Delivery of Therapeutic Agents to the Central Nervous System and the Promise of Extracellular Vesicles

Ultrasound Combined With Microbubbles Loading BDNF Retrovirus to Open Blood–Brain Barrier for Treatment of Alzheimer’s Disease

(2021) Feng Wang et al.   Frontiers in Pharmacology

Targeting and Crossing the Blood-Brain Barrier with Extracellular Vesicles

(2020) Julien Saint-Pol et al.   Cells

miR-137 boosts the neuroprotective effect of endothelial progenitor cell-derived exosomes in oxyhemoglobin-treated SH-SY5Y cells partially via COX2/PGE2 pathway

(2020) Yuchen Li et al.   Stem Cell Research & Therapy

Toward Regulatory Effects of Curcumin on Transforming Growth Factor-Beta Across Different Diseases: A Review

(2020) Milad Ashrafizadeh et al.   Frontiers in Pharmacology

Exosome-Shuttled circSHOC2 from IPASs Regulates Neuronal Autophagy and Ameliorates Ischemic Brain Injury via the miR-7670-3p/SIRT1 Axis

(2020) Wanghao Chen et al.   Molecular Therapy-Nucleic Acids

Transcytosis to Cross the Blood Brain Barrier, New Advancements and Challenges

(2019) Victor M. Pulgar   Frontiers in Neuroscience

Advances in therapeutic applications of extracellular vesicles

(2019) Oscar P. B. Wiklander et al.   Science Translational Medicine

Tumor-Derived Extracellular Vesicles Breach the Intact Blood–Brain Barrier via Transcytosis

(2019) Golnaz Morad et al.   ACS Nano

Delivery across the blood-brain barrier: nanomedicine for glioblastoma multiforme

(2019) Lynn Jena et al.   Drug Delivery and Translational Research

Neuroprotective effects of curcumin through autophagy modulation

(2019) Fatemeh Forouzanfar et al.   IUBMB LIFE

Focused Ultrasound Strategies for Brain Tumor Therapy

(2019) Adomas Bunevicius et al.   Operative Neurosurgery

Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

(2018) Tian Tian et al.   BIOMATERIALS

NRP-1 targeted and cargo-loaded exosomes facilitate simultaneous imaging and therapy of glioma in vitro and in vivo

(2018) Gang Jia et al.   BIOMATERIALS

AAV9 intracerebroventricular gene therapy improves lifespan, locomotor function and pathology in a mouse model of Niemann-Pick type C1 disease

(2018) Michael P Hughes et al.   HUMAN MOLECULAR GENETICS

Convection-enhanced delivery for diffuse intrinsic pontine glioma: a single-centre, dose-escalation, phase 1 trial

(2018) Mark M Souweidane et al.   LANCET ONCOLOGY

ARMMs as a versatile platform for intracellular delivery of macromolecules

(2018) Qiyu Wang et al.   Nature Communications

Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier

(2018) Bruno M.D.C. Godinho et al.   MOLECULAR THERAPY

Emerging Technologies for Delivery of Biotherapeutics and Gene Therapy Across the Blood–Brain Barrier

(2018) Danica B. Stanimirovic et al.   BIODRUGS

Cluster of Differentiation 46 Is the Major Receptor in Human Blood–Brain Barrier Endothelial Cells for Uptake of Exosomes Derived from Brain-Metastatic Melanoma Cells (SK-Mel-28)

(2018) Hiroki Kuroda et al.   MOLECULAR PHARMACEUTICS

Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery

(2018) Sophia Antimisiaris et al.   Pharmaceutics

AAV9-based gene therapy partially ameliorates the clinical phenotype of a mouse model of Leigh syndrome

(2017) I Di Meo et al.   GENE THERAPY

Intranasal Administration of TAT-Conjugated Lipid Nanocarriers Loading GDNF for Parkinson’s Disease

(2017) Sara Hernando et al.   MOLECULAR NEUROBIOLOGY

Hydroxyapatite Coated Iron Oxide Nanoparticles: A Promising Nanomaterial for Magnetic Hyperthermia Cancer Treatment

(2017) Sudip Mondal et al.   Nanomaterials

Survival Motor Neuron Protein is Released from Cells in Exosomes: A Potential Biomarker for Spinal Muscular Atrophy

(2017) Leslie A. Nash et al.   Scientific Reports

Elucidation of Exosome Migration Across the Blood–Brain Barrier Model In Vitro

(2016) Claire C. Chen et al.   Cellular and Molecular Bioengineering

Surface Glycoproteins of Exosomes Shed by Myeloid-Derived Suppressor Cells Contribute to Function

