Article
Immunology
Victoria G. Hall, Victor H. Ferreira, Heidi Wood, Matthew Ierullo, Beata Majchrzak-Kita, Kathy Manguiat, Alyssia Robinson, Vathany Kulasingam, Atul Humar, Deepali Kumar
Summary: Delayed dosing intervals can enhance immune response to COVID-19 vaccination, including virus neutralization against wild-type and variant viruses. This finding has significant implications for the global implementation of vaccines.
Article
Medicine, General & Internal
Robert W. Frenck, Nicola P. Klein, Nicholas Kitchin, Alejandra Gurtman, Judith Absalon, Stephen Lockhart, John L. Perez, Emmanuel B. Walter, Shelly Senders, Ruth Bailey, Kena A. Swanson, Hua Ma, Xia Xu, Kenneth Koury, Warren V. Kalina, David Cooper, Timothy Jennings, Donald M. Brandon, Stephen J. Thomas, Ozlem Tureci, Dina B. Tresnan, Susan Mather, Philip R. Dormitzer, Ugur Sahin, Kathrin U. Jansen, William C. Gruber
Summary: The BNT162b2 vaccine showed favorable safety profile and a greater immune response in 12-to-15-year-old recipients compared to young adults, and demonstrated high effectiveness against Covid-19.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
Hiroyuki Naruse, Hiroyasu Ito, Hideo Izawa, Masayoshi Sarai, Junnichi Ishii, Eirin Sakaguchi, Reiko Murakami, Tatsuya Ando, Hidetsugu Fujigaki, Kuniaki Saito
Summary: It was found that patients with cardiovascular disease have a poorer humoral response to the BNT162b2 mRNA COVID-19 vaccine, requiring closer monitoring and earlier revaccination to ensure stronger immunity and protection.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Andrea Picchianti Diamanti, Assunta Navarra, Gilda Cuzzi, Alessandra Aiello, Simonetta Salemi, Roberta Di Rosa, Chiara De Lorenzo, Daniele Vio, Giandomenico Sebastiani, Mario Ferraioli, Maurizio Benucci, Francesca Li Gobbi, Fabrizio Cantini, Vittoria Polidori, Maurizio Simmaco, Esmeralda Cialdi, Palma Scolieri, Vincenzo Bruzzese, Emanuele Nicastri, Raffaele D'Amelio, Bruno Lagana, Delia Goletti
Summary: This multicenter prospective study analyzed the safety of the BNT162b2 vaccine in rheumatoid arthritis patients. The vaccine showed good safety profile with low incidence of adverse events. Flares occurred in a small percentage of patients after vaccination. Influenza vaccination was inversely associated with adverse events after the second dose. Effectiveness of the vaccine against breakthrough infections decreased after the third dose, possibly due to Omicron variants. Overall, the study findings are important for understanding vaccine safety and effectiveness in autoimmune rheumatic diseases.
Article
Immunology
Ting-Yu Lin, Yun-Hsuan Yeh, Li-Wen Chen, Chao-Neng Cheng, Chen Chang, Jun-Neng Roan, Ching-Fen Shen
Summary: This article reports a rare but potentially fatal case of hemophagocytic lymphohistiocytosis in a 14-year-old adolescent after receiving the BNT162b2 mRNA COVID-19 vaccine. The case suggests that immune activation after COVID-19 vaccination may interfere with the adequate immune response to certain infectious pathogens, resulting in a hyperinflammatory syndrome.
