From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery

Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-β in Memory-Impaired Older Adults

(2017) Mark A. Reger et al.   JOURNAL OF ALZHEIMERS DISEASE

Testing the Neurovascular Hypothesis of Alzheimer's Disease: LRP-1 Antisense Reduces Blood-brain Barrier Clearance, Increases Brain Levels of Amyloid-β Protein, and Impairs Cognition

(2017) Laura B. Jaeger et al.   JOURNAL OF ALZHEIMERS DISEASE

The blood-brain barrier in neuroimmunology: Tales of separation and assimilation

(2015) W.A. Banks   BRAIN BEHAVIOR AND IMMUNITY

Phase 1 Safety, Tolerability and Pharmacokinetics of 3K3A-APC in Healthy Adult Volunteers

(2014) Patrick Lyden et al.   CURRENT PHARMACEUTICAL DESIGN

Role of P-Glycoprotein in Refractoriness of Seizures to Antiepileptic Drugs in Lennox-Gastaut Syndrome

(2014) Achal Kumar et al.   JOURNAL OF CHILD NEUROLOGY

Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle

(2014) Jens Niewoehner et al.   NEURON

Myristic acid conjugation of [D-Leu-4]-OB3, a biologically active leptin-related synthetic peptide amide, significantly improves its pharmacokinetic profile and efficacy

(2014) Zachary M. Novakovic et al.   PEPTIDES

Smuggling Drugs into the Brain: An Overview of Ligands Targeting Transcytosis for Drug Delivery across the Blood–Brain Barrier

(2014) Julia Georgieva et al.   Pharmaceutics

High glucose-induced mitochondrial respiration and reactive oxygen species in mouse cerebral pericytes is reversed by pharmacological inhibition of mitochondrial carbonic anhydrases: Implications for cerebral microvascular disease in diabetes

(2013) Gul N. Shah et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Immune activation of human brain microvascular endothelial cells inhibits HIV replication in macrophages

(2013) J. Li et al.   BLOOD

Loss of astrocytic leptin signaling worsens experimental autoimmune encephalomyelitis

(2013) Pramod K. Mishra et al.   BRAIN BEHAVIOR AND IMMUNITY

Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease

(2013) Susan A. Farr et al.   FREE RADICAL BIOLOGY AND MEDICINE

Blood–Brain Barrier Dysfunction as a Cause and Consequence of Alzheimer's Disease

(2013) Michelle A Erickson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Brain delivery of proteins via their fatty acid and block copolymer modifications

(2013) Xiang Yi et al.   JOURNAL OF DRUG TARGETING

Transporters of the blood–brain and blood–CSF interfaces in development and in the adult

(2013) Norman R. Saunders et al.   MOLECULAR ASPECTS OF MEDICINE

Effective Intravenous Therapy for Neurodegenerative Disease With a Therapeutic Enzyme and a Peptide That Mediates Delivery to the Brain

(2013) Yu Meng et al.   MOLECULAR THERAPY

Efficacy of verapamil as an adjunctive treatment in children with drug-resistant epilepsy: A pilot study

(2013) Francesco Nicita et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Pericyte loss influences Alzheimer-like neurodegeneration in mice

(2013) Abhay P. Sagare et al.   Nature Communications

Neuropathology of the blood–brain barrier and pharmaco-resistance in human epilepsy

(2012) Joan Y. W. Liu et al.   BRAIN

Pegylated granulocyte colony-stimulating factor conveys long-term neuroprotection and improves functional outcome in a model of Parkinson’s disease

(2012) Tobias Frank et al.   BRAIN

Deficiency in Mural Vascular Cells Coincides with Blood-Brain Barrier Disruption in Alzheimer's Disease

(2012) Jesse D. Sengillo et al.   BRAIN PATHOLOGY

Lipopolysaccharide-Induced Fever Depends on Prostaglandin E2 Production Specifically in Brain Endothelial Cells

(2012) Linda Engström et al.   ENDOCRINOLOGY

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Lipopolysaccharide impairs amyloid beta efflux from brain: altered vascular sequestration, cerebrospinal fluid reabsorption, peripheral clearance and transporter function at the blood–brain barrier

(2012) Michelle A Erickson et al.   Journal of Neuroinflammation

Turning point: Mark Lawrence

(2012) Alexandra Bell   NATURE

Human Immunodeficiency Virus-1 Uses the Mannose-6-Phosphate Receptor to Cross the Blood-Brain Barrier

(2012) Shinya Dohgu et al.   PLoS One

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Blood–brain barrier P-glycoprotein function in Alzheimer's disease

(2011) Daniëlle M. E. van Assema et al.   BRAIN

Brain Insulin Controls Adipose Tissue Lipolysis and Lipogenesis

(2011) Thomas Scherer et al.   Cell Metabolism

Topiramate Treatment Protects Blood-Brain Barrier Pericytes from Hyperglycemia-Induced Oxidative Damage in Diabetic Mice

