Immunometabolic responses according to physical fitness status and lifelong exercise during aging: New roads for exercise immunology

Immunosenescence Study of T Cells: A Systematic Review

(2021) Ivon Johanna Rodriguez et al.   Frontiers in Immunology

Levels of cardiorespiratory fitness in men exerts strong impact on lymphocyte function after mitogen stimulation

(2021) Gilson Pires Dorneles et al.   JOURNAL OF APPLIED PHYSIOLOGY

Monocytes present age‐related changes in phospholipid concentration and decreased energy metabolism

(2020) Mario Saare et al.   AGING CELL

Immunometabolism: From basic mechanisms to translation

(2020) Liza Makowski et al.   IMMUNOLOGICAL REVIEWS

M2b macrophage subset decrement as an indicator of cognitive function in Alzheimer's disease

(2020) Sun‐Wung Hsieh et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Dynamics of Anthropometric Indices in a Large Paired Cohort With 10 Years of Follow-Up: Paving the Way to Sarcopenic Obesity

(2020) Maria-Dolores Santos et al.   Frontiers in Endocrinology

Mitochondria, immunosenescence and inflammaging: a role for mitokines?

(2020) Maria Conte et al.   Seminars in Immunopathology

Acute increases in brain-derived neurotrophic factor following high or moderate-intensity exercise is accompanied with better cognition performance in obese adults

(2020) Daniela Sayuri Inoue et al.   Scientific Reports

Inflammaging, hormesis and the rationale for anti-aging strategies

(2020) Aurelia Santoro et al.   AGEING RESEARCH REVIEWS

Effects of Aging and Lifelong Aerobic Exercise on Expression of Innate Immune Components in Human Skeletal Muscle

(2020) Ryan K. Perkins et al.   JOURNAL OF APPLIED PHYSIOLOGY

High- and moderate-intensity training modify LPS-induced ex-vivo interleukin-10 production in obese men in response to an acute exercise bout

(2020) José Gerosa-Neto et al.   CYTOKINE

Physical fitness modulates the expression of CD39 and CD73 on CD4+ CD25− and CD4+ CD25+ T cells following high intensity interval exercise

(2019) Gilson P. Dorneles et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Influence of Body Fat on Oxidative Stress and Telomere Length of Master Athletes

(2019) Samuel S. Aguiar et al.   JOURNAL OF STRENGTH AND CONDITIONING RESEARCH

Lifelong exercise practice and immunosenescence: Master athletes cytokine response to acute exercise

(2019) Luciele Guerra Minuzzi et al.   CYTOKINE

Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications

(2019) Michele Longo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alpha7 Nicotinic Acetylcholine Receptor Alleviates Inflammatory Bowel Disease Through Induction of AMPK-mTOR-p70S6K-Mediated Autophagy

(2019) Bo-Zong Shao et al.   INFLAMMATION

Cardiorespiratory fitness modulates the proportions of monocytes and T helper subsets in lean and obese men

(2019) Gilson P. Dorneles et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

The Ontogeny of Monocyte Subsets

(2019) Anja A. Wolf et al.   Frontiers in Immunology

Chronic Inflammation as an Immunological Abnormality and Effectiveness of Exercise

(2019) Katsuhiko Suzuki   Biomolecules

The role of glucose homeostasis on immune function in response to exercise: The impact of low or higher energetic conditions

(2019) Ana E. Von Ah Morano et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases

(2019) Theodore S. Kapellos et al.   Frontiers in Immunology

Effects of Aging and Lifelong Aerobic Exercise on Basal and Exercise-Induced Inflammation

(2019) Kaleen M. Lavin et al.   JOURNAL OF APPLIED PHYSIOLOGY

Lower resting and exercise-induced circulating angiogenic progenitors and angiogenic T cells in older men

(2018) Mark D. Ross et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets

(2018) Claire E. Macdougall et al.   Cell Metabolism

Recommendations to maintain immune health in athletes

(2018) Neil P. Walsh   European Journal of Sport Science

Age and immunity: What is “immunosenescence”?

