Article
Engineering, Environmental
Md Saidur Rahman, Won-Ki Pang, Shehreen Amjad, Do-Yeal Ryu, Elikanah Olusayo Adegoke, Yoo-Jin Park, Myung-Geol Pang
Summary: This study evaluated the effects of exposure to mixtures containing bisphenol A and seven phthalates on liver functions and metabolic homeostasis. The results showed that exposure to EDCs at doses exceeding the human daily exposure limit had detrimental impacts on overall liver function, leading to metabolic abnormalities, steatohepatitis, and hepatic fibrosis. These findings have significant relevance for public health.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Review
Environmental Sciences
Amol Hirke, Bincy Varghese, Shruti Varade, Ramu Adela
Summary: Prenatal exposure to certain endocrine-disrupting chemicals, such as perfluorooctanoic acid (PFOA), perfluoro octane sulfonic acid (PFOS), perfluononanoic acid (PFNA), and mono-ethyl phthalate (MEP), is associated with an increased risk of gestational hypertension (GH) and preeclampsia (PE). However, exposure to bisphenol A during pregnancy does not show a significant association with the risk of PE. More research is needed to confirm these findings, as the evidence for most of these associations is limited.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Ann M. Vuong, Joseph M. Braun, Andreas Sjodin, Antonia M. Calafat, Kimberly Yolton, Bruce P. Lanphear, Aimin Chen
Summary: The study found positive associations between PBDEs and glucose and cholesterol levels during pregnancy, while some phthalate biomarkers were negatively associated with cholesterol. However, no relationship was noted for BPA or PFAS with cardiometabolic indices during pregnancy.
ENVIRONMENT INTERNATIONAL
(2021)
Review
Food Science & Technology
Matthew P. Madore, Junichi R. Sakaki, Ock K. Chun
Summary: Endocrine disrupting chemicals (EDCs) are a group of compounds that can alter the function of the endocrine system and are widely dispersed in the environment. Diet is the main source of exposure to EDCs, and polyphenols are believed to have the potential to mitigate the health detriments caused by EDCs. This review discusses the evidence of dietary exposure to two predominant EDCs, bisphenol A and phthalates, in the United States, their associations with disease outcomes, the potential role of polyphenols in reducing their harmful effects, knowledge gaps, and recommendations for future research.
FOOD SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Environmental Sciences
Ok-Jin Kim, Seyoung Kim, Eun Young Park, Jin Kyoung Oh, Soyoung Park, Sooyeon Hong, Hyun-Jin Kim, Bohyun Park, Bomi Park, Suejin Kim, Byungmi Kim
Summary: This study investigated the association between individual and combined PFAS exposure and liver function in Korean adults. The results showed that all PFAS were positively associated with liver enzymes ALT, AST, and GGT, with differences based on sex and obesity status. Additionally, increased exposure to PFAS mixtures was associated with higher levels of these liver enzymes. These findings provide additional evidence for the association between PFAS exposure and the risk of liver disease.
Article
Cell Biology
Jumpei Fujiki, Megumi Uchida, Sakurako Tsunoda, Naoyuki Maeda, Hiroki Inoue, Hiroshi Yokota, Hidetomo Iwano
Summary: Bisphenol A (BPA) may affect the growth and cell cycle of human placental cells through the sulfatase pathway, leading to adverse effects.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Xiaoning Fu, Rongchao Yang, Guangzhu Zhou, Xi Chen, Yin Liu, Jingyi Chi, Xiao Li, Hui Fang, Honglei Li, Wenpeng Li
Summary: This article summarizes the classification, risks, occurrence, fate, and treatment methods of endocrine disrupting chemicals (EDCs), with a focus on photocatalytic degradation as an ideal method for future BPA removal. The efficiency and latest progress of photocatalytic degradation are discussed, along with suggestions for improvement and a summary of the mechanism based on the free radical theory.
CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY
(2022)
Article
Obstetrics & Gynecology
Periklis Panagopoulos, Despina Mavrogianni, Chryssi Christodoulaki, Eirini Drakaki, Georgios Chrelias, Dimitrios Panagiotopoulos, Anastasios Potiris, Peter Drakakis, Sofoklis Stavros
Summary: Endocrine disrupting compounds (EDCs) are a group of mostly non-natural chemicals that can imitate hormone action and perturb physiological functions in humans and animals. Some EDCs are associated with negative effects on female fertility, including regulation of steroidogenesis, miscarriage rates, fertilization and embryo implantation rates. Among the common EDCs, Bisphenol A (BPA) is well-studied and has negative effects on the female reproductive system. This review summarizes the recent literature on the impact of EDCs in female fertility.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2023)
Review
Environmental Sciences
Linyan Zhu, Parvaneh Hajeb, Patrik Fauser, Katrin Vorkamp
Summary: Several widely used chemicals have been identified as endocrine-disrupting chemicals (EDCs), which may pose a potential risk to humans. This study reviewed the occurrence of these EDCs in indoor dust and their resulting human exposure. While some banned or restricted EDCs are still detected in indoor dust, new alternatives of EDCs have also been found. The study highlights the importance of indoor dust as a significant pathway for human exposure to EDCs.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Hannah Gardener, Vivian Nguyen, Lori A. Hoepner
Summary: Maternal exposure to phthalates and BPA during pregnancy can have adverse effects on offspring health. The study found that phthalate metabolite concentrations were highest among Hispanic women, while education level was associated with higher phthalate concentrations. These disparities were not explained by diet.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Huan-yu Tao, Jiawei Zhang, Jianghong Shi, Wei Guo, Xiaowei Liu, Mengtao Zhang, Hui Ge, Xiao-yan Li
Summary: This study found that total estrogen excretion in cows was significantly higher than in pigeons, and the form of excreted estrogens depended on livestock species and type of excrement. Bisphenol A was detected in all livestock manure and food, showing that food is a significant source of BPA entering livestock breeding.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Ruoyi Lei, Baode Xue, Xiaoyu Tian, Ce Liu, Yanlin Li, Jie Zheng, Bin Luo
Summary: This study analyzed the association between endocrine-disrupting chemicals (EDCs) exposure and metabolic dysfunction-associated fatty liver disease (MAFLD) in American adults. The results showed a significant association between increased exposure to three EDCs metabolites (arsenic, DiNP, and PFOA) and MAFLD. Further analysis revealed that phthalates had a strong impact on MAFLD, particularly in females and the elderly over 65. The study also found that higher body mass index (BMI) and inflammatory diet habits intensified the association between EDCs and MAFLD, while higher insulin sensitivity levels reduced the risk.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Engineering, Environmental
Kyndal A. Pike, Paul L. Edmiston, Jillian J. Morrison, Jennifer A. Faust
Summary: PFAS are transported in the atmosphere, leading to wet and dry deposition to the surface. Concentrations of 15 PFAS were measured at various locations in the U.S., showing significant differences between sites and indicating local point sources contribute strongly to wet deposition.
Review
Environmental Sciences
Mathilda Alsen, Catherine Sinclair, Peter Cooke, Kimia Ziadkhanpour, Eric Genden, Maaike van Gerwen
Summary: Exposure to certain flame retardants, PCBs, phthalates, and pesticides may potentially increase the risk of thyroid cancer according to existing literature, but more research is urgently needed to evaluate the carcinogenic effects of different EDCs on the thyroid gland in humans.
Article
Environmental Sciences
Samuel Olushola Abimbola, Christina Xeni, Amrit Kaur Sakhi, Behzad Heibati, Trine Husoy, Hubert Dirven, Konstantinos C. Makris
Summary: There is increasing evidence on the adverse health effects of endocrine-disrupting chemicals (EDCs), and their metabolism in humans show diurnal variations. This study examined the diurnal magnitude and variance of biomarkers of EDC exposure and found associations between EDC exposures and oxidative damage in a Norwegian adult subpopulation.