(2011) Tulin O. Price et al.   ENDOCRINOLOGY

Cell-mediated drug delivery

(2011) Elena V Batrakova et al.   Expert Opinion on Drug Delivery

Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF

(2011) Shinya Dohgu et al.   Journal of Neuroinflammation

Neurovascular dysfunction, inflammation and endothelial activation: Implications for the pathogenesis of Alzheimer's disease

(2011) Paula Grammas   Journal of Neuroinflammation

A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-  Production in Vivo

(2011) J. K. Atwal et al.   Science Translational Medicine

Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

(2011) Y. J. Yu et al.   Science Translational Medicine

ABC efflux transporters in brain vasculature of Alzheimer's subjects

(2010) Hasini C. Wijesuriya et al.   BRAIN RESEARCH

Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: Implications for Aβ accumulation in AD brain

(2010) Joshua B. Owen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β-peptide elimination from the brain

(2010) Berislav V. Zlokovic et al.   JOURNAL OF NEUROCHEMISTRY

A Pharmacologically Active Monoclonal Antibody against the Human Melanocortin-4 Receptor: Effectiveness After Peripheral and Central Administration

(2010) J. C. Peter et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Restoring Blood-Brain Barrier P-Glycoprotein Reduces Brain Amyloid-  in a Mouse Model of Alzheimer's Disease

(2010) A. M. S. Hartz et al.   MOLECULAR PHARMACOLOGY

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

Targeting the neurovascular unit for treatment of neurological disorders

(2010) Reyna L. VanGilder et al.   PHARMACOLOGY & THERAPEUTICS

Investigation of the Influence of FcRn on the Distribution of IgG to the Brain

(2009) Amit Garg et al.   AAPS Journal

Targeting carbonic anhydrase to treat diabetic retinopathy: Emerging evidences and encouraging results

(2009) Zhang Weiwei et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Minimal penetration of lipopolysaccharide across the murine blood–brain barrier

(2009) William A. Banks et al.   BRAIN BEHAVIOR AND IMMUNITY

Pegylated Leptin Antagonist Is a Potent Orexigenic Agent: Preparation and Mechanism of Activity

(2009) Eran Elinav et al.   ENDOCRINOLOGY

Cessation of Blood-to-Brain Influx of Interleukin-15 during Development of EAE

(2009) Hung Hsuchou et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cutting Edge: Natalizumab Blocks Adhesion but Not Initial Contact of Human T Cells to the Blood-Brain Barrier In Vivo in an Animal Model of Multiple Sclerosis

(2009) Caroline Coisne et al.   JOURNAL OF IMMUNOLOGY

eNOS gene deletion restores blood-brain barrier integrity and attenuates neurodegeneration in the thiamine-deficient mouse brain

(2009) Élizabeth Beauchesne et al.   JOURNAL OF NEUROCHEMISTRY

Targeting the CNS to treat type 2 diabetes

(2009) Darleen A. Sandoval et al.   NATURE REVIEWS DRUG DISCOVERY

COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats

(2009) Erwin A. van Vliet et al.   NEUROPHARMACOLOGY

CNS Delivery Via Adsorptive Transcytosis

(2008) Françoise Hervé et al.   AAPS Journal

Neuroinflammation Activates Mdr1b Efflux Transport Through NFκB: Promoter Analysis in BBB Endothelia

(2008) Chuanhui Yu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Blood-Brain Barrier and Feeding: Regulatory Roles of Saturable Transport Systems for Ingestive Peptides

(2008) Abba Kastin et al.   CURRENT PHARMACEUTICAL DESIGN

Starvation and Triglycerides Reverse the Obesity-Induced Impairment of Insulin Transport at the Blood-Brain Barrier

(2008) Akihiko Urayama et al.   ENDOCRINOLOGY

Isolation of Peptide Transport System-6 from Brain Endothelial Cells: Therapeutic Effects with Antisense Inhibition in Alzheimer and Stroke Models

(2008) Dilek Dogrukol-Ak et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The effects of natalizumab on the innate and adaptive immune system in the central nervous system

(2008) Olaf Stüve   JOURNAL OF THE NEUROLOGICAL SCIENCES

Strategies to advance translational research into brain barriers

(2008) Edward Neuwelt et al.   LANCET NEUROLOGY

Effects of triglycerides, obesity, and starvation on ghrelin transport across the blood–brain barrier

(2008) William A. Banks et al.   PEPTIDES

Chemically modified  -glucuronidase crosses blood-brain barrier and clears neuronal storage in murine mucopolysaccharidosis VII

(2008) J. H. Grubb et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Body weight, plasma insulin, and coronary events with gemfibrozil in the Veterans Affairs High-Density Lipoprotein Intervention Trial (VA-HIT)

(2007) Sander J. Robins et al.   ATHEROSCLEROSIS