(2016) Sitara Chauhan et al.   JOURNAL OF PROTEOME RESEARCH

Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing

(2016) Marie-Cécile Didiot et al.   MOLECULAR THERAPY

From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery

(2016) William A. Banks   NATURE REVIEWS DRUG DISCOVERY

Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models

(2016) Lingzhi Zhao et al.   NEUROBIOLOGY OF AGING

Efficacy and biodistribution analysis of intracerebroventricular administration of an optimized scAAV9-SMN1 vector in a mouse model of spinal muscular atrophy

(2016) Nicole Armbruster et al.   Molecular Therapy-Methods & Clinical Development

Curcumin: A Natural Product for Diabetes and its Complications

(2015) Seyed Nabavi et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Internalization of targeted quantum dots by brain capillary endothelial cells in vivo

(2015) Sarah Paris-Robidas et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Safety and tolerability of intracerebroventricular PDGF-BB in Parkinson’s disease patients

(2015) Gesine Paul et al.   JOURNAL OF CLINICAL INVESTIGATION

Exosomes as drug delivery vehicles for Parkinson's disease therapy

(2015) Matthew J. Haney et al.   JOURNAL OF CONTROLLED RELEASE

Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio

(2015) Tianzhi Yang et al.   PHARMACEUTICAL RESEARCH

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

Molecular Effects of L-dopa Therapy in Parkinson’s Disease

(2014) Jolanta Dorszewska et al.   CURRENT GENOMICS

Safety of Ommaya reservoirs in children with brain tumors: a 20-year experience with 5472 intraventricular drug administrations in 98 patients

(2014) Andreas Peyrl et al.   JOURNAL OF NEURO-ONCOLOGY

Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice

(2014) J. Mark Cooper et al.   MOVEMENT DISORDERS

Choline transporter-targeting and co-delivery system for glioma therapy

(2013) Jianfeng Li et al.   BIOMATERIALS

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

IFNγ-stimulated dendritic cell exosomes as a potential therapeutic for remyelination

(2013) Aya D. Pusic et al.   JOURNAL OF NEUROIMMUNOLOGY

Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein

(2012) J. F. Nabhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Barrier Mechanisms in the Developing Brain

(2012) Norman R. Saunders et al.   Frontiers in Pharmacology

Modern methods for delivery of drugs across the blood–brain barrier

(2011) Yan Chen et al.   ADVANCED DRUG DELIVERY REVIEWS

Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

(2011) Bence György et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Molecular-weight-dependent, Anionic-substrate-preferential Transport of β-Lactam Antibiotics via Multidrug Resistance-associated Protein 4

(2011) Shin-ichi Akanuma et al.   Drug Metabolism and Pharmacokinetics

Bidirectional control of arteriole diameter by astrocytes

(2011) Grant R. J. Gordon et al.   EXPERIMENTAL PHYSIOLOGY

Comparative Permeabilities of the Paracellular and Transcellular Pathways of Corneal Endothelial Layers

(2011) Friedrich P. Diecke et al.   JOURNAL OF MEMBRANE BIOLOGY

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

(2011) Xiaoying Zhuang et al.   MOLECULAR THERAPY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Central nervous system pericytes in health and disease

(2011) Ethan A Winkler et al.   NATURE NEUROSCIENCE

Inconsistent blood brain barrier disruption by intraarterial mannitol in rabbits: implications for chemotherapy

(2010) Shailendra Joshi et al.   JOURNAL OF NEURO-ONCOLOGY

Exosomes: Extracellular organelles important in intercellular communication

(2010) Suresh Mathivanan et al.   Journal of Proteomics

Morphine Regulates Dopaminergic Neuron Differentiation via miR-133b

(2010) F. M. Sanchez-Simon et al.   MOLECULAR PHARMACOLOGY

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

(2010) Dongmei Sun et al.   MOLECULAR THERAPY

Approaches to transport therapeutic drugs across the blood–brain barrier to treat brain diseases

(2009) Reinhard Gabathuler   NEUROBIOLOGY OF DISEASE

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

AAV-Tau Mediates Pyramidal Neurodegeneration by Cell-Cycle Re-Entry without Neurofibrillary Tangle Formation in Wild-Type Mice

(2009) Tomasz Jaworski et al.   PLoS One

Involvement of Multidrug Resistance-Associated Protein 2 (Abcc2) in Molecular Weight-Dependent Biliary Excretion of  -Lactam Antibiotics

(2008) Y. Kato et al.   DRUG METABOLISM AND DISPOSITION

Identification and Species Similarity of OATP Transporters Responsible for Hepatic Uptake of β-Lactam Antibiotics

(2008) Masanori Nakakariya et al.   Drug Metabolism and Pharmacokinetics

Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood–brain barrier (BBB)

(2008) Karsten Ulbrich et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial

(2008) William J Marks et al.   LANCET NEUROLOGY

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON

Biologically active core/shell nanoparticles self-assembled from cholesterol-terminated PEG–TAT for drug delivery across the blood–brain barrier

(2007) Lihong Liu et al.   BIOMATERIALS