(2018) Graham Pawelec   EXPERIMENTAL GERONTOLOGY

Mapping the historical development of physical activity and health research: A structured literature review and citation network analysis

(2018) Andrea Ramirez Varela et al.   PREVENTIVE MEDICINE

Macrophage polarization and meta-inflammation

(2018) Chuan Li et al.   Translational Research

Remembering Pathogen Dose: Long-Term Adaptation in Innate Immunity

(2018) Michael Bauer et al.   TRENDS IN IMMUNOLOGY

Glycolytic Stimulation Is Not a Requirement for M2 Macrophage Differentiation

(2018) Feilong Wang et al.   Cell Metabolism

Immunometabolism of T cells and NK cells: metabolic control of effector and regulatory function

(2018) Sophie M. Poznanski et al.   INFLAMMATION RESEARCH

Human Monocyte Heterogeneity as Revealed by High-Dimensional Mass Cytometry

(2018) Anouk A.J. Hamers et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Anti-inflammatory response to acute exercise is related with intensity and physical fitness

(2018) Barbara Moura Antunes et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Interleukin‐10 responses from acute exercise in healthy subjects: A systematic review

(2018) Carolina Cabral‐Santos et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Metabolism as a guiding force for immunity

(2018) Jonathan Jung et al.   NATURE CELL BIOLOGY

Exercise effects on physiological function during aging

(2018) Zsolt Radak et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lifelong training improves anti-inflammatory environment and maintains the number of regulatory T cells in masters athletes

(2017) Luciele G. Minuzzi et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Anti-inflammatory effects of exercise: role in diabetes and cardiovascular disease

(2017) Bente Klarlund Pedersen   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

mTORC1 and mTORC2 as regulators of cell metabolism in immunity

(2017) Monika Linke et al.   FEBS LETTERS

Transcriptome analysis of IL-10-stimulated (M2c) macrophages by next-generation sequencing

(2017) Emily B. Lurier et al.   IMMUNOBIOLOGY

Longer Telomere Length in Elite Master Sprinters: Relationship to Performance and Body Composition

(2017) Herbert Simoes et al.   INTERNATIONAL JOURNAL OF SPORTS MEDICINE

Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults

(2017) Leandra Abarca-Gómez et al.   LANCET

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of Inactivity in Chronic Diseases: Evolutionary Insight and Pathophysiological Mechanisms

(2017) Frank W. Booth et al.   PHYSIOLOGICAL REVIEWS

Is immunosenescence influenced by our lifetime “dose” of exercise?

(2016) James E. Turner   BIOGERONTOLOGY

Ly6C+ monocyte efferocytosis and cross-presentation of cell-associated antigens

(2016) S R Larson et al.   CELL DEATH AND DIFFERENTIATION

Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Cell Mobilization and Redistribution

(2016) Line Pedersen et al.   Cell Metabolism

Integrated regulation of the cellular metabolism and function of immune cells in adipose tissue

(2016) Yumiko Oishi et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Macrophage Polarization: Implications on Metabolic Diseases and the Role of Exercise

(2016) Loreana Sanches Silveira et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

The Immunomodulatory Effects of Physical Activity

(2016) Karsten Krüger et al.   CURRENT PHARMACEUTICAL DESIGN

The immune system

(2016) L. B. Nicholson   Essays in Biochemistry

Moderate-intensity exercise alters markers of alternative activation in circulating monocytes in females: a putative role for PPARγ

(2016) J. S. Ruffino et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

The long road to leptin

(2016) Jeffrey Friedman   JOURNAL OF CLINICAL INVESTIGATION

Killer Cell Lectin-like Receptor G1 Inhibits NK Cell Function through Activation of Adenosine 5′-Monophosphate–Activated Protein Kinase

(2016) Bojana Müller-Durovic et al.   JOURNAL OF IMMUNOLOGY

The “bioregulatory effect of exercise” on the innate/inflammatory responses

(2016) Eduardo Ortega   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

The economic burden of physical inactivity: a global analysis of major non-communicable diseases

