Netrin-1 Interrupts Amyloid-β Amplification, Increases sAβPPα in vitro and in vivo, and Improves Cognition in a Mouse Model of Alzheimer’s Disease

Convection-enhanced delivery to the central nervous system

(2015) Russell R. Lonser et al.   JOURNAL OF NEUROSURGERY

Neuron-wide RNA transport combines with netrin-mediated local translation to spatially regulate the synaptic proteome

(2015) Sangmok Kim et al.   eLife

Nerve Growth Factor Gene Therapy

(2015) Mark H. Tuszynski et al.   JAMA Neurology

Brain metabolic dysfunction at the core of Alzheimer's disease

(2014) Suzanne M. de la Monte et al.   BIOCHEMICAL PHARMACOLOGY

Prion-like Mechanisms in Alzheimer's Disease

(2014) Rui-Hua Yin et al.   Current Alzheimer Research

Targeting TNF: a therapeutic strategy for Alzheimer's disease

(2014) Xin Cheng et al.   DRUG DISCOVERY TODAY

A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death

(2014) Monica K Wetzel-Smith et al.   NATURE MEDICINE

Spreading of amyloid-β peptides via neuritic cell-to-cell transfer is dependent on insufficient cellular clearance

(2014) Jakob Domert et al.   NEUROBIOLOGY OF DISEASE

IGF2 Ameliorates Amyloidosis, Increases Cholinergic Marker Expression and Raises BMP9 and Neurotrophin Levels in the Hippocampus of the APPswePS1dE9 Alzheimer’s Disease Model Mice

(2014) Tiffany J. Mellott et al.   PLoS One

In vitro aggregation assays for the characterization of α-synuclein prion-like properties

(2014) Joanna Narkiewicz et al.   Prion

Prion-like activity of Cu/Zn superoxide dismutase

(2014) Leslie I Grad et al.   Prion

Vascular cognitive impairment, dementia, aging and energy demand. A vicious cycle

(2013) A. Popa-Wagner et al.   JOURNAL OF NEURAL TRANSMISSION

Netrin-1 Promotes Excitatory Synaptogenesis between Cortical Neurons by Initiating Synapse Assembly

(2013) J. S. Goldman et al.   JOURNAL OF NEUROSCIENCE

Convection-enhanced delivery of AAV2 in white matter—A novel method for gene delivery to cerebral cortex

(2013) N.U. Barua et al.   JOURNAL OF NEUROSCIENCE METHODS

Monitoring of β-Amyloid Dynamics after Human Traumatic Brain Injury

(2013) Niklas Marklund et al.   JOURNAL OF NEUROTRAUMA

Prion, prionoids and infectious amyloid

(2013) Pawel P. Liberski   PARKINSONISM & RELATED DISORDERS

Amyloid Precursor Protein Regulates Netrin-1-mediated Commissural Axon Outgrowth

(2012) Nicolas Rama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Netrin-1 rescues neuron loss by attenuating secondary apoptosis in ipsilateral thalamic nucleus following focal cerebral infarction in hypertensive rats

(2012) S.-J. Liao et al.   NEUROSCIENCE

Traumatic brain injury: A risk factor for Alzheimer's disease

(2012) Thamil Mani Sivanandam et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Purified and synthetic Alzheimer's amyloid beta (A ) prions

(2012) J. Stohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation

(2012) Demian Obregon et al.   Nature Communications

The presence of Aβ seeds, and not age per se, is critical to the initiation of Aβ deposition in the brain

(2011) Tsuyoshi Hamaguchi et al.   ACTA NEUROPATHOLOGICA

Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles

(2011) Jing L. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Soluble A  Seeds Are Potent Inducers of Cerebral  -Amyloid Deposition

(2011) F. Langer et al.   JOURNAL OF NEUROSCIENCE

Prion-like acceleration of a synucleinopathy in a transgenic mouse model

(2011) Anne-Laure Mougenot et al.   NEUROBIOLOGY OF AGING

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

Soluble Beta-Amyloid Precursor Protein Is Related to Disease Progression in Amyotrophic Lateral Sclerosis

(2011) Petra Steinacker et al.   PLoS One

Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells

(2011) Christian Münch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual Role of α-Secretase Cleavage in the Regulation of γ-Secretase Activity for Amyloid Production

(2010) Yuan Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design of an in-dwelling cannula for convection-enhanced delivery

(2010) Kathryn H. Rosenbluth et al.   JOURNAL OF NEUROSCIENCE METHODS

Transsynaptic Progression of Amyloid-β-Induced Neuronal Dysfunction within the Entorhinal-Hippocampal Network

(2010) Julie A. Harris et al.   NEURON

Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein

(2009) Sun Ah Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Netrin-1 interacts with amyloid precursor protein and regulates amyloid-β production

(2009) F C Lourenço et al.   CELL DEATH AND DIFFERENTIATION

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

(2009) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependence

(2009) Dale E. Bredesen   Molecular Neurodegeneration

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

(2009) Anatoly Nikolaev et al.   NATURE

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

(2009) Alan H Nagahara et al.   NATURE MEDICINE

Induction of cerebral  -amyloidosis: Intracerebral versus systemic A  inoculation

(2009) Y. S. Eisele et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of Netrin-1 Induces Neovascularization in the Adult Mouse Brain

(2008) Yongfeng Fan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM