Article
Plant Sciences
Nur Ainina Abd Wahab, Nelli Giribabu, Eswar Kumar Kilari, Naguib Salleh
Summary: Abietic acid helps to mitigate nephropathy development in diabetes mellitus by counteracting oxidative stress, inflammation, and apoptosis.
Article
Food Science & Technology
Ali Y. Naoom, Wenyi Kang, Nora F. Ghanem, Mohamed M. Abdel-Daim, Fatma M. El-Demerdash
Summary: This study aimed to evaluate the anti-hyperglycemic and antioxidant role of Actinidia deliciosa (kiwifruits) aqueous extract in streptozotocin-treated rats. Results showed that ADAE had high antioxidant and radical scavenging potency. Diabetic rats administered with ADAE showed significant restoration in LPO, antioxidant status, and biochemical indices besides tissue architecture, and genes improvement regarding STZ group.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Food Science & Technology
Yujie Zhong, Ruilin Luo, Qi Liu, Jiachang Zhu, Min Lei, Xiaofei Liang, Xin Wang, Xiaoli Peng
Summary: Jujuboside A shows renoprotective effects on type II diabetic nephropathy by inhibiting oxidative stress and apoptosis, while enhancing autophagy and mitophagy.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Luna Jimenez-Castilla, Gema Marin-Royo, Macarena Orejudo, Lucas Opazo-Rios, Teresa Caro-Ordieres, Ines Artaiz, Tatiana Suarez-Cortes, Arturo Zazpe, Gonzalo Hernandez, Carmen Gomez-Guerrero, Jesus Egido
Summary: The synthetic flavonoid hidrosmin has shown protective effects against diabetic nephropathy by reducing inflammation, oxidative stress, and senescence pathways. It may have potential as an adjuvant therapy for chronic complications of diabetes mellitus. Additionally, hidrosmin demonstrated no cytotoxicity at effective concentrations, making it a promising treatment option.
Article
Medicine, Research & Experimental
Maisa Siddiq Abduh, Mohammed A. Alzoghaibi, Abdullah M. Alzoghaibi, Albandari Bin -Ammar, Mohammed F. Alotaibi, Emadeldin M. Kamel, Ayman M. Mahmoud
Summary: This study evaluated the effect of arbutin on hyperglycemia, dyslipidemia, insulin resistance, oxidative stress, and inflammatory response in type 2 diabetes (T2D) rats. The results showed that arbutin effectively ameliorated glucose intolerance, insulin resistance, dyslipidemia, inflammation, and oxidative stress, and modulated carbohydrate-metabolizing enzymes, antioxidants, adipokines, and PPAR gamma in T2D rats.
Article
Medicine, Research & Experimental
Duojun Qiu, Shan Song, Yuhan Wang, Yawei Bian, Ming Wu, Haijiang Wu, Yonghong Shi, Huijun Duan
Summary: The study demonstrates that NQO1 plays a protective role against oxidative stress and apoptosis in diabetic nephropathy by regulating Sirt1 and increasing intracellular NAD+/NADH levels.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Yang Liu, Jin-Yan Zheng, Zhi-Tao Wei, Shu-Kun Liu, Ji-Lei Sun, Yin-Hui Mao, Yong-De Xu, Yong Yang
Summary: This study investigates the therapeutic effect of the combination of ursolic acid and insulin on diabetic nephropathy. The results show that the combined treatment has better outcomes compared to insulin-only treatment. The combination therapy improves renal function and pathological damage, reduces apoptosis and oxidative stress, and inhibits renal fibrosis and epithelial-mesenchymal transition (EMT).
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Xiaohan Wu, He Li, Zhijie Wan, Ran Wang, Jing Liu, Qingfeng Liu, Haiyun Zhao, Zhehuan Wang, Huiru Zhang, Hui Guo, Caihong Qi, Xiangyue Jiao, Xiaotian Li
Summary: This study investigates the combined effects of ursolic acid and empagliflozin in treating diabetic nephropathy using a diabetic rat model. The results showed that the combination treatment was more effective in improving blood glucose, renal function indicators, inflammation levels, oxidative stress responses, and renal fibrosis compared to monotherapy.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Immunology
Qi Jin, Tongtong Liu, Yuan Qiao, Donghai Liu, Liping Yang, Huimin Mao, Fang Ma, Yuyang Wang, Liang Peng, Yongli Zhan
Summary: Diabetic nephropathy (DN) can cause end-stage renal disease. Oxidative stress plays a crucial role in the development of DN, leading to various pathological processes and promoting inflammation. Polyphenols, such as quercetin, resveratrol, curcumin, and phenolic acid, have shown antioxidant and anti-inflammatory effects by targeting Nrf2, SIRT1, HMGB1, NF-κB, and NLRP3. However, further research is needed to fully understand the molecular mechanisms and clinical applications of polyphenols in DN.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Kiyoung Kim, Eun-Young Lee
Summary: Diabetic nephropathy is a serious complication of diabetes which is poorly understood in terms of pathogenic mechanisms. Impaired mitochondrial function and abnormal mitochondrial dynamics play crucial roles in the development and progression of DN. Studies suggest that both aberrant mitochondrial fission and excessively enlarged mitochondria are involved in the pathogenesis of DN.
Article
Food Science & Technology
Jozaa Z. ALTamimi, Nora A. AlFaris, Ghedeir M. Alshammari, Reham Alagal, Dalal H. Aljabryn, Hussain Aldera, Bahauddeen M. Alrfaei, Mahmoud A. Alkhateeb, Mohammed A. Yahya
Summary: The study showed that EA can improve diabetic nephropathy in rats through antioxidant and anti-inflammatory effects. In STZ-induced diabetic rats, EA prevented renal damage, oxidative stress, inflammation, and apoptosis.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Theodomir Dusabimana, Eun Jung Park, Jihyun Je, Kyuho Jeong, Seung Pil Yun, Hye Jung Kim, Hwajin Kim, Sang Won Park
Summary: Geniposide has been shown to have protective effects in a mouse model of diabetic nephropathy, improving renal function and reducing pathological changes through modulation of AMPK and AKT pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xing Wang, Caina Li, Yi Huan, Hui Cao, Sujuan Sun, Lei Lei, Quan Liu, Shuainan Liu, Wenming Ji, Kaixun Huang, Zhufang Shen, Jun Zhou
Summary: DPDS supplementation improved hyperglycemia, glucose intolerance, dyslipidemia, and renal pathological abnormalities in STZ-induced DN rats. It also promoted antioxidant enzyme activities, reduced pro-inflammatory factors levels, and activated the renal Nrf2/Keap1 signaling pathway while attenuating NF kappa B/MAPK signaling pathways, suggesting DPDS as a potential therapeutic approach for DN.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Chemistry, Medicinal
Leyi Ma, Fan Wu, Qingqing Shao, Guang Chen, Lijun Xu, Fuer Lu
Summary: This study demonstrated that baicalin can treat diabetic nephropathy (DN) by alleviating oxidative stress and inflammation, and its underlying mechanisms are associated with the activation of Nrf2-mediated antioxidant signaling pathway and the inhibition of MAPK-mediated inflammatory signaling pathway.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Cell Biology
Weikun Jia, Tao Bai, Jiang Zeng, Zijing Niu, Daogui Fan, Xin Xu, Meiling Luo, Peijian Wang, Qingliang Zou, Xiaozhen Dai
Summary: The combination therapy of metformin and atorvastatin showed superior protective effects against diabetic cardiomyopathy by inhibiting oxidative stress and inflammation, as well as reducing apoptosis of cardiomyocytes. This effect may be related to the activation of AMPK/SIRT1 signaling pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)