(2016) Ding Ding et al.   LANCET

Does physical activity attenuate, or even eliminate, the detrimental association of sitting time with mortality? A harmonised meta-analysis of data from more than 1 million men and women

(2016) Ulf Ekelund et al.   LANCET

Patterns of Sedentary Behavior in US Middle-Age and Older Adults

(2016) KEITH M. DIAZ et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

TOR and paradigm change: cell growth is controlled

(2016) Michael N. Hall   MOLECULAR BIOLOGY OF THE CELL

Emerging concepts of T cell metabolism as a target of immunotherapy

(2016) Chih-Hao Chang et al.   NATURE IMMUNOLOGY

Metabolic pathways in T cell activation and lineage differentiation

(2016) Luís Almeida et al.   SEMINARS IN IMMUNOLOGY

Exercise Training Alleviates Hypoxia-induced Mitochondrial Dysfunction in the Lymphocytes of Sedentary Males

(2016) Hsing-Hua Tsai et al.   Scientific Reports

Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner

(2016) Lianjun Zhang et al.   Cell Reports

Elderly men with moderate and intense training lifestyle present sustained higher antibody responses to influenza vaccine

(2015) Adriana Ladeira de Araújo et al.   AGE

Phenotypic, Functional, and Plasticity Features of Classical and Alternatively Activated Human Macrophages

(2015) Abdullah A. Tarique et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

From inflamm-aging to immune-paralysis: a slippery slope during aging for immune-adaptation

(2015) T. Fulop et al.   BIOGERONTOLOGY

Pharmacological activation of PPAR gamma ameliorates vascular endothelial insulin resistance via a non-canonical PPAR gamma-dependent nuclear factor-kappa B trans-repression pathway

(2015) Ying Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sprinters versus Long-distance Runners

(2015) Krzysztof Kusy et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Short-term high-intensity interval and moderate-intensity continuous training reduce leukocyte TLR4 in inactive adults at elevated risk of type 2 diabetes

(2015) Emily Robinson et al.   JOURNAL OF APPLIED PHYSIOLOGY

Management of obesity: improvement of health-care training and systems for prevention and care

(2015) William H Dietz et al.   LANCET

Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants

(2015) Veronica De Rosa et al.   NATURE IMMUNOLOGY

Effect of Moderate and High Resistance Training Intensity on Indices of Inflammatory and Oxidative Stress

(2015) Kamal Azizbeigi et al.   Research in Sports Medicine

Targeting T cell metabolism for therapy

(2015) David O'Sullivan et al.   TRENDS IN IMMUNOLOGY

mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation

(2015) Jong-Seok Moon et al.   Cell Reports

Aging impairs peritoneal but not bone marrow-derived macrophage phagocytosis

(2014) Eimear Linehan et al.   AGING CELL

Special issue on exercise immunology: Current perspectives on aging, health and extreme performance

(2014) Richard J. Simpson et al.   BRAIN BEHAVIOR AND IMMUNITY

Interleukin-6 and its receptors: A highly regulated and dynamic system

(2014) Janina Wolf et al.   CYTOKINE

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

(2014) Valerie A. Gerriets et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: A systems biology approach

(2014) Dulce Calçada et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells

(2014) Alessio Lanna et al.   NATURE IMMUNOLOGY

Effect of aerobic exercise training on cardiovascular parameters and CD4 cell count of people living with human immunodeficiency virus/acquired immune deficiency syndrome: A randomized controlled trial

(2014) S Lamina et al.   Nigerian Journal of Clinical Practice

Dendritic cell subsets require cis-activation for cytotoxic CD8 T-cell induction

(2014) A Nicole Desch et al.   Nature Communications

Effect of acute and regular exercise on growth hormone secretagogue receptor-1a expression in human lymphocytes, T cell subpopulation and monocytes

(2013) Nicolette C. Bishop et al.   BRAIN BEHAVIOR AND IMMUNITY

The influence of exercise training status on antigen-stimulated IL-10 production in whole blood culture and numbers of circulating regulatory T cells

(2013) Michal K. Handzlik et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Minimal Differentiation of Classical Monocytes as They Survey Steady-State Tissues and Transport Antigen to Lymph Nodes