Article
Immunology
Grant Sprow, Mohsen Afarideh, Joshua Dan, Rui Feng, Emily Keyes, Madison Grinnell, Josef Concha, Victoria P. Werth
Summary: The study found that fully vaccinated dermatomyositis patients were more likely to report exacerbation of autoimmune signs and symptoms after vaccination compared to fully vaccinated lupus erythematosus patients. However, given the risks of COVID-19, clinicians should still promote vaccination in most patients with autoimmune skin disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Georg M. N. Behrens, Joana Barros-Martins, Anne Cossmann, Gema Morillas Ramos, Metodi Stankov, Ivan Odak, Alexandra Dopfer-Jablonka, Laura Hetzel, Miriam Koehler, Gwendolyn Patzer, Christoph Binz, Christiane Ritter, Michaela Friedrichsen, Christian Schultze-Florey, Inga Ravens, Stefanie Willenzon, Anja Bubke, Jasmin Ristenpart, Anika Janssen, George Ssebyatika, Verena Kraehling, Guenter Bernhardt, Markus Hoffmann, Stefan Poehlmann, Thomas Krey, Berislav Bosnjak, Swantje Hammerschmidt, Reinhold Foerster
Summary: Heterologous prime/boost vaccination with a vector-based approach followed by an mRNA vaccine has been found to induce better protective immunity compared to homologous vaccination. A third vaccine dose enhances the waning anti-spike IgG and restores neutralizing antibody responses against several variants of the virus, except for the Omicron variant.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Chutima Seree-aphinan, Yanisa Ratanapokasatit, Poonkiat Suchonwanit, Ploysyne Rattanakaemakorn, Pichaya O-Charoen, Prapaporn Pisitkun, Thanitta Suangtamai, Chavachol Setthaudom, Sonphet Chirasuthat, Kumutnart Chanprapaph
Summary: This study aimed to determine the optimal time for COVID-19 vaccination in patients with immune-mediated dermatologic diseases (IMDD) who have been exposed to rituximab. The results showed that waiting for 9 months after rituximab treatment before vaccination maximizes the immunological benefits while avoiding unnecessary delay.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jung Yeon Heo, Yu Bin Seo, Eun Jin Kim, Jacob Lee, Young Rong Kim, Jin Gu Yoon, Ji Yun Noh, Hee Jin Cheong, Woo Joo Kim, Soo-Young Yoon, Ju-Yeon Choi, Young Jae Lee, Hye Won Lee, Sung Soon Kim, Byoungguk Kim, Joon Young Song
Summary: This study evaluated the association between reactogenicity and immunogenicity after vaccination with different COVID-19 vaccines. It found that systemic adverse events after the first dose of ChAdOx1 nCoV-19 may be related to proinflammatory cytokine responses, while fever after the second dose of BNT162b2 is positively correlated with vaccine-induced immune responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Noa Dagan, Noam Barda, Eldad Kepten, Oren Miron, Shay Perchik, Mark A. Katz, Miguel A. Hernan, Marc Lipsitch, Ben Reis, Ran D. Balicer
Summary: A study conducted in Israel on nearly 600,000 individuals showed that the BNT162b2 mRNA vaccine was effective in reducing the risk of infection, hospitalization, and severe Covid-19. The effectiveness in preventing death was 72% during the period from day 14 through day 20 after the first dose, and hospitalization was reduced by 87% for the period 7 or more days after the second dose, similar to results from a randomized trial.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Immunology
Yuxuan Hu, Yanning Wang, Taihang Shao, Wenxi Tang, Kerong Hu, Yujie Zhou, Liyun Miao, Jing Liu, Bin Wang, Wenying Yu
Summary: This study systematically assessed the safety and immunogenicity of heterologous ChAd/BNT vaccination regimens. The results showed that compared to homologous ChAd/ChAd vaccination, heterologous ChAd/BNT vaccination exhibited significantly higher immunogenicity, but also higher incidence of total adverse reactions, especially local adverse reactions. Additionally, heterologous ChAd/BNT vaccination showed similar immunogenicity and safety to homologous BNT/BNT vaccination.
