A Comprehensive Evaluation of the Relationship Between Different IgG and IgA Anti-Modified Protein Autoantibodies in Rheumatoid Arthritis

Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications

(2020) T Kissel et al.   ANNALS OF THE RHEUMATIC DISEASES

IgA subclasses have different effector functions associated with distinct glycosylation profiles

(2020) Ulrike Steffen et al.   Nature Communications

Different hierarchies of anti‐modified protein autoantibody reactivities in rheumatoid arthritis

(2020) Peter Sahlström et al.   Arthritis & Rheumatology

Autoantibodies to Malondialdehyde-Acetaldehyde Are Detected Prior to Rheumatoid Arthritis Diagnosis and After Other Disease Specific Autoantibodies

(2020) Ted R. Mikuls et al.   Arthritis & Rheumatology

Differential ACPA Binding to Nuclear Antigens Reveals a PAD-Independent Pathway and a Distinct Subset of Acetylation Cross-Reactive Autoantibodies in Rheumatoid Arthritis

(2019) Katy A. Lloyd et al.   Frontiers in Immunology

Affinity Maturation of the Anti–Citrullinated Protein Antibody Paratope Drives Epitope Spreading and Polyreactivity in Rheumatoid Arthritis

(2019) Sarah Kongpachith et al.   Arthritis & Rheumatology

Smoking, HLA-genes and serology in rheumatoid arthritis; complex relationships investigated in the Swedish EIRA case-control study

(2019) Anna Karin Hedström et al.   Arthritis & Rheumatology

Citrullination Controls Dendritic Cell Transdifferentiation into Osteoclasts

(2019) Akilan Krishnamurthy et al.   JOURNAL OF IMMUNOLOGY

Different classes of anti-modified protein antibodies are induced on exposure to antigens expressing only one type of modification

(2019) Arieke Suzanna Berendina Kampstra et al.   ANNALS OF THE RHEUMATIC DISEASES

Anticitrullinated protein antibodies facilitate migration of synovial tissue-derived fibroblasts

(2019) Meng Sun et al.   ANNALS OF THE RHEUMATIC DISEASES

Shared epitope defines distinct associations of cigarette smoking with levels of anticitrullinated protein antibody and rheumatoid factor

(2019) Yuki Ishikawa et al.   ANNALS OF THE RHEUMATIC DISEASES

Disordered Antigens and Epitope Overlap Between Anti‐Citrullinated Protein Antibodies and Rheumatoid Factor in Rheumatoid Arthritis

(2019) Zihao Zheng et al.   Arthritis & Rheumatology

Timing of elevations of autoantibody isotypes in rheumatoid arthritis prior to disease diagnosis

(2019) Lindsay B. Kelmenson et al.   Arthritis & Rheumatology

Rheumatoid arthritis patients display B-cell dysregulation already in the naïve repertoire consistent with defects in B-cell tolerance

(2019) Yan Wang et al.   Scientific Reports

Variable domain N-linked glycosylation and negative surface charge are key features of monoclonal ACPA: Implications for B-cell selection

(2018) Katy A. Lloyd et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Malondialdehyde–acetaldehyde antibody concentrations in rheumatoid arthritis and other rheumatic conditions

(2018) Ted R. Mikuls et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The combination of three autoantibodies, ACPA, RF and anti-CarP antibodies is highly specific for rheumatoid arthritis: implications for very early identification of individuals at risk to develop rheumatoid arthritis

(2018) Marije K. Verheul et al.   Arthritis & Rheumatology

Pathogenic citrulline-multispecific B cell receptor clades in rheumatoid arthritis

(2018) Philip J Titcombe et al.   Arthritis & Rheumatology

Affinity Maturation Drives Epitope Spreading and Generation of Pro-inflammatory Anti-Citrullinated Protein Antibodies in Rheumatoid Arthritis

(2018) Serra E. Elliott et al.   Arthritis & Rheumatology

Human plasma cell derived monoclonal antibodies to post-translationally modified proteins recognize amino acid motifs rather than specific proteins

(2018) Johanna Steen et al.   Arthritis & Rheumatology

Generation and characterization of anti-citrullinated protein antibody-producing B-cell clones from rheumatoid arthritis patients

