Pericyte hypoxia-inducible factor-1 (HIF-1) drives blood-brain barrier disruption and impacts acute ischemic stroke outcome

Parallel Lineage-Tracing Studies Establish Fibroblasts as the Prevailing In Vivo Adipocyte Progenitor

(2020) Paola Cattaneo et al.   Cell Reports

The blood–brain barrier in health and disease: Important unanswered questions

(2020) Caterina P. Profaci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Salvianolic Acid Alleviated Blood–Brain Barrier Permeability in Spontaneously Hypertensive Rats by Inhibiting Apoptosis in Pericytes via P53 and the Ras/Raf/MEK/ERK Pathway

(2020) Qingbin Wu et al.   Drug Design Development and Therapy

Cell-specific metabolomic responses to injury: novel insights into blood-brain barrier modulation

(2020) Sheng-Fu Huang et al.   Scientific Reports

Astrocyte glutathione maintains endothelial barrier stability

(2020) Sheng-Fu Huang et al.   Redox Biology

Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss

(2019) Angeliki M. Nikolakopoulou et al.   NATURE NEUROSCIENCE

Critical Role of Flavin and Glutathione in Complex I–Mediated Bioenergetic Failure in Brain Ischemia/Reperfusion Injury

(2018) Anja Kahl et al.   STROKE

Dynamic Remodeling of Pericytes In Vivo Maintains Capillary Coverage in the Adult Mouse Brain

(2018) Andrée-Anne Berthiaume et al.   Cell Reports

Targeting pericytes for therapeutic approaches to neurological disorders

(2018) Jinping Cheng et al.   ACTA NEUROPATHOLOGICA

Claudin-1 dependent destabilization of the blood-brain barrier in chronic stroke

(2018) Nikola Sladojevic et al.   JOURNAL OF NEUROSCIENCE

Experimental chronic cerebral hypoperfusion results in decreased pericyte coverage and increased blood–brain barrier permeability in the corpus callosum

(2017) Qinghai Liu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Corrigendum: β2-Adrenergic Receptor-Mediated HIF-1α Upregulation Mediates Blood Brain Barrier Damage in Acute Cerebral Ischemia

(2017) Yanyun Sun et al.   Frontiers in Molecular Neuroscience

Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-β signaling

(2017) Angeliki Maria Nikolakopoulou et al.   PLoS One

Stroke-induced blood–brain barrier breakdown along the vascular tree – No preferential affection of arteries in different animal models and in humans

(2016) Martin Krueger et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pericytes as Inducers of Rapid, Matrix Metalloproteinase-9-Dependent Capillary Damage during Ischemia

(2016) Robert G. Underly et al.   JOURNAL OF NEUROSCIENCE

Cerebral hypoperfusion and glucose hypometabolism: Key pathophysiological modulators promote neurodegeneration, cognitive impairment, and Alzheimer's disease

(2016) Mak Adam Daulatzai   JOURNAL OF NEUROSCIENCE RESEARCH

Pharmacological targeting of the HIF hydroxylases – A new field in medicine development

(2016) Mun Chiang Chan et al.   MOLECULAR ASPECTS OF MEDICINE

Role of Hypoxia Inducible Factor 1 in Hyperglycemia-Exacerbated Blood-Brain Barrier Disruption in Ischemic Stroke

(2016) Ziyan Zhang et al.   NEUROBIOLOGY OF DISEASE

Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury

(2016) Yejie Shi et al.   Nature Communications

HIF Hydroxylase Pathways in Cardiovascular Physiology and Medicine

(2015) T. Bishop et al.   CIRCULATION RESEARCH

Delayed Inhibition of VEGF Signaling after Stroke Attenuates Blood-Brain Barrier Breakdown and Improves Functional Recovery in a Comorbidity-Dependent Manner

(2015) P. Reeson et al.   JOURNAL OF NEUROSCIENCE

Prolyl hydroxylase regulates axonal rewiring and motor recovery after traumatic brain injury

(2015) S Miyake et al.   Cell Death & Disease

Dynamic reactive astrocytes after focal ischemia

(2015) Shinghua Ding   Neural Regeneration Research

Pericytes Contribute to the Disruption of the Cerebral Endothelial Barrier via Increasing VEGF Expression: Implications for Stroke

(2015) Ying Bai et al.   PLoS One

Blood—Brain Barrier Breakdown Involves Four Distinct Stages of Vascular Damage in Various Models of Experimental Focal Cerebral Ischemia