Article
Infectious Diseases
Itzchak Levy, Anat Wieder-Finesod, Vladyslav Litchevsky, Asaf Biber, Victoria Indenbaum, Liraz Olmer, Amit Huppert, Orna Mor, May Goldstein, Einav Gal Levin, Tammy Hod, Carmit Cohen, Yaniv Lustig, Galia Rahav
Summary: The Pfizer-BioNTech BNT162b2 mRNA vaccine demonstrates immunogenicity and safety in people living with human immunodeficiency virus type 1 (PLWH) who are receiving antiretroviral therapy with unsuppressed CD4 count and suppressed viral load. Adverse events are mainly mild, such as pain at the injection site, fatigue, and headache. Immune response to the vaccine is strong, with high levels of anti-RBD-IgG and neutralizing antibodies observed in both PLWH and immunocompetent health-care workers.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Immunology
Victoria Furer, Tali Eviatar, Devy Zisman, Hagit Peleg, Yolanda Braun-Moscovici, Alexandra Balbir-Gurman, Daphna Paran, David Levartovsky, Michael Zisapel, Ofir Elalouf, Ilana Kaufman, Adi Broyde, Ari Polachek, Joy Feld, Amir Haddad, Tal Gazitt, Muna Elias, Nizar Higazi, Fadi Kharouf, Sara Pel, Sharon Nevo, Ori Elkayam
Summary: In patients with autoimmune inflammatory rheumatic diseases (AIIRD) treated with rituximab (RTX), the predictors of a positive immunogenic response to the BNT162b2 mRNA vaccine include the number of RTX courses, cumulative RTX dose, IgG level prior to last RTX course, and interval between RTX treatment and vaccination. ANCA-associated vasculitis and inflammatory myositis patients have a low likelihood of a seropositive immunogenic response.
Article
Immunology
Simona Arientova, Katerina Matuskova, Oldrich Bartos, Michal Holub, Ondrej Beran
Summary: This study examined the dynamics and duration of immune responses after a three-dose regimen of the BNT162b2 mRNA vaccine. The results showed that the vaccine induced potent and enduring humoral and cellular immune responses, with enhanced protection after the third dose that remained stable up to a year later.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Helen Parry, Rachel Bruton, Christine Stephens, Christopher Bentley, Kevin Brown, Gayatri Amirthalingam, Bassam Hallis, Ashley Otter, Jianmin Zuo, Paul Moss
Summary: Delaying the second dose of the BNT162b2 vaccine can significantly boost antibody response in older people, providing a longer period of protection and delaying the need for booster vaccination. However, in terms of cellular-specific response, the best results were achieved with the standard vaccine interval.
Article
Endocrinology & Metabolism
R. Rodia, P. E. Meloni, C. Mascia, C. Balestrieri, V Ruggiero, G. Serra, M. Conti, M. Loi, F. Pes, S. Onali, A. Perra, R. Littera, F. Velluzzi, S. Mariotti, L. Chessa, F. Boi
Summary: This study provides evidence that DAAs have limited or no influence on the thyroid in patients with HCV-related diseases. Moreover, it suggests that subclinical non-autoimmune thyroid dysfunction may improve after HCV infection resolution obtained by DAAs.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Immunology
Cinzia Milito, Francesco Cinetto, Giulia Garzi, Andrea Palladino, Marco Puca, Elena Brambilla, Camilla De Vitis, Giulia Costanzo, Riccardo Scarpa, Alessandra Punziano, Gianluca Lagnese, Stefano Del Giacco, Giuseppe Spadaro, Isabella Quinti, Davide Firinu
Summary: During the COVID-19 vaccination campaign, safety data on vaccine administration in patients with inborn errors of immunity (IEI) shows that after receiving two doses of the vaccine, over 60% of patients experienced mild reactogenicity-related symptoms (RrS) and adverse events (AEs). As the number of vaccine doses increased, patients reported fewer AEs. Patients aged 50 years and older had a lower incidence of AEs and RrS. These safety data are important for addressing vaccine hesitancy in IEI patients and informing healthcare providers.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Loreta A. Kondili, Maria Giovanna Quaranta, Luisa Cavalletto, Vincenza Calvaruso, Luigina Ferrigno, Roberta D'Ambrosio, Ilaria Simonelli, Giuseppina Brancaccio, Giovanni Raimondo, Maurizia R. Brunetto, Anna Linda Zignego, Carmine Coppola, Andrea Iannone, Elisa Biliotti, Gabriella Verucchi, Marco Massari, Anna Licata, Francesco Barbaro, Marcello Persico, Francesco Paolo Russo, Filomena Morisco, Maurizio Pompili, Mauro Vigano, Massimo Puoti, Teresa Santantonio, Erica Villa, Antonio Craxi, Liliana Chemello
Summary: This study evaluated the long-term risk of hepatocellular carcinoma (HCC) in patients with cirrhosis after hepatitis C virus (HCV) eradication. Age, genotype 3, diabetes, platelets and albumin levels were identified as predictors of HCC risk. Furthermore, post-treatment platelet and albumin levels were found to independently predict HCC occurrence.
