Small extracellular vesicles obtained from hypoxic mesenchymal stromal cells have unique characteristics that promote cerebral angiogenesis, brain remodeling and neurological recovery after focal cerebral ischemia in mice

Mesenchymal Stromal Cell–Derived Small Extracellular Vesicles Induce Ischemic Neuroprotection by Modulating Leukocytes and Specifically Neutrophils

(2020) Chen Wang et al.   STROKE

Polymorphonuclear Neutrophils Play a Decisive Role for Brain Injury and Neurological Recovery Poststroke

(2019) Dirk M. Hermann et al.   STROKE

Exosomes — beyond stem cells for restorative therapy in stroke and neurological injury

(2019) Zheng Gang Zhang et al.   Nature Reviews Neurology

miR-370 inhibits the angiogenic activity of endothelial cells by targeting smoothened (SMO) and bone morphogenetic protein (BMP)-2

(2019) Yuan Gu et al.   FASEB JOURNAL

Overexpression of microRNA‐186 inhibits angiogenesis in retinoblastoma via the Hedgehog signaling pathway by targeting ATAD2

(2019) Shuai Wu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications

(2019) Kenneth W. Witwer et al.   Journal of Extracellular Vesicles

Exosomes Derived from miR-126-modified MSCs Promote Angiogenesis and Neurogenesis and Attenuate Apoptosis after Spinal Cord Injury in Rats

(2019) Jiang-Hu Huang et al.   NEUROSCIENCE

Exosomes Derived From Bone Marrow Mesenchymal Stem Cells Inhibit Complement Activation In Rats With Spinal Cord Injury

(2019) Chuanliang Zhao et al.   Drug Design Development and Therapy

Hypoxia Conditioned Mesenchymal Stem Cell-Derived Extracellular Vesicles Induce Increased Vascular Tube Formation in vitro

(2019) Ciarra Almeria et al.   Frontiers in Bioengineering and Biotechnology

Hypoxic mesenchymal stem cell-derived exosomes promote bone fracture healing by the transfer of miR-126

(2019) Wei Liu et al.   Acta Biomaterialia

Unraveling the Molecular Signature of Extracellular Vesicles From Endometrial-Derived Mesenchymal Stem Cells: Potential Modulatory Effects and Therapeutic Applications

(2019) Federica Marinaro et al.   Frontiers in Bioengineering and Biotechnology

Exosomes Secreted by Adipose-Derived Stem Cells Contribute to Angiogenesis of Brain Microvascular Endothelial Cells Following Oxygen–Glucose Deprivation In Vitro Through MicroRNA-181b/TRPM7 Axis

(2018) Yujia Yang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

3D visualization and quantification of microvessels in the whole ischemic mouse brain using solvent-based clearing and light sheet microscopy

(2017) Erlen Lugo-Hernandez et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Hypoxia Inducible Factor-1α Potentiates Jagged 1-Mediated Angiogenesis by Mesenchymal Stem Cell-Derived Exosomes

(2017) Hernán Gonzalez-King et al.   STEM CELLS

MicroRNA-17–92 Cluster in Exosomes Enhance Neuroplasticity and Functional Recovery After Stroke in Rats

(2017) Hongqi Xin et al.   STROKE

Human mesenchymal and murine stromal cells support human lympho-myeloid progenitor expansion but not maintenance of multipotent haematopoietic stem and progenitor cells

(2016) Stefan Radtke et al.   CELL CYCLE

Comprehensive Proteomic Analysis of Mesenchymal Stem Cell Exosomes Reveals Modulation of Angiogenesis via Nuclear Factor-KappaB Signaling

(2016) Johnathon D. Anderson et al.   STEM CELLS

Comparative proteomic analysis of extracellular vesicles isolated from porcine adipose tissue-derived mesenchymal stem/stromal cells

(2016) Alfonso Eirin et al.   Scientific Reports

Mesenchymal Stem Cell Exosomes Induce Proliferation and Migration of Normal and Chronic Wound Fibroblasts, and Enhance Angiogenesis In Vitro

(2015) Arsalan Shabbir et al.   STEM CELLS AND DEVELOPMENT

Role of Neutrophils in Exacerbation of Brain Injury After Focal Cerebral Ischemia in Hyperlipidemic Mice

(2015) Josephine Herz et al.   STROKE

Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression

(2015) Thorsten R. Doeppner et al.   Stem Cells Translational Medicine

Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke

(2014) Jens Neumann et al.   ACTA NEUROPATHOLOGICA

MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease

(2014) L Kordelas et al.   LEUKEMIA

Exosomes Derived from Mesenchymal Stem Cells Suppress Angiogenesis by Down-Regulating VEGF Expression in Breast Cancer Cells

(2014) Jong-Kuen Lee et al.   PLoS One

Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Promote Functional Recovery and Neurovascular Plasticity After Stroke in Rats

(2013) Hongqi Xin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis

(2013) Zhen Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

miR-409-3p inhibits HT1080 cell proliferation, vascularization and metastasis by targeting angiogenin

(2012) Chunhua Weng et al.   CANCER LETTERS

Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation

(2012) Dirk M Hermann et al.   LANCET NEUROLOGY

Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo

(2011) Wei Zhu et al.   CANCER LETTERS

Systematic and quantitative comparison of digest efficiency and specificity reveals the impact of trypsin quality on MS-based proteomics

(2011) Julia Maria Burkhart et al.   Journal of Proteomics

Implications of Vascular Endothelial Growth Factor for Postischemic Neurovascular Remodeling

(2009) Dirk Matthias Hermann et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM