Wake me when it’s over – Bacterial toxin–antitoxin proteins and induced dormancy

Combatting bacterial persister cells

(2015) Thomas K. Wood   BIOTECHNOLOGY AND BIOENGINEERING

Clostridium difficilerecurrent infection: possible implication of TA systems

(2015) Fernando Gil et al.   Future Microbiology

Network analysis of S. aureus response to ramoplanin reveals modules for virulence factors and resistance mechanisms and characteristic novel genes

(2015) Devika Subramanian et al.   GENE

Viable but Nonculturable and Persister Cells Coexist Stochastically and Are Induced by Human Serum

(2015) M. Ayrapetyan et al.   INFECTION AND IMMUNITY

The Mycobacterium tuberculosis relBE toxin:antitoxin genes are stress-responsive modules that regulate growth through translation inhibition

(2015) Shaleen B. Korch et al.   JOURNAL OF MICROBIOLOGY

Survivability of Microbes in Natural Environments and Their Ecological Impacts

(2015) Shin Haruta et al.   MICROBES AND ENVIRONMENTS

The role of the hok/sok locus in bacterial response to stressful growth conditions

(2015) Chinwe U. Chukwudi et al.   MICROBIAL PATHOGENESIS

Obg and Membrane Depolarization Are Part of a Microbial Bet-Hedging Strategy that Leads to Antibiotic Tolerance

(2015) Natalie Verstraeten et al.   MOLECULAR CELL

HipBA–promoter structures reveal the basis of heritable multidrug tolerance

(2015) Maria A. Schumacher et al.   NATURE

Co-evolution of quaternary organization and novel RNA tertiary interactions revealed in the crystal structure of a bacterial protein–RNA toxin–antitoxin system

(2015) Feng Rao et al.   NUCLEIC ACIDS RESEARCH

Structural and functional studies of theMycobacterium tuberculosisVapBC30 toxin-antitoxin system: implications for the design of novel antimicrobial peptides

(2015) In-Gyun Lee et al.   NUCLEIC ACIDS RESEARCH

Defining the mRNA recognition signature of a bacterial toxin protein

(2015) Marc A. Schureck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploring deep microbial life in coal-bearing sediment down to  2.5 km below the ocean floor

(2015) F. Inagaki et al.   SCIENCE

Bridging the gap between viable but non-culturable and antibiotic persistent bacteria

(2015) Mesrop Ayrapetyan et al.   TRENDS IN MICROBIOLOGY

Distinct type I and type II toxin-antitoxin modules control Salmonella lifestyle inside eukaryotic cells

(2015) Damián Lobato-Márquez et al.   Scientific Reports

YoeB toxin is activated during thermal stress

(2015) Brian D. Janssen et al.   MicrobiologyOpen

Adaptation to sustained nitrogen starvation by Escherichia coli requires the eukaryote-like serine/threonine kinase YeaG

(2015) Rita Figueira et al.   Scientific Reports

The HicA toxin fromBurkholderia pseudomalleihas a role in persister cell formation

(2014) Aaron Butt et al.   BIOCHEMICAL JOURNAL

Disorder- and Dynamics-Based Regulatory Mechanisms in Toxin–Antitoxin Modules

(2014) Remy Loris et al.   CHEMICAL REVIEWS

A widespread bacteriophage abortive infection system functions through a Type IV toxin–antitoxin mechanism

(2014) Ron L. Dy et al.   NUCLEIC ACIDS RESEARCH

Bacterial persisters: formation, eradication, and experimental systems

(2014) Sophie Helaine et al.   TRENDS IN MICROBIOLOGY

Regulating Toxin-Antitoxin Expression: Controlled Detonation of Intracellular Molecular Timebombs

(2014) Finbarr Hayes et al.   Toxins

Multiple Toxin-Antitoxin Systems in Mycobacterium tuberculosis

(2014) Ambre Sala et al.   Toxins

Post-transcriptional regulation of gene expression in bacterial pathogens by toxin-antitoxin systems

(2014) Ralph Bertram et al.   Frontiers in Cellular and Infection Microbiology

Toxin-Antitoxin systems: their role in persistence, biofilm formation, and pathogenicity

(2014) Yurong Wen et al.   Pathogens and Disease

Ribonucleases in bacterial toxin–antitoxin systems

(2013) Gregory M. Cook et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Structural overview of toxin–antitoxin systems in infectious bacteria: A target for developing antimicrobial agents

(2013) Sung Jean Park et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Relaxed Cleavage Specificity within the RelE Toxin Family

(2013) N. Goeders et al.   JOURNAL OF BACTERIOLOGY

Structure of theProteus vulgarisHigB-(HigA)2-HigB Toxin-Antitoxin Complex

(2013) Marc A. Schureck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MazF-induced Growth Inhibition and Persister Generation inEscherichia coli

(2013) Arti Tripathi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Resuscitative Effect of Pyruvate and its Analogues on VBNC (Viable But Non-Culturable) Salmonella

