Article
Endocrinology & Metabolism
Yiqing Yang, Bowen Liu, Gengxiang Wu, Jing Yang
Summary: In PCOS patients, progesterone level is correlated with clinical pregnancy rate while P/E2 ratio is not. In subgroup analysis using three different COS protocols, a significant association between progesterone level and clinical pregnancy rate can be observed in the long GnRH agonist protocol and ultralong GnRH agonist protocol. Progesterone level is significantly better than the P/E2 ratio in predicting the pregnancy outcome of PCOS patients, especially in ultralong GnRH agonist cycles.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Genna E. Moldovan, Lucio Miele, Asgerally T. Fazleabas
Summary: The Notch signaling pathway is crucial for regulating proliferation, differentiation, and cell death in the reproductive tract of mammals, playing essential roles in the development and function of both male and female reproductive systems. Specifically, hormone-regulated Notch signaling mediates key reproductive events for ovarian and uterine function in females. Aberrations in Notch signaling in female reproductive pathologies are discussed, along with potential opportunities for future investigation.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2021)
Review
Chemistry, Analytical
Pernille Hagen Hoj, Jon Moller-Sorensen, Alberte Lund Wissing, Fatima AlZahra'a Alatraktchi
Summary: Human chorionic gonadotropin, progesterone, estrogen and its metabolites, as well as relaxin, are crucial for fetal development in the first trimester and hormone imbalances during this period are directly linked to miscarriages. Conventional centralized analytical tools for hormone monitoring are limited in their ability to provide rapid responses. Electrochemical sensing, with its quick response, user-friendliness, low costs, and potential for point-of-care use, offers an ideal solution for hormone detection. This review provides an extensive overview of the advances in electrochemical detection of hormones related to the first trimester of pregnancy and highlights the challenges that need to be addressed for clinical applications.
Article
Multidisciplinary Sciences
Jarrod McKenna, Nadia Bellofiore, Evdokia Dimitriadis, Peter Temple-Smith
Summary: Egyptian spiny mice exhibit human-like reproductive features such as menstruation and postpartum ovulation. This study provides evidence for postpartum ovulation in spiny mice through endocrine and morphological changes observed during early pregnancy. The findings suggest that spiny mice could serve as models for human pregnancy disorders such as implantation failure or pre-eclampsia.
SCIENTIFIC REPORTS
(2021)
Article
Reproductive Biology
Angela Becsek, Nikolaos Tzanidakis, Miguel Blanco, Marion Schmicke, Heinrich Bollwein
Summary: The study found that maternal, hormonal, and fetal factors are related to early fetal volume in mares, but are not suitable predicting factors for the investigated outcome parameters. Furthermore, the findings suggest that sex-specific growth differences exist in early gestation.
Article
Genetics & Heredity
Carol Coughlan, R. Vitorino, L. Melado, S. Digma, J. Sibal, R. Patel, B. Lawrenz, H. Fatemi
Summary: This study demonstrates early and significant increases in serum progesterone levels following hCG trigger, which are not typically seen until later in natural menstrual cycles.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Multidisciplinary Sciences
Ashfaque Mohammed, Talha Ahmed, Rahul R. Bhat, Esha Mallik, Aashika Arulprakasam
Summary: This study aims to determine whether serum Beta hCG can be used as a tumour marker in Breast malignancies. The objective of this study is to evaluate the serum Beta hCG in various stages of breast carcinoma and to correlate its level with disease severity and prognosis.
SCIENTIFIC REPORTS
(2023)
Review
Medicine, General & Internal
Lingling Salang, Danielle M. Teixeira, Ivan Sola, Jen Sothornwit, Wellington P. Martins, Magdalena Bofill Rodriguez, Pisake Lumbiganon
Summary: Research findings suggest that luteal phase support may aid in fertility in infertile women, but the impact of progesterone dosage, administration route, and different medications on the success rate of conception remains unclear, with a lack of high-quality evidence to support the conclusions.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Environmental Sciences
Jhon Fredy Narvaez Valderrama, Vanessa Correa Gil, Viviana B. Alzate, Edison Andres Tavera, Edgar Norena, Jazmin Porras, Juan Carlos Quintana-Castillo, Juan L. Jose Garcia, Francisco P. Jose Molina, Carlos Ramos-Contreras, Julio Bueno Sanchez
Summary: This study investigated the effects of airborne PAHs on hormone production in placental cells. The results showed that PAHs can decrease the levels of beta-hCG and progesterone, potentially leading to abnormal placental development and adverse pregnancy outcomes. This may be attributed to the role of PAHs as endocrine disruptors.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Agriculture, Dairy & Animal Science
Juliana Nascimento Duarte Rodrigues, Jose Domingos Guimaraes, Paulo Sergio Cerqueira Rangel, Maria Emilia Franco Oliveira, Felipe Zandonadi Branda, Pawel Mieczyslaw Bartlewski, Jeferson Ferreira Fonseca
Summary: In artificial insemination, administering 300 IU hCG resulted in higher luteal area and luteal vascularization in goats, leading to a higher pregnancy rate.
SMALL RUMINANT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Irina V. Menzhinskaya, Stanislav V. Pavlovich, Arika G. Melkumyan, Vladimir D. Chuprynin, Ekaterina L. Yarotskaya, Gennady T. Sukhikh
Summary: The study evaluates the characteristics and significance of serum autoantibodies in ovarian endometrioma and deep infiltrative endometriosis. The results show that endometriosis is associated with autoantibodies to endometrial antigens, hormones, and alpha-enolase. These antibodies have high diagnostic value for identifying ovarian endometrioma and deep infiltrative endometriosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Developmental Biology
Ngoc Bich Thi Tran, Thanh Ngoc Cao, Quoc Huy Vu Nguyen, Linh Giang Thi Truong, Linh Manh Tran, Thao Nguyen Tran Nguyen, Tam Minh Le
Summary: This study aimed to determine the predictive value of CA-125 in combination with serum beta-hCG and progesterone in the early detection of EP. The results showed significant differences in levels of CA-125, beta-hCG, and progesterone between the EP and IUP groups, and a combination of these markers had high sensitivity and specificity in the early diagnosis of EP (92.8% and 90.9%, respectively).
Review
Endocrinology & Metabolism
Iva Pitner, Mislav Mikus, Marina Sprem Goldstajn, Antonio Simone Lagana, Vito Chiantera, Federico Ferrari, Mohsin Shah, Maurizio Nicola D'Alterio, Salvatore Giovanni Vitale, Stefano Angioni
Summary: The purpose of this narrative review is to summarize the role of progesterone levels in pregnancy outcomes for patients undergoing assisted reproductive technologies. The review found that elevated progesterone levels at different stages of the cycle can have varying effects on pregnancy rates in the in vitro fertilization cycle. Additionally, the review also discussed the differences in interpretation of elevated progesterone levels in normal and poorly responding women.
GYNECOLOGICAL ENDOCRINOLOGY
(2023)
Article
Zoology
Tian Tian, Lili Luo, Haiyan Wang, Lei Wang
Summary: This study analyzed the clinical value and nursing effect of 13-human chorionic gonadotropin and progesterone monitoring on the treatment of ectopic pregnancy with methotrexate combined with mifepristone, showing that monitoring these hormone levels is crucial for successful treatment. Additionally, increasing levels of these hormones may lower the success rate of methotrexate combined with mifepristone tablets.
PAKISTAN JOURNAL OF ZOOLOGY
(2021)
Article
Mathematical & Computational Biology
Xinsha Tan, Honglin Xi, Jing Yang, Wenfeng Wang
Summary: A prediction model for high ovarian response in IVF-ET cycles was developed and validated using factors such as AFC, AMH, and P levels. The model showed good discrimination and accuracy in identifying patients with high ovarian response, potentially improving clinical outcomes in IVF-ET cycles. Further studies are needed to confirm these findings.
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2021)
Article
Developmental Biology
Mandy Busse, Stefanie Langwisch, Kerry Tedford, Klaus-Dieter Fischer, Ana Claudia Zenclussen
Summary: B cell participation in early embryo/fetal development and the underlying molecular pathways have been explored in this study. The study suggests that B cell-specific MyD88 and IL10 expression is crucial for appropriate embryo development, and IL10+8 cells play a role in regulating uterine blood flow during pregnancy. Furthermore, B cell-specific CD19, MyD88, and IL10 expression influences susceptibility towards preterm birth.
Article
Environmental Sciences
J. L. Krause, B. Engelmann, U. Nunes da Rocha, A. Pierzchalski, H. D. Chang, A. C. Zenclussen, M. von Bergen, U. Rolle-Kampczyk, G. Herberth
Summary: This study compared the effects of BPA, BPF, and BPS on intestinal microbiota and immune cells. Results showed that BPA and BPF directly modulated MAIT cell responses at low concentrations, while high concentrations affected microbiota-mediated effects.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Genetics & Heredity
Mario Bauer, Beate Fink, Ulf Anderegg, Stefan Roeder, Ana Claudia Zenclussen
Summary: This study explores the triggers of interleukin 17F (IL17F) release in non-immune cells and finds that various stressors can induce IL17F gene expression, which is associated with cytotoxic and apoptotic signs. Inhibiting oxidative stress can alleviate the cytotoxic and IL17F-inducing effects of cigarette smoke extract. However, IL17F does not play a role in dermal fibrosis under the conditions used in this study.
