Patient-Derived Cancer Organoids as Predictors of Treatment Response

Author Correction: Establishment of patient-derived cancer organoids for drug-screening applications

(2021) Else Driehuis et al.   Nature Protocols

Modeling rectal cancer to advance neoadjuvant precision therapy

(2020) Harinarayanan Janakiraman et al.   INTERNATIONAL JOURNAL OF CANCER

Microengineered human blood–brain barrier platform for understanding nanoparticle transport mechanisms

(2020) Song Ih Ahn et al.   Nature Communications

Breast cancer organoids from a patient with giant papillary carcinoma as a high-fidelity model

(2020) Xuelu Li et al.   Cancer Cell International

Medium-throughput drug screening of patient-derived organoids from colorectal peritoneal metastases to direct personalized therapy

(2020) Vignesh Narasimhan et al.   CLINICAL CANCER RESEARCH

Patient-derived tumor organoid predicts drugs response in glioblastoma: A step forward in personalized cancer therapy?

(2020) Herbert H-F. Loong et al.   JOURNAL OF CLINICAL NEUROSCIENCE

An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity

(2020) Camilla Calandrini et al.   Nature Communications

Challenges in Establishing Pure Lung Cancer Organoids Limit Their Utility for Personalized Medicine

(2020) Krijn K. Dijkstra et al.   Cell Reports

Metabolic Heterogeneity in Patient Tumor-Derived Organoids by Primary Site and Drug Treatment

(2020) Joe T. Sharick et al.   Frontiers in Oncology

Patient-derived Organoid Pharmacotyping is a Clinically Tractable Strategy for Precision Medicine in Pancreatic Cancer

(2020) Toni T. Seppälä et al.   ANNALS OF SURGERY

Genomic characteristics and drug screening among organoids derived from non‐small cell lung cancer patients

(2020) Jing‐Hua Chen et al.   Thoracic Cancer

Patient-Derived Ovarian Cancer Organoids Mimic Clinical Response and Exhibit Heterogeneous Inter- and Intrapatient Drug Responses

(2020) Chris Jenske de Witte et al.   Cell Reports

Human Lung Adenocarcinoma-Derived Organoid Models for Drug Screening

(2020) Zhichao Li et al.   iScience

Rapid Processing and Drug Evaluation in Glioblastoma Patient-Derived Organoid Models with 4D Bioprinted Arrays

(2020) Michelle Chadwick et al.   iScience

Towards personalized induction therapy for esophageal adenocarcinoma: organoids derived from endoscopic biopsy recapitulate the pre-treatment tumor

(2020) Mathieu F. Derouet et al.   Scientific Reports

A Human Organoid Model of Aggressive Hepatoblastoma for Disease Modeling and Drug Testing

(2020) James A. Saltsman et al.   Cancers

Cancer-Associated Fibroblasts Provide a Stromal Niche for Liver Cancer Organoids That Confers Trophic Effects and Therapy Resistance

(2020) Jiaye Liu et al.   Cellular and Molecular Gastroenterology and Hepatology

Long‐term expanding human airway organoids for disease modeling

(2019) Norman Sachs et al.   EMBO JOURNAL

Heterogeneous pathway activation and drug response modelled in colorectal-tumor-derived 3D cultures

(2019) Dirk Schumacher et al.   PLoS Genetics

Mouse and human urothelial cancer organoids: A tool for bladder cancer research

(2019) Jasper Mullenders et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Establishing Pure Cancer Organoid Cultures: Identification, Selection and Verification of Cancer Phenotypes and Genotypes

(2019) Nina Wallaschek et al.   JOURNAL OF MOLECULAR BIOLOGY

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

(2019) Oded Kopper et al.   NATURE MEDICINE

Oral mucosal organoids as a potential platform for personalized cancer therapy

(2019) Else Driehuis et al.   Cancer Discovery

CFTR Expression Analysis for Subtyping of Human Pancreatic Cancer Organoids

(2019) Alexander Hennig et al.   Stem Cells International

Organoids from colorectal peritoneal metastases as a platform for improving hyperthermic intraperitoneal chemotherapy

(2019) I. Ubink et al.   BRITISH JOURNAL OF SURGERY

Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation

(2019) Cheri A. Pasch et al.   CLINICAL CANCER RESEARCH

Xenograft and organoid model systems in cancer research

(2019) Margit Bleijs et al.   EMBO JOURNAL

Pancreatic Cancer Organoids for Determining Sensitivity to Bromodomain and Extra-Terminal Inhibitors (BETi)

(2019) Benjamin Bian et al.   Frontiers in Oncology

Identification of Resistance Pathways Specific to Malignancy Using Organoid Models of Pancreatic Cancer

(2019) Mariano Ponz-Sarvise et al.   CLINICAL CANCER RESEARCH

Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening

(2019) Matteo Boretto et al.   NATURE CELL BIOLOGY

Patient-derived organoids as a potential model to predict response to PD-1/PD-L1 checkpoint inhibitors