(2013) Yuta Morishige et al.   MICROBES AND ENVIRONMENTS

Molecular Mechanism of Bacterial Persistence by HipA

(2013) Elsa Germain et al.   MOLECULAR CELL

The Fic protein Doc uses an inverted substrate to phosphorylate and inactivate EF-Tu

(2013) Daniel Castro-Roa et al.   Nature Chemical Biology

Platforms for antibiotic discovery

(2013) Kim Lewis   NATURE REVIEWS DRUG DISCOVERY

The Axe-Txe Complex of Enterococcus faecium Presents a Multilayered Mode of Toxin-Antitoxin Gene Expression Regulation

(2013) Lidia Boss et al.   PLoS One

Mycobacterial toxin MazF-mt6 inhibits translation through cleavage of 23S rRNA at the ribosomal A site

(2013) J. M. Schifano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VapC20 of Mycobacterium tuberculosis cleaves the Sarcin–Ricin loop of 23S rRNA

(2013) Kristoffer S. Winther et al.   Nature Communications

HipA-mediated antibiotic persistence via phosphorylation of the glutamyl-tRNA-synthetase

(2013) Ilana Kaspy et al.   Nature Communications

A Toxin-Antitoxin Module of Salmonella Promotes Virulence in Mice

(2013) Miguel A. De la Cruz et al.   PLoS Pathogens

Microbial Scout Hypothesis and Microbial Discovery

(2012) S. Buerger et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Microbial Scout Hypothesis, Stochastic Exit from Dormancy, and the Nature of Slow Growers

(2012) S. Buerger et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Toxin-antitoxin loci vapBC-1 and vapXD contribute to survival and virulence in nontypeable Haemophilus influenzae

(2012) Dabin Ren et al.   BMC MICROBIOLOGY

Genomic determinants of sporulation inBacilliandClostridia: towards the minimal set of sporulation-specific genes

(2012) Michael Y. Galperin et al.   ENVIRONMENTAL MICROBIOLOGY

A VapBC Toxin-Antitoxin Module Is a Posttranscriptional Regulator of Metabolic Flux in Mycobacteria

(2012) J. L. McKenzie et al.   JOURNAL OF BACTERIOLOGY

Growth and Translation Inhibition through Sequence-specific RNA Binding byMycobacterium tuberculosisVapC Toxin

(2012) Jared D. Sharp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Are Uncultivated Bacteria Really Uncultivable?

(2012) Indun Dewi Puspita et al.   MICROBES AND ENVIRONMENTS

YeeU enhances the bundling of cytoskeletal polymers of MreB and FtsZ, antagonizing the CbtA (YeeV) toxicity in Escherichia coli

(2012) Hisako Masuda et al.   MOLECULAR MICROBIOLOGY

A promiscuous antitoxin of bacteriophage T4 ensures successful viral replication

(2012) Francesca L. Short et al.   MOLECULAR MICROBIOLOGY

Alternative interactions define gyrase specificity in the CcdB family

(2012) Natalie De Jonge et al.   MOLECULAR MICROBIOLOGY

Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins

(2012) Philipp Engel et al.   NATURE

Recover the lost art of drug discovery

(2012) Kim Lewis   NATURE

A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS

(2012) Xiaoxue Wang et al.   Nature Chemical Biology

Conditional cooperativity in toxin–antitoxin regulation prevents random toxin activation and promotes fast translational recovery

(2012) Ilaria Cataudella et al.   NUCLEIC ACIDS RESEARCH

The crystal structure of the Rv0301-Rv0300 VapBC-3 toxin-antitoxin complex fromM. tuberculosisreveals a Mg2+ion in the active site and a putative RNA-binding site

(2012) Andrew B. Min et al.   PROTEIN SCIENCE

Bacterial type I toxin-antitoxin systems

(2012) Sabine Brantl   RNA Biology

Artificial activation of toxin–antitoxin systems as an antibacterial strategy

(2012) Julia J. Williams et al.   TRENDS IN MICROBIOLOGY

Role of Unusual P Loop Ejection and Autophosphorylation in HipA-Mediated Persistence and Multidrug Tolerance

(2012) Maria A. Schumacher et al.   Cell Reports

Toxin-Antitoxin Systems Are Important for Niche-Specific Colonization and Stress Resistance of Uropathogenic Escherichia coli

(2012) J. Paul Norton et al.   PLoS Pathogens

Selective Translation of Leaderless mRNAs by Specialized Ribosomes Generated by MazF in Escherichia coli

(2011) Oliver Vesper et al.   CELL

Balancing at survival's edge: the structure and adaptive benefits of prokaryotic toxin–antitoxin partners

(2011) Tim R Blower et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Bacillus subtilisMazF-bs (EndoA) is a UACAU-specific mRNA interferase

(2011) Jung-Ho Park et al.   FEBS LETTERS

A novel family of toxin/antitoxin proteins inBacillusspecies

(2011) Laura E. Holberger et al.   FEBS LETTERS

Toxin-antitoxin (TA) systems are prevalent and transcribed in clinical isolates of Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus

(2011) Julia J. Williams et al.   FEMS MICROBIOLOGY LETTERS

Bacterial Toxin RelE Mediates Frequent Codon-independent mRNA Cleavage from the 5′ End of Coding Regionsin Vivo

(2011) Jennifer M. Hurley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toxin-Antitoxin Systems ofMycobacterium smegmatisAre Essential for Cell Survival

(2011) Rebekah Frampton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ε/ζ systems: their role in resistance, virulence, and their potential for antibiotic development

(2011) Hannes Mutschler et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Microbial seed banks: the ecological and evolutionary implications of dormancy

(2011) Jay T. Lennon et al.   NATURE REVIEWS MICROBIOLOGY

Genomes of the Most Dangerous Epidemic Bacteria Have a Virulence Repertoire Characterized by Fewer Genes but More Toxin-Antitoxin Modules

(2011) Kalliopi Georgiades et al.   PLoS One

VapC Toxins from Mycobacterium tuberculosis Are Ribonucleases that Differentially Inhibit Growth and Are Neutralized by Cognate VapB Antitoxins

(2011) Bintou Ahmadou Ahidjo et al.   PLoS One

Carbon and nitrogen assimilation in deep subseafloor microbial cells

(2011) Y. Morono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deep subseafloor microbial cells on physiological standby

(2011) B. B. Jorgensen   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enteric virulence associated protein VapC inhibits translation by cleavage of initiator tRNA

(2011) K. S. Winther et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Conserved Mode of Protein Recognition and Binding in a ParD−ParE Toxin−Antitoxin Complex

(2010) Kevin M. Dalton et al.   BIOCHEMISTRY

Allostery and Intrinsic Disorder Mediate Transcription Regulation by Conditional Cooperativity

(2010) Abel Garcia-Pino et al.   CELL

The Yersinia pestis Chromosome Encodes Active Addiction Toxins

(2010) C. Goulard et al.   JOURNAL OF BACTERIOLOGY

Characterization of an interplay between a Mycobacterium tuberculosis MazF homolog, Rv1495 and its sole DNA topoisomerase I

(2010) Feng Huang et al.   NUCLEIC ACIDS RESEARCH

The PIN-domain ribonucleases and the prokaryotic VapBC toxin-antitoxin array

(2010) V. L. Arcus et al.   PROTEIN ENGINEERING DESIGN & SELECTION

New kinase regulation mechanism found in HipBA: a bacterial persistence switch

(2009) Artem Evdokimov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Structural Basis for mRNA Recognition and Cleavage by the Ribosome-Dependent Endonuclease RelE

(2009) Cajetan Neubauer et al.   CELL

Mutagenesis and Functional Characterization of the RNA and Protein Components of the toxIN Abortive Infection and Toxin-Antitoxin Locus of Erwinia

(2009) T. R. Blower et al.   JOURNAL OF BACTERIOLOGY

Characterization of YafO, an Escherichia coli Toxin

(2009) Yonglong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bacterial Toxin HigB Associates with Ribosomes and Mediates Translation-dependent mRNA Cleavage at A-rich Sites

(2009) Jennifer M. Hurley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RelB and RelE of Escherichia coli Form a Tight Complex That Represses Transcription via the Ribbon–Helix–Helix Motif in RelB

(2009) Martin Overgaard et al.   JOURNAL OF MOLECULAR BIOLOGY

Rejuvenation of CcdB-Poisoned Gyrase by an Intrinsically Disordered Protein Domain

(2009) Natalie De Jonge et al.   MOLECULAR CELL

Microbial awakenings

(2009) Slava S. Epstein   NATURE

Subseafloor sedimentary life in the South Pacific Gyre

(2009) Steven D'Hondt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The phage abortive infection system, ToxIN, functions as a protein–RNA toxin–antitoxin pair

(2009) Peter C. Fineran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanisms of HipA-Mediated Multidrug Tolerance and Its Neutralization by HipB

(2009) M. A. Schumacher et al.   SCIENCE

Comprehensive Functional Analysis of Mycobacterium tuberculosis Toxin-Antitoxin Systems: Implications for Pathogenesis, Stress Responses, and Evolution

(2009) Holly R. Ramage et al.   PLoS Genetics

Exposing plasmids as the Achilles’ heel of drug-resistant bacteria

(2008) Julia J Williams et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Structure and Proposed Activity of a Member of the VapBC Family of Toxin-Antitoxin Systems

(2008) Linda Miallau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mRNA interferases, MazF-mt3 and MazF-mt7 fromMycobacterium tuberculosistarget unique pentad sequences in single-stranded RNA

(2008) Ling Zhu et al.   MOLECULAR MICROBIOLOGY

Messenger RNA interferase RelE controlsrelBEtranscription by conditional cooperativity

(2008) Martin Overgaard et al.   MOLECULAR MICROBIOLOGY

Genomics of bacteria and archaea: the emerging dynamic view of the prokaryotic world

(2008) E. V. Koonin et al.   NUCLEIC ACIDS RESEARCH

Bacterial addiction module toxin Doc inhibits translation elongation through its association with the 30S ribosomal subunit

(2008) M. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA