COVID-19 and Alzheimer’s disease: how one crisis worsens the other

Neuroinvasion of SARS-CoV-2 in human and mouse brain

(2021) Eric Song et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structure analysis of the receptor binding of 2019-nCoV

(2020) Yun Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

(2020) Haibo Zhang et al.   INTENSIVE CARE MEDICINE

Emerging coronaviruses: Genome structure, replication, and pathogenesis

(2020) Yu Chen et al.   JOURNAL OF MEDICAL VIROLOGY

Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS

(2020) Yushun Wan et al.   JOURNAL OF VIROLOGY

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia

(2020) Qun Li et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

Host Calcium Channels and Pumps in Viral Infections

(2020) Xingjuan Chen et al.   Cells

Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations

(2020) Yanan Cao et al.   Cell Discovery

Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms

(2020) Abdul Mannan Baig et al.   ACS Chemical Neuroscience

Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses

(2020) Furong Qi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural basis for RNA replication by the SARS-CoV-2 polymerase

(2020) Quan Wang et al.   CELL

Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely correlated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients

(2020) Xiaohua Chen et al.   CLINICAL INFECTIOUS DISEASES

Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study

(2020) Jerome R. Lechien et al.   EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY

Prevalence of malnutrition and analysis of related factors in elderly patients with COVID-19 in Wuhan, China

(2020) Tao Li et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

(2020) Deepa R. J. Arachchillage et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

APOE e4 genotype predicts severe COVID-19 in the UK Biobank community cohort

(2020) Chia-Ling Kuo et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Dementia care during COVID-19

(2020) Huali Wang et al.   LANCET

Clinical and virologic characteristics of the first 12 patients with coronavirus disease 2019 (COVID-19) in the United States

(2020)   NATURE MEDICINE

Estimating clinical severity of COVID-19 from the transmission dynamics in Wuhan, China

(2020) Joseph T. Wu et al.   NATURE MEDICINE

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

(2020) Waradon Sungnak et al.   NATURE MEDICINE

Neurologic Features in Severe SARS-CoV-2 Infection

(2020) Julie Helms et al.   NEW ENGLAND JOURNAL OF MEDICINE

Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young

(2020) Thomas J. Oxley et al.   NEW ENGLAND JOURNAL OF MEDICINE

SARS-CoV-2 productively infects human gut enterocytes

(2020) Mart M. Lamers et al.   SCIENCE

Virology, Epidemiology, Pathogenesis, and Control of COVID-19

(2020) Yuefei Jin et al.   Viruses-Basel

Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China

(2020) Ling Mao et al.   JAMA Neurology

Modeling and Targeting Alzheimer’s Disease With Organoids

(2020) Angelos Papaspyropoulos et al.   Frontiers in Pharmacology

A Structural View of SARS-CoV-2 RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping

(2020) Maria Romano et al.   Cells

CNS Penetration Ability: A Critical Factor for Drugs in the Treatment of SARS-CoV-2 Brain Infection

(2020) Chhanda Charan Danta   ACS Chemical Neuroscience

Obesity and diabetes as high‐risk factors for severe coronavirus disease 2019 ( Covid ‐19)

(2020) Yue Zhou et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

The Another Side of COVID‐19 in Alzheimer’s Disease Patients: Drug‐Drug Interactions

(2020) Nisa Balli et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19)

(2020) W. Joost Wiersinga et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Neurobiology of COVID-19

(2020) Majid Fotuhi et al.   JOURNAL OF ALZHEIMERS DISEASE

Neurological diseases as mortality predictive factors for patients with COVID-19: a retrospective cohort study

(2020) Jong-moon Hwang et al.   NEUROLOGICAL SCIENCES

SARS, MERS and COVID-19: clinical manifestations and organ-system complications: a mini review

(2020) Jad Gerges Harb et al.   Pathogens and Disease

Associations of type 1 and type 2 diabetes with COVID-19-related mortality in England: a whole-population study

(2020) Emma Barron et al.   Lancet Diabetes & Endocrinology

Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia

(2020) David H. Brann et al.   Science Advances

Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium

(2020) Fadi Jacob et al.   Cell Stem Cell

Drugs targeting various stages of the SARS-CoV-2 life cycle: Exploring promising drugs for the treatment of Covid-19

(2020) Ramarao Poduri et al.   CELLULAR SIGNALLING

Fecal-oral transmission of SARS-CoV-2: review of laboratory-confirmed virus in gastrointestinal system

(2020) Dajana Cuicchi et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Cognitive Impairment Is a Common Comorbidity in Deceased COVID-19 Patients: A Hospital-Based Retrospective Cohort Study

(2020) Paloma Martín-Jiménez et al.   JOURNAL OF ALZHEIMERS DISEASE

Death Rate Due to COVID-19 in Alzheimer’s Disease and Frontotemporal Dementia

(2020) Jordi A. Matias-Guiu et al.   JOURNAL OF ALZHEIMERS DISEASE

Awareness of the COVID-19 Outbreak and Resultant Depressive Tendencies in Patients with Severe Alzheimer’s Disease