(2019) Giosue Scognamiglio et al.   BRITISH JOURNAL OF CANCER

Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer

(2019) Ye Yao et al.   Cell Stem Cell

Malignant ascites-derived organoid (MADO) cultures for gastric cancer in vitro modelling and drug screening

(2019) Jie Li et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Plocabulin Displays Strong Cytotoxic Activity in a Personalized Colon Cancer Patient-Derived 3D Organoid Assay

(2019) Alba Costales-Carrera et al.   Marine Drugs

A rectal cancer organoid platform to study individual responses to chemoradiation

(2019) Karuna Ganesh et al.   NATURE MEDICINE

Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients

(2019) Salo N. Ooft et al.   Science Translational Medicine

Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening

(2019) Minsuh Kim et al.   Nature Communications

Patient-Derived Head and Neck Cancer Organoids Recapitulate EGFR Expression Levels of Respective Tissues and Are Responsive to EGFR-Targeted Photodynamic Therapy

(2019) Else Driehuis et al.   Journal of Clinical Medicine

A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity

(2019) Fadi Jacob et al.   CELL

A Subset of Colorectal Cancers with Cross-Sensitivity to Olaparib and Oxaliplatin

(2019) Sabrina Arena et al.   CLINICAL CANCER RESEARCH

Pancreatic cancer organoids recapitulate disease and allow personalized drug screening

(2019) Else Driehuis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of Patient-Derived Gastric Cancer Organoids from Endoscopic Biopsies and Surgical Tissues

(2018) Mei Gao et al.   ANNALS OF SURGICAL ONCOLOGY

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

(2018) Norman Sachs et al.   CELL

Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer

(2018) Suk Hyung Lee et al.   CELL

Human gastric cancer modelling using organoids

(2018) Therese Seidlitz et al.   GUT

Generation of human vascularized brain organoids

(2018) Missy T. Pham et al.   NEUROREPORT

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

(2018) Georgios Vlachogiannis et al.   SCIENCE

Colorectal cancer liver metastases organoids retain characteristics of original tumor and acquire chemotherapy resistance

(2018) Jon N. Buzzelli et al.   Stem Cell Research

Patient derived organoids to model rare prostate cancer phenotypes

(2018) Loredana Puca et al.   Nature Communications

Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening

(2018) Shurong Hou et al.   SLAS Discovery

Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids

(2018) Krijn K. Dijkstra et al.   CELL

Intra-tumour diversification in colorectal cancer at the single-cell level

(2018) Sophie F. Roerink et al.   NATURE

Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics

(2018) Xiaodun Li et al.   Nature Communications

A three-dimensional organoid model recapitulates tumorigenic aspects and drug responses of advanced human retinoblastoma

(2018) Duangporn Saengwimol et al.   Scientific Reports

Organoid Models of Human Liver Cancers Derived from Tumor Needle Biopsies

(2018) Sandro Nuciforo et al.   Cell Reports

Appendiceal Cancer Patient-Specific Tumor Organoid Model for Predicting Chemotherapy Efficacy Prior to Initiation of Treatment: A Feasibility Study

(2018) Konstantinos I. Votanopoulos et al.   ANNALS OF SURGICAL ONCOLOGY

Organoid Modeling of the Tumor Immune Microenvironment

(2018) James T. Neal et al.   CELL

A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening

(2018) Helen H.N. Yan et al.   Cell Stem Cell

Application of patient‐derived liver cancer cells for phenotypic characterization and therapeutic target identification

(2018) Darko Castven et al.   INTERNATIONAL JOURNAL OF CANCER

Head and neck cancer organoids established by modification of the CTOS method can be used to predict in vivo drug sensitivity

(2018) Noriaki Tanaka et al.   ORAL ONCOLOGY

The Use of Endometrial Cancer Patient–Derived Organoid Culture for Drug Sensitivity Testing Is Feasible

(2017) Eugenia Girda et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

(2017) Laura Broutier et al.   NATURE MEDICINE

Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine

(2017) Chantal Pauli et al.   Cancer Discovery

Effect of Selumetinib and MK-2206 vs Oxaliplatin and Fluorouracil in Patients With Metastatic Pancreatic Cancer After Prior Therapy

(2017) Vincent Chung et al.   JAMA Oncology

A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo

(2016) Christopher G. Hubert et al.   CANCER RESEARCH

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Designer matrices for intestinal stem cell and organoid culture

(2016) Nikolce Gjorevski et al.   NATURE

Large variety in a panel of human colon cancer organoids in response to EZH2 inhibition

(2016) Martijn AJ Koppens et al.   Oncotarget

Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening

(2016) Carla S Verissimo et al.   eLife

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids

(2015) Ling Huang et al.   NATURE MEDICINE

A role for cancer stem cells in therapy resistance: Cellular and molecular mechanisms

(2015) Monica Cojoc et al.   SEMINARS IN CANCER BIOLOGY

Organoid Cultures Derived from Patients with Advanced Prostate Cancer

(2014) Dong Gao et al.   CELL

Influence of tumour micro-environment heterogeneity on therapeutic response

(2013) Melissa R. Junttila et al.   NATURE

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE