Surface Engineering of FLT4-Targeted Nanocarriers Enhances Cell-Softening Glaucoma Therapy

Surface chemistry-mediated modulation of adsorbed albumin folding state specifies nanocarrier clearance by distinct macrophage subsets

(2021) Michael P. Vincent et al.   Nature Communications

Molecular taxonomy of human ocular outflow tissues defined by single-cell transcriptomics

(2020) Gaurang Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell atlas of aqueous humor outflow pathways in eyes of humans and four model species provides insight into glaucoma pathogenesis

(2020) Tavé van Zyl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effect of size, charge, and peptide ligand length on kidney targeting by small, organic nanoparticles

(2020) Yi Huang et al.   Bioengineering & Translational Medicine

Targeted Delivery of Cell Softening Micelles to Schlemm's Canal Endothelial Cells for Treatment of Glaucoma

(2020) Trevor Stack et al.   Small

Long-term Safety and Ocular Hypotensive Efficacy Evaluation of Netarsudil Ophthalmic Solution

(2019) Malik Y. Kahook et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Surface Engineered Polymersomes for Enhanced Modulation of Dendritic Cells During Cardiovascular Immunotherapy

(2019) Sijia Yi et al.   ADVANCED FUNCTIONAL MATERIALS

Netarsudil/Latanoprost Fixed-Dose Combination for Elevated Intraocular Pressure: Three-Month Data from a Randomized Phase 3 Trial

(2019) Sanjay Asrani et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Clinical implications of recent advances in primary open-angle glaucoma genetics

(2019) Hélène Choquet et al.   EYE

Increased stiffness and flow resistance of the inner wall of Schlemm’s canal in glaucomatous human eyes

(2019) Amir Vahabikashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two Phase 3 Clinical Trials Comparing the Safety and Efficacy of Netarsudil to Timolol in Patients With Elevated Intraocular Pressure: Rho Kinase Elevated IOP Treatment Trial 1 and 2 (ROCKET-1 and ROCKET-2)

(2018) Janet B. Serle et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Modulation of Schlemm's canal endothelial cell stiffness via latrunculin loaded block copolymer micelles

(2018) Trevor Stack et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Rho Kinase Inhibitors as a Novel Treatment for Glaucoma and Ocular Hypertension

(2018) Angelo P. Tanna et al.   OPHTHALMOLOGY

Benchmarking Bicontinuous Nanospheres against Polymersomes for in Vivo Biodistribution and Dual Intracellular Delivery of Lipophilic and Water-Soluble Payloads

(2018) Sean D. Allen et al.   ACS Applied Materials & Interfaces

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation

(2018) Sean Allen et al.   Jove-Journal of Visualized Experiments

Flash nanoprecipitation permits versatile assembly and loading of polymeric bicontinuous cubic nanospheres

(2017) Sharan Bobbala et al.   Nanoscale

Tailoring Nanostructure Morphology for Enhanced Targeting of Dendritic Cells in Atherosclerosis

(2016) Sijia Yi et al.   ACS Nano

A comprehensive insight on ocular pharmacokinetics

(2016) Vibhuti Agrahari et al.   Drug Delivery and Translational Research

Ocular Hypotensive Safety and Systemic Absorption of AR-13324 Ophthalmic Solution in Normal Volunteers

(2015) Brian Levy et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Fixed-dose combination of AR-13324 and latanoprost: a double-masked, 28-day, randomised, controlled study in patients with open-angle glaucoma or ocular hypertension

(2015) Richard A Lewis et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

High-throughput screening for modulators of cellular contractile force

(2015) Chan Young Park et al.   Integrative Biology

Double-masked, Randomized, Dose–Response Study of AR-13324 versus Latanoprost in Patients with Elevated Intraocular Pressure

(2015) Jason Bacharach et al.   OPHTHALMOLOGY

Biomechanical strain as a trigger for pore formation in Schlemm's canal endothelial cells

(2014) Sietse T. Braakman et al.   EXPERIMENTAL EYE RESEARCH

The Schlemm’s canal is a VEGF-C/VEGFR-3–responsive lymphatic-like vessel

(2014) Aleksanteri Aspelund et al.   JOURNAL OF CLINICAL INVESTIGATION

Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040

(2014) Yih-Chung Tham et al.   OPHTHALMOLOGY

Altered mechanobiology of Schlemm's canal endothelial cells in glaucoma

(2014) D. R. Overby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Schlemm's Canal Is a Unique Vessel with a Combination of Blood Vascular and Lymphatic Phenotypes that Forms by a Novel Developmental Process

(2014) Krishnakumar Kizhatil et al.   PLOS BIOLOGY

Phase 2 Randomized Clinical Study of a Rho Kinase Inhibitor, K-115, in Primary Open-Angle Glaucoma and Ocular Hypertension

(2013) Hidenobu Tanihara et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Precision Intracellular Delivery Based on Optofluidic Polymersome Rupture

(2012) Andreas E. Vasdekis et al.   ACS Nano

Dendritic cell activation and T cell priming with adjuvant- and antigen-loaded oxidation-sensitive polymersomes

(2012) Evan A. Scott et al.   BIOMATERIALS

Effect of ligand density, receptor density, and nanoparticle size on cell targeting

(2012) Drew R. Elias et al.   Nanomedicine-Nanotechnology Biology and Medicine

PEG-b-PPS-b-PEI micelles and PEG-b-PPS/PEG-b-PPS-b-PEI mixed micelles as non-viral vectors for plasmid DNA: Tumor immunotoxicity in B16F10 melanoma

(2011) Diana Velluto et al.   BIOMATERIALS

Protein markers and differentiation in culture for Schlemm’s canal endothelial cells

(2011) K.M. Perkumas et al.   EXPERIMENTAL EYE RESEARCH

Gene therapy for retinal ganglion cell neuroprotection in glaucoma

(2011) A M Wilson et al.   GENE THERAPY

Mechanical responsiveness of the endothelial cell of Schlemm's canal: scope, variability and its potential role in controlling aqueous humour outflow

(2011) E. H. Zhou et al.   Journal of the Royal Society Interface

Strategies in the design of nanoparticles for therapeutic applications

(2010) Robby A. Petros et al.   NATURE REVIEWS DRUG DISCOVERY