(2013) Claudia Jakubzick et al.   IMMUNITY

Metabolic Pathways in Immune Cell Activation and Quiescence

(2013) Erika L. Pearce et al.   IMMUNITY

The role of mitochondria in aging

(2013) Ana Bratic et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolism of inflammation limited by AMPK and pseudo-starvation

(2013) Luke A. J. O'Neill et al.   NATURE

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

(2013) Hu Zeng et al.   NATURE

mTOR and metabolic pathways in T cell quiescence and functional activation

(2013) Kai Yang et al.   SEMINARS IN IMMUNOLOGY

Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function

(2012) Anna C. Hearps et al.   AGING CELL

Regulation of Immune Responses by mTOR

(2012) Jonathan D. Powell et al.   Annual Review of Immunology

The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism

(2012) Arvand Haschemi et al.   Cell Metabolism

Orchestration of Metabolism by Macrophages

(2012) Subhra K. Biswas et al.   Cell Metabolism

Leptin and Cognition

(2012) Matthew W. Warren et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

mTOR, metabolism, and the regulation of T-cell differentiation and function

(2012) Adam T. Waickman et al.   IMMUNOLOGICAL REVIEWS

Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy

(2012) I-Min Lee et al.   LANCET

Global physical activity levels: surveillance progress, pitfalls, and prospects

(2012) Pedro C Hallal et al.   LANCET

Innate immunosenescence: Effect of aging on cells and receptors of the innate immune system in humans

(2012) Rafael Solana et al.   SEMINARS IN IMMUNOLOGY

Mechanisms of T Cell Development and Transformation

(2011) Ute Koch et al.   Annual Review of Cell and Developmental Biology

The mitochondrial citrate carrier: a new player in inflammation

(2011) Vittoria Infantino et al.   BIOCHEMICAL JOURNAL

Aerobic fitness is associated with lower proportions of senescent blood T-cells in man

(2011) Guillaume Spielmann et al.   BRAIN BEHAVIOR AND IMMUNITY

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

Leukocyte β2-Adrenergic Receptor Expression in Response to Resistance Exercise

(2011) MAREN S. FRAGALA et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

Manipulating the Bioenergetics of Alloreactive T Cells Causes Their Selective Apoptosis and Arrests Graft-Versus-Host Disease

(2011) E. Gatza et al.   Science Translational Medicine

Nomenclature of monocytes and dendritic cells in blood

(2010) L. Ziegler-Heitbrock et al.   BLOOD

Metabolism in T cell activation and differentiation

(2010) Erika L Pearce   CURRENT OPINION IN IMMUNOLOGY

Aging of the innate immune system

(2010) Albert C Shaw et al.   CURRENT OPINION IN IMMUNOLOGY

Aging, Persistent Viral Infections, and Immunosenescence

(2010) Richard J. Simpson   EXERCISE AND SPORT SCIENCES REVIEWS

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Exercise affects tissue lymphocyte apoptosis via redox-sensitive and Fas-dependent signaling pathways

(2009) K. Krüger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Mortality, Health Outcomes, and Body Mass Index in the Overweight Range

(2009) Cora E. Lewis et al.   CIRCULATION

Reactive oxygen species are signalling molecules for skeletal muscle adaptation

(2009) Scott K. Powers et al.   EXPERIMENTAL PHYSIOLOGY

mTOR: taking cues from the immune microenvironment

(2009) Greg M. Delgoffe et al.   IMMUNOLOGY

The diseasome of physical inactivity - and the role of myokines in muscle-fat cross talk

(2009) Bente K. Pedersen   JOURNAL OF PHYSIOLOGY-LONDON

De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR

(2008) Johnthomas Kang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Exercise-induced redistribution of T lymphocytes is regulated by adrenergic mechanisms

(2007) K. Krüger et al.   BRAIN BEHAVIOR AND IMMUNITY

Endurance exercise performance in Masters athletes: age-associated changes and underlying physiological mechanisms

(2007) Hirofumi Tanaka et al.   JOURNAL OF PHYSIOLOGY-LONDON