Article
Immunology
Lea S. S. Lentz, Annika J. J. Stutz, Nicole Meyer, Kristin Schubert, Isabel Karkossa, Martin von Bergen, Ana C. C. Zenclussen, Anne Schumacher
Summary: Maintaining a balance between proinflammatory and anti-inflammatory immune responses is crucial for maternal tolerance of the fetus during pregnancy. This study found that fetal tissue-derived factor human chorionic gonadotropin (hCG) can increase the frequency of regulatory T cells (Tregs), inhibit the differentiation of proinflammatory Th17 cells, and mitigate the negative effects of proinflammatory Th17 cells on pregnancy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Violeta Stojanovska, Susanne Arnold, Mario Bauer, Hermann Voss, Stefan Fest, Ana Claudia Zenclussen
Summary: This study characterized three different 3D cultures derived from trophoblast cell lines and compared them to primary fetal trophoblasts and placental tissue. The results showed that these 3D cell culture models exhibit similar functionality and gene expression profiles to primary placental tissue, making them ideal models for studying the placenta.
Article
Cell Biology
Mandy Busse, Ana Claudia Zenclussen
Summary: IL-10-secreting B cells play a crucial role in immune balance during pregnancy, and their deficiency can lead to preterm birth with increased inflammation and reduced anti-inflammatory response.
Article
Cell Biology
Florence Fischer, Anne Schumacher, Nicole Meyer, Beate Fink, Mario Bauer, Violeta Stojanovska, Ana Claudia Zenclussen
Summary: In this article, the authors propose a new perspective on the role of YB-1 in pregnancy and pregnancy-related complications, highlighting its importance at the feto-maternal interface.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemical Research Methods
Arkadiusz Pierzchalski, Ana C. Zenclussen, Gunda Herberth
Summary: This newly established 24-color (30-marker) panel is designed to characterize the main human immune cell subtypes in human whole blood. It covers all major leukocyte populations and includes subsets of monocytes, dendritic cells, innate lymphoid cells, and lymphocytes. The panel also focuses on various T cell subsets, B cells, NK cells, and NKT cells. Surface markers are used to assess activation status and differentiation of immune cells without the need for fixation and permeabilization steps. This panel offers the potential to identify altered immune phenotypes and their association with diseases.
Article
Biochemistry & Molecular Biology
Juliane Schulz, Erik Schilling, Claire Fabian, Ana Claudia Zenclussen, Violeta Stojanovska, Claudia Claus
Summary: This study investigated the interaction between RuV and BeWo trophoblast cell line and found that RuV infection led to abundant production of type III interferon (IFN) and inhibition of RuV replication. In addition, RuV infection resulted in a decrease in trophoblast cell number and detachment of cells, but had no significant effect on metabolic activity. Syncytia formation restricted RuV infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Anna Kotsakis Ruehlmann, Sara Sammallahti, Andrea P. Cortes Hidalgo, Kelly M. Bakulski, Elisabeth B. Binder, Megan Loraine Campbell, Doretta Caramaschi, Charlotte A. M. Cecil, Elena Colicino, Cristiana Cruceanu, Darina Czamara, Linda Dieckmann, John Dou, Janine F. Felix, Josef Frank, Siri E. Haberg, Gunda Herberth, Thanh T. Hoang, Lotte C. Houtepen, Anke Huls, Nastassja Koen, Stephanie J. London, Maria C. Magnus, Giulia Mancano, Rosa H. Mulder, Christian M. Page, Katri Raikkonen, Stefan Roeder, Rebecca J. Schmidt, Tabea S. Send, Gemma Sharp, Dan J. Stein, Fabian Streit, Johanna Tuhkanen, Stephanie H. Witt, Heather J. Zar, Ana C. Zenclussen, Yining Zhang, Lea Zillich, Rosalind Wright, Jari Lahti, Kelly J. Brunst
Summary: Prenatal maternal stressful life events are associated with adverse neurodevelopmental outcomes in offspring. This meta-analysis examined the association between maternal stressful life events during pregnancy and DNA methylation in cord blood. Children whose mothers reported higher levels of cumulative maternal stressful life events during pregnancy exhibited differential methylation of specific genes implicated in neurodevelopment, neurodegeneration, immune and cellular functions, regulation of global methylation levels, metabolism, and schizophrenia risk. These findings provide novel insights into potential mechanisms of neurodevelopment in offspring.