(2014) Martin Krueger et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice

(2014) Ruoli L. Chen et al.   JOURNAL OF NEUROCHEMISTRY

Capillary pericytes regulate cerebral blood flow in health and disease

(2014) Catherine N. Hall et al.   NATURE

Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke

(2014) Daniel Knowland et al.   NEURON

Cdh5/VE-cadherin Promotes Endothelial Cell Interface Elongation via Cortical Actin Polymerization during Angiogenic Sprouting

(2014) Loïc Sauteur et al.   Cell Reports

Selective Small Molecule Probes for the Hypoxia Inducible Factor (HIF) Prolyl Hydroxylases

(2013) Rasheduzzaman Chowdhury et al.   ACS Chemical Biology

Cell-specific blood-brain barrier regulation in health and disease: a focus on hypoxia

(2013) S Engelhardt et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of Endothelial Cell Metabolism in Vessel Sprouting

(2013) Katrien De Bock et al.   Cell Metabolism

Differential Effects of Paracrine Factors on the Survival of Cells of the Neurovascular Unit during Oxygen Glucose Deprivation

(2013) Zoran B. Redzic et al.   International Journal of Stroke

Cerebral ischaemia and matrix metalloproteinase-9 modulate the angiogenic function of early and late outgrowth endothelial progenitor cells

(2013) Anna Morancho et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Hypoxia Selectively Disrupts Brain Microvascular Endothelial Tight Junction Complexes Through a Hypoxia-Inducible Factor-1 (HIF-1) Dependent Mechanism

(2013) Sabrina Engelhardt et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Evidence that collaboration between HIF-1α and Notch-1 promotes neuronal cell death in ischemic stroke

(2013) Yi-Lin Cheng et al.   NEUROBIOLOGY OF DISEASE

Hypoxic retinal Müller cells promote vascular permeability by HIF-1–dependent up-regulation of angiopoietin-like 4

(2013) Xiaoban Xin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vascular Endothelial Growth Factor Promotes Pericyte Coverage of Brain Capillaries, Improves Cerebral Blood Flow During Subsequent Focal Cerebral Ischemia, and Preserves the Metabolic Penumbra

(2013) Anil Zechariah et al.   STROKE

Early Loss of Pericytes and Perivascular Stromal Cell-Induced Scar Formation after Stroke

(2012) Francisco Fernández-Klett et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Blood–Spinal Cord Barrier Pericyte Reductions Contribute to Increased Capillary Permeability

(2012) Ethan A Winkler et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neurovascular Unit: a Focus on Pericytes

(2012) Inês Sá-Pereira et al.   MOLECULAR NEUROBIOLOGY

Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo

(2012) Fabrizio Orsenigo et al.   Nature Communications

HIF-1 is involved in high glucose-induced paracellular permeability of brain endothelial cells

(2011) Jingqi Yan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

(2011) Annika Armulik et al.   DEVELOPMENTAL CELL

Specific Role of Tight Junction Proteins Claudin-5, Occludin, and ZO-1 of the Blood–Brain Barrier in a Focal Cerebral Ischemic Insult

(2011) Haixia Jiao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Differential Effects of HIF-1 Inhibition by YC-1 on the Overall Outcome and Blood-Brain Barrier Damage in a Rat Model of Ischemic Stroke

(2011) Jingqi Yan et al.   PLoS One

Blood–Brain Barrier Permeability Abnormalities in Vascular Cognitive Impairment

(2011) Saeid Taheri et al.   STROKE

Selective Inhibition of Early-but Not Late-Expressed HIF-1α Is Neuroprotective in Rats after Focal Ischemic Brain Damage

(2010) Shiu-Hwa Yeh et al.   BRAIN PATHOLOGY

Astrocytes and Pericytes Differentially Modulate Blood—Brain Barrier Characteristics during Development and Hypoxic Insult

(2010) Abraham Al Ahmad et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

Mechanisms and targets for angiogenic therapy after stroke

(2010) Deepti Navaratna et al.   Cell Adhesion & Migration

The neurovascular unit in the setting of stroke

(2009) G. J. del Zoppo   JOURNAL OF INTERNAL MEDICINE

Functional testing in a mouse stroke model induced by occlusion of the distal middle cerebral artery

(2009) Judith Lubjuhn et al.   JOURNAL OF NEUROSCIENCE METHODS

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Maintaining blood-brain barrier integrity: Pericytes perform better than astrocytes during prolonged oxygen deprivation

(2008) A. Al Ahmad et al.   JOURNAL OF CELLULAR PHYSIOLOGY

VE-cadherin and claudin-5: it takes two to tango

(2008) Julie Gavard et al.   NATURE CELL BIOLOGY

The blood–brain barrier is continuously open for several weeks following transient focal cerebral ischemia

(2008) D. Strbian et al.   NEUROSCIENCE