Liver metastases: Microenvironments and ex-vivo models

Engineered In Vitro Disease Models

(2015) Kambez H. Benam et al.   Annual Review of Pathology-Mechanisms of Disease

Molecular targets and pathways involved in liver metastasis of colorectal cancer

(2015) Ulrich H. Weidle et al.   CLINICAL & EXPERIMENTAL METASTASIS

Fluorescent protein biosensors applied to microphysiological systems

(2015) Nina Senutovitch et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

A human liver microphysiology platform for investigating physiology, drug safety, and disease models

(2015) Lawrence A Vernetti et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Tissue-engineered models of human tumors for cancer research

(2015) Aranzazu Villasante et al.   Expert Opinion on Drug Discovery

Process of hepatic metastasis from pancreatic cancer: biology with clinical significance

(2015) Haojun Shi et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Proof of prometastatic niche induction by hepatic stellate cells

(2015) Clarisse Eveno et al.   JOURNAL OF SURGICAL RESEARCH

Mechanisms involved in breast cancer liver metastasis

(2015) Rui Ma et al.   Journal of Translational Medicine

Bioreactor technologies to support liver function in vitro

(2014) Mohammad R. Ebrahimkhani et al.   ADVANCED DRUG DELIVERY REVIEWS

Spontaneous dormancy of metastatic breast cancer cells in an all human liver microphysiologic system

(2014) S E Wheeler et al.   BRITISH JOURNAL OF CANCER

The relevance and potential roles of microphysiological systems in biology and medicine

(2014) John P Wikswo   EXPERIMENTAL BIOLOGY AND MEDICINE

A microphysiological system model of therapy for liver micrometastases

(2014) Amanda M Clark et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

In vitro platforms for evaluating liver toxicity

(2014) Shyam Sundhar Bale et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Engineering liver

(2014) Linda G. Griffith et al.   HEPATOLOGY

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Bimodal role of Kupffer cells during colorectal cancer liver metastasis

(2013) Shu Wen Wen et al.   CANCER BIOLOGY & THERAPY

The Emerging Role of Immunosurveillance in Dictating Metastatic Spread in Breast Cancer

(2013) C. Y. Slaney et al.   CANCER RESEARCH

Mechanisms Governing Metastatic Dormancy and Reactivation

(2013) Filippo G. Giancotti   CELL

Liver resection for metastatic melanoma: Equivalent survival for cutaneous and ocular primaries

(2013) Seung Wook Ryu et al.   JOURNAL OF SURGICAL ONCOLOGY

Matrikine and matricellular regulators of EGF receptor signaling on cancer cell migration and invasion

(2013) Jelena Grahovac et al.   LABORATORY INVESTIGATION

Influence of tumour micro-environment heterogeneity on therapeutic response

(2013) Melissa R. Junttila et al.   NATURE

The perivascular niche regulates breast tumour dormancy

(2013) Cyrus M. Ghajar et al.   NATURE CELL BIOLOGY

Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells

(2013) M. A. Nieto   SCIENCE

The Matrikine Tenascin-C Protects Multipotential Stromal Cells/Mesenchymal Stem Cells from Death Cytokines Such as FasL

(2013) Melanie Rodrigues et al.   TISSUE ENGINEERING PART A

Targeting tumor cell motility as a strategy against invasion and metastasis

(2013) Alan Wells et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

All-human microphysical model of metastasis therapy

(2013) Sarah E Wheeler et al.   Stem Cell Research & Therapy

Mesenchymal–epithelial transition (MET) as a mechanism for metastatic colonisation in breast cancer

(2012) N. P. A. Devika Gunasinghe et al.   CANCER AND METASTASIS REVIEWS

Melanoma Cell Invasiveness Is Promoted at Least in Part by the Epidermal Growth Factor–Like Repeats of Tenascin-C

(2012) Jelena Grahovac et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Claudin-2 Promotes Breast Cancer Liver Metastasis by Facilitating Tumor Cell Interactions with Hepatocytes

(2012) S. Tabaries et al.   MOLECULAR AND CELLULAR BIOLOGY

Hepatocyte induced re-expression of E-cadherin in breast and prostate cancer cells increases chemoresistance

(2011) Yvonne Chao et al.   CLINICAL & EXPERIMENTAL METASTASIS

Hepatic stellate cells: Partners in crime for liver metastases?

(2011) Ningling Kang et al.   HEPATOLOGY

Activated hepatic stellate cells promote hepatocellular carcinoma development in immunocompetent mice

(2011) Wenxiu Zhao et al.   INTERNATIONAL JOURNAL OF CANCER

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Hepatic Stellate Cells Accelerate the Malignant Behavior of Cholangiocarcinoma Cells

(2010) Hirohisa Okabe et al.   ANNALS OF SURGICAL ONCOLOGY

E-Cadherin Protects Primary Hepatocyte Spheroids from Cell Death by a Caspase-Independent Mechanism

(2010) Jennifer L. Luebke-Wheeler et al.   CELL TRANSPLANTATION

Interactions between colon cancer cells and hepatocytes in rats in relation to metastasis

(2010) O. R. F. Mook et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Molecular interactions in cancer cell metastasis

(2009) Susan A. Brooks et al.   ACTA HISTOCHEMICA

Hepatic Stellate Cells Promote Liver Metastasis of Colon Cancer Cells by the Action of SDF-1/CXCR4 Axis

(2009) Ryo Matsusue et al.   ANNALS OF SURGICAL ONCOLOGY

Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human

(2009) P. Chao et al.   BIOCHEMICAL PHARMACOLOGY

A microfluidic hepatic coculture platform for cell-based drug metabolism studies

(2009) Eric Novik et al.   BIOCHEMICAL PHARMACOLOGY

Rapid clearance of the circulating metastatic factor autotaxin by the scavenger receptors of liver sinusoidal endothelial cells

(2009) Silvia Jansen et al.   CANCER LETTERS

Activated hepatic stellate cells promote tumorigenicity of hepatocellular carcinoma

(2009) Thomas Amann et al.   CANCER SCIENCE

Intercellular Transfer of Proteins as Identified by Stable Isotope Labeling of Amino Acids in Cell Culture

(2009) Ming Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Perfused multiwell plate for 3D liver tissue engineering

(2009) Karel Domansky et al.   LAB ON A CHIP

Real-time imaging reveals the single steps of brain metastasis formation

(2009) Yvonne Kienast et al.   NATURE MEDICINE

E-cadherin as an indicator of mesenchymal to epithelial reverting transitions during the metastatic seeding of disseminated carcinomas

(2008) Alan Wells et al.   CLINICAL & EXPERIMENTAL METASTASIS

Three-dimensional context regulation of metastasis

(2008) Janine T. Erler et al.   CLINICAL & EXPERIMENTAL METASTASIS

Hepatic stellate cells display a functional vascular smooth muscle cell phenotype in a three-dimensional co-culture model with endothelial cells

(2008) W. Wirz et al.   DIFFERENTIATION

Hepatic Stellate Cells Secrete Angiopoietin 1 That Induces Angiogenesis in Liver Fibrosis

(2008) Kojiro Taura et al.   GASTROENTEROLOGY

Platelet-Derived Growth Factor Signaling Through Ephrin-B2 Regulates Hepatic Vascular Structure and Function

(2008) David Semela et al.   GASTROENTEROLOGY

Can cancer be reversed by engineering the tumor microenvironment?

(2008) Donald E. Ingber   SEMINARS IN CANCER BIOLOGY