(2018) Kristine Germar et al.   Arthritis & Rheumatology

Autoreactivity to malondialdehyde-modifications in rheumatoid arthritis is linked to disease activity and synovial pathogenesis

(2017) Caroline Grönwall et al.   JOURNAL OF AUTOIMMUNITY

Brief Report: Anti-Carbamylated Protein Antibodies in Rheumatoid Arthritis Patients Are Reactive With Specific Epitopes of the Human Fibrinogen β-Chain

(2017) Jonathan D. Jones et al.   Arthritis & Rheumatology

Antimodified protein antibody response pattern influences the risk for disease relapse in patients with rheumatoid arthritis tapering disease modifying antirheumatic drugs

(2016) Camille P Figueiredo et al.   ANNALS OF THE RHEUMATIC DISEASES

Modulation of natural IgM autoantibodies to oxidative stress-related neo-epitopes on apoptotic cells in newborns of mothers with anti-Ro autoimmunity

(2016) Caroline Grönwall et al.   JOURNAL OF AUTOIMMUNITY

Correction: Lineage tracing of human B cells reveals the in vivo landscape of human antibody class switching

(2016) Felix Horns et al.   eLife

Elevated IgA Plasmablast Levels in Subjects at Risk of Developing Rheumatoid Arthritis

(2016) Jennifer D. Kinslow et al.   Arthritis & Rheumatology

Autoantibodies against Modified Histone Peptides in SLE Patients Are Associated with Disease Activity and Lupus Nephritis

(2016) Jürgen Dieker et al.   PLoS One

Identification of novel antiacetylated vimentin antibodies in patients with early inflammatory arthritis

(2015) Maria Juarez et al.   ANNALS OF THE RHEUMATIC DISEASES

Autoantibodies to citrullinated proteins induce joint pain independent of inflammation via a chemokine-dependent mechanism

(2015) Gustaf Wigerblad et al.   ANNALS OF THE RHEUMATIC DISEASES

Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss

(2015) Akilan Krishnamurthy et al.   ANNALS OF THE RHEUMATIC DISEASES

Protein Arginine Deiminases and Associated Citrullination: Physiological Functions and Diseases Associated with Dysregulation

(2015) Erin Witalison et al.   CURRENT DRUG TARGETS

Mechanisms involved in triggering rheumatoid arthritis

(2015) Anca I. Catrina et al.   IMMUNOLOGICAL REVIEWS

Anti-carbamylated Protein Antibodies Are Present Prior to Rheumatoid Arthritis and Are Associated with Its Future Diagnosis

(2015) R. W. Gan et al.   JOURNAL OF RHEUMATOLOGY

Associations With Smoking and Shared Epitope Differ Between IgA- and IgG-Class Antibodies to Cyclic Citrullinated Peptides in Early Rheumatoid Arthritis

(2015) Anna Svärd et al.   Arthritis & Rheumatology

Malondialdehyde-Acetaldehyde Adducts and Anti-Malondialdehyde-Acetaldehyde Antibodies in Rheumatoid Arthritis

(2015) Geoffrey M. Thiele et al.   Arthritis & Rheumatology

Local Joint Inflammation and Histone Citrullination in a Murine Model of the Transition From Preclinical Autoimmunity to Inflammatory Arthritis

(2015) Dong Hyun Sohn et al.   Arthritis & Rheumatology

Fine Mapping Seronegative and Seropositive Rheumatoid Arthritis to Shared and Distinct HLA Alleles by Adjusting for the Effects of Heterogeneity

(2014) Buhm Han et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Anti-CarP antibodies in two large cohorts of patients with rheumatoid arthritis and their relationship to genetic risk factors, cigarette smoking and other autoantibodies

(2014) Xia Jiang et al.   ANNALS OF THE RHEUMATIC DISEASES

IgM rheumatoid factor amplifies the inflammatory response of macrophages induced by the rheumatoid arthritis-specific immune complexes containing anticitrullinated protein antibodies

(2014) Lætitia Laurent et al.   ANNALS OF THE RHEUMATIC DISEASES

Acetylated histones contribute to the immunostimulatory potential of neutrophil extracellular traps in systemic lupus erythematosus

(2014) E. Pieterse et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

IgA measurements in over 12 000 Swedish twins reveal sex differential heritability and regulatory locus near CD30L

