Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer’s disease pathologies

Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression

(2020) Bing Bai et al.   NEURON

Longitudinal tau and metabolic PET imaging in relation to novel CSF tau measures in Alzheimer’s disease

(2019) Antoine Leuzy et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer’s disease pathologies

(2019) Jie Xiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decreased Netrin-1 and Correlated Th17/Tregs Balance Disorder in Aβ1–42 Induced Alzheimer’s Disease Model Rats

(2019) Lina Sun et al.   Frontiers in Aging Neuroscience

Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer’s Disease

(2019) Zhi-Hao Wang et al.   Cell Reports

Mechanism of Tau Hyperphosphorylation Involving Lysosomal Enzyme Asparagine Endopeptidase in a Mouse Model of Brain Ischemia

(2018) Gustavo Basurto-Islas et al.   JOURNAL OF ALZHEIMERS DISEASE

Key mechanisms underlying netrin-1 prevention of impaired spatial and object memory in Aβ1-42 CA1-injected rats

(2018) Elham Zamani et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer’s Disease

(2017) Zhi-Hao Wang et al.   MOLECULAR CELL

Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease

(2017) Zhentao Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease

(2017) Zhentao Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure and function of legumain in health and disease

(2016) Elfriede Dall et al.   BIOCHIMIE

Netrin-1 Interrupts Amyloid-β Amplification, Increases sAβPPα in vitro and in vivo, and Improves Cognition in a Mouse Model of Alzheimer’s Disease

(2016) Patricia R. Spilman et al.   JOURNAL OF ALZHEIMERS DISEASE

An Alzheimer Disease-linked Rare Mutation Potentiates Netrin Receptor Uncoordinated-5C-induced Signaling That Merges with Amyloid β Precursor Protein Signaling

(2016) Yuichi Hashimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Impact of UNC5C Genetic Variations on Neuroimaging in Alzheimer’s Disease

(2015) Jia-Hao Sun et al.   MOLECULAR NEUROBIOLOGY

Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease

(2015) Zhentao Zhang et al.   Nature Communications

Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage

(2014) Lixia Zhao et al.   CELL RESEARCH

A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death

(2014) Monica K Wetzel-Smith et al.   NATURE MEDICINE

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

(2014) Zhentao Zhang et al.   NATURE MEDICINE

Amyloid Precursor Protein Regulates Netrin-1-mediated Commissural Axon Outgrowth

(2012) Nicolas Rama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The UNC5C Netrin Receptor Regulates Dorsal Guidance of Mouse Hindbrain Axons

(2011) D. Kim et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's Disease: The Challenge of the Second Century

(2011) D. M. Holtzman et al.   Science Translational Medicine

Netrin-1 interacts with amyloid precursor protein and regulates amyloid-β production

(2009) F C Lourenço et al.   CELL DEATH AND DIFFERENTIATION

Netrin-1 and its dependence receptors as original targets for cancer therapy

(2009) Patrick Mehlen et al.   CURRENT OPINION IN ONCOLOGY

Netrin-1 acts as a survival factor for aggressive neuroblastoma

(2009) Céline Delloye-Bourgeois et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Netrin-1 up-regulation in inflammatory bowel diseases is required for colorectal cancer progression

(2009) A. Paradisi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Netrin-1: Diversity in development

(2008) DanaKai Bradford et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Neuroprotective Actions of PIKE-L by Inhibition of SET Proteolytic Degradation by Asparagine Endopeptidase

(2008) Zhixue Liu et al.   MOLECULAR CELL

Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B

(2008) Xiaoling Tang et al.   NATURE CELL BIOLOGY