DIGESTIVE AND LIVER DISEASE
(2023)
Review
Clinical Neurology
Monica Puligheddu, Michela Figorilli, Patrizia Congiu, Rosamaria Lecca, Elisa Casaglia, Ludovica Tamburrino, Riccardo Orru, Federico Meloni, Raffaele Ferri
Summary: This review focuses on the scoring methods of REM sleep without atonia (RSWA). Considering the diverse methods used in the quantification of RSWA in the past decade, a systematic revision is necessary. A search was conducted in PubMed, Embase, Scopus, and Web of Science databases from 2010 to December 2021, with terms including RSWA, scoring methods, IRBD, alphasyn disease, neurodegenerative disease, and specific sleep disorders. The study also includes a meta-analysis of the diagnostic performance of RSWA scoring methods, showing comparable prediction areas for visual methods and the automated REM sleep atonia index (RAI).
SLEEP MEDICINE REVIEWS
(2023)
Article
Allergy
Sebastiano Gangemi, Alessandro Tonacci, Giulia Costanzo, Davide Firinu, Stefano Del Giacco
Summary: Asthma is a chronic respiratory disease that affects a large number of people worldwide. Analysing big data on asthma from different countries can provide a detailed understanding of the current disease burden. Our study investigates the correlations between asthma and key socio-demographic parameters from different world databases. We found that asthma prevalence is directly correlated with higher GDP and HDI, indicating a higher prevalence in wealthier and more developed countries.
WORLD ALLERGY ORGANIZATION JOURNAL
(2023)
Article
Agronomy
Melinda Mandaresu, Ludovica Dessi, Andrea Lallai, Marco Porceddu, Maria Enrica Boi, Gianluigi Bacchetta, Tiziana Pivetta, Raffaela Lussu, Riccardo Ardu, Marika Pinna, Federico Meloni, Enrico Sanjust, Elena Tamburini
Summary: This study aims to combine phytoremediation and the use of suitable amendments to maximize their favorable effects on mitigating petroleum hydrocarbon contaminations in terrestrial ecosystems. The addition of wood chips as an amendment significantly increased the survival rate of the selected Mediterranean shrub and reduced the residual amount of PHCs in the soil.
Article
Immunology
Roberta Parente, Silvio Sartorio, Luisa Brussino, Tiziana De Pasquale, Alessandra Zoli, Stefano Agolini, Ester Di Agosta, Paolina Quattrocchi, Paolo Borrelli, Donatella Bignardi, Angelica Petraroli, Riccardo Senter, Valentina Popescu Janu, Chiara Cogliati, Maria Domenica Guarino, Oliviero Rossi, Davide Firinu, Stefano Pucci, Giuseppe Spadaro, Massimo Triggiani, Mauro Cancian, Andrea Zanichelli
Summary: This study aimed to collect data on the safety and tolerability of COVID-19 vaccines in patients with angioedema due to C1 inhibitor deficiency. The results showed no increase in the frequency of acute attacks within 72 hours following COVID-19 vaccinations compared to the rate before vaccination. This suggests that adult patients with angioedema due to C1 inhibitor deficiency can safely receive SARS-CoV-2 vaccination in a controlled medical setting and should have access to on-demand therapy.
Article
Biochemistry & Molecular Biology
Martino Deidda, Antonio Noto, Davide Firinu, Cristina Piras, William Cordeddu, Claudia Depau, Giulia Costanzo, Stefano Del Giacco, Luigi Atzori, Giuseppe Mercuro, Christian Cadeddu Dessalvi
Summary: This study evaluated the three-dimensional echocardiographic parameters of the right ventricle (RV) and the metabolomic profile in patients with systemic lupus erythematosus (SLE), and found correlations between the two and the severity of SLE. The results suggest that RV dysfunction caused by chronic inflammatory state in SLE can be detected early by three-dimensional echocardiography, and its severity is related to systemic organ damage.
