Senataxin: A New Guardian of the Female Germline Important for Delaying Ovarian Aging

Understanding oocyte ageing: can we influence the process as clinicians?

(2021) Hayden Anthony Homer   CURRENT OPINION IN OBSTETRICS & GYNECOLOGY

Mitochondrial Dysfunction and Ovarian Aging

(2020) Işıl Kasapoğlu et al.   ENDOCRINOLOGY

NAD+ Repletion Rescues Female Fertility during Reproductive Aging

(2020) Michael J. Bertoldo et al.   Cell Reports

Oocytes mount a noncanonical DNA damage response involving APC-Cdh1–mediated proteolysis

(2020) Goutham Narayanan Subramanian et al.   JOURNAL OF CELL BIOLOGY

Sirt1 sustains female fertility by slowing age‐related decline in oocyte quality required for post‐fertilization embryo development

(2020) Juvita D. Iljas et al.   AGING CELL

Nampt-mediated spindle sizing secures a post-anaphase increase in spindle speed required for extreme asymmetry

(2020) Zhe Wei et al.   Nature Communications

Premature ovarian ageing following heterozygous loss of Senataxin

(2020) G N Subramanian et al.   MOLECULAR HUMAN REPRODUCTION

Disruption of Spermatogenesis and Infertility in Ataxia with Oculomotor Apraxia Type 2 (AOA2)

(2019) Olivier J. Becherel et al.   CEREBELLUM

BRCA-related ATM-mediated DNA double-strand break repair and ovarian aging

(2019) Volkan Turan et al.   HUMAN REPRODUCTION UPDATE

The importance of DNA repair for maintaining oocyte quality in response to anti-cancer treatments, environmental toxins and maternal ageing

(2018) Amy L Winship et al.   HUMAN REPRODUCTION UPDATE

Oocyte DNA damage quality control requires consecutive interplay of CHK2 and CK1 to activate p63

(2018) Marcel Tuppi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Oocyte DNA damage quality control requires consecutive interplay of CHK2 and CK1 to activate p63

(2018) Marcel Tuppi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cdk1 inactivation induces post-anaphase-onset spindle migration and membrane protrusion required for extreme asymmetry in mouse oocytes

(2018) Zhe Wei et al.   Nature Communications

Regulation of chromosome segregation in oocytes and the cellular basis for female meiotic errors

(2017) Jessica Greaney et al.   HUMAN REPRODUCTION UPDATE

Senataxin: Genome Guardian at the Interface of Transcription and Neurodegeneration

(2017) Matthias Groh et al.   JOURNAL OF MOLECULAR BIOLOGY

DNA damage response during mouse oocyte maturation

(2016) Alexandra Mayer et al.   CELL CYCLE

Inhibitory phosphorylation of Cdk1 mediates prolonged prophase I arrest in female germ cells and is essential for female reproductive lifespan

(2016) Deepak Adhikari et al.   CELL RESEARCH

ESHRE Guideline: management of women with premature ovarian insufficiency

(2016)   HUMAN REPRODUCTION

Ovarian ageing: the role of mitochondria in oocytes and follicles

(2016) Pascale May-Panloup et al.   HUMAN REPRODUCTION UPDATE

Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging

(2015) Assaf Ben-Meir et al.   AGING CELL

DNA damage-induced metaphase I arrest is mediated by the spindle assembly checkpoint and maternal age

(2015) Petros Marangos et al.   Nature Communications

DNA damage induces a meiotic arrest in mouse oocytes mediated by the spindle assembly checkpoint

(2015) Josie K. Collins et al.   Nature Communications

Digital multiplexed mRNA analysis of functionally important genes in single human oocytes and correlation of changes in transcript levels with oocyte protein expression

(2014) Solon Riris et al.   FERTILITY AND STERILITY

Reversal of Female Infertility by Chk2 Ablation Reveals the Oocyte DNA Damage Checkpoint Pathway

(2014) E. Bolcun-Filas et al.   SCIENCE

The regulation of maturation promoting factor during prophase I arrest and meiotic entry in mammalian oocytes

(2013) Deepak Adhikari et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

SETX mutations are a frequent genetic cause of juvenile and adult onset cerebellar ataxia with neuropathy and elevated serum alpha-fetoprotein

(2013) Lorenzo Nanetti et al.   Orphanet Journal of Rare Diseases

The APC/C in female mammalian meiosis I

(2013) Hayden Homer   REPRODUCTION

Impairment of BRCA1-Related DNA Double-Strand Break Repair Leads to Ovarian Aging in Mice and Humans

(2013) S. Titus et al.   Science Translational Medicine

Senataxin Plays an Essential Role with DNA Damage Response Proteins in Meiotic Recombination and Gene Silencing

(2013) Olivier J. Becherel et al.   PLoS Genetics

The DNA damage response in mammalian oocytes

(2013) John Carroll et al.   Frontiers in Genetics

Oocytes Progress beyond Prophase in the Presence of DNA Damage

(2012) Petros Marangos et al.   CURRENT BIOLOGY

DNA Damage-Induced Primordial Follicle Oocyte Apoptosis and Loss of Fertility Require TAp63-Mediated Induction of Puma and Noxa

(2012) Jeffrey B. Kerr et al.   MOLECULAR CELL

New Insights into the Genetic Regulation of Homologue Disjunction in Mammalian Oocytes

(2011) H. Homer   CYTOGENETIC AND GENOME RESEARCH

The APC/C activator FZR1 coordinates the timing of meiotic resumption during prophase I arrest in mammalian oocytes

(2011) J. E. Holt et al.   DEVELOPMENT

Defining ovarian reserve to better understand ovarian aging

(2011) Norbert Gleicher et al.   Reproductive Biology and Endocrinology

Oxidative Damage Increases and Antioxidant Gene Expression Decreases with Aging in the Mouse Ovary

(2010) J. Lim et al.   BIOLOGY OF REPRODUCTION

Understanding follicle growth in vivo

(2010) O. Oktem et al.   HUMAN REPRODUCTION

Portrait of an oocyte: our obscure origin

(2010) Roger Gosden et al.   JOURNAL OF CLINICAL INVESTIGATION

Prophase I arrest and progression to metaphase I in mouse oocytes: comparison of resumption of meiosis and recovery from G2-arrest in somatic cells

(2010) P. Solc et al.   MOLECULAR HUMAN REPRODUCTION

Human Ovarian Reserve from Conception to the Menopause

(2010) W. Hamish B. Wallace et al.   PLoS One

Ataxia with oculomotor apraxia type 2: clinical, biological and genotype/phenotype correlation study of a cohort of 90 patients

(2009) M. Anheim et al.   BRAIN

Aberrant Splicing of the Senataxin Gene in a Patient with Ataxia with Oculomotor Apraxia Type 2

(2009) Brent L. Fogel et al.   CEREBELLUM

Sensorimotor neuronopathy in ataxia with oculomotor apraxia type 2

(2009) José Gazulla et al.   MUSCLE & NERVE

Inhibition of the c-Abl–TAp63 pathway protects mouse oocytes from chemotherapy-induced death

(2009) Stefania Gonfloni et al.   NATURE MEDICINE

Age-associated increase in aneuploidy and changes in gene expression in mouse eggs

(2008) Hua Pan et al.   DEVELOPMENTAL BIOLOGY