MOLECULAR PSYCHIATRY
(2023)
Article
Immunology
Roald Pfannes, Arkadiusz Pierzchalski, Ambra Maddalon, Alexandra Simion, Christos C. Zouboulis, Gerhard Behre, Ana Claudia Zenclussen, Sabine Westphal, Stefan Fest, Gunda Herberth
Summary: This study evaluated the adaptive immune response elicited after SARS-CoV-2 vaccination in cancer patients, specifically hematologic malignancy patients. The results showed that hematologic malignancy patients developed a robust cellular immune response to the vaccine, especially CD4 and Tfh cell responses. Immunomodulatory treatment before vaccination may enhance the antigen-specific immune response. These findings suggest that a strong cellular immune response is crucial for preventing SARS-CoV-2 infection in hematologic malignancy patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Latha Kadalayil, Md. Zahangir Alam, Cory Haley White, Akram Ghantous, Esther Walton, Olena Gruzieva, Simon Kebede Merid, Ashish Kumar, Ritu P. Roy, Olivia Solomon, Karen Huen, Brenda Eskenazi, Peter Rzehak, Veit Grote, Jean-Paul Langhendries, Elvira Verduci, Natalia Ferre, Darek Gruszfeld, Lu Gao, Weihua Guan, Xuehuo Zeng, Enrique F. Schisterman, John F. Dou, Kelly M. Bakulski, Jason I. Feinberg, Munawar Hussain Soomro, Giancarlo Pesce, Nour Baiz, Elena Isaevska, Michelle Plusquin, Marina Vafeiadi, Theano Roumeliotaki, Sabine A. S. Langie, Arnout Standaert, Catherine Allard, Patrice Perron, Luigi Bouchard, Evelien R. van Meel, Janine F. Felix, Vincent W. V. Jaddoe, Paul D. Yousefi, Cecilia H. Ramlau-Hansen, Caroline L. Relton, Elmar W. Tobi, Anne P. Starling, Ivana V. Yang, Maria Llambrich, Gillian Santorelli, Johanna Lepeule, Lucas A. Salas, Mariona Bustamante, Susan L. Ewart, Hongmei Zhang, Wilfried Karmaus, Stefan Roeder, Ana Claudia Zenclussen, Jianping Jin, Wenche Nystad, Christian M. Page, Maria Magnus, Dereje D. Jima, Cathrine Hoyo, Rachel L. Maguire, Tuomas Kvist, Darina Czamara, Katri Raikkonen, Tong Gong, Vilhelmina Ullemar, Sheryl L. Rifas-Shiman, Emily Oken, Catarina Almqvist, Robert Karlsson, Jari Lahti, Susan K. Murphy, Siri E. Haberg, Stephanie London, Gunda Herberth, Hasan Arshad, Jordi Sunyer, Regina Grazuleviciene, Dana Dabelea, Regine P. M. Steegers-Theunissen, Ellen A. Nohr, Thorkild I. A. Sorensen, Liesbeth Duijts, Marie-France Hivert, Vera Nelen, Maja Popovic, Manolis Kogevinas, Tim S. Nawrot, Zdenko Herceg, Isabella Annesi-Maesano, M. Daniele Fallin, Edwina Yeung, Carrie V. Breton, Berthold Koletzko, Nina Holland, Joseph L. Wiemels, Erik Melen, Gemma C. Sharp, Matt J. Silver, Faisal Rezwan, John W. Holloway
Summary: This study found significant associations between DNA methylation and birth season at birth and in childhood. The differential methylation regions (DMRs) identified were related to genes involved in tumorigenesis, psychiatric/neurological disorders, inflammation, and immunity. Furthermore, the associations between birth season and DNA methylation were influenced by birth latitude, particularly in higher latitude regions.
CLINICAL EPIGENETICS
(2023)
Article
Biochemistry & Molecular Biology
Gina Marie Uehre, Svetlana Tchaikovski, Atanas Ignatov, Ana Claudia Zenclussen, Mandy Busse
Summary: The signaling of B cells is crucial in the pathogenesis of preterm birth. Deficiency or loss of specific signaling molecules in B cells can lead to a shift from immune regulation to inflammation, resulting in preterm birth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Allergy
Emek Kocaturk, Indrashis Podder, Ana C. Zenclussen, Alicja Kasperska Zajac, Daniel Elieh-Ali-Komi, Martin K. Church, Marcus Maurer
Summary: Chronic urticaria predominantly affects women of reproductive age. Pregnancy can modulate the course of the disease due to changes in sex hormones and pregnancy-associated changes in the immune system. Limited evidence is available on the effects of pregnancy on chronic urticaria and the safety of urticaria treatments during pregnancy.
FRONTIERS IN ALLERGY
(2022)
Article
Nutrition & Dietetics
Olivia Schuette, Larissa Bachmann, Nitin Shivappa, James R. Hebert, Janine F. Felix, Stefan Roeder, Ulrich Sack, Michael Borte, Wieland Kiess, Ana C. Zenclussen, Gabriele I. Stangl, Gunda Herberth, Kristin M. Junge
Summary: This population-based cohort study found that a pro-inflammatory dietary pattern in 10-year-old children was associated with a higher risk of atopic dermatitis and food allergy. This suggests a link between diet composition and allergic outcomes.
FRONTIERS IN NUTRITION
(2022)