken Itoh, Eriko Sugano, Hiroshi Tomita, Tomokazu Fukuda, Taku Ozaki
Summary: The study found that mitochondrial calpain-5 plays an important role in the occurrence and development of ischemia-reperfusion injury and is expressed in the human and mouse brains. Targeting the expression or activity of mitochondrial calpain-5 may have significant implications for suppressing inflammation during I/R injuries such as cerebrovascular diseases.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Aline Dias da Purificaca, Victor Debbas, Leonardo Yuji Tanaka, Gabriele Veronica de Mello Gabriel, Joao Wosniak Junior, Tiphany Coralie De Bessa, Sheila Garcia-Rosa, Francisco Rafael Martins Laurindo, Percillia Victoria Santos Oliveira
Summary: The ER transmembrane chaperones DNAJB12 and DNAJB14 play important roles in protein folding and ER stress response. They are regulated by thiol redox processes and are involved in ER protein reflux.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Ekaterina O. Bryanskaya, Andrey Y. Vinokurov, Angelina I. Dolgikh, Andrey Dunaev, Plamena R. Angelova, Andrey Y. Abramov
Summary: FAD autofluorescence in cells can assess enzymatic activity, and its intensity variations may be related to different cell types and tissues. High levels of FAD autofluorescence can indicate cell pathology and potentially predict the occurrence of apoptosis and necrosis.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Rumei Luan, Manyu Luo, Dongyan Ding, Xin Su, Junling Yang
Summary: Zinc deficiency can worsen obesity-related lung damage, and Nrf2 activation is one of the important mechanisms of this protective effect. Regulating zinc homeostasis can contribute to the prevention and treatment of obesity-related lung injury.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)