(2014) Alexander Viktorin et al.   HUMAN MOLECULAR GENETICS

Antihomocitrullinated Fibrinogen Antibodies are Specific to Rheumatoid Arthritis and Frequently Bind Citrullinated Proteins/peptides

(2014) M. Scinocca et al.   JOURNAL OF RHEUMATOLOGY

Identification of anticitrullinated protein antibody reactivities in a subset of anti-CCP-negative rheumatoid arthritis: association with cigarette smoking and HLA-DRB1 ‘shared epitope’ alleles

(2013) Catriona A Wagner et al.   ANNALS OF THE RHEUMATIC DISEASES

Natural antibodies of newborns recognize oxidative stress-related malondialdehyde acetaldehyde adducts on apoptotic cells and atherosclerotic plaques

(2013) Chunguang Wang et al.   INTERNATIONAL IMMUNOLOGY

Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile

(2012) Karin Lundberg et al.   ANNALS OF THE RHEUMATIC DISEASES

Brief Report: Anti-Carbamylated Protein Antibodies Are Present in Arthralgia Patients and Predict the Development of Rheumatoid Arthritis

(2012) Jing Shi et al.   ARTHRITIS AND RHEUMATISM

Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin

(2012) Ulrike Harre et al.   JOURNAL OF CLINICAL INVESTIGATION

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis

(2012) Soumya Raychaudhuri et al.   NATURE GENETICS

Autoantibody Epitope Spreading in the Pre-Clinical Phase Predicts Progression to Rheumatoid Arthritis

(2012) Jeremy Sokolove et al.   PLoS One

Monoclonal anti-citrullinated protein antibodies selected on citrullinated fibrinogen have distinct targets with different cross-reactivity patterns

(2012) L. A. van de Stadt et al.   RHEUMATOLOGY

Validation of a multiplex chip-based assay for the detection of autoantibodies against citrullinated peptides

(2012) Monika Hansson et al.   ARTHRITIS RESEARCH & THERAPY

Protective Roles of Natural IgM Antibodies

(2012) Caroline Grönwall et al.   Frontiers in Immunology

Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage

(2011) J. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis

(2010) D. van der Woude et al.   ANNALS OF THE RHEUMATIC DISEASES

A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis

(2010) L. Padyukov et al.   ANNALS OF THE RHEUMATIC DISEASES

Anticitrulline antibodies can be caused by homocitrulline-containing proteins in rabbits

(2010) Sanna Turunen et al.   ARTHRITIS AND RHEUMATISM

Immune complexes containing citrullinated fibrinogen costimulate macrophages via Toll-like receptor 4 and Fcγ receptor

(2010) Jeremy Sokolove et al.   ARTHRITIS AND RHEUMATISM

Patients with early rheumatoid arthritis who smoke are less likely to respond to treatment with methotrexate and tumor necrosis factor inhibitors: Observations from the Epidemiological Investigation of Rheumatoid Arthritis and the Swedish Rheumatology Reg

(2010) Saedis Saevarsdottir et al.   ARTHRITIS AND RHEUMATISM

2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative

(2010) Daniel Aletaha et al.   ARTHRITIS AND RHEUMATISM

Malondialdehyde–acetaldehyde adduct is the dominant epitope after MDA modification of proteins in atherosclerosis

(2010) Michael J. Duryee et al.   FREE RADICAL BIOLOGY AND MEDICINE

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans

(2009) Meng-Yun Chou et al.   JOURNAL OF CLINICAL INVESTIGATION

Induction of macrophage secretion of tumor necrosis factor α through Fcγ receptor IIa engagement by rheumatoid arthritis–specific autoantibodies to citrullinated proteins complexed with fibrinogen

(2008) Cyril Clavel et al.   ARTHRITIS AND RHEUMATISM

Antibodies to citrullinated α-enolase peptide 1 are specific for rheumatoid arthritis and cross-react with bacterial enolase

(2008) Karin Lundberg et al.   ARTHRITIS AND RHEUMATISM

IgG1 and IgG4 are the predominant subclasses among auto-antibodies against two citrullinated antigens in RA

(2008) R. Engelmann et al.   RHEUMATOLOGY