Evolutionary crossroads of cell signaling: PP1 and PP2A substrate sites in intrinsically disordered regions

Phosphoproteome and drug response effects mediated by the three Protein Phosphatase 2A inhibitor proteins CIP2A, SET and PME-1

(2020) Otto Kauko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of site‐specific dephosphorylation and kinase opposition imposed by PP2A regulatory subunits

(2020) Thomas Kruse et al.   EMBO JOURNAL

Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling

(2020) Callie P. Wigington et al.   MOLECULAR CELL

Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A

(2020) Bernhard Hoermann et al.   Nature Communications

Hidden dynamic signatures drive substrate selectivity in the disordered phosphoproteome

(2020) Min-Hyung Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme

(2020) Roman O Fedoryshchak et al.   eLife

Global and Site-Specific Effect of Phosphorylation on Protein Turnover

(2020) Chongde Wu et al.   DEVELOPMENTAL CELL

ASPP proteins discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail

(2019) M. Teresa Bertran et al.   Nature Communications

Mechanism of IRSp53 inhibition by 14-3-3

(2019) David J. Kast et al.   Nature Communications

Evolution of protein kinase substrate recognition at the active site

(2019) David Bradley et al.   PLOS BIOLOGY

Why do eukaryotic proteins contain more intrinsically disordered regions?

(2019) Walter Basile et al.   PLoS Computational Biology

Proteome-wide signatures of function in highly diverged intrinsically disordered regions

(2019) Taraneh Zarin et al.   eLife

High throughput discovery of functional protein modifications by Hotspot Thermal Profiling

(2019) Jun X. Huang et al.   NATURE METHODS

Protein kinases phosphorylate long disordered regions in intrinsically disordered proteins

(2019) Ryotaro Koike et al.   PROTEIN SCIENCE

Molecular basis for the binding and selective dephosphorylation of Na+/H+ exchanger 1 by calcineurin

(2019) Ruth Hendus-Altenburger et al.   Nature Communications

Histone chaperone exploits intrinsic disorder to switch acetylation specificity

(2019) Nataliya Danilenko et al.   Nature Communications

Cdc14 and PP2A Phosphatases Cooperate to Shape Phosphoproteome Dynamics during Mitotic Exit

(2019) Sandra A. Touati et al.   Cell Reports

PP2A‐B56 binds to Apc1 and promotes Cdc20 association with the APC/C ubiquitin ligase in mitosis

(2019) Kazuyuki Fujimitsu et al.   EMBO REPORTS

A Consensus Binding Motif for the PP4 Protein Phosphatase

(2019) Yumi Ueki et al.   MOLECULAR CELL

The functional landscape of the human phosphoproteome

(2019) David Ochoa et al.   NATURE BIOTECHNOLOGY

Protein Serine/Threonine Phosphatases: Keys to Unlocking Regulators and Substrates

(2018) David L. Brautigan et al.   Annual Review of Biochemistry

Phosphoproteome dynamics during mitotic exit in budding yeast

(2018) Sandra A Touati et al.   EMBO JOURNAL

Kinase inhibitors: the road ahead

(2018) Fleur M. Ferguson et al.   NATURE REVIEWS DRUG DISCOVERY

Multisite Substrate Recognition in Asf1-Dependent Acetylation of Histone H3 K56 by Rtt109

(2018) Lin Zhang et al.   CELL

UniProt: a worldwide hub of protein knowledge

(2018)   NUCLEIC ACIDS RESEARCH

PP2A Cdc55 Phosphatase Imposes Ordered Cell-Cycle Phosphorylation by Opposing Threonine Phosphorylation

(2017) Molly Godfrey et al.   MOLECULAR CELL

Mechanisms regulating phosphatase specificity and the removal of individual phosphorylation sites during mitotic exit

(2016) Samuel Rogers et al.   BIOESSAYS

A PP2A-B55 recognition signal controls substrate dephosphorylation kinetics during mitotic exit

(2016) Michael J. Cundell et al.   JOURNAL OF CELL BIOLOGY

A Conserved Motif Provides Binding Specificity to the PP2A-B56 Phosphatase

(2016) Emil Peter Thrane Hertz et al.   MOLECULAR CELL

Early signaling dynamics of the epidermal growth factor receptor

(2016) Raven J. Reddy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expanding the PP2A Interactome by Defining a B56-Specific SLiM

(2016) Xinru Wang et al.   STRUCTURE

14-3-3-Pred: improved methods to predict 14-3-3-binding phosphopeptides

(2015) Fábio Madeira et al.   BIOINFORMATICS

Global Phosphoproteomic Mapping of Early Mitotic Exit in Human Cells Identifies Novel Substrate Dephosphorylation Motifs

(2015) Rachael A. McCloy et al.   MOLECULAR & CELLULAR PROTEOMICS

Intrinsically disordered proteins in cellular signalling and regulation

(2015) Peter E. Wright et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

FDA-approved small-molecule kinase inhibitors

(2015) Peng Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Intrinsically Disordered Proteins and Intrinsically Disordered Protein Regions

(2014) Christopher J. Oldfield et al.   Annual Review of Biochemistry

DISOPRED3: precise disordered region predictions with annotated protein-binding activity

(2014) David T. Jones et al.   BIOINFORMATICS

Classification of Intrinsically Disordered Regions and Proteins

(2014) Robin van der Lee et al.   CHEMICAL REVIEWS

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling

(2014) Kirti Sharma et al.   Cell Reports

A Correction to the Editors' Choice Summary Titled "Keeping Bone Where Bone Belongs" by Leslie K. Ferrarelli

(2013)   Science Signaling

Regulation of protein phosphatase 1 by intrinsically disordered proteins

(2012) Meng S. Choy et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Rapid Determination of Multiple Linear Kinase Substrate Motifs by Mass Spectrometry

(2012) Arminja N. Kettenbach et al.   CHEMISTRY & BIOLOGY

D2P2: database of disordered protein predictions

(2012) Matt E. Oates et al.   NUCLEIC ACIDS RESEARCH

Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells

(2011) A. N. Kettenbach et al.   Science Signaling

14-3-3 proteins as signaling integration points for cell cycle control and apoptosis

(2011) Alexandra K. Gardino et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Proteome-wide post-translational modification statistics: frequency analysis and curation of the swiss-prot database

(2011) George A. Khoury et al.   Scientific Reports

Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites

(2010) Michael J Ragusa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The extended PP1 toolkit: designed to create specificity

(2010) Mathieu Bollen et al.   TRENDS IN BIOCHEMICAL SCIENCES

14-3-3 Mediates Histone Cross-Talk during Transcription Elongation in Drosophila

(2010) Caline S. Karam et al.   PLoS Genetics

Docking Motif-Guided Mapping of the Interactome of Protein Phosphatase-1

(2009) Annick Hendrickx et al.   CHEMISTRY & BIOLOGY

14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response

(2009) Duaa H. Mohammad et al.   DNA REPAIR

Improved visualization of protein consensus sequences by iceLogo

(2009) Niklaas Colaert et al.   NATURE METHODS

Global Analysis of Cdk1 Substrate Phosphorylation Sites Provides Insights into Evolution

(2009) L. J. Holt et al.   SCIENCE

Detailed Structural Characterization of Unbound Protein Phosphatase 1 Inhibitors†

(2008) Barbara Dancheck et al.   BIOCHEMISTRY