(2020) Akito Tsugawa et al.   JOURNAL OF ALZHEIMERS DISEASE

Molecular basis of the potential interaction of SARS-CoV-2 spike protein to CD147 in COVID-19 associated-lymphopenia

(2020) Mohamed A. Helal et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Neurobiochemical Cross-talk Between COVID-19 and Alzheimer’s Disease

(2020) Mohammad Azizur Rahman et al.   MOLECULAR NEUROBIOLOGY

Recognition of the coronavirus disease 2019 pandemic and face mask wearing in patients with Alzheimer's disease: an investigation at a medical centre for dementia in Japan

(2020) Ryota Kobayashi et al.   Psychogeriatrics

Histological Evidence for the Enteric Nervous System and the Choroid Plexus as Alternative Routes of Neuroinvasion by SARS-CoV2

(2020) Felix Deffner et al.   Frontiers in Neuroanatomy

Large-Scale Multi-omic Analysis of COVID-19 Severity

(2020) Katherine A. Overmyer et al.   Cell Systems

COVID-19 Epidemic in Argentina: Worsening of Behavioral Symptoms in Elderly Subjects With Dementia Living in the Community

(2020) Gabriela Cohen et al.   Frontiers in Psychiatry

The noncoding and coding transcriptional landscape of the peripheral immune response in patients with COVID‐19

(2020) Hao Tang et al.   Clinical and Translational Medicine

Aging in COVID-19: Vulnerability, immunity and intervention

(2020) Yiyin Chen et al.   AGEING RESEARCH REVIEWS

Neuroprotective immunity by essential nutrient “Choline” for the prevention of SARS CoV2 infections: An in silico study by molecular dynamics approach

(2020) Papia Chowdhury et al.   CHEMICAL PHYSICS LETTERS

Multi-route transmission potential of SARS-CoV-2 in healthcare facilities

(2020) Baihuan Feng et al.   JOURNAL OF HAZARDOUS MATERIALS

The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood–brain barrier

(2020) Tetyana P. Buzhdygan et al.   NEUROBIOLOGY OF DISEASE

Obesity, malnutrition, and trace element deficiency in the coronavirus disease (COVID-19) pandemic: An overview

(2020) Debora Fedele et al.   NUTRITION

Mapping community-level determinants of COVID-19 transmission in nursing homes: A multi-scale approach

(2020) Margaret M. Sugg et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Ginkgo biloba Extract (EGb761), Cholinesterase Inhibitors, and Memantine for the Treatment of Mild-to-Moderate Alzheimer’s Disease: A Network Meta-Analysis

(2019) Onnita Thancharoen et al.   DRUGS & AGING

Coronavirus envelope protein: current knowledge

(2019) Dewald Schoeman et al.   Virology Journal

Systemic inflammation impairs microglial Aβ clearance through NLRP 3 inflammasome

(2019) Dario Tejera et al.   EMBO JOURNAL

Glutaminase C Regulates Microglial Activation and Pro-inflammatory Exosome Release: Relevance to the Pathogenesis of Alzheimer’s Disease

(2019) Ge Gao et al.   Frontiers in Cellular Neuroscience

Theories of Aging and the Prevalence of Alzheimer’s Disease

(2019) Kaynara Trevisan et al.   Biomed Research International

Herpes simplex virus type 1 and Alzheimer’s disease: link and potential impact on treatment

(2019) Roberta Mancuso et al.   Expert Review of Anti-Infective Therapy

Apolipoprotein C1: Its Pleiotropic Effects in Lipid Metabolism and Beyond

(2019) Elena V. Fuior et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

HHV-6A infection dysregulates autophagy/UPR interplay increasing beta amyloid production and tau phosphorylation in astrocytoma cells as well as in primary neurons, possible molecular mechanisms linking viral infection to Alzheimer's disease

(2019) Maria Anele Romeo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System?

(2019) Marc Desforges et al.   Viruses-Basel

HHV-6A infection induces amyloid-beta expression and activation of microglial cells

(2019) Daria Bortolotti et al.   Alzheimers Research & Therapy

Alzheimer’s Disease Pharmacotherapy in Relation to Cholinergic System Involvement

(2019) Gabriela Dumitrita Stanciu et al.   Biomolecules

Aging and Alzheimer’s disease: Comparison and associations from molecular to system level

(2018) Xian Xia et al.   AGING CELL

Angiotensin 1-7 ameliorates 6-hydroxydopamine lesions in hemiparkinsonian rats through activation of MAS receptor/PI3K/Akt/BDNF pathway and inhibition of angiotensin II type-1 receptor/NF-κB axis

(2018) Mostafa A. Rabie et al.   BIOCHEMICAL PHARMACOLOGY

Viral Hypothesis and Antiviral Treatment in Alzheimer’s Disease

(2018) D. P. Devanand   Current Neurology and Neuroscience Reports

Medical Comorbidity in Alzheimer’s Disease: A Nested Case-Control Study

(2018) Jen-Hung Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Malnutrition Identified by Academy of Nutrition and Dietetics/American Society for Parenteral and Enteral Nutrition Is Associated With More 30-Day Readmissions, Greater Hospital Mortality, and Longer Hospital Stays: A Retrospective Analysis of Nutrition A