Review
Endocrinology & Metabolism
Rupsha Fraser, Ana Claudia Zenclussen
Summary: NK cells play an important role in the immune regulation of the uterus and have different functional phenotypes during different stages of the menstrual cycle and early pregnancy. The transient secretory-stage dNK cells have a unique angiodevelopmental profile, while abnormal transition into the angiomodulatory dNK phenotype in early pregnancy leads to adverse pregnancy outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Christine Weissenborn, Sophie von Lenthe, Nicole Hinz, Stefanie Langwisch, Mandy Busse, Anne Schumacher, Ana C. Zenclussen, Stefan Fest
Summary: This study found that transient ablation of Tregs hindered the growth of neuroblastoma (NB), while the absence of Bregs had no effect on NB growth, providing important evidence for targeting Tregs as a potential therapy for this aggressive childhood tumor.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Immunology
Kim-Norina Jutta Campe, Anke Redlich, Ana Claudia Zenclussen, Mandy Busse
Summary: The etiology of preterm birth (PTB) is a complex interaction between gestational hormones, the immune system, and reproductive tissues. This study found increased levels of pro-inflammatory cytokines and enhanced expression of PR-A on B cells in PTB patients. In addition, significant differences in cytokine levels and PR-A+CD19+ B cell percentages were observed between patients who delivered preterm and those who did not. These findings suggest that PTB is associated with an inflammatory pathway and the induction of PR-A by B cells, leading to disrupted maternal-fetal tolerance and premature delivery.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Mario Bauer, Beate Fink, Ulf Anderegg, Stefan Roeder, Ana Claudia Zenclussen
Summary: This study explores the triggers of interleukin 17F (IL17F) release in non-immune cells and finds that various stressors can induce IL17F gene expression, which is associated with cytotoxic and apoptotic signs. Inhibiting oxidative stress can alleviate the cytotoxic and IL17F-inducing effects of cigarette smoke extract. However, IL17F does not play a role in dermal fibrosis under the conditions used in this study.
Article
Immunology
Lea S. S. Lentz, Annika J. J. Stutz, Nicole Meyer, Kristin Schubert, Isabel Karkossa, Martin von Bergen, Ana C. C. Zenclussen, Anne Schumacher
Summary: Maintaining a balance between proinflammatory and anti-inflammatory immune responses is crucial for maternal tolerance of the fetus during pregnancy. This study found that fetal tissue-derived factor human chorionic gonadotropin (hCG) can increase the frequency of regulatory T cells (Tregs), inhibit the differentiation of proinflammatory Th17 cells, and mitigate the negative effects of proinflammatory Th17 cells on pregnancy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemical Research Methods
Arkadiusz Pierzchalski, Ana C. Zenclussen, Gunda Herberth
Summary: This newly established 24-color (30-marker) panel is designed to characterize the main human immune cell subtypes in human whole blood. It covers all major leukocyte populations and includes subsets of monocytes, dendritic cells, innate lymphoid cells, and lymphocytes. The panel also focuses on various T cell subsets, B cells, NK cells, and NKT cells. Surface markers are used to assess activation status and differentiation of immune cells without the need for fixation and permeabilization steps. This panel offers the potential to identify altered immune phenotypes and their association with diseases.
Article
Biochemistry & Molecular Biology
Juliane Schulz, Erik Schilling, Claire Fabian, Ana Claudia Zenclussen, Violeta Stojanovska, Claudia Claus
Summary: This study investigated the interaction between RuV and BeWo trophoblast cell line and found that RuV infection led to abundant production of type III interferon (IFN) and inhibition of RuV replication. In addition, RuV infection resulted in a decrease in trophoblast cell number and detachment of cells, but had no significant effect on metabolic activity. Syncytia formation restricted RuV infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Anna Kotsakis Ruehlmann, Sara Sammallahti, Andrea P. Cortes Hidalgo, Kelly M. Bakulski, Elisabeth B. Binder, Megan Loraine Campbell, Doretta Caramaschi, Charlotte A. M. Cecil, Elena Colicino, Cristiana Cruceanu, Darina Czamara, Linda Dieckmann, John Dou, Janine F. Felix, Josef Frank, Siri E. Haberg, Gunda Herberth, Thanh T. Hoang, Lotte C. Houtepen, Anke Huls, Nastassja Koen, Stephanie J. London, Maria C. Magnus, Giulia Mancano, Rosa H. Mulder, Christian M. Page, Katri Raikkonen, Stefan Roeder, Rebecca J. Schmidt, Tabea S. Send, Gemma Sharp, Dan J. Stein, Fabian Streit, Johanna Tuhkanen, Stephanie H. Witt, Heather J. Zar, Ana C. Zenclussen, Yining Zhang, Lea Zillich, Rosalind Wright, Jari Lahti, Kelly J. Brunst
Summary: Prenatal maternal stressful life events are associated with adverse neurodevelopmental outcomes in offspring. This meta-analysis examined the association between maternal stressful life events during pregnancy and DNA methylation in cord blood. Children whose mothers reported higher levels of cumulative maternal stressful life events during pregnancy exhibited differential methylation of specific genes implicated in neurodevelopment, neurodegeneration, immune and cellular functions, regulation of global methylation levels, metabolism, and schizophrenia risk. These findings provide novel insights into potential mechanisms of neurodevelopment in offspring.
MOLECULAR PSYCHIATRY
(2023)
Article
Toxicology
Jermaine Ford, Cal Riutta, Patricia A. Kosian, Katherine O'Shaughessy, Mary Gilbert
Summary: Numerous xenobiotics can affect thyroid hormone signaling. Measuring thyroid hormone in the brain is more directly linked to neurodevelopmental toxicity induced by thyroid system-disrupting chemicals. However, extracting and measuring thyroid hormone in the brain tissue is challenging. This study reports optimized analytical procedures for thyroid hormone extraction in rat brain tissue and reveals age-dependent increases in brain thyroid hormone levels.
TOXICOLOGICAL SCIENCES
(2023)
Article
Immunology
Roald Pfannes, Arkadiusz Pierzchalski, Ambra Maddalon, Alexandra Simion, Christos C. Zouboulis, Gerhard Behre, Ana Claudia Zenclussen, Sabine Westphal, Stefan Fest, Gunda Herberth
Summary: This study evaluated the adaptive immune response elicited after SARS-CoV-2 vaccination in cancer patients, specifically hematologic malignancy patients. The results showed that hematologic malignancy patients developed a robust cellular immune response to the vaccine, especially CD4 and Tfh cell responses. Immunomodulatory treatment before vaccination may enhance the antigen-specific immune response. These findings suggest that a strong cellular immune response is crucial for preventing SARS-CoV-2 infection in hematologic malignancy patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Katherine L. O'Shaughnessy, Benjamin D. McMichael, Aubrey L. Sasser, Kiersten S. Bell, Cal Riutta, Jermaine L. Ford, Tammy E. Stoker, Rachel D. Grindstaff, Arun R. Pandiri, Mary E. Gilbert
Summary: Thyroid hormone plays an important role in the spatiotemporal control of brain development. Perinatal hypothyroidism causes the formation of periventricular heterotopia in rats, which is preceded by the loss of radial glia cell polarity. In this study, the authors investigated the role of thyroid hormone in cell signaling in the ventricular zone (VZ) by using laser capture microdissection and RNA-Seq. The results showed that hypothyroidism affected various processes in the VZ, including extracellular matrix maintenance, cytoskeleton, cell adhesion, and cell migration. This study also revealed potential effects of hypothyroidism on the blood-brain and blood-cerebrospinal fluid barriers in newborns.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Neurosciences
Katherine L. O'Shaughnessy, Michelle G. Hotchkiss, Angela K. Buckalew, Ashley S. Murr, Mary E. Gilbert, Tammy E. Stoker
Summary: This study aims to demonstrate the feasibility of measuring serum T4 using a commercially available assay. By modifying the assay, it was possible to measure serum T4 in fetuses exposed to propylthiouracil.