Article
Neurosciences
Rosamaria Lecca, Michela Figorilli, Elisa Casaglia, Carla Cucca, Federico Meloni, Roberto Loscerbo, Sara De Matteis, Pierluigi Cocco, Monica Puligheddu
Summary: Several studies have indicated that female nightshift workers are more susceptible to sleep deprivation and insomnia. To investigate gender-related differences in nightshift work adaptation, we conducted a cross-sectional survey in two different occupational settings. Our findings suggested that women were more likely to experience daytime sleepiness and poor sleep quality. Additionally, nightshift work and being married were associated with an increased risk of daytime sleepiness.
Article
Biochemistry & Molecular Biology
Giulia Guadalupi, Cristina Contini, Federica Iavarone, Massimo Castagnola, Irene Messana, Gavino Faa, Simona Onali, Luchino Chessa, Rui Vitorino, Francisco Amado, Giacomo Diaz, Barbara Manconi, Tiziana Cabras, Alessandra Olianas
Summary: This study investigated the quantitative variations on the salivary proteome in autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC) patients. Several differentially expressed proteins related to the diseases were identified. Machine learning analysis confirmed the potential of the salivary proteome to discriminate AIH and PBC patients. The functional enrichment analysis highlighted the involvement of the immune system, liver fibrosis process, and antimicrobial activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Pierluigi Cocco, Giannina Satta, Valerio Cancedda, Federico Meloni, Simone Milia, Ilaria Pilia, Mariagrazia Zucca, Sara De Matteis
Summary: This study aimed to investigate the association between the use of household pesticides and the risk of lymphoma. The results showed no significant association between the use of household insecticides and the risk of lymphoma, except for a potential slight increase in the risk of multiple myeloma.
Article
Biology
Andrea Giovanni Ledda, Giulia Costanzo, Giada Sambugaro, Cristiano Caruso, Martina Bullita, Maria Luisa Di Martino, Paolo Serra, Davide Firinu, Stefano Del Giacco
Summary: This study investigated the effects of dupilumab on inflammatory biomarkers in patients with asthma and chronic rhinosinusitis with nasal polyps (CRSwNP). The results showed that after treatment with dupilumab, levels of eosinophils and eosinophil cationic protein initially increased and then gradually declined, returning to baseline levels. Additionally, serum total IgE and fractional exhaled nitric oxide levels decreased over time, while FEV1 and FEV1% improved significantly.
Article
Biology
Patrick Bez, Giancarlo D'ippolito, Carla Maria Deiana, Renato Finco Gambier, Andrea Pica, Giulia Costanzo, Giulia Garzi, Riccardo Scarpa, Nicholas Landini, Francesco Cinetto, Davide Firinu, Cinzia Milito
Summary: This article reports a case series of 5 immunocompromised patients who were treated with combination therapy or multiple therapeutic lines for SARS-CoV-2 infection. The results suggest that combination therapy may be effective in combating SARS-CoV-2 infection in patients with antibody deficiency and impaired vaccine response.
Article
Pharmacology & Pharmacy
M. G. Carta, G. Orru, R. Littera, D. Firinu, L. Chessa, G. Cossu, D. Primavera, S. Del Giacco, E. Tramontano, N. Manocchio, C. Buonomo, A. Scano
Summary: This review compares the responses of different countries to the pandemic and their impact on citizens' health. It emphasizes the importance of global coordination and strategic choices in effectively addressing a global phenomenon.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Medicine, Research & Experimental
Marina Di Pino, Maria Filomena Ruberto, Giulia Costanzo, Davide Firinu, Maria Sebastiana Piras, Mario Nicola Mura, Stefano Del Giacco, Ferdinando Coghe, Francesco Marongiu, Doris Barcellona
Summary: Chronic spontaneous urticaria (CSU) is closely linked to the coagulation cascade and inflammation pathways, possibly indicating a low-grade disseminated intravascular coagulation (DIC) and increased platelet turnover. Omalizumab does not affect the relationship between the immune and hemostatic systems.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)