(2018) Lauren Hudson et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

IL-6 deficiency alters spatial memory in 4- and 24-month-old mice

(2018) Izabela Bialuk et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus

(2018) Ben Readhead et al.   NEURON

TISSUES 2.0: an integrative web resource on mammalian tissue expression

(2018) Oana Palasca et al.   Database-The Journal of Biological Databases and Curation

Molecular Mechanisms for Herpes Simplex Virus Type 1 Pathogenesis in Alzheimer’s Disease

(2018) Steven A. Harris et al.   Frontiers in Aging Neuroscience

Independent associations of TOMM40 and APOE variants with body mass index

(2018) Alexander M. Kulminski et al.   AGING CELL

Serum tumour necrosis factor-α and interleukin-6 levels in Alzheimer's disease and mild cognitive impairment

(2017) Yo Sup Kim et al.   Psychogeriatrics

Serum tumour necrosis factor-α and interleukin-6 levels in Alzheimer's disease and mild cognitive impairment

(2017) Yo Sup Kim et al.   Psychogeriatrics

Protective role of the apolipoprotein E2 allele in age-related disease traits and survival: evidence from the Long Life Family Study

(2016) Alexander M. Kulminski et al.   BIOGERONTOLOGY

Increased serum concentrations of transforming growth factor-β1 (TGF-β1) in patients with Guillain-Barré syndrome

(2016) Kuo-Hsuan Chang et al.   CLINICA CHIMICA ACTA

Nutritional Status of Patients with Alzheimer’s Disease and Their Caregivers

(2016) Mario Tombini et al.   JOURNAL OF ALZHEIMERS DISEASE

Microbes and Alzheimer’s Disease

(2016) Ruth F. Itzhaki et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Angiotensin-converting enzyme 2 is reduced in Alzheimer’s disease in association with increasing amyloid-β and tau pathology

(2016) Patrick Gavin Kehoe et al.   Alzheimers Research & Therapy

Structure, Function, and Evolution of Coronavirus Spike Proteins

(2016) Fang Li   Annual Review of Virology

Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

(2015) Celeste M. Karch et al.   BIOLOGICAL PSYCHIATRY

Posttraumatic Stress Disorder-Like Induction Elevates  -Amyloid Levels, Which Directly Activates Corticotropin-Releasing Factor Neurons to Exacerbate Stress Responses

(2015) N. J. Justice et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Angiotensin-(1-7) is Reduced and Inversely Correlates with Tau Hyperphosphorylation in Animal Models of Alzheimer’s Disease

(2015) Teng Jiang et al.   MOLECULAR NEUROBIOLOGY

Potential for primary prevention of Alzheimer's disease: an analysis of population-based data

(2014) Sam Norton et al.   LANCET NEUROLOGY

ACE2-Ang-(1-7)-Mas Axis in Brain: A Potential Target for Prevention and Treatment of Ischemic Stroke

(2013) Teng Jiang et al.   Current Neuropharmacology

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

(2013) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

The Adult Respiratory Distress Syndrome Cognitive Outcomes Study

(2012) Mark E. Mikkelsen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inflammation Induced by Infection Potentiates Tau Pathological Features in Transgenic Mice

(2011) Michael Sy et al.   AMERICAN JOURNAL OF PATHOLOGY

Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled study

(2011) Harvey Moldofsky et al.   BMC Neurology

Apolipoprotein E in Alzheimer's disease and other neurological disorders

(2011) Philip B Verghese et al.   LANCET NEUROLOGY

Soluble amyloid  -protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

(2011) M. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex- and brain region-specific acceleration of β-amyloidogenesis following behavioral stress in a mouse model of Alzheimer's disease

(2010) Latha Devi et al.   Molecular Brain

Chronic Cortical and Subcortical Pathology with Associated Neurological Deficits Ensuing Experimental Herpes Encephalitis

(2009) Anibal G. Armien et al.   BRAIN PATHOLOGY

Inflammation, microglia, and alzheimer's disease

(2009) Brent Cameron et al.   NEUROBIOLOGY OF DISEASE

Selective targeting of perivascular macrophages for clearance of  -amyloid in cerebral amyloid angiopathy

(2009) C. A. Hawkes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epidemiological Pathology of Dementia: Attributable-Risks at Death in the Medical Research Council Cognitive Function and Ageing Study

(2009) Fiona E. Matthews et al.   PLOS MEDICINE

Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques

(2008) MA Wozniak et al.   JOURNAL OF PATHOLOGY

Severe Acute Respiratory Syndrome Coronavirus Infection Causes Neuronal Death in the Absence of Encephalitis in Mice Transgenic for Human ACE2

(2008) J. Netland et al.   JOURNAL OF VIROLOGY

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Linking Calcium to Aβ and Alzheimer's Disease

(2008) Kim N. Green et al.   NEURON

Seropositivity to Herpes Simplex Virus Antibodies and Risk of Alzheimer's Disease: A Population-Based Cohort Study

(2008) Luc Letenneur et al.   PLoS One

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

(2008) Ilya Bezprozvanny et al.   TRENDS IN NEUROSCIENCES