NEUROTOXICOLOGY AND TERATOLOGY
(2023)
Article
Oncology
Latha Kadalayil, Md. Zahangir Alam, Cory Haley White, Akram Ghantous, Esther Walton, Olena Gruzieva, Simon Kebede Merid, Ashish Kumar, Ritu P. Roy, Olivia Solomon, Karen Huen, Brenda Eskenazi, Peter Rzehak, Veit Grote, Jean-Paul Langhendries, Elvira Verduci, Natalia Ferre, Darek Gruszfeld, Lu Gao, Weihua Guan, Xuehuo Zeng, Enrique F. Schisterman, John F. Dou, Kelly M. Bakulski, Jason I. Feinberg, Munawar Hussain Soomro, Giancarlo Pesce, Nour Baiz, Elena Isaevska, Michelle Plusquin, Marina Vafeiadi, Theano Roumeliotaki, Sabine A. S. Langie, Arnout Standaert, Catherine Allard, Patrice Perron, Luigi Bouchard, Evelien R. van Meel, Janine F. Felix, Vincent W. V. Jaddoe, Paul D. Yousefi, Cecilia H. Ramlau-Hansen, Caroline L. Relton, Elmar W. Tobi, Anne P. Starling, Ivana V. Yang, Maria Llambrich, Gillian Santorelli, Johanna Lepeule, Lucas A. Salas, Mariona Bustamante, Susan L. Ewart, Hongmei Zhang, Wilfried Karmaus, Stefan Roeder, Ana Claudia Zenclussen, Jianping Jin, Wenche Nystad, Christian M. Page, Maria Magnus, Dereje D. Jima, Cathrine Hoyo, Rachel L. Maguire, Tuomas Kvist, Darina Czamara, Katri Raikkonen, Tong Gong, Vilhelmina Ullemar, Sheryl L. Rifas-Shiman, Emily Oken, Catarina Almqvist, Robert Karlsson, Jari Lahti, Susan K. Murphy, Siri E. Haberg, Stephanie London, Gunda Herberth, Hasan Arshad, Jordi Sunyer, Regina Grazuleviciene, Dana Dabelea, Regine P. M. Steegers-Theunissen, Ellen A. Nohr, Thorkild I. A. Sorensen, Liesbeth Duijts, Marie-France Hivert, Vera Nelen, Maja Popovic, Manolis Kogevinas, Tim S. Nawrot, Zdenko Herceg, Isabella Annesi-Maesano, M. Daniele Fallin, Edwina Yeung, Carrie V. Breton, Berthold Koletzko, Nina Holland, Joseph L. Wiemels, Erik Melen, Gemma C. Sharp, Matt J. Silver, Faisal Rezwan, John W. Holloway
Summary: This study found significant associations between DNA methylation and birth season at birth and in childhood. The differential methylation regions (DMRs) identified were related to genes involved in tumorigenesis, psychiatric/neurological disorders, inflammation, and immunity. Furthermore, the associations between birth season and DNA methylation were influenced by birth latitude, particularly in higher latitude regions.
CLINICAL EPIGENETICS
(2023)
Article
Biochemistry & Molecular Biology
Gina Marie Uehre, Svetlana Tchaikovski, Atanas Ignatov, Ana Claudia Zenclussen, Mandy Busse
Summary: The signaling of B cells is crucial in the pathogenesis of preterm birth. Deficiency or loss of specific signaling molecules in B cells can lead to a shift from immune regulation to inflammation, resulting in preterm birth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Allergy
Emek Kocaturk, Indrashis Podder, Ana C. Zenclussen, Alicja Kasperska Zajac, Daniel Elieh-Ali-Komi, Martin K. Church, Marcus Maurer
Summary: Chronic urticaria predominantly affects women of reproductive age. Pregnancy can modulate the course of the disease due to changes in sex hormones and pregnancy-associated changes in the immune system. Limited evidence is available on the effects of pregnancy on chronic urticaria and the safety of urticaria treatments during pregnancy.
FRONTIERS IN ALLERGY
(2022)
